Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2347411313', 'doi': 'https://doi.org/10.1161/circresaha.116.308699', 'title': 'Pyroptosis as a Regulated Form of Necrosis', 'display_name': 'Pyroptosis as a Regulated Form of Necrosis', 'publication_year': 2016, 'publication_date': '2016-05-13', 'ids': {'openalex': 'https://openalex.org/W2347411313', 'doi': 'https://doi.org/10.1161/circresaha.116.308699', 'mag': '2347411313', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27174943', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5137941'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.116.308699', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.116.308699', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'editorial', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.116.308699', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056647947', 'display_name': 'Jun‐ichi Abe', 'orcid': 'https://orcid.org/0000-0001-7439-7774'}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jun-ichi Abe', 'raw_affiliation_strings': ['Aab Cardiovascular Research Institute, University of Rochester, NY (C.M.).', 'From the Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston (J.i.A); and Aab Cardiovascular Research Institute, University of Rochester, NY (C.M.).'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston (J.i.A); and Aab Cardiovascular Research Institute, University of Rochester, NY (C.M.).', 'institution_ids': ['https://openalex.org/I5388228', 'https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'Aab Cardiovascular Research Institute, University of Rochester, NY (C.M.).', 'institution_ids': ['https://openalex.org/I5388228']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5025487414', 'display_name': 'Craig N. Morrell', 'orcid': 'https://orcid.org/0000-0001-9131-4862'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}, {'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Craig Morrell', 'raw_affiliation_strings': ['Aab Cardiovascular Research Institute, University of Rochester, NY (C.M.).', 'From the Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston (J.i.A); and Aab Cardiovascular Research Institute, University of Rochester, NY (C.M.).'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston (J.i.A); and Aab Cardiovascular Research Institute, University of Rochester, NY (C.M.).', 'institution_ids': ['https://openalex.org/I1343551460', 'https://openalex.org/I5388228']}, {'raw_affiliation_string': 'Aab Cardiovascular Research Institute, University of Rochester, NY (C.M.).', 'institution_ids': ['https://openalex.org/I5388228']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 41, 'citation_normalized_percentile': {'value': 0.997778, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '118', 'issue': '10', 'first_page': '1457', 'last_page': '1460'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11078', 'display_name': 'Molecular Mechanisms of Inflammasome Activation and Regulation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11078', 'display_name': 'Molecular Mechanisms of Inflammasome Activation and Regulation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11153', 'display_name': 'Global Burden of Group A Streptococcal Diseases', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11139', 'display_name': 'Uric Acid in Cardiovascular and Renal Health', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/2727', 'display_name': 'Nephrology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/necroptosis', 'display_name': 'Necroptosis', 'score': 0.588518}, {'id': 'https://openalex.org/keywords/pyroptosis', 'display_name': 'Pyroptosis', 'score': 0.58117}, {'id': 'https://openalex.org/keywords/neuroprotection', 'display_name': 'Neuroprotection', 'score': 0.528108}, {'id': 'https://openalex.org/keywords/apoptosis', 'display_name': 'Apoptosis', 'score': 0.516801}], 'concepts': [{'id': 'https://openalex.org/C17172800', 'wikidata': 'https://www.wikidata.org/wiki/Q7263707', 'display_name': 'Pyroptosis', 'level': 4, 'score': 0.7635273}, {'id': 'https://openalex.org/C503630168', 'wikidata': 'https://www.wikidata.org/wiki/Q178069', 'display_name': 'Necrosis', 'level': 2, 'score': 0.66115844}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.45886916}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.35799044}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.34083605}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.2446017}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.22389597}, {'id': 'https://openalex.org/C2777209026', 'wikidata': 'https://www.wikidata.org/wiki/Q412405', 'display_name': 'Inflammasome', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017304', 'descriptor_name': 'Annexin A5', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020170', 'descriptor_name': 'Caspase 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053453', 'descriptor_name': 'Caspase 9', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000069292', 'descriptor_name': 'Pyroptosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017304', 'descriptor_name': 'Annexin A5', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020170', 'descriptor_name': 'Caspase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053453', 'descriptor_name': 'Caspase 9', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009336', 'descriptor_name': 'Necrosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069292', 'descriptor_name': 'Pyroptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.116.308699', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.116.308699', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5137941', 'pdf_url': 'https://europepmc.org/articles/pmc5137941?