Title: Relationship between the Expression of E-cadherin and Clinic-pathologic Characteristics and Prognosis in Pancreatic Ductal Adenocarcinoma
Abstract: Objective: To explore the relationship between the expression of E-cadherin and its clinic-pathologic characteristics and prognosis in pancreatic ductal adenocarcinoma(PDAC).Methods: The expression of E-cadherin in 106 cases of PDAC tissues and 12 cases of normal pancreatic tissues were examined by En Vision method.Results: The 'partial loss' rate of E-cadherin was 53.8%(57/106) and 'total loss' rate was 11.3%(12/106) in PDAC tissues.The loss rate of E-cadherin was 0% in normal tissues,the difference was statistically significant(P0.01).The expression of E-cadherin protein were not correlated with gender,age,clinical stage,lymph node metastasis and perineural invasion,but correlated with differentiation.The median overall survival of of E-cadherin 'total loss' ex-pression cases was 7 months,lower than 19 months in 'partial loss' expression ceases and 25 months in 'intact' expression eases(P0.01).Univariate analysis showed differentiation,lymph node metastasis,resection margin and E-cadherin expression influenced the survival of PDAC patients.While multivariate analysis showed E-cadherin expression and resection margin were the only factors related to the prog-nosis of PDAC patients(P0.01).Conclusion: E-cadherin may be used as a molecular marker to identify and predict the prognosis of PDAC.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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