Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2345290534', 'doi': 'https://doi.org/10.1212/wnl.0000000000002694', 'title': 'Distinct molecular mechanisms of <i>HTRA1</i> mutants in manifesting heterozygotes with CARASIL', 'display_name': 'Distinct molecular mechanisms of <i>HTRA1</i> mutants in manifesting heterozygotes with CARASIL', 'publication_year': 2016, 'publication_date': '2016-05-24', 'ids': {'openalex': 'https://openalex.org/W2345290534', 'doi': 'https://doi.org/10.1212/wnl.0000000000002694', 'mag': '2345290534', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27164673'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1212/wnl.0000000000002694', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S79704628', 'display_name': 'Neurology', 'issn_l': '0028-3878', 'issn': ['0028-3878', '1526-632X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047653745', 'display_name': 'Hiroaki Nozaki', 'orcid': 'https://orcid.org/0000-0001-5320-550X'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hiroaki Nozaki', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076825700', 'display_name': 'Taisuke Kato', 'orcid': 'https://orcid.org/0000-0001-5696-7104'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Taisuke Kato', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037342056', 'display_name': 'Megumi Nihonmatsu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Megumi Nihonmatsu', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103018395', 'display_name': 'Yohei Saito', 'orcid': 'https://orcid.org/0000-0003-2313-8339'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yohei Saito', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018665946', 'display_name': 'Ikuko Mizuta', 'orcid': 'https://orcid.org/0000-0002-2775-2507'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ikuko Mizuta', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027335426', 'display_name': 'Tomoko Noda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tomoko Noda', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017544295', 'display_name': 'Ryoko Koike', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ryoko Koike', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037851657', 'display_name': 'Kazuhide Miyazaki', 'orcid': 'https://orcid.org/0000-0002-5802-8845'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kazuhide Miyazaki', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047836751', 'display_name': 'Muichi Kaito', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Muichi Kaito', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101965741', 'display_name': 'Shoichi Ito', 'orcid': 'https://orcid.org/0000-0003-4704-234X'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shoichi Ito', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074306514', 'display_name': 'Masahiro Makino', 'orcid': 'https://orcid.org/0009-0001-2048-5020'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Masahiro Makino', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041713585', 'display_name': 'Akihide Koyama', 'orcid': 'https://orcid.org/0009-0003-1508-8586'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Akihide Koyama', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035025328', 'display_name': 'Atsushi Shiga', 'orcid': 'https://orcid.org/0000-0002-1446-1284'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Atsushi Shiga', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006124000', 'display_name': 'Masahiro Uemura', 'orcid': 'https://orcid.org/0000-0003-0645-0099'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Masahiro Uemura', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019396018', 'display_name': 'Yumi Sekine', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yumi Sekine', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014944575', 'display_name': 'Ayuka Murakami', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ayuka Murakami', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025489625', 'display_name': 'Suzuko Moritani', 'orcid': 'https://orcid.org/0000-0002-4796-5083'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Suzuko Moritani', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077891214', 'display_name': 'Kenju Hara', 'orcid': 'https://orcid.org/0000-0002-9068-9483'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kenju Hara', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001892591', 'display_name': 'Akio Yokoseki', 'orcid': 'https://orcid.org/0000-0002-9610-3869'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Akio Yokoseki', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005287215', 'display_name': 'Ryozo Kuwano', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ryozo Kuwano', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031581472', 'display_name': 'Naoto Endo', 'orcid': 'https://orcid.org/0000-0003-1330-3177'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Naoto Endo', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008435774', 'display_name': 'Takeshi Momotsu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Takeshi Momotsu', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013784750', 'display_name': 'Mari Yoshida', 'orcid': 'https://orcid.org/0000-0002-8520-6184'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mari Yoshida', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102920849', 'display_name': 'Masatoyo Nishizawa', 'orcid': 'https://orcid.org/0000-0001-9442-6827'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Masatoyo Nishizawa', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010300845', 'display_name': 'Toshiki Mizuno', 'orcid': 