Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2340673151', 'doi': 'https://doi.org/10.1016/j.bbrc.2016.04.100', 'title': 'A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation', 'display_name': 'A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation', 'publication_year': 2016, 'publication_date': '2016-05-01', 'ids': {'openalex': 'https://openalex.org/W2340673151', 'doi': 'https://doi.org/10.1016/j.bbrc.2016.04.100', 'mag': '2340673151', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27107697', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4872870'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbrc.2016.04.100', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc4872870?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061628025', 'display_name': 'Jinqi Ren', 'orcid': 'https://orcid.org/0000-0001-7461-0491'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jinqi Ren', 'raw_affiliation_strings': ['Departments of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034330437', 'display_name': 'Aaron A. Cook', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Aaron A. Cook', 'raw_affiliation_strings': ['Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA'], 'affiliations': [{'raw_affiliation_string': 'Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073613118', 'display_name': 'Wolfgang Bergmeier', 'orcid': 'https://orcid.org/0000-0002-1211-8861'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wolfgang Bergmeier', 'raw_affiliation_strings': ['Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA'], 'affiliations': [{'raw_affiliation_string': 'Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002265218', 'display_name': 'John Sondek', 'orcid': 'https://orcid.org/0000-0002-1127-8310'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'John Sondek', 'raw_affiliation_strings': ['Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA', 'Departments of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA', 'Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA', 'institution_ids': ['https://openalex.org/I114027177']}, {'raw_affiliation_string': 'Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA', 'institution_ids': ['https://openalex.org/I114027177']}, {'raw_affiliation_string': 'Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5002265218'], 'corresponding_institution_ids': ['https://openalex.org/I114027177'], 'apc_list': {'value': 2770, 'currency': 'USD', 'value_usd': 2770, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.373, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.683517, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '474', 'issue': '1', 'first_page': '193', 'last_page': '198'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11533', 'display_name': 'Mammalian MAP Kinase Signaling Pathways', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11533', 'display_name': 'Mammalian MAP Kinase Signaling Pathways', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/negative-feedback', 'display_name': 'Negative feedback', 'score': 0.64012104}, {'id': 'https://openalex.org/keywords/positive-feedback', 'display_name': 'Positive feedback', 'score': 0.6328822}, {'id': 'https://openalex.org/keywords/phosphorylation-cascade', 'display_name': 'Phosphorylation cascade', 'score': 0.58865845}, {'id': 'https://openalex.org/keywords/small-gtpase', 'display_name': 'Small GTPase', 'score': 0.54934835}, {'id': 'https://openalex.org/keywords/cell-regulation', 'display_name': 'Cell Regulation', 'score': 0.518883}, {'id': 'https://openalex.org/keywords/mek-inhibition', 'display_name': 'MEK Inhibition', 'score': 0.507114}, {'id': 'https://openalex.org/keywords/erk-pathway', 'display_name': 'ERK pathway', 'score': 0.504982}, {'id': 'https://openalex.org/keywords/linker', 'display_name': 'Linker', 'score': 0.46460125}, {'id': 'https://openalex.org/keywords/feedback-regulation', 'display_name': 'Feedback regulation', 'score': 0.41636112}], 'concepts': [{'id': 'https://openalex.org/C126619667', 'wikidata': 'https://www.wikidata.org/wiki/Q901088', 'display_name': 'Guanine nucleotide exchange factor', 'level': 3, 'score': 0.8937278}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.7459722}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.7094779}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.66067994}, {'id': 'https://openalex.org/C93586867', 'wikidata': 'https://www.wikidata.org/wiki/Q62527', 'display_name': 'Negative feedback', 'level': 3, 'score': 0.64012104}, {'id': 'https://openalex.org/C48207687', 'wikidata': 'https://www.wikidata.org/wiki/Q918004', 'display_name': 'Positive feedback', 'level': 2, 'score': 0.6328822}, {'id': 'https://openalex.org/C104551158', 'wikidata': 'https://www.wikidata.org/wiki/Q7187581', 'display_name': 'Phosphorylation cascade', 'level': 5, 'score': 0.58865845}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.55116326}, {'id': 'https://openalex.org/C2780298669', 'wikidata': 'https://www.wikidata.org/wiki/Q415071', 'display_name': 'Small GTPase', 'level': 3, 'score': 0.54934835}, {'id': 'https://openalex.org/C207332259', 'wikidata': 'https://www.wikidata.org/wiki/Q769143', 'display_name': 'GTPase', 'level': 2, 'score': 0.54053426}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.52682537}, {'id': 'https://openalex.org/C2780557392', 'wikidata': 'https://www.wikidata.org/wiki/Q523796', 'display_name': 'Linker', 'level': 2, 'score': 0.46460125}, {'id': 'https://openalex.org/C3017962763', 'wikidata': 'https://www.wikidata.org/wiki/Q427492', 'display_name': 'Feedback regulation', 'level': 2, 'score': 0.41636112}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.41389978}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.399846}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.34975004}, {'id': 