Publication Information

{'id': 'https://openalex.org/W2346347145', 'doi': 'https://doi.org/10.1371/journal.pone.0154130', 'title': 'Circulating Serum miRNAs as Diagnostic Markers for Colorectal Cancer', 'display_name': 'Circulating Serum miRNAs as Diagnostic Markers for Colorectal Cancer', 'publication_year': 2016, 'publication_date': '2016-05-02', 'ids': {'openalex': 'https://openalex.org/W2346347145', 'doi': 'https://doi.org/10.1371/journal.pone.0154130', 'mag': '2346347145', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27135244', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4852935'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0154130', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0154130&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0154130&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047078549', 'display_name': 'Abdel‐Rahman N. Zekri', 'orcid': 'https://orcid.org/0000-0003-3939-0416'}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': True, 'raw_author_name': 'Abdel-Rahman N. Zekri', 'raw_affiliation_strings': ['Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024357259', 'display_name': 'Amira Salah El-Din Youssef', 'orcid': 'https://orcid.org/0000-0003-3091-691X'}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': True, 'raw_author_name': 'Amira Salah El-Din Youssef', 'raw_affiliation_strings': ['Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069733754', 'display_name': 'Mai M. Lotfy', 'orcid': 'https://orcid.org/0000-0001-8282-8773'}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': True, 'raw_author_name': 'Mai M. Lotfy', 'raw_affiliation_strings': ['Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002092476', 'display_name': 'Reham Mohamed Gabr', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': True, 'raw_author_name': 'Reham Gabr', 'raw_affiliation_strings': ['Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101888358', 'display_name': 'Ola S. Ahmed', 'orcid': 'https://orcid.org/0000-0001-6201-0907'}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': True, 'raw_author_name': 'Ola S. Ahmed', 'raw_affiliation_strings': ['Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053342577', 'display_name': 'Auhood Nassar', 'orcid': 'https://orcid.org/0000-0002-5704-9281'}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': True, 'raw_author_name': 'Auhood Nassar', 'raw_affiliation_strings': ['Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106036766', 'display_name': 'Nehal Hussein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': True, 'raw_author_name': 'Nehal Hussein', 'raw_affiliation_strings': ['Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025384297', 'display_name': 'Dalia Omran', 'orcid': 'https://orcid.org/0000-0002-5513-6955'}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': True, 'raw_author_name': 'Dalia Omran', 'raw_affiliation_strings': ['Tropical Medicine Department, Kasr El- Aini hospital, Faculty of Medicine, Cairo University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Tropical Medicine Department, Kasr El- Aini hospital, Faculty of Medicine, Cairo University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112410845', 'display_name': 'Eman Medhat', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': True, 'raw_author_name': 'Eman Medhat', 'raw_affiliation_strings': ['Tropical Medicine Department, Kasr El- Aini hospital, Faculty of Medicine, Cairo University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Tropical Medicine Department, Kasr El- Aini hospital, Faculty of Medicine, Cairo University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109501233', 'display_name': 'Salam Eid', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': True, 'raw_author_name': 'Salam Eid', 'raw_affiliation_strings': ['Medical Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034000985', 'display_name': 'Marwa Hussein', 'orcid': 'https://orcid.org/0000-0002-7619-7087'}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': True, 'raw_author_name': 'Marwa Mahmoud Hussein', 'raw_affiliation_strings': ['Medical Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004421570', 'display_name': 'Maha Yahia Ismail', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': True, 'raw_author_name': 'Maha Yahia Ismail', 'raw_affiliation_strings': ['Medical Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109943389', 'display_name': 'Faris Q Alenzi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28022161', 'display_name': 'King Saud University', 'ror': 'https://ror.org/02f81g417', 'country_code': 'SA', 'type': 'education', 'lineage': ['https://openalex.org/I28022161']}], 'countries': ['SA'], 'is_corresponding': True, 'raw_author_name': 'Faris Q. Alenzi', 'raw_affiliation_strings': ['Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Alkharaj, Saudi Arabia'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Alkharaj, Saudi Arabia', 'institution_ids': ['https://openalex.org/I28022161']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016320447', 'display_name': 'Abeer A. Bahnassy', 'orcid': 'https://orcid.org/0000-0001-5454-6576'}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': True, 'raw_author_name': 'Abeer A. Bahnassy', 'raw_affiliation_strings': ['Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt', 'institution_ids': ['https://openalex.org/I145487455']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5047078549', 'https://openalex.org/A5024357259', 'https://openalex.org/A5069733754', 'https://openalex.org/A5002092476', 'https://openalex.org/A5101888358', 'https://openalex.org/A5053342577', 'https://openalex.org/A5106036766', 'https://openalex.org/A5025384297', 'https://openalex.org/A5112410845', 'https://openalex.org/A5109501233', 'https://openalex.org/A5034000985', 'https://openalex.org/A5004421570', 'https://openalex.org/A5109943389', 'https://openalex.org/A5016320447'], 'corresponding_institution_ids': ['https://openalex.org/I145487455', 'https://openalex.org/I145487455', 'https://openalex.org/I145487455', 'https://openalex.org/I145487455', 'https://openalex.org/I145487455', 'https://openalex.org/I145487455', 'https://openalex.org/I145487455', 'https://openalex.org/I145487455', 'https://openalex.org/I145487455', 'https://openalex.org/I145487455', 'https://openalex.org/I145487455', 'https://openalex.org/I145487455', 'https://openalex.org/I28022161', 'https://openalex.org/I145487455'], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 4.091, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 74, 'citation_normalized_percentile': {'value': 0.999898, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '11', 'issue': '5', 'first_page': 'e0154130', 'last_page': 'e0154130'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11765', 'display_name': 'Circular RNAs in diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/fold-change', 'display_name': 'Fold change', 'score': 0.5163592}], 'concepts': [{'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.82008433}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.772449}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.716628}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6963509}, {'id': 'https://openalex.org/C58471807', 'wikidata': 'https://www.wikidata.org/wiki/Q327120', 'display_name': 'Receiver operating characteristic', 'level': 2, 'score': 0.5431856}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.54263085}, {'id': 'https://openalex.org/C2778260677', 'wikidata': 'https://www.wikidata.org/wiki/Q917447', 'display_name': 'Inflammatory bowel disease', 'level': 3, 'score': 0.52634346}, {'id': 'https://openalex.org/C76318530', 'wikidata': 'https://www.wikidata.org/wiki/Q16833590', 'display_name': 'Area under the curve', 'level': 2, 'score': 0.51784784}, {'id': 'https://openalex.org/C2779018089', 'wikidata': 'https://www.wikidata.org/wiki/Q17014303', 'display_name': 'Fold change', 'level': 4, 'score': 0.5163592}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.49901915}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.48772225}, {'id': 'https://openalex.org/C48023723', 'wikidata': 'https://www.wikidata.org/wiki/Q856198', 'display_name': 'Real-time polymerase chain reaction', 'level': 3, 'score': 0.45524946}, {'id': 'https://openalex.org/C146304588', 'wikidata': 'https://www.wikidata.org/wiki/Q961652', 'display_name': 'Case-control study', 'level': 2, 'score': 0.42780262}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.42714304}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.16168442}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.14207092}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.075904876}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016022', 'descriptor_name': 'Case-Control Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003111', 'descriptor_name': 'Colonic Polyps', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D003111', 'descriptor_name': 'Colonic Polyps', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003111', 'descriptor_name': 'Colonic Polyps', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015212', 'descriptor_name': 'Inflammatory Bowel Diseases', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D015212', 'descriptor_name': 'Inflammatory Bowel Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015212', 'descriptor_name': 'Inflammatory Bowel Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012372', 'descriptor_name': 'ROC Curve', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0154130', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0154130&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/145bac5c52ce44d9ab88c303663f21ee', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4852935', 'pdf_url': 'https://europepmc.org/articles/pmc4852935?