Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2346773409', 'doi': 'https://doi.org/10.1016/j.ajo.2016.04.020', 'title': 'Clinical Efficacy and Safety of Ranibizumab Versus Dexamethasone for Central Retinal Vein Occlusion (COMRADE C): A European Label Study', 'display_name': 'Clinical Efficacy and Safety of Ranibizumab Versus Dexamethasone for Central Retinal Vein Occlusion (COMRADE C): A European Label Study', 'publication_year': 2016, 'publication_date': '2016-09-01', 'ids': {'openalex': 'https://openalex.org/W2346773409', 'doi': 'https://doi.org/10.1016/j.ajo.2016.04.020', 'mag': '2346773409', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27401725'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ajo.2016.04.020', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S50016660', 'display_name': 'American Journal of Ophthalmology', 'issn_l': '0002-9394', 'issn': ['0002-9394', '1879-1891'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016685929', 'display_name': 'Hans Hoerauf', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I74656192', 'display_name': 'University of Göttingen', 'ror': 'https://ror.org/01y9bpm73', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I74656192']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Hans Hoerauf', 'raw_affiliation_strings': ['Department of Ophthalmology, Georg-August-University Göttingen, Göttingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Georg-August-University Göttingen, Göttingen, Germany', 'institution_ids': ['https://openalex.org/I74656192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015160966', 'display_name': 'Nicolas Feltgen', 'orcid': 'https://orcid.org/0000-0002-6857-3003'}, 'institutions': [{'id': 'https://openalex.org/I74656192', 'display_name': 'University of Göttingen', 'ror': 'https://ror.org/01y9bpm73', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I74656192']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Nicolas Feltgen', 'raw_affiliation_strings': ['Department of Ophthalmology, Georg-August-University Göttingen, Göttingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Georg-August-University Göttingen, Göttingen, Germany', 'institution_ids': ['https://openalex.org/I74656192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033461983', 'display_name': 'Claudia Weiß', 'orcid': 'https://orcid.org/0000-0001-5016-9208'}, 'institutions': [{'id': 'https://openalex.org/I4210086790', 'display_name': 'Novartis (Germany)', 'ror': 'https://ror.org/0013shd50', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I1283582996', 'https://openalex.org/I4210086790']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Claudia Weiss', 'raw_affiliation_strings': ['Novartis Pharma GmbH, Nuremberg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Novartis Pharma GmbH, Nuremberg, Germany', 'institution_ids': ['https://openalex.org/I4210086790']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048797041', 'display_name': 'Margitta Worm', 'orcid': 'https://orcid.org/0000-0002-3449-1245'}, 'institutions': [{'id': 'https://openalex.org/I4210086790', 'display_name': 'Novartis (Germany)', 'ror': 'https://ror.org/0013shd50', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I1283582996', 'https://openalex.org/I4210086790']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Eva-Maria Paulus', 'raw_affiliation_strings': ['Novartis Pharma GmbH, Nuremberg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Novartis Pharma GmbH, Nuremberg, Germany', 'institution_ids': ['https://openalex.org/I4210086790']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076944459', 'display_name': 'Steffen Schmitz-Valckenberg', 'orcid': 'https://orcid.org/0000-0003-3358-9942'}, 'institutions': [{'id': 'https://openalex.org/I135140700', 'display_name': 'University of Bonn', 'ror': 'https://ror.org/041nas322', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I135140700']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Steffen Schmitz-Valckenberg', 'raw_affiliation_strings': ['GRADE Reading Center, Department of Ophthalmology, University of Bonn, Bonn, Germany'], 'affiliations': [{'raw_affiliation_string': 'GRADE Reading Center, Department of Ophthalmology, University of Bonn, Bonn, Germany', 