Title: Differentiation on Concomitant of non-diabetic renal disease from diabetic nephropathy in type 2 diabetes Mellitus
Abstract: Objective To analyse the differences between the clinical symptoms, clinical course and renal pathologic features in type 2 diabetes mellitus(DM) patients with non-diabetic renal disease(NDRD) or diabetic nephropathy(DN).Methods 34 patients with type 2 diabetes and renal involvement were studied and divided into 2 groups.There were 22 patients in a group of NDRD and 12 in a group of DN.Comparison was carried out between the two groups on age incidence,clinical course,proteinuria,hematuria,renal function,blood pressure,retinopathy and pathologic appearance of renal biopsy.Results The average clinical course of NDRD was shorter than that of DN.The quantity of proteinuria was similar in both groups.There was one patient showing hematuria alone and 11 patients showing hematuria and proteinuria in the group NDRD;the incidence of hematuria was a little more than that in DN.The renal function was more seriously impaired in NDRD than in DN.75% of the patients was hypertensive in group DN,being more than that in group NDRD(50%).All the patients in group DN had stage Ⅱ~Ⅳ diabetic retinopathy,but only 2 patients had stage Ⅱ diabetic retinopathy in group NDRD.Renal biopsy was done in 30 patients.The 12 patients in group DN were shown to be in different stages of DN.18 in group NDRD were diagnosed with different kinds of glomerulonephritis.Conclusion When diabetic patients have a clincal course of less than five years;rapid emergence of massive proteinuria or severe edema,relatively normal renal function;glomerular hematuria alone or hematuria plus proteinuria;rapid appearance of renal insufficiency;absence of diabetic retinopathy and serious impairment of renal tubular function,the possibility of diabetes mellitus with concomitant non-diabetic renal disease should be considered. [
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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Cited By Count: 1
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