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137941', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27174943', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.116.308699', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.116.308699', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 19, 'referenced_works': ['https://openalex.org/W1864325817', 'https://openalex.org/W1882905539', 'https://openalex.org/W1891826181', 'https://openalex.org/W1969778213', 'https://openalex.org/W1980005230', 'https://openalex.org/W2003605139', 'https://openalex.org/W2047909212', 'https://openalex.org/W2055727949', 'https://openalex.org/W2068619092', 'https://openalex.org/W2080827095', 'https://openalex.org/W2081053802', 'https://openalex.org/W2106917466', 'https://openalex.org/W2139552156', 'https://openalex.org/W2143102054', 'https://openalex.org/W2159590959', 'https://openalex.org/W2175794645', 'https://openalex.org/W2178911832', 'https://openalex.org/W2273649406', 'https://openalex.org/W2304527713'], 'related_works': ['https://openalex.org/W4327963739', 'https://openalex.org/W4315754280', 'https://openalex.org/W4286252599', 'https://openalex.org/W3031052312', 'https://openalex.org/W3030255104', 'https://openalex.org/W3016527951', 'https://openalex.org/W3006826877', 'https://openalex.org/W2991971006', 'https://openalex.org/W2904552328', 'https://openalex.org/W2748952813'], 'abstract_inverted_index': {'HomeCirculation': [0], 'ResearchVol.': [1], '118,': [2, 3686], 'No.': [3], '10Pyroptosis': [4], 'as': [5, 26, 136, 407, 794, 979, 1203, 1658, 1667, 1701, 1712, 1898, 2551], 'a': [6, 27, 137, 181, 199, 215, 253, 296, 363, 466, 474, 570, 577, 685, 756, 1056, 1063, 1078, 1209, 1241, 1273, 1320, 1695, 1713, 1856, 2552, 3193], 'Regulated': [7, 28, 1724], 'Form': [8, 29], 'of': [9, 30, 53, 56, 70, 81, 84, 98, 139, 229, 247, 278, 286, 314, 478, 525, 546, 607, 642, 725, 765, 790, 821, 833, 846, 861, 867, 878, 885, 906, 913, 925, 956, 960, 1040, 1066, 1095, 1106, 1116, 1137, 1148, 1181, 1199, 1224, 1230, 1238, 1275, 1302, 1355, 1380, 1433, 1461, 1474, 1482, 1494, 1571, 1583, 1594, 1620, 1631, 1644, 1748, 1767, 1787, 1799, 1816, 1819, 1836, 1870, 1883, 1896, 1913, 1918, 1952, 1966, 1969, 1985, 1992, 1996, 2007, 2024, 2028, 2043, 2047, 2058, 2067, 2099, 2128, 2166, 2227, 2299, 2406, 2516, 2571, 2614, 2617, 2799, 2871, 2925, 3074, 3109, 3151, 3201, 3206, 3225, 3268, 3288, 3398, 3441, 3471, 3549, 3574, 3602, 3666], 'Necrosis': [10], 'Free': [11], 'AccessEditorialPDF/EPUBAboutView': [12], 'PDFView': [13], 'EPUBSections': [14], 'ToolsAdd': [15], 'to': [16, 417, 505, 553, 664, 805, 863, 1153, 1297, 1334, 1375, 1394, 1408, 1531, 1555, 1650, 1721, 1811, 1825, 1981, 2009, 2052, 2317, 2484, 2588, 2833, 2921, 3478], 'favoritesDownload': [17], 'citationsTrack': [18], 'citationsPermissions': [19], 'ShareShare': [20], 'onFacebookTwitterLinked': [21], 'InMendeleyReddit': [22], 'Jump': [23], 'toFree': [24], 'AccessEditorialPDF/EPUBPyroptosis': [25], 'NecrosisPI+/Annexin': [31], 'V−/High': [32], 'Caspase': [33, 35], '1/Low': [34], '9': [36, 3638], 'Activity': [37], 'in': [38, 113, 128, 165, 244, 259, 299, 319, 337, 365, 401, 436, 444, 469, 528, 560, 616, 647, 680, 696, 798, 981, 1010, 1018, 1050, 1084, 1102, 1188, 1194, 1244, 1312, 1360, 1427, 1455, 1487, 1498, 1524, 1560, 1610, 1694, 1859, 1874, 1885, 1904, 1915, 1926, 1972, 1988, 2036, 2210, 2230, 2258, 2620, 2667, 2762, 2795, 2830, 2907, 3006, 3143, 3191, 3281, 3358, 3420, 3476, 3522, 3553, 3559, 3577, 3583, 3597, 3632, 3669, 3678], 'Cells': [39], '=': [40], 'Pyroptosis?': [41], 'Jun-ichi': [42, 47, 2053], 'Abe': [43, 49, 2011, 3309], 'and': [44, 64, 74, 92, 119, 186, 210, 224, 227, 233, 263, 288, 316, 324, 340, 357, 379, 391, 399, 405, 413, 426, 446, 453, 464, 490, 502, 508, 593, 599, 614, 638, 644, 693, 700, 714, 767, 784, 824, 829, 835, 841, 844, 852, 888, 949, 973, 1060, 1069, 1090, 1150, 1172, 1248, 1277, 1304, 1340, 1357, 1367, 1382, 1399, 1450, 1458, 1477, 1533, 1604, 1628, 1662, 1684, 1697, 1735, 1764, 1777, 1804, 1827, 1850, 1872, 1929, 1934, 1944, 2015, 2017, 2169, 2235, 2408, 2479, 2487, 2514, 2602, 2611, 2653, 2662, 2709, 2748, 2790, 2797, 2802, 2822, 2859, 2874, 2901, 2918, 2955, 2997, 3002, 3008, 3053, 3061, 3071, 3077, 3095, 3137, 3153, 3186, 3219, 3226, 3231, 3235, 3262, 3276, 3308, 3314, 3317, 3346, 3363, 3384, 3400, 3412, 3436, 3448, 3465, 3512, 3543, 3569, 3580, 3591, 3618, 3624, 3634, 3657, 3675], 'Craig': [45, 75], 'Morrell': [46, 77, 2018, 2021], 'AbeJun-ichi': [48], 'From': [50, 78], 'the': [51, 79, 114, 151, 166, 192, 225, 257, 276, 284, 293, 311, 366, 433, 526, 544, 561, 565, 604, 629, 653, 726, 799, 817, 842, 856, 868, 876, 882, 909, 916, 931, 954, 958, 982, 1021, 1031, 1047, 1074, 1093, 1103, 1111, 1114, 1132, 1154, 1169, 1189, 1195, 1222, 1236, 1245, 1299, 1361, 1378, 1411, 1462, 1479, 1492, 1495, 1525, 1535, 1601, 1611, 1618, 1797, 1813, 1829, 1839, 1847, 1867, 1880, 1894, 1911, 1916, 1942, 1963, 1979, 1982, 1997, 2004, 2029, 2044, 2048, 2125, 2233, 2236, 2476, 2480, 2517, 3068, 3202, 3396, 3663], 'Department': [52, 80, 2057], 'Cardiology,': [54, 82, 2059], 'University': [55, 69, 83, 97, 2066], 'Texas': [57, 85, 2068], 'MD': [58, 86, 2069], 'Anderson': [59, 87, 2070], 'Cancer': [60, 88, 2071], 'Center,': [61, 89, 2072], 'Houston': [62, 90], '(J.i.A);': [63, 91], 'Aab': [65, 93], 'Cardiovascular': [66, 94], 'Research': [67, 95, 249, 3161], 'Institute,': [68, 96], 'Rochester,': [71, 99], 'NY': [72, 100], '(C.M.).': [73, 101], 'MorrellCraig': [76], 'Originally': [102, 3699], 'published13': [103], 'May': [104, 3683], '2016https://doi.org/10.1161/CIRCRESAHA.116.308699Circulation': [105], 'Research.': [106], '2016;118:1457–1460Pyroptosis': [107], 'is': [108, 134, 198, 441, 473, 569, 908, 946, 1160, 1178, 1183, 1226, 1240, 1251, 1272, 1279, 1319, 1392, 1406, 1598, 1648, 1686, 1726, 1823, 1956, 2022, 2403], 'characterized': [109, 1728, 1774, 1795], 'by': [110, 150, 157, 237, 275, 283, 460, 589, 612, 631, 655, 669, 684, 775, 922, 929, 953, 985, 1024, 1140, 1636, 1675, 1729, 1745, 1775, 1796, 2001, 2101, 2295], 'pore': [111, 163, 1289, 1335, 2483], 'formation': [112, 164, 1271], 'plasma': [115, 167, 1287, 1730], 'membrane,': [116, 168, 1527], 'cell': [117, 322, 338, 419, 497, 698, 1512, 1526, 1654, 1672, 1716, 1788, 2106, 2130, 2146, 2538, 2553, 2669, 2756, 2912, 2916, 3004, 3279, 3422, 3474], 'swelling,': [118], 'membrane': [120, 1288, 1537, 1731], 'disruption.1,2': [121], 'These': [122, 1740], 'cellular': [123, 373, 1722, 1738, 2575], 'events': [124], 'are': [125, 359, 381, 428, 450, 457, 1402, 1548, 1607, 1743, 2039, 2453], 'also': [126, 500, 554, 584, 676, 970, 1543, 1608, 1782, 1923], 'noted': [127], 'necrosis,': [129, 1750, 1821, 1838, 3232], 'but': [130, 499, 1013, 1125, 1192, 1291, 1585, 1624, 1781, 2758], 'not': [131, 494, 515, 950, 1054, 1193, 1252, 1436, 1771, 1961, 2040, 2759], 'apoptosis,': [132, 185, 3229], 'which': [133, 220, 549, 936, 1324, 1364, 1719], 'defined': [135, 148, 1700, 1709], 'mode': [138, 1818], 'regulated': [140, 1702, 1710, 1749, 1820, 1837, 1953, 1970, 1986], 'or': [141, 393, 706, 1042, 1211, 1670, 1737, 2046], 'programmed': [142, 156, 496, 3278, 3421], 'necrosis.2': [143, 1703], 'Jorgensen': [144, 2142], 'et': [145, 239, 591, 595, 633, 657, 671, 721, 898, 987, 1000, 1026, 1344, 1420, 1439, 1467, 1506, 1587, 1706, 1862, 2369], 'al3': [146], 'have': [147, 550, 900, 1002, 1015, 1346, 1422, 1441, 1508, 1708, 1783, 1864], 'pyroptosis': [149, 223, 262, 318, 530, 579, 618, 646, 