Title: Recovery of antibacterial sensitivity of ESBLs-producing fowl <I>E. coli</I> by sulbactam and EDTA
Abstract: To determine effect of sulbactam and EDTA on antibacterial activity of antimicrobial drugs in vitro,MIC of 10 antimicrobial agents alone and their respective combinations with sulbactam,EDTA and sulbactam+ EDTA against ESBLs-producing E.coli,were determined by using broth microdilution method.The results showed that sulbactam and EDTA can enhance antibacterial activity of parts of antimicrobial agents,the resistant rate of ESBIs-producing isolates to third generation cephalosporin ceftiofur,cefotaxime was higher than 80% and the resistant rates to fluoroquinolones,doxycycline,florfenicol,amikacin and fosfomycin were up to 100%.All the ESBIs-producing isolates were sensitive to cefepime.The resistant rate to third generation cephalosporin cefotaxime,florfenicol,amikacin and fosfomycin combinations with sulbactam,were lower than that to antibacterial drugs alone,is 0,88.9%,88.9%,0 respectively.The resistant rate to gatifloxacin,doxycycline,florfenicol,amikacin and fosfomycin combinations with EDTA,were lower than that to antibacterial drugs alone,is 30%,11.1%,22.2%,11.1%,0 respectively.The resistant rates of most strains to sulbactom+EDTA amikacin,fosfomycin,florfenicol and ceftiofur combinations were much lower than those combinations either only sulbactam or EDTA and were all 0.
Publication Year: 2010
Publication Date: 2010-06-30
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 1
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