'https://orcid.org/0000-0002-7907-8243'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Toshiki Mizuno', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5088062381', 'display_name': 'Osamu Onodera', 'orcid': 'https://orcid.org/0000-0003-3354-5472'}, 'institutions': [{'id': 'https://openalex.org/I1314596251', 'display_name': 'Allen Institute for Brain Science', 'ror': 'https://ror.org/00dcv1019', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1314596251', 'https://openalex.org/I4210140341']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Osamu Onodera', 'raw_affiliation_strings': ['From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medical Technology, School of Health Sciences, Faculty of Medicine (H.N.), Department of Molecular Neuroscience, Resource Branch for Brain Disease, Brain Research Institute (T.K., A.Y., O.O.), Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute (M. Nihonmatsu, Y. Saito, A.K., A.S., M.U., Y. Sekine, M. Nishizawa), Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery (N.E.), and Department of Molecular Genetics,...', 'institution_ids': ['https://openalex.org/I1314596251']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.917, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 92, 'citation_normalized_percentile': {'value': 0.999909, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '86', 'issue': '21', 'first_page': '1964', 'last_page': '1974'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13648', 'display_name': 'Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13648', 'display_name': 'Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13223', 'display_name': 'Role of CCN Proteins in Signaling Pathways', 'score': 0.9612, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10816', 'display_name': 'Diagnosis and Treatment of Carotid Artery Disease', 'score': 0.9335, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/htra1-mutations', 'display_name': 'HtrA1 mutations', 'score': 0.568667}, {'id': 'https://openalex.org/keywords/small-vessel-disease', 'display_name': 'small vessel disease', 'score': 0.512807}, {'id': 'https://openalex.org/keywords/heterozygote-advantage', 'display_name': 'Heterozygote advantage', 'score': 0.45881444}, {'id': 'https://openalex.org/keywords/compound-heterozygosity', 'display_name': 'Compound heterozygosity', 'score': 0.4563466}], 'concepts': [{'id': 'https://openalex.org/C75563809', 'wikidata': 'https://www.wikidata.org/wiki/Q2656896', 'display_name': 'Missense mutation', 'level': 4, 'score': 0.7773589}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.65784454}, {'id': 'https://openalex.org/C2778583010', 'wikidata': 'https://www.wikidata.org/wiki/Q3237081', 'display_name': 'Leukoencephalopathy', 'level': 3, 'score': 0.51670575}, {'id': 'https://openalex.org/C153471976', 'wikidata': 'https://www.wikidata.org/wiki/Q2873354', 'display_name': 'Heterozygote advantage', 'level': 4, 'score': 0.45881444}, {'id': 'https://openalex.org/C12125453', 'wikidata': 'https://www.wikidata.org/wiki/Q5156837', 'display_name': 'Compound heterozygosity', 'level': 4, 'score': 0.4563466}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.42749614}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.40108722}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.38811535}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37681392}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.37668717}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.34651995}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.33424896}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3282674}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.3236732}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3015211}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.16291529}], 'mesh': [{'descriptor_ui': 'D000505', 'descriptor_name': 'Alopecia', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000505', 'descriptor_name': 'Alopecia', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D006579', 'descriptor_name': 'Heterozygote', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D056784', 'descriptor_name': 'Leukoencephalopathies', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D056784', 'descriptor_name': 'Leukoencephalopathies', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D020125', 'descriptor_name': 'Mutation, Missense', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D013122', 'descriptor_name': 'Spinal Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D013122', 'descriptor_name': 'Spinal Diseases', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D000505', 'descriptor_name': 'Alopecia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000505', 'descriptor_name': 'Alopecia', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000505', 'descriptor_name': 'Alopecia', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D002850', 'descriptor_name': 'Chromatography, Gel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019281', 'descriptor_name': 'Dimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005190', 'descriptor_name': 'Family', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000074289', 'descriptor_name': 'High-Temperature Requirement A Serine Peptidase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056784', 'descriptor_name': 'Leukoencephalopathies', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D056784', 'descriptor_name': 'Leukoencephalopathies', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D056784', 'descriptor_name': 'Leukoencephalopathies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008279', 'descriptor_name': 'Magnetic Resonance