840, 928, 945, 963, 1012, 1035, 1058, 1083, 1104, 1164, 1314, 1470, 1500, 1559, 1590, 1612, 1627, 1659, 1884, 1897, 1931, 2407, 2486, 2663, 2968, 3060, 3150, 3521], 'following': [152], '4': [153, 452], 'criteria:': [154], '(1)': [155], 'an': [158, 556, 1227, 1453, 1668, 1908, 2404, 2573], 'inflammatory': [159, 430, 501, 521, 2102, 2425], 'caspase': [160, 216, 331, 757], 'activation,': [161], '(2)': [162], '(3)': [169], 'DNA': [170, 194], 'damage': [171, 1889], 'with': [172, 362, 384, 432, 520, 625, 723, 3395], 'terminal': [173], 'deoxynucleotidyl': [174], 'transferase': [175], 'dUTP': [176], 'nick-end': [177], 'labeling': [178], 'positivity': [179], 'at': [180, 890, 1846], 'lower': [182], 'intensity': [183], 'than': [184, 996], '(4)': [187], 'ADP-ribose': [188], 'polymerase': [189], 'activation': [190, 920, 1136, 1257, 1351, 1451, 1457, 1460, 2206, 2294, 2355, 2515, 2868, 3518], 'after': [191, 1037, 1471, 1591], 'pyroptosis-mediated': [193], 'damage.': [195], 'The': [196, 667, 810, 831, 1166, 1430, 1642, 3223], 'inflammasome': [197, 294, 535, 581, 716, 801, 1200, 1232, 1256, 1398, 1464, 2164, 2205, 2293, 2354, 2377, 2520, 2867, 3517], 'large': [200, 1064], 'complex': [201], 'containing': [202, 214, 755, 1208], 'NOD': [203, 747], '(nucleotide': [204, 748], 'oligomerization': [205, 749, 828], 'domain)-like': [206, 750], 'receptors': [207, 2456], '(NLRs),': [208], 'procaspase-1,': [209], 'apoptosis-associated': [211, 1205], 'speck-like': [212, 753, 1206], 'protein': [213, 679, 742, 754, 1207, 1801], 'recruitment': [217, 758], 'domain': [218, 396, 435, 1808], '(CARD),': [219], 'regulates': [221, 3101], 'both': [222, 849], 'maturation': [226], 'secretion': [228, 845, 2761], 'proinflammatory': [230], 'interleukin': [231], '(IL)-1β': [232], 'IL-18.4': [234], 'A': [235, 2601, 2708, 3013, 3094, 3417], 'study': [236, 630, 654, 668, 984, 1023, 1615, 1812, 1976, 1984], 'Xi': [238, 986, 1025, 1419, 1466, 1586, 2179], 'al5': [240, 1421, 1468, 1588, 1863], 'from': [241, 543, 597, 628, 635, 652, 659, 673, 719, 1565, 1660, 2003], "Wang's": [242], 'laboratory': [243, 637, 661, 675, 1541], 'this': [245, 305, 539, 1292, 1416, 1639, 1933, 2037], 'issue': [246], 'Circulation': [248, 2720], 'has': [250, 334, 481, 514, 531, 583, 802, 1118, 1315, 1542, 1680, 1793, 1855, 1890, 1977], 'now': [251, 1687], 'indicated': [252], 'critical': [254, 467, 523], 'role': [255, 298, 468, 524, 540, 571, 606, 1009, 1017, 1301, 1481, 1815, 1858, 1869, 1912, 3195], 'for': [256, 372, 572, 712, 1162, 1185, 1254, 1833, 2163, 2375, 2410, 2457, 3196, 3629], 'caspase-1–inflammasome': [258, 527], 'regulating': [260, 300, 529, 1488, 1886, 3123], 'hyperhomocysteinemia-induced': [261, 301, 1428, 1875, 1887], 'apoptosis.': [264, 1019], 'In': [265, 304, 511, 575, 792, 1020, 1072, 1110, 1234, 1415, 1878, 3481], 'particular,': [266], 'they': [267], 'show': [268], 'that': [269, 292, 368, 485, 875, 902, 1004, 1046, 1077, 1179, 1221, 1281, 1348, 1377, 1443, 1510, 1545, 1600, 1689, 1948, 1958], 'hyperhomocysteinemia-mediated': [270, 1489, 1499, 1919], 'aortic': [271], 'endothelial': [272, 302, 321, 326, 1876, 1888, 1920, 1973, 1990, 2211], 'dysfunction': [273, 1921, 3065], 'induced': [274, 921, 1139, 1674], 'depletion': [277, 285, 832, 955, 1115, 1379], 'cystathionine': [279], 'β-synthase': [280], 'was': [281, 541, 873, 965, 1100, 1664], 'rescued': [282], 'caspase-1': [287, 613, 919, 1425, 1871], 'NLRP3.': [289], 'This': [290, 1159, 1614, 1678, 1938, 1975], 'suggests': [291], 'plays': [295, 1007], 'crucial': [297, 605, 1300, 1868], 'dysfunction.': [303, 1877, 1974], 'editorial,': [306], 'we': [307, 1959], 'will': [308], 'briefly': [309], 'review': [310], 'regulatory': [312], 'mechanism': [313], 'caspase-1–': [315], '4/5/11–mediated': [317], 'modulating': [320], 'pyroptosis/apoptosis': [323], 'consequent': [325], 'dysfunction.Article,': [327], 'see': [328], 'p': [329], '1525The': [330], 'protease': [332], 'family': [333], 'central': [335], 'roles': [336], 'death': [339, 498, 1513, 1655, 1673, 1717, 2131, 2147, 2229, 2550, 2757, 3005, 3280, 3393, 3475], 'inflammation.': [341], 'Mammalian': [342], 'caspases': [343, 361, 383, 389, 415, 431, 451, 486, 850, 2103, 2426, 2452], 'can': [344, 492, 772, 969, 1267, 1578, 1633, 1691, 1770], 'be': [345, 773, 1055, 1502, 1517, 1634, 1773, 1907, 1924], 'divided': [346], 'into': [347], '3': [348, 3586], 'groups': [349], 'based': [350], 'on': [351, 977, 1121, 1129, 1216, 1387, 1424, 1617], 'their': [352], 'functions.6': [353], 'Caspases': [354, 375, 421], '3,': [355, 488], '6,': [356], '7': [358, 974], 'executioner': [360, 412], 'prodomain': [364], 'NH2-terminus': [367, 403, 438, 870], 'cleaves': [369, 1143, 1352, 2372], 'substrates': [370], 'essential': [371], 'homeostasis.': [374], '2,': [376, 487], '8,': [377, 489], '9,': [378], '10': [380, 491, 3688], 'initiator': [382, 414], '2': [385, 398], 'DED': [386], '(death-effector': [387], 'domain;': [388, 759], '8': [390, 3682], '10)': [392], '1': [394, 851, 1803], 'CARD': [395, 434, 812, 827], '(caspases': [397], '9)': [400], 'its': [402, 437, 447], 'region': [404], 'act': [406], 'proteolitic': [408], 'signal': [409, 704], 'transducers.': [410], 'Both': [411, 587], 'contribute': [416], 'apoptotic': [418, 1068, 3003], 'death.': [420, 1789], '1,': [422], '4,': [423], '5,': [424], '11,': [425], '12': [427], 'so-called': [429], 'region.': [439], 'Caspase-11': [440, 2371], 'present': [442], 'only': [443, 495, 947, 1772], 'rodents,': [445], 'human': [448, 2908, 3144, 3282], 'counterparts': [449], '5': [454], '(caspase-4/5/11).': [455], 'They': [456], 'directly': [458, 518, 806, 854, 1285, 2427], 'activated': [459, 774], 'cytosolic': [461, 808, 838, 1141, 1338, 1353, 2167], 'bacterial': [462, 2170], 'lipopolysaccharide': [463, 1043, 1142, 1175], 'play': [465], 'endotoxic': [470, 2260, 2488], 'shock.7,8': [471], 'Caspase-12': [472], 'dominant': [475], 'negative': [476], 'regulator': [477], 'caspase-1.9': [479], 'It': [480, 872, 1955], 'recently': [482], 'been': [483, 517, 532, 551, 585, 803, 1316, 1681, 1794, 1891], 'shown': [484, 552, 1866], 'regulate': [493, 2511], 'immune': [503, 2455, 2835], 'reactions': [504], 'dying': [506], 'cells': [507, 1087, 1515, 1547, 1606, 1905, 3064, 3274], 'microbial': [509], 'stimuli.9': [510], 'contrast,': [512, 793, 1235], 'caspase-9': [513, 1079, 1098, 1902], 'yet': [516], 'associated': [519], 'responses.9The': [522], 'reported': [533, 603, 804, 901, 1347, 1442], '(canonical': [534], 'pathway3;': [536], 'Figure).': [537], 'However,': [538, 989, 1893], 'deduced': [542], 'use': [545], 'caspas-1–deficient': [547], 'mice,': [548], 'carry': [555], 