'institution_ids': ['https://openalex.org/I135140700']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042876597', 'display_name': 'Amelie Pielen', 'orcid': 'https://orcid.org/0000-0001-9401-2501'}, 'institutions': [{'id': 'https://openalex.org/I2801240073', 'display_name': 'University Medical Center Freiburg', 'ror': 'https://ror.org/03vzbgh69', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801240073']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Amelie Pielen', 'raw_affiliation_strings': ['University Eye Hospital, Universitätsklinikum Freiburg, Freiburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'University Eye Hospital, Universitätsklinikum Freiburg, Freiburg, Germany', 'institution_ids': ['https://openalex.org/I2801240073']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060652405', 'display_name': 'Prem Puri', 'orcid': 'https://orcid.org/0000-0003-4964-0095'}, 'institutions': [{'id': 'https://openalex.org/I2799342194', 'display_name': 'Royal Derby Hospital', 'ror': 'https://ror.org/005r9p256', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799342194', 'https://openalex.org/I4210149821']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Pankaj Puri', 'raw_affiliation_strings': ['Department of Ophthalmology, Royal Derby Hospital, Derby, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Royal Derby Hospital, Derby, United Kingdom', 'institution_ids': ['https://openalex.org/I2799342194']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087352416', 'display_name': 'Hüsnü Berk', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210108472', 'display_name': 'St. Elisabeth-Hospital Bochum', 'ror': 'https://ror.org/01mxnn839', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108472', 'https://openalex.org/I4210153564']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hüsnü Berk', 'raw_affiliation_strings': ['Department of Ophthalmology, St. Elisabeth-Hospital, Koeln-Hohenlind, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, St. Elisabeth-Hospital, Koeln-Hohenlind, Germany', 'institution_ids': ['https://openalex.org/I4210108472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037018029', 'display_name': 'Nicole Eter', 'orcid': 'https://orcid.org/0000-0001-5617-346X'}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Nicole Eter', 'raw_affiliation_strings': ['Department of Ophthalmology, University of Münster Medical Center, Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, University of Münster Medical Center, Münster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018272749', 'display_name': 'Peter Wiedemann', 'orcid': 'https://orcid.org/0000-0002-5540-6847'}, 'institutions': [{'id': 'https://openalex.org/I926574661', 'display_name': 'Leipzig University', 'ror': 'https://ror.org/03s7gtk40', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I926574661']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Peter Wiedemann', 'raw_affiliation_strings': ['Department of Ophthalmology, University of Leipzig, Leipzig, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, University of Leipzig, Leipzig, Germany', 'institution_ids': ['https://openalex.org/I926574661']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068316441', 'display_name': 'Gabriele E. Lang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196349391', 'display_name': 'Universität Ulm', 'ror': 'https://ror.org/032000t02', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I196349391']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Gabriele E. Lang', 'raw_affiliation_strings': ['Department of Ophthalmology, University of Ulm, Ulm, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, University of Ulm, Ulm, Germany', 'institution_ids': ['https://openalex.org/I196349391']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046963723', 'display_name': 'Matúš Rehák', 'orcid': 'https://orcid.org/0000-0002-3257-6181'}, 'institutions': [{'id': 'https://openalex.org/I926574661', 'display_name': 'Leipzig University', 'ror': 'https://ror.org/03s7gtk40', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I926574661']}, {'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Matus Rehak', 'raw_affiliation_strings': ['Department of Ophthalmology, Charité - Universitätsmedizin, Berlin, Germany', 