Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2345874683', 'doi': 'https://doi.org/10.1530/jme-16-0048', 'title': 'Transcriptional activation of the wild-type and mutant vitamin D receptors by vitamin D3 analogs', 'display_name': 'Transcriptional activation of the wild-type and mutant vitamin D receptors by vitamin D3 analogs', 'publication_year': 2016, 'publication_date': '2016-05-07', 'ids': {'openalex': 'https://openalex.org/W2345874683', 'doi': 'https://doi.org/10.1530/jme-16-0048', 'mag': '2345874683', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27154546'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1530/jme-16-0048', 'pdf_url': 'https://jme.bioscientifica.com/downloadpdf/journals/jme/57/1/23.pdf', 'source': {'id': 'https://openalex.org/S15622159', 'display_name': 'Journal of Molecular Endocrinology', 'issn_l': '0952-5041', 'issn': ['0952-5041', '1479-6813'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319937', 'host_organization_name': 'Bioscientifica', 'host_organization_lineage': ['https://openalex.org/P4310319937'], 'host_organization_lineage_names': ['Bioscientifica'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://jme.bioscientifica.com/downloadpdf/journals/jme/57/1/23.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076363373', 'display_name': 'Kumi Futawaka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I112821123', 'display_name': "Mukogawa Women's University", 'ror': 'https://ror.org/009x65438', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I112821123']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Kumi Futawaka', 'raw_affiliation_strings': ["Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan"], 'affiliations': [{'raw_affiliation_string': "Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan", 'institution_ids': ['https://openalex.org/I112821123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047200294', 'display_name': 'Tetsuya Tagami', 'orcid': 'https://orcid.org/0000-0001-6266-3027'}, 'institutions': [{'id': 'https://openalex.org/I3017590076', 'display_name': 'Kyoto Medical Center', 'ror': 'https://ror.org/045kb1d14', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3017590076', 'https://openalex.org/I4210137409']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tetsuya Tagami', 'raw_affiliation_strings': ['Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I3017590076']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018875767', 'display_name': 'Yuki Fukuda', 'orcid': 'https://orcid.org/0000-0001-6006-4696'}, 'institutions': [{'id': 'https://openalex.org/I112821123', 'display_name': "Mukogawa Women's University", 'ror': 'https://ror.org/009x65438', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I112821123']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuki Fukuda', 'raw_affiliation_strings': ["Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan"], 'affiliations': [{'raw_affiliation_string': "Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan", 'institution_ids': ['https://openalex.org/I112821123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002745712', 'display_name': 'Rie Koyama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I112821123', 'display_name': "Mukogawa Women's University", 'ror': 'https://ror.org/009x65438', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I112821123']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Rie Koyama', 'raw_affiliation_strings': ["Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan"], 'affiliations': [{'raw_affiliation_string': "Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan", 'institution_ids': ['https://openalex.org/I112821123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031457236', 'display_name': 'Ayaka Nushida', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I112821123', 'display_name': "Mukogawa Women's University", 'ror': 'https://ror.org/009x65438', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I112821123']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ayaka Nushida', 'raw_affiliation_strings': ["Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan"], 'affiliations': [{'raw_affiliation_string': "Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan", 'institution_ids': ['https://openalex.org/I112821123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057828416', 'display_name': 'Shoko Nezu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I112821123', 'display_name': "Mukogawa Women's University", 'ror': 'https://ror.org/009x65438', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I112821123']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shoko Nezu', 'raw_affiliation_strings': ["Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan"], 'affiliations': [{'raw_affiliation_string': "Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan", 