Title: Tumor Locating Property of ~(99)Tc~m-MAVGG-glucose
Abstract: To develop 99Tcm labeled glucose derivatives for imaging tumor with SPECT,β-N-mercaptoacetyl-Val-Gly-Gly-glucose(MAVGG-Glu) was labeled with 99Tcm.The labelled compound was injected into the mice bearing S180 tumors,and biodistribution was measured at 3 h and 5 h postinjection.The biodistribution of 18F-2-fluoro-desoxy glucose(18F-FDG) at 5 h postinjection was also studied for comparison.The results showed that 99Tcm labeling yield was greater than 90%.The tumor uptakes at 3 h and 5 h postinjection were 1.46±0.41 and 1.28±0.24%ID/g,respectively.The T/NTs were greater than 1.8 for tumor over all other normal tissues excepted for kidney and liver at 5 h postinjection.T/NT of tumor to blood,tumor to muscle and tumor to brain were 4.41,4.00 and 8.53,respectively.Tumor was visualized at 3 h postinjection,and the contrast became slightly sharper with time lasted.The results suggested the potential utility of 99Tcm-MAVGG-Glu as a suitable tumor imaging agent.Compared with 18F-FDG,99Tcm-MAVGG-Glu had lower tumor uptake and T/NTs for most tissues.But its T/NTs for tumor to muscle,heart,spleen and brain,especially for tumor to brain,were higher,which indicated that 99Tcm-MAVGG-Glu may have advantages in imaging brain tumor and the tumor near brain.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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