Effect of Praziquantel on Antigenemia in Murine Schistosomiasis

Name: Work Video:
Duration: 3 min 30 s
Description: Abstract. A substantial portion (63%) of circulating schistosomal antigen was cleared from the serum of hyperinfected mice within 72 hours after treatment with the helminthocide, praziquantel. This result suggests that circulating antigen may be a diagnostically useful marker for active schistosomiasis.
Joel K. Weltman
{'id': 'https://openalex.org/W2346681087', 'doi': 'https://doi.org/10.4269/ajtmh.1982.31.1294', 'title': 'Effect of Praziquantel on Antigenemia in Murine Schistosomiasis', 'display_name': 'Effect of Praziquantel on Antigenemia in Murine Schistosomiasis', 'publication_year': 1982, 'publication_date': '1982-11-01', 'ids': {'openalex': 'https://openalex.org/W2346681087', 'doi': 'https://doi.org/10.4269/ajtmh.1982.31.1294', 'mag': '2346681087', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6756180'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.4269/ajtmh.1982.31.1294', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S100045985', 'display_name': 'American Journal of Tropical Medicine and Hygiene', 'issn_l': '0002-9637', 'issn': ['0002-9637', '1476-1645'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315658', 'host_organization_name': 'American Society of Tropical Medicine and Hygiene', 'host_organization_lineage': ['https://openalex.org/P4310315658'], 'host_organization_lineage_names': ['American Society of Tropical Medicine and Hygiene'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5057218178', 'display_name': 'Joel K. Weltman', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Joel K. Weltman', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5057218178'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.502, 'has_fulltext': False, 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.522577, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 77}, 'biblio': {'volume': '31', 'issue': '6', 'first_page': '1294', 'last_page': '1296'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10695', 'display_name': 'Parasites and Host Interactions', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10695', 'display_name': 'Parasites and Host Interactions', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10815', 'display_name': 'Parasite Biology and Host Interactions', 'score': 0.9801, 'subfield': {'id': 'https://openalex.org/subfields/2303', 'display_name': 'Ecology'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11074', 'display_name': 'Helminth infection and control', 'score': 0.9721, 'subfield': {'id': 'https://openalex.org/subfields/3404', 'display_name': 'Small Animals'}, 'field': {'id': 'https://openalex.org/fields/34', 'display_name': 'Veterinary'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/clearance', 'display_name': 'Clearance', 'score': 0.73322785}], 'concepts': [{'id': 'https://openalex.org/C2779744950', 'wikidata': 'https://www.wikidata.org/wiki/Q424145', 'display_name': 'Praziquantel', 'level': 4, 'score': 0.98140085}, {'id': 'https://openalex.org/C2776225656', 'wikidata': 'https://www.wikidata.org/wiki/Q221159', 'display_name': 'Schistosomiasis', 'level': 3, 'score': 0.95353603}, {'id': 'https://openalex.org/C138944611', 'wikidata': 'https://www.wikidata.org/wiki/Q1163287', 'display_name': 'Clearance', 'level': 2, 'score': 0.73322785}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.68379116}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.63560045}, {'id': 'https://openalex.org/C2779726973', 'wikidata': 'https://www.wikidata.org/wiki/Q578994', 'display_name': 'Helminthiasis', 'level': 2, 'score': 0.54928154}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.45884216}, {'id': 'https://openalex.org/C2776863245', 'wikidata': 'https://www.wikidata.org/wiki/Q2324689', 'display_name': 'Schistosoma mansoni', 'level': 4, 'score': 0.42629337}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3341312}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.3338232}, {'id': 'https://openalex.org/C165901193', 'wikidata': 'https://www.wikidata.org/wiki/Q3129936', 'display_name': 'Helminths', 'level': 2, 'score': 0.26985478}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000941', 'descriptor_name': 'Antigens', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D007546', 'descriptor_name': 'Isoquinolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011223', 'descriptor_name': 'Praziquantel', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D012552', 'descriptor_name': 'Schistosomiasis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000941', 'descriptor_name': 'Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006168', 'descriptor_name': 'Guinea Pigs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007124', 'descriptor_name': 'Immunoenzyme Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007546', 'descriptor_name': 'Isoquinolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011223', 'descriptor_name': 'Praziquantel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012550', 'descriptor_name': 'Schistosoma mansoni', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D012550', 'descriptor_name': 'Schistosoma mansoni', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012552', 'descriptor_name': 'Schistosomiasis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D012552', 'descriptor_name': 'Schistosomiasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.4269/ajtmh.1982.31.1294', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S100045985', 'display_name': 'American Journal of Tropical Medicine and Hygiene', 'issn_l': '0002-9637', 'issn': ['0002-9637', '1476-1645'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315658', 'host_organization_name': 'American Society of Tropical Medicine and Hygiene', 'host_organization_lineage': ['https://openalex.org/P4310315658'], 'host_organization_lineage_names': ['American Society of Tropical Medicine and Hygiene'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6756180', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.47, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3186949440', 'https://openalex.org/W2580606762', 'https://openalex.org/W2346681087', 'https://openalex.org/W2326083430', 'https://openalex.org/W2292312332', 'https://openalex.org/W2095210382', 'https://openalex.org/W2091746068', 'https://openalex.org/W2081326772', 'https://openalex.org/W2075015532', 'https://openalex.org/W2066835202'], 'abstract_inverted_index': {'Abstract.': [0], 'A': [1], 'substantial': [2], 'portion': [3], '(63%)': [4], 'of': [5, 14], 'circulating': [6, 30], 'schistosomal': [7], 'antigen': [8, 31], 'was': [9], 'cleared': [10], 'from': [11], 'the': [12, 23], 'serum': [13], 'hyperinfected': [15], 'mice': [16], 'within': [17], '72': [18], 'hours': [19], 'after': [20], 'treatment': [21], 'with': [22], 'helminthocide,': [24], 'praziquantel.': [25], 'This': [26], 'result': [27], 'suggests': [28], 'that': [29], 'may': [32], 'be': [33], 'a': [34], 'diagnostically': [35], 'useful': [36], 'marker': [37], 'for': [38], 'active': [39], 'schistosomiasis.': [40]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2346681087', 'counts_by_year': [], 'updated_date': '2024-12-10T08:48:14.945114', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
