Title: Breast secretory carcinoma:Clinicopathological and immunohistochemical studies
Abstract: Purpose To study the clinicopathological,immunohistochemical,and special staining features of breast secretory carcinoma(BSC),and to discuss the association of them with the biological behavior.Methods Three cases of breast secretory carcinoma were collected from the archival materials from 1988 to 2005 and analyzed with review of clinical data and HE slides.Special staining of mucin carmine(MC),periodic-acid-Schiff reaction(PAS)with and without diastase pretreatment and Alcian blue(AB),immunohistochemical staining of ER,PR,Ki-67,p53,p63,c-erbB-2,S-100,CK7,SMA,CK1/3,EMA,CEA and CK34βE12 by ABC method were performed.Results BSC accounted for only 0.36%(3/842)of all breast carcinoma in the same period.The average age was 48.7 years with range of 38~59.They were characterized by mild atypia of carcinoma cells,prominent microcystic architecture and much secretory material in the cytoplasm and cysts positive for PAS,AB and mucin carmine staining.We also found that signet ring cell and some high columnar glandular pattern,as well as diffuse hyaline degeneration and collagen sclerotic scar formation after atrophy and disappearance of cancer cells,which suggested the characteristics of high secretion activity and relatively indolent growth pattern.Although negative or only focal positive reaction to ER,PR,the complete negative or only focal and mild positive to the prognosis associated genes of p53 and c-erbB-2,as well as the low proliferation index of 6.3% by Ki-67,it may be related to the relatively good histology and better prognosis.No positive lymphatic node was observed.Conclusions BSC is a rare tumor and may occur in middle-aged and old women.The aggressiveness and metastatic potential are relatively low and it therefore has better prognosis.By histological pattern,assisted by histochemical and immunohistochemical features,definite pathological diagnosis could be made.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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