Title: Effect of losartan on part vascular active peptides in patients with hypertension
Abstract: AIM: To investigate the effect of losartan on blood pressure, vascular active peptides in patients with essential hypertension. METHODS: Forty seven patients with mild to moderate essential hypertensive patients were given 50 100 mg of losartan once daily for 4 wk. The blood pressure was measured every morning during treatment. At the same time, the serum levels of angiotensin Ⅱ(Ang Ⅱ), endothelins(ET), atrial natriuretic factor(ANF), and calcitonin generelated peptide(CGRP) were measured before and after therapy. RESULTS: Losartan significantly reduced both systolic and diastolic blood pressure SBP(22.0± s 2.4) kPa vs (19.9± 2.4 )kPa, P 0.01;DBP(13.4±1.2) kPa vs (12.4±1.4 ) kPa, P 0.01. Ang II and CGRP were increased respectively, (103±50) ng·L -1 vs (150±85) ng·L -1 , P 0.01;(30±17) ng·L -1 vs (45±18) ng·L -1 , P 0.01) ,while ANF decreased after therapy in patients with hypertension (275±17 )ng·L -1 vs (186±7) ng·L -1 , P 0.01. There were no significantly changes in ET. CONCLUSION: Losartan can lower hypertension persistently and smoothly. Losartan can also affect the unusual excretion of part vascular active peptides in patients with essential hypertension.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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