Publication Information

{'id': 'https://openalex.org/W2341231354', 'doi': 'https://doi.org/10.3389/conf.fbioe.2016.01.01153', 'title': 'Synthetic platelet (SynthoPlate) technology enhances hemostasis in both prophylactic and emergency administration in mouse models of bleeding', 'display_name': 'Synthetic platelet (SynthoPlate) technology enhances hemostasis in both prophylactic and emergency administration in mouse models of bleeding', 'publication_year': 2016, 'publication_date': '2016-01-01', 'ids': {'openalex': 'https://openalex.org/W2341231354', 'doi': 'https://doi.org/10.3389/conf.fbioe.2016.01.01153', 'mag': '2341231354'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/conf.fbioe.2016.01.01153', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2595131146', 'display_name': 'Frontiers in Bioengineering and Biotechnology', 'issn_l': '2296-4185', 'issn': ['2296-4185'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.3389/conf.fbioe.2016.01.01153', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035462508', 'display_name': 'Pawlowski Christa', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Pawlowski Christa', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025109984', 'display_name': 'Didar Singh Sekhon Ujjal', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Didar Singh Sekhon Ujjal', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058867517', 'display_name': 'Betapudi Venkaiah', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Betapudi Venkaiah', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029634434', 'display_name': 'Meenal Shukla', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Shukla Meenal', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076115653', 'display_name': 'Mccrae Keith', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mccrae Keith', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028873614', 'display_name': 'Sen Gupta Anirban', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sen Gupta Anirban', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.446582, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 66, 'max': 73}, 'biblio': {'volume': '4', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Treatments', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Treatments', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10693', 'display_name': 'Blood transfusion and management', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/2704', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12352', 'display_name': 'Heparin-Induced Thrombocytopenia and Thrombosis', 'score': 0.9876, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778589496', 'wikidata': 'https://www.wikidata.org/wiki/Q487937', 'display_name': 'Hemostasis', 'level': 2, 'score': 0.71854925}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.67633104}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6624065}, {'id': 'https://openalex.org/C2778382381', 'wikidata': 'https://www.wikidata.org/wiki/Q179217', 'display_name': 'Coagulation', 'level': 2, 'score': 0.41363168}, {'id': 'https://openalex.org/C3018697912', 'wikidata': 'https://www.wikidata.org/wiki/Q179217', 'display_name': 'Platelet activation', 'level': 3, 'score': 0.41007808}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.37201783}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.31548715}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/conf.fbioe.2016.01.01153', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2595131146', 'display_name': 'Frontiers in Bioengineering and Biotechnology', 'issn_l': '2296-4185', 'issn': ['2296-4185'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/conf.fbioe.2016.01.01153', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2595131146', 