'https://openalex.org/C87325107', 'wikidata': 'https://www.wikidata.org/wiki/Q7251493', 'display_name': 'Protein phosphorylation', 'level': 4, 'score': 0.16016105}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.11368871}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.089656115}, {'id': 'https://openalex.org/C145420912', 'wikidata': 'https://www.wikidata.org/wiki/Q853077', 'display_name': 'Mathematics education', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C165801399', 'wikidata': 'https://www.wikidata.org/wiki/Q25428', 'display_name': 'Voltage', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C119599485', 'wikidata': 'https://www.wikidata.org/wiki/Q43035', 'display_name': 'Electrical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C111919701', 'wikidata': 'https://www.wikidata.org/wiki/Q9135', 'display_name': 'Operating system', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D025461', 'descriptor_name': 'Feedback, Physiological', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D019950', 'descriptor_name': 'Mitogen-Activated Protein Kinase 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025461', 'descriptor_name': 'Feedback, Physiological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019950', 'descriptor_name': 'Mitogen-Activated Protein Kinase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbrc.2016.04.100', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4872870', 'pdf_url': 'https://europepmc.org/articles/pmc4872870?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872870', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.17615/1v9z-yb26', 'pdf_url': 'https://cdr.lib.unc.edu/downloads/2j62s938t', 'source': {'id': 'https://openalex.org/S4306401075', 'display_name': 'Carolina Digital Repository (University of North Carolina at Chapel Hill)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I114027177', 'host_organization_name': 'University of North Carolina at Chapel Hill', 'host_organization_lineage': ['https://openalex.org/I114027177'], 'host_organization_lineage_names': ['University of North Carolina at Chapel Hill'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27107697', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4872870', 'pdf_url': 'https://europepmc.org/articles/pmc4872870?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01-HL106009'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01-CA161160'}], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1887383255', 'https://openalex.org/W1963760725', 'https://openalex.org/W1973568352', 'https://openalex.org/W1974515407', 'https://openalex.org/W1978605633', 'https://openalex.org/W1979572498', 'https://openalex.org/W1987604803', 'https://openalex.org/W1994373703', 'https://openalex.org/W1994481836', 'https://openalex.org/W1996310767', 'https://openalex.org/W2000581759', 'https://openalex.org/W2005684912', 'https://openalex.org/W2010250176', 'https://openalex.org/W2037519578', 'https://openalex.org/W2041239456', 'https://openalex.org/W2057777105', 'https://openalex.org/W2062289724', 'https://openalex.org/W2073209241', 'https://openalex.org/W2087839240', 'https://openalex.org/W2090799728', 'https://openalex.org/W2095169768', 'https://openalex.org/W2096045103', 'https://openalex.org/W2103746902', 'https://openalex.org/W2123333705', 'https://openalex.org/W2123347941', 'https://openalex.org/W2145416541', 'https://openalex.org/W2147641326', 'https://openalex.org/W2156470803', 'https://openalex.org/W2274414600'], 'related_works': ['https://openalex.org/W2972417308', 'https://openalex.org/W2897954926', 'https://openalex.org/W2884945502', 'https://openalex.org/W2773320882', 'https://openalex.org/W2340673151', 'https://openalex.org/W2106469366', 'https://openalex.org/W2028403946', 'https://openalex.org/W2017101110', 'https://openalex.org/W1975461839', 'https://openalex.org/W1766634275'], 'abstract_inverted_index': {'The': [0], 'dynamic': [1], 'regulation': [2], 'of': [3, 27, 40, 63, 89, 110], 'ERK1': [4], 'and': [5, 18, 91, 108], '-2': [6], '(ERK1/2)': [7], 'is': [8], 'required': [9], 'for': [10], 'precise': [11], 'signal': [12], 'transduction': [13], 'controlling': [14], 'cell': [15], 'proliferation,': [16], 'differentiation,': [17], 'survival.': [19], 'However,': [20], 'the': [21, 25, 53, 74, 98, 106], 'underlying': [22], 'mechanisms': [23], 'regulating': [24], 'activation': [26, 62], 'ERK1/2': [28, 64, 90], 'are': [29], 'not': [30], 'completely': [31], 'understood.': [32], 'In': [33], 'this': [34], 'study,': [35], 'we': [36], 'show': [37], 'that': [38, 57, 96], 'phosphorylation': [39], 'RasGRP2,': [41], 'a': [42, 86, 93], 'guanine': [43], 'nucleotide': [44], 'exchange': [45], 'factor': [46], '(GEF),': [47], 'inhibits': [48], 'its': [49, 79], 'ability': [50], 'to': [51, 60], 'activate': [52], 'small': [54], 'GTPase': [55], 'Rap1': [56], 'ultimately': [58], 'leads': [59], 'decreased': [61], 'in': [65, 73, 78], 'cells.': [66], 'ERK2': [67], 'phosphorylates': [68], 'RasGRP2': [69, 84], 'at': [70], 'Ser394': [71], 'located': [72], 'linker': [75], 'region': [76], 'implicated': [77], 'autoinhibition.': [80], 'These': [81], 'studies': [82], 'identify': [83], 'as': [85], 'novel': [87], 'substrate': [88], 'define': [92], 'negative-feedback': [94, 103], 'loop': [95, 104], 'regulates': [97], 'BRaf–MEK–ERK': [99], 'signaling': [100], 'cascade.': [101], 'This': [102], 'determines': [105], 'amplitude': [107], 'duration': [109], 'active': [111], 'ERK1/2.': [112]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2340673151', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-09-11T17:37:56.373196', 'created_date': '2016-06-24'}