'Department of Ophthalmology, University of Leipzig, Leipzig, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, University of Leipzig, Leipzig, Germany', 'institution_ids': ['https://openalex.org/I926574661']}, {'raw_affiliation_string': 'Department of Ophthalmology, Charité - Universitätsmedizin, Berlin, Germany', 'institution_ids': ['https://openalex.org/I7877124']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075076772', 'display_name': 'Armin Wolf', 'orcid': 'https://orcid.org/0000-0002-6991-2214'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Armin Wolf', 'raw_affiliation_strings': ['Department of Ophthalmology, Ludwig-Maximilians University, Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Ludwig-Maximilians University, Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050859090', 'display_name': 'Thomas Bertelmann', 'orcid': 'https://orcid.org/0000-0002-4017-2224'}, 'institutions': [{'id': 'https://openalex.org/I4210086790', 'display_name': 'Novartis (Germany)', 'ror': 'https://ror.org/0013shd50', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I1283582996', 'https://openalex.org/I4210086790']}, {'id': 'https://openalex.org/I161103922', 'display_name': 'Philipps University of Marburg', 'ror': 'https://ror.org/01rdrb571', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161103922']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Thomas Bertelmann', 'raw_affiliation_strings': ['Department of Ophthalmology, Philipps-University Marburg, Marburg, Germany', 'Novartis Pharma GmbH, Nuremberg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Novartis Pharma GmbH, Nuremberg, Germany', 'institution_ids': ['https://openalex.org/I4210086790']}, {'raw_affiliation_string': 'Department of Ophthalmology, Philipps-University Marburg, Marburg, Germany', 'institution_ids': ['https://openalex.org/I161103922']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010137447', 'display_name': 'Lars‐Olof Hattenbach', 'orcid': 'https://orcid.org/0000-0002-5275-8118'}, 'institutions': [{'id': 'https://openalex.org/I4210130435', 'display_name': 'Klinikum Ludwigshafen', 'ror': 'https://ror.org/037wq4b75', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210130435']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Lars-Olof Hattenbach', 'raw_affiliation_strings': ['Department of Ophthalmology, Ludwigshafen Hospital, Ludwigshafen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Ludwigshafen Hospital, Ludwigshafen, Germany', 'institution_ids': ['https://openalex.org/I4210130435']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 13, 'corresponding_author_ids': ['https://openalex.org/A5016685929'], 'corresponding_institution_ids': ['https://openalex.org/I74656192'], 'apc_list': {'value': 4390, 'currency': 'USD', 'value_usd': 4390, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 10.343, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 67, 'citation_normalized_percentile': {'value': 0.999866, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '169', 'issue': None, 'first_page': '258', 'last_page': '267'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10170', 'display_name': 'Age-Related Macular Degeneration Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10170', 'display_name': 'Age-Related Macular Degeneration Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10993', 'display_name': 'Role of Complement System in Immune Response', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12599', 'display_name': 'Ocular Manifestations of COVID-19', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/retinal-artery-occlusion', 'display_name': 'Retinal Artery Occlusion', 'score': 0.513823}, {'id': 'https://openalex.org/keywords/pro-re-nata', 'display_name': 'Pro re nata', 'score': 0.49786043}], 'concepts': [{'id': 'https://openalex.org/C2781100027', 'wikidata': 'https://www.wikidata.org/wiki/Q414270', 'display_name': 'Ranibizumab', 'level': 4, 'score': 0.95897126}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9284673}, {'id': 'https://openalex.org/C2780401358', 'wikidata': 'https://www.wikidata.org/wiki/Q422252', 'display_name': 'Dexamethasone', 'level': 2, 'score': 0.8302019}, {'id': 'https://openalex.org/C2778257484', 'wikidata': 'https://www.wikidata.org/wiki/Q555066', 'display_name': 'Visual acuity', 'level': 2, 'score': 0.6457956}, {'id': 'https://openalex.org/C118487528', 'wikidata': 'https://www.wikidata.org/wiki/Q161437', 'display_name': 'Ophthalmology', 'level': 1, 'score': 0.5961997}, {'id': 'https://openalex.org/C2780347916', 'wikidata': 'https://www.wikidata.org/wiki/Q1813737', 'display_name': 'Macular edema', 'level': 3, 'score': 0.5211877}, {'id': 'https://openalex.org/C2778844676', 'wikidata': 'https://www.wikidata.org/wiki/Q190831', 'display_name': 'Central retinal vein occlusion', 'level': 4, 'score': 0.5129654}, {'id': 'https://openalex.org/C168563851', 'wikidata': 'https://www.wikidata.org/wiki/Q1436668', 'display_name': 'Randomized controlled trial', 'level': 2, 'score': 0.5093318}, {'id': 'https://openalex.org/C2780699112', 'wikidata': 'https://www.wikidata.org/wiki/Q7246796', 'display_name': 'Pro re nata', 'level': 5, 'score': 0.49786043}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.4614128}, {'id': 'https://openalex.org/C2777802072', 'wikidata': 'https://www.wikidata.org/wiki/Q413299', 'display_name': 'Bevacizumab', 'level': 3, 'score': 0.30632862}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.28559995}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.21216026}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.096330404}], 'mesh': [{'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D003907', 'descriptor_name': 'Dexamethasone', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D005938', 'descriptor_name': 'Glucocorticoids', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D008269', 'descriptor_name': 'Macular Edema', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000069579', 'descriptor_name': 'Ranibizumab', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D012170', 'descriptor_name': 'Retinal Vein Occlusion', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D003907', 'descriptor_name': 'Dexamethasone', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D003907', 'descriptor_name': 'Dexamethasone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004343', 'descriptor_name': 'Drug Implants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005060', 'descriptor_name': 'Europe', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005938', 'descriptor_name': 'Glucocorticoids', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D005938', 'descriptor_name': 'Glucocorticoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006304', 'descriptor_name': 'Health Status', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058449', 'descriptor_name': 'Intravitreal Injections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008269', 'descriptor_name': 'Macular Edema', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008269', 'descriptor_name': 'Macular Edema', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011788', 'descriptor_name': 'Quality of Life', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069579', 'descriptor_name': 'Ranibizumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069579', 'descriptor_name': 'Ranibizumab', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D012170', 'descriptor_name': 'Retinal Vein Occlusion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012170', 'descriptor_name': 'Retinal Vein Occlusion', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D041623', 'descriptor_name': 'Tomography, Optical Coherence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D014792', 'descriptor_name': 'Visual Acuity', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D014792', 'descriptor_name': 'Visual Acuity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ajo.2016.04.020', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S50016660', 'display_name': 'American Journal of Ophthalmology', 'issn_l': '0002-9394', 'issn': ['0002-9394', '1879-1891'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27163237', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W1965030185', 'https://openalex.org/W1967175861', 'https://openalex.org/W1974243302', 'https://openalex.org/W1978704499', 'https://openalex.org/W1988096181', 'https://openalex.org/W2011493848', 'https://openalex.org/W2029793104', 'https://openalex.org/W2031246040', 