Title: Relation of COX-2 expression and its inhibitor with angiogenesis and lymphangiogenesis in colorectal adenocarcinoma
Abstract: Objective To investigate the relationships among the expression of cyclooxygenase-2(COX-2),microvessel density(MVD) and lymphatic vessel density(LVD) in colorectal adenocarcinoma and to explore the antitumor effects of COX-2 specific inhibitor celecoxib.Methods The expressions of COX-2,MVD and LVD were studied by immunohistochemistry in 64 cases of colorectal adenocarcinomas,and the relationships among COX-2,MVD ,LVD and the clinicopathological characteristics were analyzed.Seven cases of advanced colorectal cancer whose tumor could not be removed,were treated with celecoxib enema twice a day for fifteen days,the changes of LVD and MVD were evaluated.Results The expression of COX-2 was correlated with tumor stage(P=0.003) and histological type(P=0.004) in colorectal carcinoma.MVD and LVD in COX-2 strong expression group were higher than those in COX-2 weak expression group(P0.05).Treatment of celecoxib enema could reduce MVD but not LVD in colorectal carcinoma.Conclusion COX-2 may be involved in the tumor formation and development of colorectal adenocarcinoma through promotion of angiogenesis and lymphangiogenesis.Celecoxib enema might suppress angiogenesis in colorectal adenocarcinoma.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot