Publication Information

{'id': 'https://openalex.org/W2346455216', 'doi': 'https://doi.org/10.18632/oncotarget.7598', 'title': 'Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells', 'display_name': 'Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells', 'publication_year': 2016, 'publication_date': '2016-02-22', 'ids': {'openalex': 'https://openalex.org/W2346455216', 'doi': 'https://doi.org/10.18632/oncotarget.7598', 'mag': '2346455216', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26930718', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4914246'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7598', 'pdf_url': 'https://www.oncotarget.com/article/7598/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/7598/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023686570', 'display_name': 'Masanori Hasegawa', 'orcid': 'https://orcid.org/0000-0002-4354-6105'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Masanori Hasegawa', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077310835', 'display_name': 'Hidekazu Takahashi', 'orcid': 'https://orcid.org/0000-0003-0779-407X'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP', 'US'], 'is_corresponding': False, 'raw_author_name': 'Hidekazu Takahashi', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'Department of Gastrointestinal Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}, {'raw_affiliation_string': 'Department of Gastrointestinal Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049901416', 'display_name': 'Hasan Rajabi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hasan Rajabi', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109389698', 'display_name': 'Maroof Alam', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maroof Alam', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001060485', 'display_name': 'Yozo Suzuki', 'orcid': 'https://orcid.org/0000-0002-4567-3802'}, 'institutions': [{'id': 'https://openalex.org/I4210108563', 'display_name': 'Osaka Police Hospital', 'ror': 'https://ror.org/015x7ap02', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108563']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['JP', 'US'], 'is_corresponding': False, 'raw_author_name': 'Yozo Suzuki', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'Department of Gastroenterological Surgery, Osaka Police Hospital, Osaka City, Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterological Surgery, Osaka Police Hospital, Osaka City, Osaka, Japan', 'institution_ids': ['https://openalex.org/I4210108563']}, {'raw_affiliation_string': 'Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100451129', 'display_name': 'Yin Li', 'orcid': 'https://orcid.org/0000-0002-7102-323X'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Li Yin', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011605314', 'display_name': 'Ashujit Tagde', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ashujit Tagde', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035237919', 'display_name': 'Takahiro Maeda', 'orcid': 'https://orcid.org/0000-0003-4530-6460'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Takahiro Maeda', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063268324', 'display_name': 'Masayuki Hiraki', 'orcid': 'https://orcid.org/0000-0001-6445-7390'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Masayuki Hiraki', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022619172', 'display_name': 'Vikas P. Sukhatme', 'orcid': 'https://orcid.org/0000-0002-1825-6034'}, 'institutions': [{'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vikas P. Sukhatme', 'raw_affiliation_strings': ['Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I1316535847', 'https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067054634', 'display_name': 'Donald Küfe', 'orcid': 'https://orcid.org/0000-0001-5743-8888'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Donald Kufe', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I4210117453']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5067054634'], 'corresponding_institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I4210117453'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.157, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 165, 'citation_normalized_percentile': {'value': 0.999984, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '7', 'issue': '11', 'first_page': '11756', 'last_page': '11769'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation and Glycoproteins Research', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/triple-negative-breast-cancer', 'display_name': 'Triple-negative breast cancer', 'score': 0.65658796}, {'id': 'https://openalex.org/keywords/cytoprotection', 'display_name': 'Cytoprotection', 'score': 0.42556608}], 'concepts': [{'id': 'https://openalex.org/C2780110267', 'wikidata': 'https://www.wikidata.org/wiki/Q7843332', 'display_name': 'Triple-negative breast cancer', 'level': 4, 'score': 0.65658796}, {'id': 'https://openalex.org/C2780932548', 'wikidata': 'https://www.wikidata.org/wiki/Q1056532', 