Title: Study on Synthesis of 3-Chloro-2-nitrophenylacetonitrile
Abstract: Tert-butyl 2-cyano-2(3-chloro-2-nitrophenyl)acetate was prepared from 2,6-dichloronitrobenzene and tert-butyl cyanoacetate.3-chloro-2-nitro benzyl cyanide was further synthesized using tert-butyl 2-cyano-2(3-chloro-2-nitrophenyl) acetate as raw material and paratoluenesulfonic acid as catalyst by decarboxylic reaction.The effects of feed composition,reaction temperature and reaction time on the yield of 3-chloro-2-niro benzyl cyanide were investigated.The optimized conditions was: n[tert-butyl 2-cyano-2(3-chloro-2-nitrophenyl) acetate]∶n(paratoluenesulfonic acid)=1∶0.075;temperature,100°C;and reaction time,2 h.The yield of 3-chloro-2-nitro benzyl cyanide reached 89.3%.The product was characterized by IR,()~1H NMR and MS.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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