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852935', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27135244', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0154130', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0154130&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.83, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W144423133', 'https://openalex.org/W1551449061', 'https://openalex.org/W1969037652', 'https://openalex.org/W1970471141', 'https://openalex.org/W1971588341', 'https://openalex.org/W1974590880', 'https://openalex.org/W1978162793', 'https://openalex.org/W1979538859', 'https://openalex.org/W1980388821', 'https://openalex.org/W2020892166', 'https://openalex.org/W2023121881', 'https://openalex.org/W2031621381', 'https://openalex.org/W2040935952', 'https://openalex.org/W2043878795', 'https://openalex.org/W2060379087', 'https://openalex.org/W2065094420', 'https://openalex.org/W2078465018', 'https://openalex.org/W2085659118', 'https://openalex.org/W2088558156', 'https://openalex.org/W2100975741', 'https://openalex.org/W2114015736', 'https://openalex.org/W2124486266', 'https://openalex.org/W2135810600', 'https://openalex.org/W2135919238', 'https://openalex.org/W2140245250', 'https://openalex.org/W2149274167', 'https://openalex.org/W2150291212', 'https://openalex.org/W2150536104', 'https://openalex.org/W2158734599', 'https://openalex.org/W2159099751', 'https://openalex.org/W2162102504', 'https://openalex.org/W2163482204', 'https://openalex.org/W2165948908', 'https://openalex.org/W2166046948', 'https://openalex.org/W4212962560'], 'related_works': ['https://openalex.org/W644162512', 'https://openalex.org/W4228997586', 'https://openalex.org/W3131317785', 'https://openalex.org/W3030392802', 'https://openalex.org/W3013357068', 'https://openalex.org/W2801752099', 'https://openalex.org/W2410941155', 'https://openalex.org/W2378194452', 'https://openalex.org/W2052999120', 'https://openalex.org/W1493334061'], 'abstract_inverted_index': {'Aim': [0], 'The': [1, 33, 133], 'study': [2, 34], 'was': [3, 142, 174, 196, 247], 'designed': [4], 'to': [5, 23, 99, 144, 169], 'assess': [6, 100], 'the': [7, 101, 105, 126, 136, 146, 150, 163, 207, 240, 268, 291], 'possibility': [8, 26], 'of': [9, 149, 160, 270], 'using': [10, 125], 'circulating': [11], 'miRNAs': [12, 93, 107, 152], '(serum': [13], 'miRNAs)': [14], 'as': [15, 27, 79, 285, 300], 'diagnostic': [16, 147, 286, 301], 'biomarkers': [17, 287, 302], 'in': [18, 177, 190, 236, 250, 267], 'colorectal': [19, 48, 154, 271], 'cancer': [20, 155], '(CRC)': [21], 'and': [22, 65, 82, 122, 213, 224, 227, 233, 280, 295, 305], 'identify': [24], 'their': [25], 'candidates': [28], 'for': [29, 104, 153, 288, 303], 'targeted': [30], 'therapy.': [31], 'Methods': [32], 'involved': [35, 266], 'two': [36], 'sample': [37], 'sets:': [38], '1-': [39], 'a': [40, 84], 'training': [41, 164], 'set': [42, 86, 165, 242], 'which': [43, 87], 'included': [44, 88], '90': [45], 'patients': [46, 178, 191, 252], 'with': [47, 52, 55, 61, 67, 179, 192], 'related': [49], 'disease': [50, 58], '(30': [51], 'CRC,': [53], '18': [54, 60], 'inflammatory': [56], 'bowel': [57], '(IBD),': [59], 'colonic': [62, 69, 193], 'polyps': [63], '(CP)': [64], '24': [66], 'different': [68], 'symptoms': [70], 'but': [71], 'without': [72], 'any': [73], 'colonoscopic': [74], 'abnormality': [75], 'who': [76], 'were': [77, 94, 215], 'enrolled': [78], 'control': [80, 170], 'group)': [81], '2-': [83], 'validation': [85, 241], '100': [89], 'CRC': [90, 237, 251], 'patients.': [91, 238], 'Serum': [92], 'extracted': [95], 'from': [96, 162], 'all': [97], 'subjects': [98], 'expression': [102], 'profiles': [103], 'following': [106], '(miR-17,': [108, 277], 'miR-18a,': [109], 'miR-19a,': [110, 211, 278], 'miR-19b,': [111], 'miR-20a,': [112], 'miR-21,': [113], 'miR-146a,': [114], 'miR-223,': [115], 'miR-24,': [116], 'miR-454,': [117], 'miR-183,': [118], 'miR-135a,': [119], 'miR-': [120, 123], '135b': [121], '92a)': [124], 'custom': [127], 'miScript': [128], 'miRNA': [129, 161, 262], 'PCR-based': [130], 'sybergreen': [131], 'array.': [132], 'area': [134], 'under': [135], 'receiver': [137], 'operating': [138], 'characteristic': [139], 'curve': [140], '(AUC)': [141], 'used': [143, 284, 299], 'evaluate': [145], 'performance': [148], 'studied': [151], 'diagnosis.': [156], 'Results': [157], 'Data': [158], 'analysis': [159], 'showed': [166, 243], 'that;': [167], 'compared': [168], 'group,': [171], 'only': [172, 245], 'miR-19b': [173, 294], 'significantly': [175, 197, 216, 248], 'up-regulated': [176, 198, 217, 249], 'IBD': [180, 306], 'group': [181], '(fold': [182, 199, 218, 253], 'change': [183, 200, 219, 254], '=': [184, 187, 201, 204, 220, 229, 255, 258], '5.24,': [185], 'p': [186], '0.016),': [188], 'whereas': [189], 'polyps,': [194], 'miR-18a': [195, 296], '3.49,': [202], 'p-value': [203, 228, 257], '0.018).': [205], 'On': [206, 290], 'other': [208, 292], 'hand,': [209, 293], 'miR-17,': [210], 'miR-20a': [212, 279], 'miR-223': [214, 246], '2.35,': [221], '3.07,': [222], '2.38': [223], '10.35;': [225], 'respectively': [226, 235], '0.02,': [230], '0.015,': [231], '0.017': [232], '0.016;': [234], 'However,': [239], 'that': [244, 276], '4.06,': [256], '0.04).': [259], 'Conclusion': [260], 'Aberrant': [261], 'expressions': [263], 'are': [264], 'highly': [265], 'cascade': [269], 'carcinogenesis.': [272], 'We': [273], 'have': [274], 'found': [275], 'miR-223)': [281], 'could': [282, 297], 'be': [283, 298], 'CRC.': [289], 'CP': [304], 'respectively.': [307]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2346347145', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 18}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2024-12-08T17:46:06.856958', 'created_date': '2016-06-24'}