Title: Nickel-Catalyzed Reductive Coupling of Aryl Bromides with Tertiary Alkyl Halides
Abstract: A mild Ni-catalyzed reductive arylation of tertiary alkyl halides with aryl bromides has been developed that delivers products bearing all-carbon quaternary centers in moderate to excellent yields with excellent functional group tolerance. Electron-deficient arenes are generally more effective in inhibiting alkyl isomerization. The reactions proceed successfully with pyridine or 4-(dimethylamino)pyridine, while imidazolium salts slightly enhance the coupling efficiency.
Publication Year: 2015
Publication Date: 2015-09-03
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 242
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