'institution_ids': ['https://openalex.org/I112821123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068070892', 'display_name': 'Hironori Yamamoto', 'orcid': 'https://orcid.org/0000-0002-3601-1153'}, 'institutions': [{'id': 'https://openalex.org/I23430985', 'display_name': 'Jin-ai University', 'ror': 'https://ror.org/04rkxwr48', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I23430985']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hironori Yamamoto', 'raw_affiliation_strings': ['Department of Health and Nutrition, Faculty of Human Life, Jin-ai University, Fukui, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Health and Nutrition, Faculty of Human Life, Jin-ai University, Fukui, Japan', 'institution_ids': ['https://openalex.org/I23430985']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045391562', 'display_name': 'Miyuki Imamoto', 'orcid': 'https://orcid.org/0000-0002-0022-8924'}, 'institutions': [{'id': 'https://openalex.org/I4210087340', 'display_name': 'Kobe Medical Center', 'ror': 'https://ror.org/00161f548', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087340', 'https://openalex.org/I4210137409']}, {'id': 'https://openalex.org/I4210167395', 'display_name': 'Foundation for Biomedical Research and Innovation', 'ror': 'https://ror.org/05xe40a72', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210167395']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Miyuki Imamoto', 'raw_affiliation_strings': ['Department of Nephrology and Blood Purification, Institute of Biomedical Research and Innovation, Kobe Medical Frontier Center, Kobe, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology and Blood Purification, Institute of Biomedical Research and Innovation, Kobe Medical Frontier Center, Kobe, Japan', 'institution_ids': ['https://openalex.org/I4210087340', 'https://openalex.org/I4210167395']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059173275', 'display_name': 'Masato Kasahara', 'orcid': 'https://orcid.org/0000-0002-1833-9075'}, 'institutions': [{'id': 'https://openalex.org/I4210087340', 'display_name': 'Kobe Medical Center', 'ror': 'https://ror.org/00161f548', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087340', 'https://openalex.org/I4210137409']}, {'id': 'https://openalex.org/I4210167395', 'display_name': 'Foundation for Biomedical Research and Innovation', 'ror': 'https://ror.org/05xe40a72', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210167395']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masato Kasahara', 'raw_affiliation_strings': ['Department of Nephrology and Blood Purification, Institute of Biomedical Research and Innovation, Kobe Medical Frontier Center, Kobe, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology and Blood Purification, Institute of Biomedical Research and Innovation, Kobe Medical Frontier Center, Kobe, Japan', 'institution_ids': ['https://openalex.org/I4210087340', 'https://openalex.org/I4210167395']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039919959', 'display_name': 'Kenji Moriyama', 'orcid': 'https://orcid.org/0000-0001-7830-7641'}, 'institutions': [{'id': 'https://openalex.org/I112821123', 'display_name': "Mukogawa Women's University", 'ror': 'https://ror.org/009x65438', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I112821123']}, {'id': 'https://openalex.org/I3017590076', 'display_name': 'Kyoto Medical Center', 'ror': 'https://ror.org/045kb1d14', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3017590076', 'https://openalex.org/I4210137409']}, {'id': 'https://openalex.org/I4210087340', 'display_name': 'Kobe Medical Center', 'ror': 'https://ror.org/00161f548', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087340', 'https://openalex.org/I4210137409']}, {'id': 'https://openalex.org/I4210167395', 'display_name': 'Foundation for Biomedical Research and Innovation', 'ror': 'https://ror.org/05xe40a72', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210167395']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenji Moriyama', 'raw_affiliation_strings': ['Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan', "Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan", 'Department of Nephrology and Blood Purification, Institute of Biomedical Research and Innovation, Kobe Medical Frontier Center, Kobe, Japan'], 'affiliations': [{'raw_affiliation_string': "Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan", 'institution_ids': ['https://openalex.org/I112821123']}, {'raw_affiliation_string': 'Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I3017590076']}, {'raw_affiliation_string': 'Department of Nephrology and Blood Purification, Institute of Biomedical Research and Innovation, Kobe Medical Frontier Center, Kobe, Japan', 'institution_ids': ['https://openalex.org/I4210087340', 