'display_name': 'CD44', 'level': 3, 'score': 0.59216505}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.47810382}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.45802248}, {'id': 'https://openalex.org/C538909803', 'wikidata': 'https://www.wikidata.org/wiki/Q116907', 'display_name': 'Glutathione', 'level': 3, 'score': 0.44691545}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.44033507}, {'id': 'https://openalex.org/C61174792', 'wikidata': 'https://www.wikidata.org/wiki/Q420510', 'display_name': 'Glutamate receptor', 'level': 3, 'score': 0.42614272}, {'id': 'https://openalex.org/C2780967304', 'wikidata': 'https://www.wikidata.org/wiki/Q246156', 'display_name': 'Cytoprotection', 'level': 3, 'score': 0.42556608}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4209501}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.41847086}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.40344316}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.31949118}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26844877}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.18065724}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.16570696}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.16426164}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15682715}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D027182', 'descriptor_name': 'Amino Acid Transport System y+', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003553', 'descriptor_name': 'Cystine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018698', 'descriptor_name': 'Glutamic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018960', 'descriptor_name': 'Hyaluronan Receptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018396', 'descriptor_name': 'Mucin-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D064726', 'descriptor_name': 'Triple Negative Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027182', 'descriptor_name': 'Amino Acid Transport System y+', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003553', 'descriptor_name': 'Cystine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018698', 'descriptor_name': 'Glutamic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018960', 'descriptor_name': 'Hyaluronan Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018396', 'descriptor_name': 'Mucin-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064726', 'descriptor_name': 'Triple Negative Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064726', 'descriptor_name': 'Triple Negative Breast Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7598', 'pdf_url': 'https://www.oncotarget.com/article/7598/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4914246', 'pdf_url': 'https://europepmc.org/articles/pmc4914246?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914246', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://nrs.harvard.edu/urn-3:HUL.InstRepos:27822261', 'pdf_url': 'https://dash.harvard.edu/bitstream/1/27822261/1/4914246.pdf', 'source': {'id': 'https://openalex.org/S4306401540', 'display_name': 'Digital Access to Scholarship at Harvard (DASH) (Harvard University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I136199984', 'host_organization_name': 'Harvard University', 'host_organization_lineage': ['https://openalex.org/I136199984'], 'host_organization_lineage_names': ['Harvard University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26930718', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7598', 'pdf_url': 'https://www.oncotarget.com/article/7598/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.86, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1868543250', 'https://openalex.org/W1956018566', 'https://openalex.org/W1968489617', 'https://openalex.org/W1980058210', 'https://openalex.org/W1987384630', 'https://openalex.org/W1996344455', 'https://openalex.org/W1997183854', 'https://openalex.org/W1999294081', 'https://openalex.org/W2000087607', 'https://openalex.org/W2006192061', 'https://openalex.org/W2012204343', 'https://openalex.org/W2019104650', 'https://openalex.org/W2034102636', 'https://openalex.org/W2034451570', 'https://openalex.org/W2034530633', 'https://openalex.org/W2035644586', 'https://openalex.org/W2041399911', 'https://openalex.org/W2048189477', 'https://openalex.org/W2049063169', 'https://openalex.org/W2052394132', 'https://openalex.org/W2061686036', 'https://openalex.org/W2061820966', 'https://openalex.org/W2062518702', 'https://openalex.org/W2065173155', 'https://openalex.org/W2067001456', 'https://openalex.org/W2067634655', 'https://openalex.org/W2069850205', 'https://openalex.org/W2085288412', 'https://openalex.org/W2086816631', 'https://openalex.org/W2090880672', 'https://openalex.org/W2095782040', 'https://openalex.org/W2097822945', 'https://openalex.org/W2099775353', 'https://openalex.org/W2114857075', 'https://openalex.org/W2116798103', 'https://openalex.org/W2118642421', 'https://openalex.org/W2121804957', 'https://openalex.org/W2126873190', 'https://openalex.org/W2146426819', 