Imaging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010375', 'descriptor_name': 'Pedigree', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017422', 'descriptor_name': 'Sequence Analysis, DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013122', 'descriptor_name': 'Spinal Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013122', 'descriptor_name': 'Spinal Diseases', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D013122', 'descriptor_name': 'Spinal Diseases', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1212/wnl.0000000000002694', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S79704628', 'display_name': 'Neurology', 'issn_l': '0028-3878', 'issn': ['0028-3878', '1526-632X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27164673', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1939498487', 'https://openalex.org/W1963506045', 'https://openalex.org/W1965643593', 'https://openalex.org/W1984858480', 'https://openalex.org/W1985877318', 'https://openalex.org/W1994117795', 'https://openalex.org/W1996800405', 'https://openalex.org/W2003867389', 'https://openalex.org/W2021438363', 'https://openalex.org/W2026258231', 'https://openalex.org/W2035371711', 'https://openalex.org/W2037002542', 'https://openalex.org/W2050676589', 'https://openalex.org/W2060949146', 'https://openalex.org/W2067418729', 'https://openalex.org/W2075733499', 'https://openalex.org/W2077250628', 'https://openalex.org/W2095673891', 'https://openalex.org/W2096209101', 'https://openalex.org/W2114054511', 'https://openalex.org/W2115252318', 'https://openalex.org/W2130718151', 'https://openalex.org/W2147684460', 'https://openalex.org/W2159243541', 'https://openalex.org/W2160993714', 'https://openalex.org/W2161379765', 'https://openalex.org/W2259948660', 'https://openalex.org/W2316701015', 'https://openalex.org/W2466425029', 'https://openalex.org/W4252097774'], 'related_works': ['https://openalex.org/W3126480584', 'https://openalex.org/W2614546484', 'https://openalex.org/W2363132949', 'https://openalex.org/W2359850611', 'https://openalex.org/W2162187627', 'https://openalex.org/W2144143213', 'https://openalex.org/W2126382616', 'https://openalex.org/W2090410200', 'https://openalex.org/W2054509832', 'https://openalex.org/W1993854347'], 'abstract_inverted_index': {'<h3>Objective:</h3>': [0], 'To': [1], 'elucidate': [2], 'the': [3, 34, 63, 220], 'molecular': [4], 'mechanism': [5], 'of': [6, 33, 140, 243], 'mutant': [7, 126, 142, 229], 'HTRA1-dependent': [8], 'cerebral': [9, 26, 122, 146], 'small': [10, 27, 123], 'vessel': [11, 28], 'disease': [12], 'in': [13, 62, 71, 80, 83, 103, 110, 120, 145, 174, 192, 201, 211, 232, 237], 'heterozygous': [14, 59], 'individuals.': [15], '<h3>Methods:</h3>': [16], 'We': [17, 39, 56], 'recruited': [18], '113': [19, 75], 'unrelated': [20, 76, 85], 'index': [21, 77], 'patients': [22, 73, 78], 'with': [23, 87, 116, 149], 'clinically': [24], 'diagnosed': [25], 'disease.': [29], 'The': [30, 89, 228], 'coding': [31], 'sequences': [32], '<i>HTRA1</i>': [35, 64], 'gene': [36, 65], 'were': [37, 190], 'analyzed.': [38], 'evaluated': [40], 'HTRA1': [41, 49, 136, 162, 165, 199, 225, 240, 244], 'protease': [42, 131], 'activities': [43, 132], 'using': [44, 51], 'casein': [45], 'assays': [46], 'and': [47, 69, 79, 133, 152, 156, 170, 182, 204], 'oligomeric': [48], 'formation': [50], 'gel': [52], 'filtration': [53], 'chromatography.': [54], '<h3>Results:</h3>': [55], 'found': [57], '4': [58], 'missense': [60], 'mutations': [61, 189, 218], '(p.G283E,': [66], 'p.P285L,': [67], 'p.R302Q,': [68], 'p.T319I)': [70], '6': [72], 'from': [74], '2': [81, 84, 139], 'siblings': [82], 'families': [86], 'p.R302Q.': [88], 'mean': [90], 'age': [91], 'at': [92], 'cognitive': [93], 'impairment': [94], 'onset': [95], 'was': [96, 101, 108], '51.1': [97], 'years.': [98], 'Spondylosis': [99], 'deformans': [100], 'observed': [102, 109, 173, 210, 231], 'all': [104], 'cases,': [105], 'whereas': [106, 138], 'alopecia': [107], '3': [111, 141], 'cases;': [112], 'an': [113, 238], 'autopsied': [114], 'case': [115], 'p.G283E': [117], 'showed': [118, 128], 'arteriopathy': [119, 148], 'their': [121, 188], 'arteries.': [124], 'These': [125], 'HTRA1s': [127, 143, 184, 230], 'markedly': [129], 'decreased': [130], 'inhibited': [134], 'wild-type': [135, 161], 'activity,': [137], 'reported': [144], 'autosomal-recessive': [147], 'subcortical': [150], 'infarcts': [151], 'leukoencephalopathy': [153], '(CARASIL)': [154], '(A252T': [155], 'V297M)': [157], 'did': [158, 177], 'not': [159, 178], 'inhibit': [160], 'activity.': [163], 'Wild-type': [164], 'forms': [166], 'trimers;': [167], 'however,': [168], 'G283E': [169], 'T319I': [171], 'HTRA1,': [172], 'manifesting': [175, 233], 'heterozygotes,': [176], 'form': [179, 249], 'trimers.': [180, 251], 'P285L': [181], 'R302Q': [183], 'formed': [185, 214], 'trimers,': [186], 'but': [187, 216], 'located': [191], 'domains': [193, 221], 'that': [194], 'are': [195], 'important': [196, 222], 'for': [197, 223], 'trimer-associated': [198, 224], 'activation;': [200], 'contrast,': [202], 'A252T': [203], 'V297M': [205], 'HTRA1s,': [206], 'which': [207], 'have': [208], 'been': [209], 'CARASIL,': [212], 'also': [213], 'trimers': [215], 'had': [217], 'outside': [219], 'activation.': [226], '<h3>Conclusions:</h3>': [227], 'heterozygotes': [234], 'might': [235], 'result': [236], 'impaired': [239], 'activation': [241], 'cascade': [242], 'or': [245], 'be': [246], 'unable': [247], 'to': [248], 'stable': [250]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2345290534', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': '2024-09-12T04:43:01.102132', 'created_date': '2016-06-24'}