'inactivating': [557], 'passenger': [558], 'mutation': [559], 'caspase-11': [562, 643, 797, 811, 826, 836, 1350, 1448, 2512], 'gene,': [563], 'raising': [564, 1092], 'question': [566, 1094], 'whether': [567, 1851], 'there': [568, 1371], 'caspase-11–related': [573], 'effects.10': [574], 'addition,': [576, 1073, 1879], 'caspase-1/inflammasome-independent': [578], '(noncannonical': [580], 'pathway)': [582], 'proposed.': [586], 'studies': [588], 'Kayagaki': [590, 632, 720, 2267, 2325, 2363], 'al11': [592, 634, 722], 'Shi': [594, 656, 897, 999, 2079, 2085, 2436, 2683, 3380], 'al1': [596, 658, 1001], "Dixit's": [598, 636], "Shao's": [600, 660, 1540], 'laboratories,': [601], 'respectively,': [602], 'gasdermin': [608, 2373], 'D': [609, 2374, 2402, 2655, 2753, 3185, 3411], '(GSDMD)': [610], 'cleaved': [611, 932], '4/5/11': [615, 853], 'eliciting': [617], '(Figure).': [619, 896, 1465], 'An': [620], 'unbiased': [621], 'forward': [622], 'genetic': [623], 'screen': [624], 'ethyl-N-mutagenized': [626], 'mice': [627], 'CRISPR-Cas9': [639], 'nuclease': [640], 'screens': [641], 'caspase-1–mediated': [645, 944, 1011], 'mouse': [648, 1561, 3472], 'bone': [649, 3523], 'marrow': [650], 'macrophages': [651, 1562], 'link': [662], 'GSDMD': [663, 678, 690, 834, 862, 865, 879, 886, 893, 907, 933, 978, 991, 1117, 1149, 1156, 1182, 1218, 1225, 1239, 1249, 1265, 1282, 1914, 2100], 'lipopolysaccharide-mediated': [665], 'pyroptosis.': [666, 1269, 1342, 1369, 1490], 'He': [670, 2384, 2467], 'al12': [672], "Han's": [674], 'detected': [677, 1101, 1589, 1609], 'nigericin-induced': [681], 'NLRP3': [682, 1873, 2519, 2866, 3099, 3350, 3516], 'inflammasomes': [683, 926], 'quantitative': [686], 'mass': [687], 'spectrometry–based': [688], 'analysis.': [689], 'shows': [691, 1126], 'cytoplasmic': [692, 1733], 'membranous': [694], 'expression': [695, 1449, 2513], 'many': [697], 'types': [699, 789, 924], 'lacks': [701], 'any': [702], 'obvious': [703], 'peptide': [705], 'transmembrane': [707], 'segments.1Download': [708], 'figureDownload': [709], 'PowerPointFigure.': [710], 'Scheme': [711], 'canonical': [713, 917, 1112, 1170, 1196, 1246], 'noncanonical': [715, 800, 1133, 1463], 'signaling.': [717], 'Modified': [718], 'permission': [724], 'publisher.': [727], 'Copyright': [728], '©2015,': [729], 'Nature': [730], 'Publishing': [731], 'Group.': [732], 'dsDNA': [733], 'indicates': [734], 'double-strand': [735, 782], 'DNA;': [736], 'Hhcy,': [737], 'hyperhomocysteinemia;': [738], 'JNK,': [739], 'c-Jun': [740], 'N-terminal': [741], 'kinase;': [743], 'LPS,': [744], 'lipopolysaccharide;': [745], 'NLRP3/ASC,': [746], 'receptor': [751, 1306], 'P3/apoptosis-associated': [752], 'pro-GSDMD,': [760], '53-kDa': [761, 857, 1144], 'inactive': [762, 858, 1145], 'precursor': [763, 859, 1146], 'form': [764, 860, 1147, 1835, 1951], 'GSDMD;': [766], 'ROS,': [768], 'reactive': [769, 1444, 1483], 'oxygen': [770, 1445, 1484, 2509], 'species.Caspase-1': [771], 'various': [776, 923, 1967, 3479], 'stimuli,': [777], 'including': [778, 1327, 1751], 'ATP,': [779], 'cholesterol': [780], 'crystals,': [781], 'DNA,': [783], 'flagellin': [785], 'via': [786, 816, 1452, 2664, 2837, 2869, 2969, 3673], 'several': [787], 'different': [788, 1843], 'inflammasomes.3,4': [791], 'stated': [795], 'above,': [796], 'sense': [807], 'lipopolysaccharide.': [809], 'binds': [813], 'lipopolysaccharide,': [814], 'presumably': [815], 'acidic': [818], 'phosphate': [819], 'moieties': [820], 'lipid': [822], 'A,': [823, 2117, 2286, 2309, 2594, 2894, 2990, 3092, 3181], 'causes': [825, 1368], 'activation.3,13,14': [830], 'inhibited': [837, 952, 1030, 1082], 'lipopolysaccharide-induced': [839, 1349, 2961], 'processing': [843, 1124, 1187], 'IL-1β.': [847], 'Interestingly,': [848], 'cleave': [855, 971], 'generate': [864], 'p30': [866, 934, 1157, 1250, 1266, 1283], 'propyroptotic': [869, 883], 'fragment.': [871], 'thought': [874], 'COOH-terminus': [877], '(p23)': [880], 'inhibits': [881, 2865], 'function': [884], 'p30,': [887], 'cleavage': [889, 992, 1006, 1180, 1223, 1237], 'D276↓G277': [891], 'releases': [892, 1325, 1358], 'p23–mediated': [894], 'inhibition': [895], 'al1,11': [899], 'aa': [903], 'residues': [904], '1–243': [905], 'minimal': [910], 'fragment': [911], 'capable': [912], 'triggering': [914, 3194], 'pyroptosis.In': [915], 'pathway,': [918, 1113, 1134, 2839], 'triggers': [927], 'releasing': [930], 'fragment,': [935], 'bears': [937], 'intrinsic': [938], 'pyroptosis-inducing': [939], 'activity': [940, 1099, 1426, 1903], 'described': [941, 980, 1509], 'above.1,11': [942], 'Because': [943, 1370], 'delayed': [948], 'completely': [951], 'GSDMD,': [957, 1298], 'existence': [959], 'another': [961], 'caspase-1–dependent': [962, 1122], 'pathway': [964, 1191, 1247, 1497, 1832, 3070], 'suggested': [966, 1003, 1280], '(Figure).11': [967, 1258], 'Caspase-1': [968, 3661], 'caspases-3': [972], '(3/7)': [975], 'independently': [976], 'current': [983, 1022, 1417], 'al.5': [988], 'because': [990, 1521], 'occurred': [993], 'much': [994], 'earlier': [995], 'caspase-3/7': [997, 1005], 'cleavage,': [998, 1219], 'no': [1008, 1119, 1214, 1385], 'may': [1014, 1053, 1061, 1284, 1906, 1922], 'some': [1016, 1127], 'al,5': [1027], 'caspase-3': [1028], 'inhibitor': [1029, 1080], 'R1': [1032, 1048], 'fraction': [1033, 1049, 1059, 1105], '(so-called': [1034], 'fraction)': [1036], '24': [1038, 1472, 1592], 'hours': [1039, 1473, 1582, 1593], 'L-Hcy': [1041], 'stimulation,': [1044], 'suggesting': [1045, 1220], 'Figure': [1051], '3B': [1052], 'pure': [1057, 1557], 'include': [1062], 'number': [1065], 'late': [1067, 1602], 'necroptotic': [1070, 1605], 'cells.': [1071, 1109], 'authors': [1075, 1998], 'showed': [1076, 1213, 1384, 1478], 'significantly': [1081], 'PI+/annexin': [1085, 1107, 1621, 1899], 'V−': [1086, 1108], '(Figure': [1088], '3A': [1089], '3B)': [1091], 'how': [1096, 1264], 'low': [1097], 'effect': [1120, 1128, 1215, 1386, 3073], 'IL-1β': [1123, 1130, 3399, 3674], 'release.11In': [1131], 'direct': [1135], 'caspase-4/5/11': [1138, 1434], 'converts': [1151], 'it': [1152, 1261, 1278, 1405, 1597, 1685, 1822], 'mature': [1155], 'form.': [1158], 'sufficient': [1161], 'inducing': [1163], '(Figure).1': [1165], 'difference': [1167], 'between': [1168, 1626, 1841], '(nonlipopolysaccharide)': [1171], 'noncannonical': [1173, 1190, 1496], '(cytosolic': [1174], 'dependent)': [1176], 'pathways': [1177, 1845, 2666], 'required': [1184, 1253, 2409], 'caspase-1/IL-1β': [1186], 'pathway.': [1197], 'Loss': [1198], 'components,': [1201], 'such': [1202, 1657], 'NLRP3,': [1204], 'CARD,': [1210], 'caspase-1,': [1212], 