'display_name': 'Frontiers in Bioengineering and Biotechnology', 'issn_l': '2296-4185', 'issn': ['2296-4185'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.68}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4315754442', 'https://openalex.org/W4302324012', 'https://openalex.org/W4253143603', 'https://openalex.org/W4248554551', 'https://openalex.org/W3003900439', 'https://openalex.org/W2387103638', 'https://openalex.org/W2062077711', 'https://openalex.org/W1988467799', 'https://openalex.org/W1967892882', 'https://openalex.org/W1547709928'], 'abstract_inverted_index': {'Event': [0, 4], 'Abstract': [1, 705, 707, 783], 'Back': [2, 785], 'to': [3, 66, 121, 226, 397, 577, 602, 691, 786, 800], 'Synthetic': [5, 539], 'platelet': [6, 87, 97, 132, 217, 263, 540], '(SynthoPlate)': [7, 541], 'technology': [8, 409, 429, 542], 'enhances': [9, 279, 543], 'hemostasis': [10, 254, 296, 544], 'in': [11, 17, 63, 86, 130, 246, 285, 304, 311, 317, 324, 361, 381, 430, 545, 551, 570, 609, 710, 778, 794, 798], 'both': [12, 305, 546], 'prophylactic': [13, 306, 362, 547], 'and': [14, 34, 53, 115, 140, 161, 191, 215, 237, 258, 260, 294, 307, 320, 363, 375, 377, 417, 462, 471, 518, 534, 548, 584, 605, 647, 654, 664, 671, 696], 'emergency': [15, 308, 549], 'administration': [16, 309, 550], 'mouse': [18, 552], 'models': [19, 323, 436, 553], 'of': [20, 106, 148, 163, 187, 197, 203, 240, 256, 272, 292, 335, 344, 356, 391, 406, 427, 437, 554, 618, 634, 658], 'bleeding': [21, 68, 303, 322, 329, 359], 'Christa': [22, 712, 728, 745, 761], 'Pawlowski1,': [23], 'Ujjal': [24, 714, 730, 747, 763], 'Didar': [25, 524, 715, 731, 748, 764], 'Singh': [26, 525, 716, 732, 749, 765], 'Sekhon1,': [27], 'Venkaiah': [28, 718, 734, 751, 767], 'Betapudi2,': [29], 'Meenal': [30, 720, 736, 753, 769], 'Shukla2,': [31], 'Keith': [32, 722, 738, 755, 771], 'Mccrae2': [33], 'Anirban': [35, 724, 740, 757, 773], 'Sen': [36, 460, 469, 535, 725, 741, 758, 774], 'Gupta1': [37], '1': [38], 'Case': [39], 'Western': [40], 'Reserve': [41], 'University,': [42], 'Biomedical': [43], 'Engineering,': [44], 'United': [45, 56], 'States': [46, 57], '2': [47], 'Cleveland': [48], 'Clinic': [49], 'Foundation,': [50], 'Hematologic': [51], 'Oncology': [52], 'Blood': [54], 'Disorders,': [55], 'Platelet': [58], 'transfusions': [59, 92], 'are': [60, 354, 368, 420, 585, 591, 636, 666], 'routinely': [61], 'used': [62], 'the': [64, 179, 235, 336, 372, 382, 389, 404, 407, 424, 428, 595, 610, 616, 632, 656, 662, 803], 'clinic': [65], 'treat': [67], 'complications': [69], 'stemming': [70], 'from': [71], 'trauma,': [72], 'surgery,': [73], 'malignancy': [74], 'or': [75, 89, 165, 582, 621, 701], 'drug': [76], 'related': [77], 'bone': [78], 'marrow': [79], 'suppression,': [80], 'as': [81, 83, 410, 599, 629, 631], 'well': [82, 630], 'congenital': [84], 'defects': [85], 'number': [88], 'function.': [90], 'These': [91, 401], 'primarily': [93], 'use': [94], 'allogeneic': [95], 'natural': [96], 'concentrates': [98], '(PCs)': [99], 'that': [100, 134, 248, 268, 289, 351, 388], 'have': [101, 172, 378, 385, 573], 'limited': [102], 'availability,': [103], 'high': [104], 'risk': [105], 'bacterial': [107], 'contamination,': [108], 'very': [109], 'short': [110], 'shelf': [111], 'life': [112], '(~3-5': [113], 'days),': [114], 'several': [116], 'biologic': [117, 164], 'side': [118], 'effects[1].': [119], 'Due': [120], 'these': [122, 241, 249, 392], 'issues,': [123], 'there': [124], 'is': [125, 613, 789], 'a': [126, 174, 411, 440, 600, 639], 'significant': [127], 'clinical': [128], 'interest': [129], 'synthetic': [131, 177, 414], 'substitutes': [133], 'can': [135, 394], 'render': [136, 