'https://openalex.org/W2148397203', 'https://openalex.org/W2161098075', 'https://openalex.org/W2164740289', 'https://openalex.org/W2168121702'], 'related_works': ['https://openalex.org/W4387523696', 'https://openalex.org/W409409094', 'https://openalex.org/W3030228103', 'https://openalex.org/W2903919886', 'https://openalex.org/W2474077680', 'https://openalex.org/W2410365038', 'https://openalex.org/W2356613539', 'https://openalex.org/W2158551725', 'https://openalex.org/W2064898491', 'https://openalex.org/W2008369604'], 'abstract_inverted_index': {'//': [0, 99], 'Masanori': [1], 'Hasegawa': [2], '1': [3, 11, 15, 23, 27, 31, 35, 44, 45], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36], 'Hidekazu': [5], 'Takahashi': [6], '1,3': [7], 'Hasan': [9], 'Rajabi': [10], 'Maroof': [13], 'Alam': [14], 'Yozo': [17], 'Suzuki': [18], '1,4': [19], 'Li': [21], 'Yin': [22], 'Ashujit': [25], 'Tagde': [26], 'Takahiro': [29], 'Maeda': [30], 'Masayuki': [33], 'Hiraki': [34], 'Vikas': [37], 'P.': [38], 'Sukhatme': [39], '2': [40, 55], 'and': [41, 168, 179, 207, 216, 226, 241, 265, 297], 'Donald': [42, 96], 'Kufe': [43], 'Dana-Farber': [46], 'Cancer': [47], 'Institute,': [48], 'Harvard': [49, 61], 'Medical': [50, 59, 62], 'School,': [51, 63], 'Boston,': [52, 64], 'MA,': [53, 65], 'USA': [54, 66], 'Beth': [56], 'Israel': [57], 'Deaconess': [58], 'Center,': [60], '3': [67], 'Department': [68, 83], 'of': [69, 74, 84, 127, 137, 142, 231, 274, 278, 293, 299, 303], 'Gastrointestinal': [70], 'Surgery,': [71, 86], 'Graduate': [72], 'School': [73], 'Medicine,': [75], 'Osaka': [76, 87, 90], 'University,': [77], 'Suita': [78], 'City,': [79, 91], 'Osaka,': [80, 92], 'Japan': [81, 93], '4': [82], 'Gastroenterological': [85], 'Police': [88], 'Hospital,': [89], 'Correspondence': [94], 'to:': [95], 'Kufe,': [97], 'email:': [98], 'Keywords': [100], ':': [101, 108, 113, 118], 'xCT,': [102, 159], 'MUC1-C,': [103], 'CD44v,': [104], 'epigenetics,': [105], 'ferroptosis': [106], 'Received': [107], 'December': [109], '11,': [110], '2015': [111], 'Accepted': [112], 'January': [114], '26,': [115], '2016': [116, 121], 'Published': [117], 'February': [119], '22,': [120], 'Abstract': [122], 'The': [123, 148, 197, 237], 'xCT': [124, 192, 206, 215, 232, 242, 251], 'light': [125], 'chain': [126], 'the': [128, 140, 208, 234, 247, 255, 269, 275, 279], 'cystine/glutamate': [129], 'transporter': [130], '(system': [131], 'X': [132, 294], 'C': [133, 295], '-': [134, 296], ')': [135], 'is': [136, 152, 173, 187, 243], 'importance': [138], 'for': [139, 322], 'survival': [141], 'triple-negative': [143], 'breast': [144], 'cancer': [145], '(TNBC)': [146], 'cells.': [147, 196], 'MUC1-C': [149, 178, 186, 201, 221, 240, 285], 'transmembrane': [150], 'oncoprotein': [151], 'aberrantly': [153], 'overexpressed': [154], 'in': [155, 191, 194, 227, 233], 'TNBC': [156, 195, 324], 'and,': [157], 'like': [158], 'has': [160], 'been': [161], 'linked': [162], 'to': [163], 'maintaining': [164], 'glutathione': [165], '(GSH)': [166], 'levels': [167], 'redox': [169], 'balance.': [170], 'However,': [171], 'there': [172], 'no': [174], 'known': [175], 'interaction': [176, 238], 'between': [177, 239], 'xCT.': [180], 'Here': [181], 'we': [182, 282], 'show': [183, 283], 'that': [184, 200, 249, 284, 310], 'silencing': [185, 253], 'associated': [188], 'with': [189, 205, 214, 224, 252, 289], 'decreases': [190], 'expression': [193], 'results': [198], 'demonstrate': [199], 'forms': [202], 'a': [203, 301, 318], 'complex': [204], 'CD44': [209], 'variant': [210], '(CD44v),': [211], 'which': [212], 'interacts': [213], 'thereby': [217], 'controls': [218], 'GSH': [219], 'levels.': [220], 'binds': [222], 'directly': [223], 'CD44v': [225], 'turn': [228], 'promotes': [229], 'stability': [230], 'cell': [235, 305, 325], 'membrane.': [236], 'further': [244], 'supported': [245], 'by': [246, 262], 'demonstration': [248], 'targeting': [250, 311], 'or': [254], 'inhibitor': [256, 292], 'sulfasalazine': [257], 'suppresses': [258], 'MUC1': [259, 270], 'gene': [260], 'transcription': [261], 'increasing': [263], 'histone': [264], 'DNA': [266], 'methylation': [267], 'on': [268], 'promoter.': [271], 'In': [272], 'terms': [273], 'functional': [276], 'significance': [277], 'MUC1-C/xCT': [280, 314], 'interaction,': [281], 'protects': [286], 'against': [287], 'treatment': [288], 'erastin,': [290], 'an': [291], 'inducer': [298], 'ferroptosis,': [300], 'form': [302], 'non-apoptotic': [304], 'death.': [306, 326], 'These': [307], 'findings': [308], 'indicate': [309], 'this': [312], 'novel': [313], 'pathway': [315], 'could': [316], 'represent': [317], 'potential': [319], 'therapeutic': [320], 'approach': [321], 'promoting': [323]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2346455216', 'counts_by_year': [{'year': 2024, 'cited_by_count': 16}, {'year': 2023, 'cited_by_count': 31}, {'year': 2022, 'cited_by_count': 39}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 20}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 15}], 'updated_date': '2024-12-08T17:45:32.469841', 'created_date': '2016-06-24'}