'https://openalex.org/W2034477424', 'https://openalex.org/W2038005713', 'https://openalex.org/W2038183722', 'https://openalex.org/W2044968030', 'https://openalex.org/W2052204551', 'https://openalex.org/W2056682653', 'https://openalex.org/W2058312539', 'https://openalex.org/W2068100937', 'https://openalex.org/W2075780935', 'https://openalex.org/W2078775150', 'https://openalex.org/W2091445280', 'https://openalex.org/W2091989599', 'https://openalex.org/W2128701654', 'https://openalex.org/W2144771657', 'https://openalex.org/W2152957810', 'https://openalex.org/W2285674438'], 'related_works': ['https://openalex.org/W4380150408', 'https://openalex.org/W36880521', 'https://openalex.org/W3031917678', 'https://openalex.org/W2955043754', 'https://openalex.org/W2586424183', 'https://openalex.org/W2404930177', 'https://openalex.org/W2208998862', 'https://openalex.org/W2128391312', 'https://openalex.org/W2121621777', 'https://openalex.org/W2014260690'], 'abstract_inverted_index': {'To': [0], 'compare': [1], 'the': [2, 7, 99, 177, 181, 187, 209, 222, 234], 'efficacy': [3, 191, 207], 'and': [4, 90, 109, 114, 196, 201], 'safety': [5], 'of': [6, 10, 131, 165, 221], 'European': [8, 188], 'labels': [9], 'ranibizumab': [11, 43, 108, 144, 166, 182, 195, 204], '0.5': [12], 'mg': [13, 17], 'vs': [14, 149, 185], 'dexamethasone': [15, 57, 110, 147, 178, 197, 212, 226, 240], '0.7': [16], 'in': [18, 73, 88, 105, 126, 129, 173, 176, 180], 'patients': [19, 175, 227], 'with': [20, 143, 146], 'macular': [21], 'edema': [22], 'secondary': [23], 'to': [24, 39, 80, 119, 253], 'central': [25], 'retinal': [26], 'vein': [27], 'occlusion': [28], '(CRVO).Phase': [29], 'IIIb,': [30], 'multicenter,': [31], 'double-masked,': [32], 'randomized': [33, 37], 'clinical': [34, 238], 'trial.Patients': [35], 'were': [36, 69, 171, 251], '(1:1)': [38], 'receive': [40], 'either': [41], 'monthly': [42], 'followed': [44, 59], 'by': [45, 60], 'pro': [46], 're': [47], 'nata': [48], '(PRN)': [49], 'treatment': [50, 232], '(n': [51, 64], '=': [52, 65], '124)': [53], 'or': [54], '1': [55, 82, 113, 200], 'sustained-release': [56], 'implant': [58], 'PRN': [61], 'sham': [62], 'injections': [63], '119).': [66], 'Main': [67], 'outcomes': [68], 'mean': [70, 86, 136], 'average': [71, 137], 'change': [72, 87], 'best-corrected': [74], 'visual': [75], 'acuity': [76], '(BCVA)': [77], 'from': [78, 214], 'baseline': [79], 'month': [81, 84, 117, 120, 134, 215], 'through': [83], '6,': [85, 121, 135], 'BCVA,': [89], 'adverse': [91], 'events': [92], '(AEs).Of': [93], '243': [94], 'patients,': [95], '185': [96], '(76.1%)': [97], 'completed': [98], 'study.': [100, 236], 'No': [101], 'difference': [102, 125, 152], 'was': [103, 123, 140, 167, 192, 224], 'observed': [104, 193], 'BCVA': [106, 127, 138], 'between': [107], 'at': [111, 198], 'months': [112, 199], '2.': [115, 202], 'From': [116], '3': [118, 216], 'there': [122], 'significant': [124], 'gains': [128], 'favor': [130], 'ranibizumab.': [132], 'At': [133], 'gain': [139], 'significantly': [141], 'higher': [142], 'than': [145, 179, 246], '(12.86': [148], '2.96': [150], 'letters;': [151], '9.91': [153], 'letters,': [154], '95%': [155], 'confidence': [156], 'interval': [157], '[6.51-13.30];': [158], 'P': [159], '<': [160], '.0001).': [161], 'Mean': [162], 'injection': [163], 'number': [164], '4.52.': [168], 'Ocular': [169], 'AEs': [170], 'reported': [172], 'more': [174], 'group': [183], '(86.6%': [184], '55.6%).Using': [186], 'labels,': [189], 'similar': [190, 252], 'for': [194], 'However,': [203], 'maintained': [205], 'its': [206], 'throughout': [208], 'study,': [210], 'whereas': [211], 'declined': [213], 'onward.': [217], 'The': [218], 'main': [219], 'limitation': [220], 'study': [223], 'that': [225], 'received': [228], 'only': [229], 'a': [230], 'single': [231], 'during': [233], '6-month': [235], 'In': [237], 'practice,': [239], 'retreatment': [241], 'may': [242], 'be': [243], 'required': [244], 'earlier': [245], '6': [247], 'months.': [248], 'Safety': [249], 'findings': [250], 'those': [254], 'previously': [255], 'reported.': [256]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2346773409', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2024-08-15T14:18:04.114279', 'created_date': '2016-06-24'}