'caspase-11–mediated': [1217, 1313, 1388], 'upstream': [1228], 'event': [1229, 1243], 'caspase-4/5/11–mediated': [1231], 'activation.': [1233], 'downstream': [1242], 'initial': [1255], 'Of': [1259], 'note,': [1260], 'remains': [1262], 'unclear': [1263], 'induce': [1268, 1286], 'Pore': [1270], 'feature': [1274], 'pyroptosis,': [1276], 'formation,12': [1290], 'needs': [1293], 'further': [1294, 1390], 'investigation.In': [1295], 'addition': [1296], 'pannexin-1': [1303, 1356, 1381, 2477], 'purinergic': [1305, 2481], 'P2X': [1307], 'ligand–gated': [1308], 'ion': [1309, 3198], 'channel': [1310, 2478], '(P2X7)': [1311], 'reported.15': [1317], 'Pannexin-1': [1318], 'nonselective,': [1321], 'large-pore': [1322], 'channel,': [1323], 'nucleotide,': [1326], 'ATP.': [1328], 'Exogenous': [1329], 'ATP': [1330, 1359], 'activates': [1331, 1365, 2255], 'P2X7,': [1332], 'leads': [1333, 1720], 'formation,': [1336], 'depletes': [1337], 'K+,': [1339], 'induces': [1341, 2660, 3059, 3277, 3390], 'Yang': [1343, 2185, 2201, 2396, 2465, 2689, 3035, 3041], 'al15': [1345], 'domains': [1354], 'extracellular': [1362, 1761], 'medium,': [1363], 'P2X7': [1366, 1383, 2482], 'were': [1372, 1435, 1999], 'contradictory': [1373], 'data': [1374], 'suggest': [1376], 'events,10': [1389], 'investigation': [1391], 'necessary': [1393], 'resolve': [1395], 'these': [1396, 1768, 1842], 'discrepancies.Because': [1397], 'pyropotosis': [1400], 'regulation': [1401], 'so': [1403], 'complex,': [1404], 'difficult': [1407, 1635], 'definitively': [1409], 'demonstrate': [1410], 'signaling': [1412, 1798, 1831, 1844, 2316, 3313], 'mechanisms': [1413, 1780, 1947, 2162, 2570], 'involved.': [1414], 'issue,': [1418], 'focused': [1423], 'pyropotosis.': [1429], 'potential': [1431], 'contributions': [1432], 'explored.': [1437], 'Lupfer': [1438, 2495], 'al16': [1440], 'species': [1446, 1485, 2510], 'increases': [1447], 'increase': [1454], 'JNK': [1456], 'subsequently': [1459], 'studied': [1469], 'Hcy': [1475], 'treatment': [1476], 'important': [1480, 1824, 1925], 'induction': [1486], 'Therefore,': [1491, 1596, 1810], 'involvement': [1493], 'cannot': [1501], 'excluded': [1503], 'yet.': [1504], 'Miao': [1505, 2144, 2252, 2423, 2531], 'al17': [1507], 'pyroptotic': [1511, 1546, 2105, 2537], 'pathway–activated': [1514], 'should': [1516], 'annexin': [1518, 1529, 1549], 'V': [1519, 1530, 1622], 'positive': [1520], 'pores': [1522], 'open': [1523], 'permitting': [1528], 'enter': [1532], 'stain': [1534], 'inner': [1536], 'leaflet.': [1538], 'Dr': [1539, 1566], 'found': [1544], 'V+': [1550], 'using': [1551, 1638], 'anthrax': [1552], 'lethal': [1553], 'toxin': [1554], 'trigger': [1556], 'caspse-1–dependent': [1558], '(personal': [1563], 'communication': [1564], 'Feng': [1567, 2647, 2818, 3372], 'Shao,': [1568], 'National': [1569, 2005], 'Institute': [1570, 2006], 'Biological': [1572, 3110], 'Sciences,': [1573, 2879, 3207, 3320, 3604], 'Beijing,': [1574], '102206,': [1575], 'China).': [1576], 'Pyroptosis': [1577, 2715, 3353], 'occur': [1579], 'within': [1580], '6': [1581], 'stimulation,1': [1584], 'stimulation.': [1595], 'possible': [1599, 1881], 'apoptosis': [1603, 1661, 2661], 'fraction.': [1613], 'relied': [1616], 'fractionation': [1619], 'cells,': [1623, 3285], 'distinguishing': [1625], 'other': [1629, 1746, 1935], 'forms': [1630, 1747], 'necrosis': [1632, 1690, 1711, 1725, 1971, 1987, 3707], 'simply': [1637], 'narrow': [1640], 'definition.': [1641], 'development': [1643], 'additional': [1645], 'reliable': [1646], 'markers': [1647], 'needed': [1649], 'better': [1651], 'differentiate': [1652], 'caspase-mediated': [1653], 'process,': [1656, 1718], 'necrosis.Necrosis': [1663], 'once': [1665], 'recognized': [1666], 'accidental': [1669], 'physical': [1671], 'physiochemical': [1676], 'stress.2': [1677], 'view': [1679], 'greatly': [1682], 'changed,': [1683], 'clear': [1688, 1957], 'take': [1692], 'place': [1693], 'genetically': [1696, 1714], 'well-controlled': [1698], 'manner': [1699], 'Vanden': [1704, 2113, 2565], 'Berghe': [1705, 2114, 2566], 'al2': [1707], 'controlled': [1715], 'leakage.': [1723], 'morphologically': [1727], 'rupture,': [1732], 'granulation/vacuolization,': [1734], 'organelle': [1736], 'swelling.2,18,19': [1739], 'morphological': [1741], 'hallmarks': [1742], 'shared': [1744], 'necroptosis,': [1752], 'parthanatos,': [1753], 'oxytosis,': [1754], 'ferroptosis,': [1755], 'ETosis': [1756], '(extracelllar': [1757], 'trap),': [1758, 1762], 'NETosis': [1759, 3124], '(neutrophil': [1760], 'pyronecrosis,': [1763], 'pyroptosis.2': [1765], 'All': [1766], 'processes': [1769], 'unique': [1776, 1830, 1945], 'distinct': [1778, 1857, 1943], 'molecular': [1779, 1848, 1946], 'numerous': [1784], 'overlapping': [1785], 'features': [1786], 'For': [1790], 'example,': [1791], 'necroptosis': [1792], 'receptor-interacting': [1800], 'kinase': [1802, 1807], 'mixed': [1805], 'lineage': [1806], 'like.2': [1809], 'pathological': [1814], 'each': [1817, 1834, 1852, 1950], 'define': [1826], 'clarify': [1828], 'interplay': [1840], 'level,': [1849], 'path': [1853], 'really': [1854], 'disease': [1860, 1936], 'processes.Xi': [1861], 'nicely': [1865], 'contribution': [1882, 1965], 'suggested.': [1892], 'definition': [1895], 'V−/high': [1900], 'caspase-1/low': [1901], 'oversimplification.': [1909], 'Determining': [1910], 'process': [1917], 'clearly': [1927], 'defining': [1928, 2232], 'identifying': [1930], 'during': [1932, 2521], 'processes.': [1937], 'would': [1939], 'involve': [1940], 'exploring': [1941], 'control': [1949], 'necrosis.': [1954], 'do': [1960], 'know': [1962], 'exact': [1964], 'modes': [1968], 'opened': [1978], 'door': [1980], 'future': [1983], 'controlling': [1989], 'dysfunction.Sources': [1991], 'FundingThe': [1993], 'research': [1994], 'activities': [1995], 'supported': [2000], 'grant': [2002], 'Health': [2008], 'Drs': [2010], '(HL-130193,': [2012], 'HL-123346,': [2013], 'HL-118462,': [2014], 'HL-108551)': [2016], '(HL124018-01A).': [2019], 'Dr.': [2020], 'recipient': [2023], 'Established': [2025], 'Investigator': [2026], 'Awards': [2027], 'American': [2030, 2049, 3694], 'Heart': [2031, 2050, 3695], 'Association': [2032], '(13EIA14250023).DisclosuresNone.FootnotesThe': [2033], 'opinions': [2034], 'expressed': [2035], 'article': [2038], 'necessarily': [2041], 'those': [2042], 'editors': [2045], 'Association.Correspondence': [2051], 'Abe,': [2054], 'MD,': [2055], 'PhD,': [2056], '2121': [2060], 'W,': [2061, 2443, 3337], 'Holcombe': [2062], 'Blvd,': [2063], 'Unit': [2064], '1101,': [2065], 'Houston,': [2073], 'TX,': [2074], '77030.': [2075], 'E-mail': [2076], '[email': [2077], 