'https://openalex.org/I4210167395']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5076363373'], 'corresponding_institution_ids': ['https://openalex.org/I112821123'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.474646, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 80, 'max': 81}, 'biblio': {'volume': '57', 'issue': '1', 'first_page': '23', 'last_page': '32'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10277', 'display_name': 'Vitamin D and Health Outcomes', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10277', 'display_name': 'Vitamin D and Health Outcomes', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13199', 'display_name': 'Genetic Adaptation of Lactase Persistence in Humans', 'score': 0.9678, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12554', 'display_name': 'Role of Vitamin C in Health and Disease', 'score': 0.9654, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vitamin-d', 'display_name': 'Vitamin D', 'score': 0.560415}], 'concepts': [{'id': 'https://openalex.org/C179639408', 'wikidata': 'https://www.wikidata.org/wiki/Q417057', 'display_name': 'Calcitriol receptor', 'level': 3, 'score': 0.9675821}, {'id': 'https://openalex.org/C2776079296', 'wikidata': 'https://www.wikidata.org/wiki/Q139195', 'display_name': 'Calcitriol', 'level': 3, 'score': 0.95335996}, {'id': 'https://openalex.org/C124490489', 'wikidata': 'https://www.wikidata.org/wiki/Q7936963', 'display_name': 'Vitamin D and neurology', 'level': 2, 'score': 0.53872967}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.51299566}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.47732693}, {'id': 'https://openalex.org/C2776940978', 'wikidata': 'https://www.wikidata.org/wiki/Q34956', 'display_name': 'Vitamin', 'level': 2, 'score': 0.4345459}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42032468}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4186419}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.41421166}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37156034}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.34486112}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.32838514}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.24515879}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.22061124}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.13970944}], 'mesh': [{'descriptor_ui': 'D002762', 'descriptor_name': 'Cholecalciferol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018167', 'descriptor_name': 'Receptors, Calcitriol', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015090', 'descriptor_name': '25-Hydroxyvitamin D3 1-alpha-Hydroxylase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015090', 'descriptor_name': '25-Hydroxyvitamin D3 1-alpha-Hydroxylase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002117', 'descriptor_name': 'Calcitriol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002117', 'descriptor_name': 'Calcitriol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002117', 'descriptor_name': 'Calcitriol', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002762', 'descriptor_name': 'Cholecalciferol', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D002762', 'descriptor_name': 'Cholecalciferol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018167', 'descriptor_name': 'Receptors, Calcitriol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018167', 'descriptor_name': 'Receptors, Calcitriol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1530/jme-16-0048', 'pdf_url': 'https://jme.bioscientifica.com/downloadpdf/journals/jme/57/1/23.pdf', 'source': {'id': 'https://openalex.org/S15622159', 'display_name': 'Journal of Molecular Endocrinology', 'issn_l': '0952-5041', 'issn': ['0952-5041', '1479-6813'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319937', 'host_organization_name': 'Bioscientifica', 'host_organization_lineage': ['https://openalex.org/P4310319937'], 'host_organization_lineage_names': ['Bioscientifica'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27154546', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1530/jme-16-0048', 'pdf_url': 'https://jme.bioscientifica.com/downloadpdf/journals/jme/57/1/23.pdf', 'source': {'id': 'https://openalex.org/S15622159', 'display_name': 'Journal of Molecular Endocrinology', 'issn_l': '0952-5041', 'issn': ['0952-5041', '1479-6813'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319937', 'host_organization_name': 'Bioscientifica', 'host_organization_lineage': ['https://openalex.org/P4310319937'], 'host_organization_lineage_names': ['Bioscientifica'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.78, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1526873178', 'https://openalex.org/W1591599721', 'https://openalex.org/W1965395294', 'https://openalex.org/W1980557999', 