251], 'efficient': [137], 'hemostasis,': [138], 'leveraging': [139], 'amplifying': [141], 'endogenous': [142], 'clotting': [143], 'mechanisms': [144, 186, 255, 275], 'while': [145], 'allowing': [146], 'advantages': [147], 'large-scale': [149], 'manufacture,': [150], 'minimum': [151], 'contamination': [152], 'risks,': [153], 'longer': [154], 'shelf-life,': [155], 'no': [156], 'need': [157], 'for': [158, 328, 442, 513], 'blood-type': [159], 'matching': [160], 'absence': [162], 'pathogenic': [166], 'effects.': [167], 'To': [168, 699], 'this': [169, 290, 571, 806], 'end,': [170], 'we': [171], 'developed': [173], 'unique': [175], 'platelet-inspired': [176], 'hemostat,': [178], 'SynthoPlate,': [180], 'which': [181], 'integrates': [182], 'platelet’s': [183], 'key': [184], 'hemostatic': [185, 274, 281, 425], 'injury': [188], 'site-specific': [189], 'adhesion': [190], 'aggregation': [192], 'by': [193, 276, 298, 341, 588, 615], 'heteromultivalent': [194], 'surface': [195], 'presentation': [196], 'multiple': [198], 'peptide': [199], 'types': [200], 'via': [201, 371], 'self-assembly': [202], 'lipid-peptide': [204], 'conjugates.': [205], 'Specifically,': [206], 'lipids': [207], 'bearing': [208], 'vWF-binding': [209], 'peptides': [210, 213, 222], '(VBP),': [211], 'collagen-binding': [212], '(CBP)': [214], 'active': [216, 262], 'integrin': [218], 'GPIIb-IIIa': [219], 'binding': [220], 'fibrinogen-mimetic': [221], '(FMP)': [223], 'were': [224], 'self-assembled': [225], 'produce': [227], '~150nm': [228], 'diameter': [229], 'SynthoPlate': [230, 277, 299, 352, 408], 'vesicles[2]-[4].': [231], 'We': [232, 243, 265, 287, 384], 'first': [233], 'established': [234], 'sterilizability': [236], 'long-term': [238], 'stability': [239], 'particles.': [242], 'then': [244], 'demonstrated,': [245], 'vitro,': [247], 'particles': [250, 278, 337, 353, 367, 393], 'platelet-mimetic': [252, 412], 'primary': [253, 273, 293], 'VWF-': [257], 'collagen-adhesion,': [259], 'site-selective': [261, 270], 'aggregation.': [264], 'further': [266], 'demonstrated': [267, 387], 'such': [269], 'amplification': [271], 'secondary': [280, 295], 'output': [282], '(fibrin': [283], 'generation),': [284], 'vitro.': [286], 'hypothesized': [288], 'combination': [291], 'enhancement': [297], 'will': [300], 'significantly': [301], 'reduce': [302], 'scenarios,': [310], 'vivo.': [312], 'The': [313, 333, 348, 366, 568, 607, 708], 'hypothesis': [314], 'was': [315, 331, 338], 'tested': [316], 'appropriate': [318], 'tail': [319], 'liver': [321], 'mice,': [325], 'where': [326], 'time': [327, 360], 'stoppage': [330], 'measured.': [332], 'biodistribution': [334], 'also': [339, 386], 'analyzed': [340], 'fluorescence': [342], 'measurement': [343], 'excised': [345], 'tissue': [346], 'homogenates.': [347], 'results': [349, 402], 'establish': [350], 'capable': [355], 'dose-dependently': [357], 'reducing': [358], 'emergent': [364], 'conditions.': [365], 'cleared': [369], 'mostly': [370], 'liver,': [373], 'spleen': [374], 'kidney': [376], 'minimal': [379], 'accumulation': [380], 'lung.': [383], 'surface-decoration': [390], 'be': [395, 650, 655, 692], 'adapted': [396, 653], 'other': [398], 'particle': [399], 'platforms[5].': [400], 'demonstrate': [403], 'promise': [405], 'intravenous': [413], 'hemostat.': [415], 'Ongoing': [416], 'future': [418], 'studies': [419], 'focused': [421], 'on': [422, 805], 'evaluating': [423], 'efficacy': [426], 'clinically': [431], 'motivated': [432], 'large': [433], 'animal': [434], '(porcine)': [435], 'bleeding,': [438], 'with': [439, 694], 'vision': [441], 'translation.': [443], 'References:[1]': [444], 'Modery-Pawlowski': [445, 452], 'et': [446, 453, 479], 'al,': [447], 'Biomaterials': [448, 455, 496, 512, 563], '2013,': [449, 456], '34(2):': [450], '526-541.