'protected]References1.': [2078], 'J,': [2080, 2194, 2198, 2282, 2337, 2343, 2347, 2437, 2445, 2650, 2690, 2731, 2850, 2890, 2896, 2936, 3462, 3499, 3566, 3654], 'Zhao': [2081, 2158, 2438, 3332], 'Y,': [2082, 2088, 2092, 2159, 2182, 2184, 2200, 2249, 2341, 2422, 2439, 2441, 2468, 2628, 2686, 2815, 2854, 2948, 3050, 3335, 3377, 3497, 3505], 'Wang': [2083, 2087, 2095, 2193, 2203, 2392, 2440, 2701, 2812, 3033, 3039, 3651], 'K,': [2084, 2280, 2339, 2706, 3171, 3179, 3183], 'X,': [2086, 2188, 2190, 2192, 2196, 2202, 2393, 2640, 2694, 2700, 2942, 2946, 3028, 3044, 3048, 3132, 3503, 3507, 3642, 3644], 'Huang': [2089, 2394, 2639, 2643], 'H,': [2090, 2121, 2180, 2387, 2636, 2642, 2684, 2737, 2952, 3175, 3247, 3509, 3540], 'Zhuang': [2091], 'Cai': [2093, 2654], 'T,': [2094, 2115, 2567, 3032, 3375, 3538], 'F,': [2096, 2704, 2776, 2784, 3640], 'Shao': [2097, 2160, 2450], 'F.Cleavage': [2098], 'determines': [2104], 'death.Nature.': [2107], '2015;': [2108, 2153, 2379, 2414, 2431, 2490], '526:660–665.': [2109], 'doi:': [2110, 2139, 2155, 2176, 2216, 2241, 2264, 2303, 2322, 2360, 2381, 2416, 2433, 2462, 2492, 2528, 2543, 2558, 2583], '10.1038/nature15514.CrossrefMedlineGoogle': [2111], 'Scholar2.': [2112], 'Linkermann': [2116], 'Jouan-Lanhouet': [2118], 'S,': [2119, 2278, 2311, 2328, 2335, 2345, 2696, 2729, 2739, 2813, 2888, 2938, 2944, 2986, 2992, 2994, 3046, 3088, 3090, 3251, 3331, 3652], 'Walczak': [2120], 'Vandenabeele': [2122, 2561], 'P.Regulated': [2123], 'necrosis:': [2124], 'expanding': [2126], 'network': [2127], 'non-apoptotic': [2129], 'pathways.Nat': [2132], 'Rev': [2133, 2577], 'Mol': [2134, 2578], 'Cell': [2135, 2579, 2766, 2974, 3160, 3445, 3526, 3556, 3633], 'Biol.': [2136, 2580], '2014;': [2137, 2460, 2526], '15:135–147.': [2138], '10.1038/nrm3737.CrossrefMedlineGoogle': [2140], 'Scholar3.': [2141], 'I,': [2143, 2735], 'EA.Pyroptotic': [2145], 'defends': [2148], 'against': [2149], 'intracellular': [2150, 2296, 2458, 2827], 'pathogens.Immunol': [2151], 'Rev.': [2152, 2540], '265:130–142.': [2154], '10.1111/imr.12287.CrossrefMedlineGoogle': [2156], 'Scholar4.': [2157], 'F.Diverse': [2161], 'sensing': [2165], 'bacteria': [2168], 'virulence.Curr': [2171], 'Opin': [2172], 'Microbiol.': [2173], '2016;': [2174, 2214, 2320], '29:37–42.': [2175], '10.1016/j.mib.2015.10.003.CrossrefMedlineGoogle': [2177], 'Scholar5.': [2178], 'Zhang': [2181, 2281, 2346, 2695, 2703, 2941, 3133, 3385, 3500, 3610, 3612, 3614], 'Xu': [2183, 3647], 'WY,': [2186], 'Jiang': [2187, 2943, 3029], 'Sha': [2189], 'Cheng': [2191], 'Qin': [2195], 'Yu': [2197], 'Ji': [2199], 'H.Caspase-1': [2204], 'mediates': [2207, 2754, 3519], 'homocysteine-induced': [2208], 'pyrop-apoptosis': [2209], 'cells.Circ': [2212], 'Res.': [2213, 2413, 2430], '118:1525–1539.': [2215], '10.1161/CIRCRESAHA.116.308501.LinkGoogle': [2217], 'Scholar6.': [2218], 'Ribe': [2219], 'EM,': [2220], 'Serrano-Saiz': [2221], 'E,': [2222], 'Akpan': [2223], 'N,': [2224, 2268, 2326, 2364, 2597, 2646, 3034, 3038, 3299, 3305, 3460], 'Troy': [2225], 'CM.Mechanisms': [2226], 'neuronal': [2228], 'disease:': [2231], 'models': [2234], 'players.Biochem': [2237], 'J.': [2238], '2008;': [2239], '415:165–182.': [2240], '10.1042/BJ20081118.CrossrefMedlineGoogle': [2242], 'Scholar7.': [2243], 'Hagar': [2244, 2419], 'JA,': [2245, 2420], 'Powell': [2246], 'DA,': [2247], 'Aachoui': [2248, 2421], 'Ernst': [2250], 'RK,': [2251], 'EA.Cytoplasmic': [2253], 'LPS': [2254, 2297], 'caspase-11:': [2256], 'implications': [2257], 'TLR4-independent': [2259], 'shock.Science.': [2261], '2013;': [2262, 2301], '341:1250–1253.': [2263], '10.1126/science.1240988.CrossrefMedlineGoogle': [2265], 'Scholar8.': [2266], 'Wong': [2269], 'MT,': [2270], 'Stowe': [2271, 2365], 'IB,': [2272, 2366], 'Ramani': [2273], 'SR,': [2274], 'Gonzalez': [2275], 'LC,': [2276], 'Akashi-Takamura': [2277], 'Miyake': [2279], 'Lee': [2283, 2348, 2367, 2851, 3091, 3570], 'WP,': [2284, 2349], 'Muszyński': [2285], 'Forsberg': [2287], 'LS,': [2288], 'Carlson': [2289], 'RW,': [2290], 'Dixit': [2291, 2352], 'VM.Noncanonical': [2292], 'independent': [2298], 'TLR4.Science.': [2300], '341:1246–1249.': [2302], '10.1126/science.1240248.CrossrefMedlineGoogle': [2304], 'Scholar9.': [2305], 'Galluzzi': [2306, 2563], 'L,': [2307, 2333, 2389, 2449, 2564, 2632, 2698, 3030, 3036, 3249, 3609, 3613], 'López-Soto': [2308], 'Kumar': [2310, 2993], 'Kroemer': [2312, 2568], 'G.Caspases': [2313], 'connect': [2314], 'cell-death': [2315], 'organismal': [2318], 'homeostasis.Immunity.': [2319], '44:221–231.': [2321], '10.1016/j.immuni.2016.01.020.CrossrefMedlineGoogle': [2323], 'Scholar10.': [2324], 'Warming': [2327], 'Lamkanfi': [2329, 2505], 'M,': [2330, 2351, 2506, 2733, 2741, 2745, 2852, 2898, 3177, 3259, 3339, 3371, 3373, 3381, 3611], 'Vande': [2331], 'Walle': [2332], 'Louie': [2334], 'Dong': [2336, 2687, 3541], 'Newton': [2338], 'Qu': [2340], 'Liu': [2342, 2471, 2499, 2814, 2889, 2935, 2956, 3043, 3045, 3338, 3496, 3508, 3539], 'Heldens': [2344], 'Roose-Girma': [2350], 'VM.Non-canonical': [2353], 'targets': [2356], 'caspase-11.Nature.': [2357], '2011;': [2358, 2541], '479:117–121.': [2359], '10.1038/nature10558.CrossrefMedlineGoogle': [2361], 'Scholar11.': [2362], 'BL,': [2368], 'al.': [2370], 'non-canonical': [2376, 2518], 'signalling.Nature.': [2378], '526:666–671.': [2380], '10.1038/nature15541.CrossrefMedlineGoogle': [2382], 'Scholar12.': [2383], 'WT,': [2385], 'Wan': [2386], 'Hu': [2388, 2448, 2625, 2705], 'Chen': [2390, 2651, 2951, 3215, 3498, 3504], 'P,': [2391, 2447, 2504, 2562, 3026, 3650], 'Z,': [2395, 2500, 2626, 2688, 2702, 3040, 3255, 3329, 3379, 3501, 3646], 'ZH,': [2397], 'Zhong': [2398], 'CQ,': [2399], 'Han': [2400], 'J.Gasdermin': [2401], 'executor': [2405], 'interleukin-1β': [2411, 2760], 'secretion.Cell': [2412], '25:1285–1298.': [2415], '10.1038/cr.2015.139.CrossrefMedlineGoogle': [2417], 'Scholar13.': [2418], 'EA.WildCARDs:': [2424], 'detect': [2428], 'LPS.Cell': [2429], '25:149–150.': [2432], '10.1038/cr.2014.128.CrossrefMedlineGoogle': [2434], 'Scholar14.': [2435], 'Gao': [2442, 2635, 2685, 2691, 3037], 'Ding': [2444, 2953, 3645], 'Li': [2446, 2693, 2816, 2947, 2949, 3376, 3537, 3616, 3619, 3641, 3643], 'F.Inflammatory': [2451], 'innate': [2454], 'LPS.Nature.': [2459], '514:187–192.': [2461], '10.1038/nature13683.CrossrefMedlineGoogle': [2463], 'Scholar15.': [2464], 'D,': [2466, 2599, 2644, 2988, 3173, 3245, 3615], 'Muñoz-Planillo': [2469], 'R,': [2470, 2692, 2787, 3303, 3648], 'Q,': [2472, 2819, 2940, 3130, 3216, 3341], 'Núñez': [2473], 'G.Caspase-11': [2474], 'requires': [2475], 'mediate': [2485], 