Publication Information

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'双自杀基因系统（Ad-KDRP-CD/TK）': [3], '联合': [4], 'survivin': [5], '基因干扰对肝癌细胞在裸鼠体内生长的抑制作用。': [6], '方法：将20': [7], '只裸鼠随机分均为模型组（皮下植入BEL-7402': [8], '肝癌细胞成瘤，不加任何处理）、双自杀': [9], '基因转染组（皮下植入转染Ad-KDRP-CD/TK': [10], '的BEL-7402': [11], '细胞，成瘤后瘤内注射前药更昔洛韦与5-': [12], '氟': [13], '胞嘧啶）、survivin': [14], 'siRNA': [15, 21], '转染组（皮下注射BEL-7402': [16], '肝癌细胞，成瘤后瘤内注射survivin': [17], 'siRNA/Lip-': [18], 'DMEM': [19], '转染混合物）、联合转染组（双自杀基因转染+survivin': [20], '转染处理）。治疗2': [22], '周后处死各组': [23], '小鼠，称取肿瘤质量，计算肿瘤抑制率，检测瘤组织微血管密度（MVD）及survivin': [24], 'mRNA': [25, 29], '与蛋白表达。': [26], '结果：各治疗组的肿瘤质量明显小于模型组（均P<0.05），且联合转染组的抑瘤率最大（均P<0.05）；': [27], '肿瘤组织MVD、survivin': [28], '与蛋白水平均明显降低，': [30], '且联合转染组的降低程度最为明显（': [31], '均': [32], 'P<0.05）。': [33], '结论：双自杀基因联合survivin': [34], '干扰是抑制鼠肝癌细胞在体内生长的有效途径。': [35]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2345340067', 'counts_by_year': [], 'updated_date': '2024-12-13T09:42:01.077987', 'created_date': '2016-06-24'}