Title: Detection of D2-40 Marked Lymphatic Vessel Density in Gastric Cancer and Its Clinical Signincance
Abstract: Objective To investigate the characteristics of distribution,density,and morphology of lymphatic vessel in gastric cancer and the correlation with its clinicopathological factors,and analyse the possible mechanism of lymph node metastasis in gastric cancer.Methods Monoclonal antibody D2-40 was used to detect the lymphatic invasion in 69 cases of primary gastric adenocarcinomas,and the relationships between lymphatic invasion and clinicopathological findings or lymph node micrometasis were analyzed.Results Compared with the region of human gastric cancer the tumor borderline was found with a significantly high lymphatic vessel density(LVD).The LVD in the borderline had positive correlation to the depth of tumor invasion,lymph node metastasis and the diferenfiation degree(P0.01)but there was no significant difference in age and sex.Conclusions(1)The lymphatic vesseles with heterogeneity appear in the gastric cancer,and mainly distribute in the tumor borderline.The LVD in the tumor borderline has correlation with lymph node metastasis,diferenfiaton degree,and the depth of tumor invasion.The increase of LVD may be related to the invasion and metastasis of gastric cancer in the tumor borderline.(2)The detection of LVD in the adjacent tissue of gastric cancer can be a important affiliated marker to evaluate the lymph node metastasis.It also can measure the prognosis of gastric cancer and provide experimental and theoretical foundation to confirm the clinical treatment methods.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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