Title: Clinical application of glargine in elderly severe patients with abnormal blood glucose
Abstract: Objective To compare the efficacy and safety between glargine and insulin pump in treatment of elderly severe patients with abnormal blood glucose.Methods 44 elderly severe patients with glucose abnormalities hospitalized from 2008 to 2009 were divided into glargine group and insulin pump therapy group.According to blood glucose level,the glargine group could be combined with short-acting insulin,the insulin pump group was given or not given large doses before meals.The two groups could be combined with oral hypoglycemic drugs.Results There was no significant difference in the average age,fasting glucose,average blood glucose and coefficient of variation before treatment.After 10d treatment,fasting glucose[(6.50±1.01)mmol/L,(6.02±1.05) mmol/L,respectively],average blood glucose[(7.37±0.63) mmol/L,(7.12±0.62) mmol/L,respectively] and coefficient of variation[(39.5±12.7)%,(43.2±12.8)%,respectively] decreased significantly in the two groups compared with before treatment.There was no significant difference between the two groups(P0.05).The average blood glucose decline rate in the insulin pump group(37.8± 10.3) % was slightly higher than that in the insulin glargine group(35.7±9.5)%,but not statistically significant(P0.05).The frequency of hypoglycemia was similar.Both groups did not observe severe hypoglycemia events.Conclusion The efficacy and safety of insulin glargine and insulin pump in the treatment of the elderly severe patients with abnormal blood glucose are well-matched.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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