Title: Optimal dose of sufentanil combined with sevoflurane for general anesthesia induction in the absence muscle relaxant
Abstract: Objective To explore the optimal dose of sufentanil combined with sevoflurane in the absence of muscle relaxant during general anesthesia induction.Methods A total of 120 patients undergoing elective laparoscopic oophorocystectomy were randomly divided into 4 groups with 30 cases each. The anesthesia was induced with sevoflurane and 0.2,0.3,0.4,0.5 μg/kg sufentanil(S1,S2,S3,S4 group). Mean arterial pressure (MAP) and heart rate (HR) were measured at baseline (T0),before intubation (T1),1,3,5,10 min after intubation (T2-6),at the end of surgery (T7),and 1 min before extubation (T8). Intubation scores were also recorded. Results The intubation scores were as the following sequence:S4 S3 S2 S1 (P0.05). Compared with T0,MAP and HR decreased in each group at T1 while increased at T2,8 in group S1(P 0.05). Compared with group S1,MAP was lower at T4-6,8 in groups S2-4 (P 0.05). Compared with group S2,MAP was lower at T2-6 in groups S3,4 (P 0.05). The consumption of ephedrine and atropine was more in group S4 than group S3 (P 0.05). Conclusion Sufentanil 0.4 μg/kg combined with sevoflurane without muscle relaxant can provide excellent intubating conditions and stable hemodynamics during anesthesia induction in patients undergoing gynecologic surgery.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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