[2]': [451], 'al.,': [454, 480], '34(12):': [457], '3031-': [458], '41.[3]': [459], 'Gupta': [461, 470, 536, 726, 742, 759, 775], 'Ravikumar,': [463], '2015,': [464, 473], 'US': [465, 474], 'Patent': [466, 475], 'No.': [467, 476], '9107845.[4]': [468], 'Modery,': [472], '9107963.[5]': [477], 'Anselmo': [478], 'ACS': [481], 'Nano': [482], '2014;': [483], '8(11):': [484], '11243-11253.': [485], 'Keywords:': [486], 'Biomimetic,': [487], 'nanoparticle,': [488], 'Surface': [489], 'modification,': [490], 'Clinical': [491], 'relevance': [492], 'Conference:': [493], '10th': [494, 561], 'World': [495, 562], 'Congress,': [497], 'Montréal,': [498], 'Canada,': [499], '17': [500], 'May': [501], '-': [502], '22': [503], 'May,': [504], '2016.': [505, 684], 'Presentation': [506], 'Type:': [507], 'New': [508], 'Frontier': [509], 'Oral': [510], 'Topic:': [511], 'cardiovascular': [514], 'applications,': [515], 'vascular': [516], 'grafts': [517], 'embolic': [519], 'devices': [520], 'Citation:': [521], 'Pawlowski': [522, 713, 729, 746, 762], 'C,': [523], 'Sekhon': [526, 717, 733, 750, 766], 'U,': [527], 'Betapudi': [528, 719, 735, 752, 768], 'V,': [529], 'Shukla': [530, 721, 737, 754, 770], 'M,': [531], 'Mccrae': [532, 723, 739, 756, 772], 'K': [533], 'A': [537], '(2016).': [538], 'bleeding.': [555], 'Front.': [556], 'Bioeng.': [557], 'Biotechnol.': [558], 'Conference': [559], 'Abstract:': [560], 'Congress.': [564], 'doi:': [565], '10.3389/conf.FBIOE.2016.01.01153': [566], 'Copyright:': [567], 'abstracts': [569, 612], 'collection': [572, 633], 'not': [574, 586], 'been': [575], 'subject': [576, 657], 'any': [578], 'Frontiers': [579, 596, 665, 695, 711, 779], 'peer': [580], 'review': [581], 'checks,': [583], 'endorsed': [587], 'Frontiers.': [589], 'They': [590], 'made': [592], 'available': [593], 'through': [594], 'publishing': [597], 'platform': [598], 'service': [601], 'conference': [603], 'organizers': [604], 'presenters.': [606], 'copyright': [608], 'individual': [611], 'owned': [614], 'author': [617], 'each': [619], 'abstract': [620], 'his/her': [622], 'employer': [623], 'unless': [624], 'otherwise': [625], 'stated.': [626], 'Each': [627], 'abstract,': [628], 'abstracts,': [635], 'published': [637], 'under': [638], 'Creative': [640], 'Commons': [641], 'CC-BY': [642], '4.0': [643], '(attribution)': [644], 'licence': [645], '(https://creativecommons.org/licenses/by/4.0/)': [646], 'may': [648], 'thus': [649], 'reproduced,': [651], 'translated,': [652], 'derivative': [659], 'works': [660], 'provided': [661], 'authors': [663], 'attributed.': [667], 'For': [668], 'Frontiers’': [669], 'terms': [670], 'conditions': [672], 'please': [673], 'see': [674, 801], 'https://www.frontiersin.org/legal/terms-and-conditions.': [675], 'Received:': [676], '27': [677], 'Mar': [678, 683], '2016;': [679], 'Published': [680], 'Online:': [681], '30': [682], 'Login': [685], 'Required': [686], 'This': [687], 'action': [688], 'requires': [689], 'you': [690], 'registered': [693], 'logged': [697], 'in.': [698], 'register': [700], 'login': [702], 'click': [703], 'here.': [704], 'Info': [706], 'Authors': [709], 'Google': [727, 743, 780], 'Scholar': [744, 781], 'PubMed': [760, 782], 'Related': [776], 'Article': [777], 'Close': [784], 'top': [787], 'Javascript': [788, 793], 'disabled.': [790], 'Please': [791], 'enable': [792], 'your': [795], 'browser': [796], 'settings': [797], 'order': [799], 'all': [802], 'content': [804], 'page.': [807]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2341231354', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}], 'updated_date': '2025-01-13T01:51:47.031722', 'created_date': '2016-06-24'}