Title: Comparative use of butorphanol and fentanyl for gerneral anaesthesia in short-time operation
Abstract: Objective To evaluate the clinical effect and safety of butorphanol induced general anesthesia in short-time operation against the fentanyl induced one.Methods Forty patients,with ASA grades Ⅰ and Ⅱ,diagnosed to have polyp of vocal cord for extirpation,were randomly divided into 2 groups of 20 each: butorphanol group(group B) and fentanyl group(group F).Anesthesia was induced with butorphanol(20 μg·kg-1) in group B and with fentanyl(5μg·kg-1) in group F.Four min later,intravenous propofol(2 mg·kg-1) and anectine(1.5 mg·kg-1) were given to intubate the trachea and start mechanical ventilation.The anesthesia was then maintained with intravenous propofol,remifentanil and anectine during the operation.The heart rate(HR),mean arterial blood pressure(MAP),respiratory rate(RR),saturation of pulse oxygen(SpO2) and adverse effects were noticed before and during the operation and after the extubation.The quality of analgesia and sedation was scored after extubation,with the time of extubation put down.Results There were no significant changes in RR and SpO2 in group B after the intravenous butorphanol and the operation(P0.05).But the RR dropped significantly in group F after intravenous fentanyl and the operation(P0.05),so the time of extubation had to be postponed.The MAP and HR were not altered in group B,but the HR dropped markedly in group F(P0.05).The VAS value after extubation was significantly lower in group B than in group F(P0.05).The adverse gagging,bucking,shivering and respiratory depression were significantly less marked in group B than in group F(P0.05).Conclusion It is safe and feasible to use butorphanol(20 μg·kg-1) to perform general anesthesia for short-time operation,with lower incidence of side effects.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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