'https://openalex.org/W1997418235', 'https://openalex.org/W2004709016', 'https://openalex.org/W2011467252', 'https://openalex.org/W2011725731', 'https://openalex.org/W2013592813', 'https://openalex.org/W2018381121', 'https://openalex.org/W2034071735', 'https://openalex.org/W2034124626', 'https://openalex.org/W2039846724', 'https://openalex.org/W2040725058', 'https://openalex.org/W2047638828', 'https://openalex.org/W2052417817', 'https://openalex.org/W2054281547', 'https://openalex.org/W2055754838', 'https://openalex.org/W2055973599', 'https://openalex.org/W2060402787', 'https://openalex.org/W2060962596', 'https://openalex.org/W2073870011', 'https://openalex.org/W2077420287', 'https://openalex.org/W2085397623', 'https://openalex.org/W2090517179', 'https://openalex.org/W2090622441', 'https://openalex.org/W2097724305', 'https://openalex.org/W2121579525', 'https://openalex.org/W2144885140', 'https://openalex.org/W2145221641', 'https://openalex.org/W2152575852', 'https://openalex.org/W2172256092', 'https://openalex.org/W2332207559', 'https://openalex.org/W2398211484', 'https://openalex.org/W2991739943', 'https://openalex.org/W4234935451', 'https://openalex.org/W4247895161', 'https://openalex.org/W4251328738'], 'related_works': ['https://openalex.org/W4389008136', 'https://openalex.org/W4206339686', 'https://openalex.org/W3138685881', 'https://openalex.org/W2345874683', 'https://openalex.org/W2224184415', 'https://openalex.org/W2181887882', 'https://openalex.org/W2158721638', 'https://openalex.org/W2154754144', 'https://openalex.org/W2109512925', 'https://openalex.org/W2074715016'], 'abstract_inverted_index': {'The': [0, 45, 140], 'active': [1], 'form': [2], 'of': [3, 18, 52, 58, 78, 150, 166, 178, 189, 206, 232, 241], 'vitamin': [4, 23], 'D3': [5], '(1α,25(OH)': [6], '2': [7], 'D': [8, 24], '3': [9, 62, 82, 125], ',': [10], 'also': [11, 223], 'known': [12], 'as': [13], 'calcitriol)': [14], 'controls': [15], 'the': [16, 22, 42, 55, 70, 75, 151, 167, 170, 187], 'expression': [17, 132], 'target': [19], 'genes': [20], 'via': [21], 'receptor': [25], '(VDR).': [26], 'Vitamin': [27], 'D-dependent': [28], 'rickets': [29], 'type': [30], 'II': [31], '(VDDRII)': [32], 'is': [33, 47, 222], 'a': [34, 175, 183, 199], 'congenital': [35], 'disease': [36], 'caused': [37, 182], 'by': [38, 129], 'inactivating': [39], 'mutations': [40, 89], 'in': [41, 91, 103, 174, 186], 'VDR': [43, 95, 168, 200], '.': [44], 'condition': [46], 'treated': [48, 237], 'with': [49, 84, 123, 169, 238], 'high': [50, 230], 'doses': [51, 231, 240], 'calcitriol,': [53], 'but': [54], 'therapeutic': [56, 211], 'effects': [57, 212], 'other': [59], 'synthetic': [60], 'VD': [61, 81, 124], 'analogs': [63, 83, 126], 'have': [64], 'not': [65], 'yet': [66], 'been': [67], 'investigated.': [68], 'In': [69], 'present': [71], 'study,': [72], 'we': [73], 'analyzed': [74, 128], 'transcriptional': [76, 121, 148, 164], 'activity': [77], 'seven': [79, 98], 'different': [80], 'VDRs': [85, 100, 156], 'carrying': [86], 'ligand-binding': [87], 'domain': [88], 'identified': [90, 173], 'VDDRII': [92, 216, 226], 'patients.': [93], 'Wild-type': [94], '(WT-VDR)': [96], 'and': [97, 114, 119, 136, 153, 208], 'mutant': [99, 155, 191], 'were': [101, 127], 'expressed': [102], 'TSA201': [104], 'human': [105, 110], 'embryonic': [106], 'kidney': [107], 'cells,': [108, 113, 118], 'HepG2': [109], 'liver': [111], 'cancer': [112], 'MC3T3-E1': [115], 'mouse': [116], 'calvaria': [117], 'their': [120], 'activation': [122, 149, 165, 188, 201], 'performing': [130], 'transient': [131], 'assays,': [133], 'western': [134], 'blotting,': [135], 'quantitative': [137], 'real-time': [138], 'PCR.': [139], 'results': [141], 'demonstrated': [142], 'that': [143, 196, 205, 225], 'falecalcitriol': [144, 181, 197], 'stimulated': [145], 'significantly': [146], 'higher': [147], 'WT-VDR': [152], 'some': [154], 'than': [157], 'did': [158], 'calcitriol.': [159, 220], 'Calcitriol': [160], 'showed': [161], 'almost': [162], 'no': [163], 'I268T': [171], 'mutation': [172], 'severe': [176], 'case': [177], 'VDDRII,': [179], 'whereas': [180], 'dose-dependent': [184], 'increase': [185], 'this': [190], 'VDR.': [192], 'Our': [193], 'findings': [194], 'demonstrate': [195], 'has': [198], 'profile': [202], 'distinct': [203], 'from': [204], 'calcitriol': [207, 233], 'may': [209], 'exhibit': [210], 'even': [213], 'on': [214], 'difficult-to-treat': [215], 'cases': [217], 'resistant': [218], 'to': [219, 229], 'It': [221], 'possible': [224], 'patients': [227], 'responding': [228], 'could': [234], 'be': [235], 'appropriately': [236], 'low': [239], 'falecalcitriol.': [242]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2345874683', 'counts_by_year': [{'year': 2022, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-09-18T02:44:56.565860', 'created_date': '2016-06-24'}