Title: Four tumor markers for diagnoing colorectal cancer
Abstract: Objectives To evaluate the application of four tumor markers in diagnosing colorectal cancer and use their appropriate combination to raise the sensitivity and validity in detecting the cancer.Methods CEA and CA19 9 were detected by microparticle enzyme immunoassay. CA72 4 and CA242 were detected by sandwich assay using streptavidin technology. 29 healthy adults and 58 patients with colorectal cancer (Dukes′ stage) were detected.Results In the healthy group, CEA, CA19 9, CA72 4 and CA242 were (2.1±1.7) μg/L, 9.9± 9.0×10 3 U/L, (4.6±2.1)×10 3 U/L, (7.5±5.5)×10 3 U/L, respectively. The level of the four tumor markers in patients with colorectal cancer (Dukes′ Ⅱ, Ⅲ, Ⅳ) was higher in the patients than in the healthy group ( P 0.05). Before operation, CEA, CA19 9, CA72 4, and CA242 were (34.2±78.7) μg/L, (209.5± 736.8)×10 3 U/L, (7.2±4.8)×10 3 U/L, (110.6±179.0)×10 3 U/L, respectively. After operation, a marked decrease in these values was observed ( P 0.05). The sensitivity of 2, 7, 9, 11 groups was 62.1%, 65.5%, 67.2%, and 69.0%, respectively. They were higher than those of the single tumor marker ( P 0.05). Conclusion The four tumor markers are of value in detecting colorectal cancer. Combined CEA and CA72 4 is more economic than others.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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