Title: The efficacy and toxicities of cisplatin chemotherapy intraperitoneal infusion plus CTX in treatment of advanced epithelial ovarian cancer
Abstract: OBJECTIVE To study the efficacy and toxicities of intraperitoneal infusion plus CTX in treatment of advanced epithelial ovarian cancer.METHODS Resrospective analysis was utilized to analyze the clinical materials of 43 cases of advanced epithelial ovarian cancer in our hospital from June 2000 to June 2005.They were all recerived cisplatin chemotherapy intraperitoneal infusion plus ctx each 3~4weeks,ranging from 1~12 cycles.Analysis their response and prgnosis.RESULTS Ⅲ CR10 cases of patients,PR 14 n,SD6 cases,PD1,the ORR was 77.4%.Ⅳ patients with CR3 cases,PR5 cases,SD3 cases,PD1 cases,PR5 cases,SD3 cases,PD1 cases,the ORR was 66.7%,no significant difference between the two groups.However,Ⅲ and Ⅳ of 3-year survival rate and 5-year survival rates were significantly different.43 patients,the PFS was 21.5 months,the average survival time was 37.5 months.CONCLUSION Cisplatin chemotherapy intraperitoneal infusion plus ctx chemotherapy in ovarian cancer is effective and safe.Prognosis is related with pathological type,histological grade,postoperative residual tumor size and chemotherapy treatment.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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