'shock.Immunity.': [2489], '43:923–932.': [2491], '10.1016/j.immuni.2015.10.009.CrossrefMedlineGoogle': [2493], 'Scholar16.': [2494], 'CR,': [2496], 'Anand': [2497], 'PK,': [2498], 'Stokes': [2501], 'KL,': [2502], 'Vogel': [2503], 'Kanneganti': [2507], 'TD.Reactive': [2508], 'enteric': [2522, 2922], 'pathogen': [2523], 'infection.PLoS': [2524], 'Pathog.': [2525], '10:e1004410.': [2527], '10.1371/journal.ppat.1004410.CrossrefMedlineGoogle': [2529], 'Scholar17.': [2530], 'EA,': [2532], 'Rajan': [2533], 'JV,': [2534], 'Aderem': [2535], 'A.Caspase-1-induced': [2536], 'death.Immunol': [2539], '243:206–214.': [2542], '10.1111/j.1600-065X.2011.01044.x.CrossrefMedlineGoogle': [2544], 'Scholar18.': [2545], 'Zong': [2546, 3510], 'WX,': [2547], 'Thompson': [2548], 'CB.Necrotic': [2549], 'fate.Genes': [2554], 'Dev.': [2555], '2006;': [2556], '20:1–15.': [2557], '10.1101/gad.1376506.CrossrefMedlineGoogle': [2559], 'Scholar19.': [2560], 'G.Molecular': [2569], 'necroptosis:': [2572], 'ordered': [2574], 'explosion.Nat': [2576], '2010;': [2581], '11:700–714.': [2582], '10.1038/nrm2970.CrossrefMedlineGoogle': [2584], 'Scholar': [2585], 'Previous': [2586], 'Back': [2587], 'top': [2589], 'Next': [2590], 'FiguresReferencesRelatedDetailsCited': [2591], 'By': [2592], 'Riestra': [2593], 'de': [2595], 'Miguel': [2596], 'Dessi': [2598], 'Simoes-Barbosa': [2600], 'Mercer': [2603], 'F': [2604], '(2022)': [2605, 3546, 3594, 3621], 'Trichomonas': [2606], 'vaginalis:': [2607], 'Lifestyle,': [2608], 'Cellular': [2609, 3316, 3364, 3483], 'Biology,': [2610, 2927, 3636], 'Molecular': [2612, 3318, 3603, 3679], 'Mechanisms': [2613, 3628], 'Pathogenesis': [2615], 'Lifecycles': [2616], 'Pathogenic': [2618], 'Protists': [2619], 'Humans,': [2621], '10.1007/978-3-030-80682-8_12,': [2622], '(541-617),': [2623], '.': [2624, 3128, 3369], 'Lai': [2627], 'Ma': [2629, 2697, 3502], 'C,': [2630, 2743, 2892, 2950, 3134], 'Zuo': [2631], 'Xiao': [2633], 'G,': [2634, 2779, 2782, 2817, 3042, 3257], 'Xie': [2637, 3374], 'B,': [2638, 2648, 2856, 3253, 3333, 3343], 'Gan': [2641], 'Yao': [2645, 3027], 'Ru': [2649], 'Y': [2652, 3136, 3139, 3345, 3511, 3620, 3659], '(2021)': [2656, 2712, 2751, 2793, 2825, 2862, 3572, 3660], 'Cordyceps': [2657], 'militaris': [2658], 'extract': [2659], 'caspase‐3/PARP/GSDME': [2665], 'A549': [2668], 'line': [2670], ',': [2671], 'Food': [2672, 3076], 'Science': [2673, 3712], '&': [2674, 2976, 3162, 3425, 3484, 3528], 'Nutrition,': [2675], '10.1002/fsn3.2636,': [2676], '10:1,': [2677, 3165], '(21-38),': [2678], 'Online': [2679, 2724, 2771, 2808, 2845, 2883, 2931, 2981, 3021, 3083, 3115, 3166, 3211, 3240, 3294, 3324, 3406, 3430, 3455, 3492, 3533], 'publication': [2680, 2725, 2772, 2809, 2846, 2884, 2932, 2982, 3022, 3084, 3116, 3167, 3212, 3241, 3295, 3325, 3407, 3431, 3456, 3493, 3534], 'date:': [2681, 2726, 2773, 2810, 2847, 2885, 2933, 2983, 3023, 3085, 3117, 3168, 3213, 3242, 3296, 3326, 3408, 3432, 3457, 3494, 3535], '1-Jan-2022.': [2682], 'Sun': [2699, 2707, 3054], 'Ge': [2710, 3653], 'J': [2711, 2750, 2824, 3218, 3310, 3545, 3656], 'GSDMD-Mediated': [2713], 'Cardiomyocyte': [2714], 'Promotes': [2716], 'Myocardial': [2717, 3355], 'I/R': [2718], 'Injury,': [2719], 'Research,': [2721, 2841], '129:3,': [2722], '(383-396),': [2723], '23-Jul-2021.': [2727], 'Theobald': [2728], 'Gräb': [2730], 'Fritsch': [2732], 'Suárez': [2734], 'Eisfeld': [2736], 'Winter': [2738], 'Koch': [2740], 'Hölscher': [2742], 'Pasparakis': [2744], 'Kashkar': [2746], 'H': [2747, 3590], 'Rybniker': [2749], 'Gasdermin': [2752], 'host': [2755], 'Mycobacterium': [2763], 'tuberculosis-infected': [2764], 'macrophages,': [2765, 2803, 3525], 'Death': [2767, 2975, 3527], 'Discovery,': [2768], '10.1038/s41420-021-00716-5,': [2769], '7:1,': [2770], '1-Dec-2021.': [2774, 2886], 'Ceciliani': [2775], 'Ávila': [2777], 'Morales': [2778], 'De': [2780], 'Matteis': [2781], 'Grandoni': [2783], 'Furioso': [2785], 'Ferreira': [2786], 'Roccabianca': [2788], 'P': [2789, 3188, 3467], 'Lecchi': [2791], 'C': [2792, 2903, 3221, 3261, 3542, 3617], 'Methods': [2794], 'isolation': [2796], 'characterization': [2798], 'bovine': [2800], 'monocytes': [2801], 'Methods,': [2804], '10.1016/j.ymeth.2020.06.017,': [2805], '186,': [2806], '(22-41),': [2807], '1-Feb-2021.': [2811], 'Hou': [2820], 'M': [2821, 2900, 2996, 2999, 3264, 3383, 3568], 'Peng': [2823], 'Reduced': [2826], 'antioxidant': [2828], 'capacity': [2829], 'platelets': [2831], 'contributes': [2832], 'primary': [2834], 'thrombocytopenia': [2836], 'ROS-NLRP3-caspase-1': [2838], 'Thrombosis': [2840], '10.1016/j.thromres.2020.12.008,': [2842], '199,': [2843], '(1-9),': [2844], '1-Mar-2021.': [2848], 'Park': [2849, 3087], 'Seo': [2853], 'Kang': [2855, 2860, 3217], 'Lim': [2857], 'S': [2858, 3052, 3435], 'K': [2861, 3307, 3464, 3571], 'GPR40': [2863], 'agonist': [2864], 'modulation': [2870], 'nuclear': [2872, 3106], 'factor-κB': [2873], 'sarco/endoplasmic': [2875], 'reticulum': [2876], 'Ca2+-ATPase,': [2877], 'Life': [2878, 3319], '10.1016/j.lfs.2021.120127,': [2880], '287,': [2881], '(120127),': [2882], 'Dillon': [2887], 'Purba': [2891], 'Christians': [2893], 'Kibbie': [2895], 'Castleman': [2897], 'McCarter': [2899], 'Wilson': [2902], '(2019)': [2904, 3056, 3098, 3121, 3140], 'Age‐related': [2905], 'alterations': [2906], 'gut': [2909], 'CD4': [2910], 'T': [2911, 2914, 3097], 'phenotype,': [2913], 'helper': [2915], 'frequencies,': [2917], 'functional': [2919], 'responses': [2920], 'bacteria,': [2923], 'Journal': [2924, 3108, 3287, 3601], 'Leukocyte': [2926], '10.1002/JLB.5A0919-177RR,': [2928], '107:1,': [2929], '(119-132),': [2930], '1-Jan-2020.': [2934], 'Du': [2937, 3506], 'Kong': [2939], 'Cao': [2945], 'Z': [2954, 3348], 'L': [2957], '(2020)': [2958, 3000], 'HSPA12A': [2959], 'attenuates': [2960], 'liver': [2962], 'injury': [2963], 'through': [2964, 3066, 3104, 3156], 'inhibiting': [2965], 'caspase-11-mediated': [2966], 'hepatocyte': [2967], 'PGC-1α-dependent': [2970], 'acyloxyacyl': [2971], 'hydrolase': [2972], 'expression,': [2973], 'Differentiation,': [2977], '10.1038/s41418-020-0536-x,': [2978], '27:9,': [2979], '(2651-2667),': [2980], '1-Sep-2020.': [2984], 'Sadaf': [2985], 'Awasthi': [2987], 'Singh': [2989], 'Nagarkoti': [2991], 'Barthwal': [2995], 'Dikshit': [2998], 'Pyroptotic': [3001], 'iNOS': [3007], 'nNOS': [3009], 'overexpressing': [3010], 'K562': [3011], 'cells:': [3012], 'mechanistic': [3014], 'insight,': [3015], 'Biochemical': [3016], 'Pharmacology,': [3017, 3560], '10.1016/j.bcp.2019.113779,': [3018], '176,': [3019], '(113779),': [3020], '1-Jun-2020.': [3024], 'Pei': [3025], 'Qiu': [3031, 3328], 'Jia': [3047], 'Tao': [3049], 'Wei': [3051], 'X': [3055, 3386], 'Inorganic': [3057], 'arsenic': [3058], 'pancreatic': [3062], 'β': [3063], 'stimulating': [3067], 'IRE1α/TNF-α': [3069], 'protective': [3072], 'taurine,': [3075], 'Chemical': [3078], 'Toxicology,': [3079, 3584], '10.1016/j.fct.2019.01.015,': [3080], '125,': [3081], '(392-402),': [3082], '1-Mar-2019.': [3086], 'Ham': [3089], 'Möller': [3093], 'Kim': [3096], 'negatively': [3100], 'Treg': [3102], 'differentiation': [3103], 'Kpna2-mediated': [3105], 'translocation,': [3107], 'Chemistry,': [3111], '10.1074/jbc.RA119.010545,': [3112], '294:47,': [3113], '(17951-17961),': [3114], '1-Nov-2019.': [3118], 'Rai': [3119], 'G': [3120, 3514], 'Factors': [3122], 'Netosis,': [3125], '10.1016/B978-0-12-816147-0.00003-4,': [3126], '(57-88),': [3127], 'Mao': [3129], 'Liang': [3131], 'Pang': [3135], 'Lu': [3138, 3513], 'LncRNA': [3141], 'KLF3-AS1': [3142], 'mesenchymal': [3145], 'stem': [3146], 'cell-derived': [3147], 'exosomes': [3148], 'ameliorates': [3149], 'cardiomyocytes': [3152], 'myocardial': [3154], 'infarction': [3155], 'miR-138-5p/Sirt1': [3157], 'axis,': [3158], 'Stem': [3159], 'Therapy,': [3163, 3237], '10.1186/s13287-019-1522-4,': [3164], '1-Dec-2019.': [3169], 'Vats': [3170], 'Sarmah': [3172], 'Kaur': [3174], 'Wanve': [3176], 'Kalia': [3178], 'Borah': [3180], 'Dave': [3182], 'Yavagal': [3184], 'Bhattacharya': [3187], '(2018)': [3189, 3222, 3265], 'Inflammasomes': [3190], 'stroke:': [3192], 'acid-sensing': [3197], 'channels,': [3199], 'Annals': [3200], 'New': [3203, 3626], 'York': [3204], 'Academy': [3205], '10.1111/nyas.13852,': [3208], '1431:1,': [3209], '(14-24),': [3210], '1-Nov-2018.': [3214], 'Fu': [3220], 'independence': [3224], 'associations': [3227], 'among': [3228], 'autophagy,': [3230], 'Signal': [3233], 'Transduction': [3234], 'Targeted': [3236], '10.1038/s41392-018-0018-5,': [3238], '3:1,': [3239], '1-Dec-2018.': [3243], 'Baumann': [3244], 'Salia': [3246], 'Greune': [3248], 'Norkowski': [3250], 'Körner': [3252], 'Uckeley': [3254], 'Frankel': [3256], 'Guenot': [3258], 'Rüter': [3260], 'Schmidt': [3263], 'Multitalented': [3266], 'EspB': [3267], 'enteropathogenic': [3269], 'Escherichia': [3270], 'coli': [3271], '(EPEC)': [3272], 'enters': [3273], 'autonomously': [3275], 'monocytic': [3283], 'THP-1': [3284], 'International': [3286, 3600], 'Medical': [3289], 'Microbiology,': [3290], '10.1016/j.ijmm.2018.03.005,': [3291], '308:3,': [3292], '(387-404),': [3293], '1-Apr-2018.': [3297], 'Le': [3298], 'Sandhu': [3300], 'U,': [3301], 'Quintana-Quezada': [3302], 'Hoang': [3304], 'Fujiwara': [3306], '(2016)': [3311], 'Flow': [3312], 'atherosclerosis,': [3315], '10.1007/s00018-016-2442-4,': [3321], '74:10,': [3322], '(1835-1858),': [3323], '1-May-2017.': [3327], 'Lei': [3330], 'Wu': [3334, 3655], 'Su': [3336], 'Meng': [3340], 'Zhou': [3342], 'Leng': [3344], 'Xia': [3347], '(2017)': [3349, 3387, 3415, 3439, 3468, 3515], 'Inflammasome': [3351], 'Activation-Mediated': [3352], 'Aggravates': [3354], 'Ischemia/Reperfusion': [3356], 'Injury': [3357], 'Diabetic': [3359], 'Rats,': [3360], 'Oxidative': [3361], 'Medicine': [3362], 'Longevity,': [3365], '10.1155/2017/9743280,': [3366], '2017,': [3367], '(1-17),': [3368], 'Dai': [3370, 3639], 'Ruan': [3378], 'Liao': [3382], 'ALV-J': [3388], 'infection': [3389], 'chicken': [3391], 'monocyte': [3392], 'accompanied': [3394], 'production': [3397], 'IL-18,': [3401, 3676], 'Oncotarget,': [3402], '10.18632/oncotarget.21906,': [3403], '8:59,': [3404], '(99889-99900),': [3405], '21-Nov-2017.': [3409], 'Dhanasekaran': [3410], 'Reddy': [3413], 'E': [3414], 'JNK-signaling:': [3416], 'multiplexing': [3418], 'hub': [3419], 'death,': [3423], 'Genes': [3424], 'Cancer,': [3426], '10.18632/genesandcancer.155,': [3427], '8:9-10,': [3428], '(682-694),': [3429], '2-Nov-2017.': [3433], 'Suwanmanee': [3434], 'Luplertlop': [3437], 'N': [3438], 'Immunopathogenesis': [3440], 'Dengue': [3442], 'Virus-Induced': [3443], 'Redundant': [3444], 'Death:': [3446], 'Apoptosis': [3447], 'Pyroptosis,': [3449, 3623], 'Viral': [3450], 'Immunology,': [3451], '10.1089/vim.2016.0092,': [3452], '30:1,': [3453], '(13-19),': [3454], '1-Jan-2017.': [3458], 'Luehong': [3459], 'Khaowmek': [3461], 'Wongsawan': [3463], 'Chuammitri': [3466], 'Preferential': [3469], 'pattern': [3470], 'neutrophil': [3473], 'response': [3477], 'stimulants,': [3480], 'Vitro': [3482], 'Developmental': [3485, 3635], 'Biology': [3486, 3716], '-': [3487], 'Animal,': [3488], '10.1007/s11626-016-0129-7,': [3489], '53:6,': [3490], '(513-524),': [3491], '1-Jun-2017.': [3495], 'radiation-induced': [3520], 'marrow-derived': [3524], 'Disease,': [3529], '10.1038/cddis.2016.460,': [3530], '8:2,': [3531], '(e2579-e2579),': [3532], '1-Feb-2017.': [3536], 'Lyu': [3544], 'Prognostic': [3547], 'Implications': [3548], 'Pyroptosis-Related': [3550], 'Gene': [3551], 'Signatures': [3552], 'Lung': [3554], 'Squamous': [3555], 'Carcinoma,': [3557], 'Frontiers': [3558, 3582, 3631, 3677], '10.3389/fphar.2022.806995,': [3561], '13': [3562], 'Favor': [3563], 'O,': [3564, 3588], 'Pestka': [3565], 'Bates': [3567], 'Centrality': [3573], 'Myeloid-Lineage': [3575], 'Phagocytes': [3576], 'Particle-Triggered': [3578], 'Inflammation': [3579], 'Autoimmunity,': [3581], '10.3389/ftox.2021.777768,': [3585], 'Mandolfo': [3587], 'Parker': [3589], 'Bigger': [3592], 'B': [3593], 'Innate': [3595], 'Immunity': [3596], 'Mucopolysaccharide': [3598], 'Diseases,': [3599], '10.3390/ijms23041999,': [3605], '23:4,': [3606], '(1999)': [3607], 'Lin': [3608], 'Autophagy,': [3622], 'Ferroptosis:': [3625], 'Regulatory': [3627], 'Atherosclerosis,': [3630], '10.3389/fcell.2021.809955,': [3637], 'Yin': [3649], 'Zou': [3658], 'Abrogates': [3662], 'Salutary': [3664], 'Effects': [3665], 'Hypertrophic': [3667], 'Preconditioning': [3668], 'Pressure': [3670], 'Overload': [3671], 'Hearts': [3672], 'Biosciences,': [3680], '10.3389/fmolb.2021.641585,': [3681], '13,': [3684, 3701], '2016Vol': [3685], 'Issue': [3687], 'Advertisement': [3689, 3710], 'Article': [3690], 'InformationMetrics': [3691], '©': [3692], '2016': [3693, 3702], 'Association,': [3696], 'Inc.https://doi.org/10.1161/CIRCRESAHA.116.308699PMID:': [3697], '27174943': [3698], 'publishedMay': [3700], 'KeywordsEditorialsGsdm': [3703], 'protein,': [3704], 'mousecaspase': [3705], '1inflammasomes': [3706], 'pyroptosisPDF': [3708], 'download': [3709], 'SubjectsBasic': [3711], 'ResearchCell': [3713], 'Signaling/Signal': [3714], 'TransductionInflammationVascular': [3715]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2347411313', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-11T17:42:41.380401', 'created_date': '2016-06-24'}