Publication Information

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2493, 2563, 2576, 2651, 2668, 2765, 2836, 3198, 3203, 3292, 3418], 'an': [6, 181, 357, 542, 604, 722, 832, 1203, 1242, 1344, 1445, 1823, 2007, 2177, 2547, 2933, 3096, 3194, 3346], 'autosomal': [7, 182, 358], 'recessive': [8, 183, 359], 'inherited': [9, 184], 'neurodegenerative': [10, 185], 'disorder': [11, 25, 186, 200, 360], 'caused': [12, 187, 361], 'by': [13, 188, 362, 397, 430, 700, 721, 810, 831, 929, 968, 1002, 1146, 1228, 1258, 1362, 1433, 1465, 1570, 1633, 1726, 1765, 1833, 1857, 1901, 2176, 2310, 2419, 2478, 2525, 2546, 2911, 2932, 2950, 3087, 3135, 3275, 3324, 3345], 'the': [14, 17, 24, 32, 35, 66, 70, 79, 118, 138, 161, 189, 192, 199, 207, 210, 241, 245, 254, 293, 313, 337, 363, 366, 398, 406, 413, 474, 479, 486, 492, 495, 503, 517, 557, 561, 581, 583, 630, 696, 739, 806, 867, 916, 951, 1022, 1044, 1132, 1152, 1162, 1181, 1237, 1255, 1271, 1295, 1302, 1379, 1383, 1395, 1460, 1477, 1503, 1531, 1540, 1548, 1584, 1589, 1608, 1618, 1621, 1626, 1629, 1664, 1673, 1676, 1694, 1722, 1742, 1797, 1806, 1811, 1814, 1829, 1846, 1850, 1873, 1880, 1902, 1919, 1939, 1976, 1980, 1986, 1989, 2000, 2017, 2026, 2030, 2057, 2089, 2109, 2120, 2128, 2133, 2186, 2189, 2197, 2259, 2306, 2325, 2331, 2338, 2347, 2350, 2358, 2432, 2521, 2556, 2559, 2564, 2568, 2589, 2610, 2633, 2643, 2656, 2659, 2716, 2733, 2756, 2779, 2797, 2802, 2831, 2857, 2882, 2907, 2945, 3009, 3024, 3033, 3036, 3043, 3049, 3061, 3065, 3083, 3088, 3102, 3111, 3127, 3140, 3143, 3150, 3166, 3176, 3181, 3240, 3247, 3253, 3262, 3320, 3361, 3367, 3406, 3412, 3460, 3493, 3498], 'deficiency': [15, 190, 364, 381, 528], 'of': [16, 23, 34, 49, 72, 115, 124, 135, 140, 158, 191, 198, 209, 224, 247, 290, 299, 310, 315, 334, 365, 382, 400, 405, 433, 461, 478, 488, 494, 505, 529, 546, 560, 608, 627, 635, 644, 692, 732, 741, 754, 802, 863, 919, 953, 961, 995, 997, 1024, 1046, 1121, 1134, 1141, 1193, 1196, 1218, 1232, 1254, 1267, 1394, 1482, 1491, 1522, 1526, 1574, 1583, 1617, 1628, 1647, 1663, 1672, 1718, 1738, 1754, 1773, 1799, 1813, 1835, 1852, 1879, 1892, 1906, 1911, 1938, 1948, 1957, 1973, 1988, 1999, 2010, 2012, 2016, 2025, 2037, 2039, 2043, 2059, 2066, 2072, 2074, 2086, 2097, 2103, 2111, 2122, 2194, 2208, 2256, 2261, 2280, 2302, 2320, 2333, 2340, 2342, 2349, 2362, 2377, 2396, 2409, 2413, 2428, 2445, 2517, 2558, 2567, 2570, 2598, 2622, 2632, 2637, 2662, 2703, 2711, 2718, 2737, 2781, 2804, 2824, 2833, 2849, 2852, 2868, 2878, 2903, 3011, 3020, 3035, 3046, 3054, 3082, 3090, 3153, 3156, 3165, 3180, 3187, 3208, 3223, 3243, 3252, 3259, 3316, 3366, 3377, 3391, 3409, 3414, 3431, 3462, 3497], 'lysosomal': [18, 193, 367], 'enzyme': [19, 194, 368, 481, 519], 'β-galactosylceramidase.': [20, 195], 'The': [21, 40, 110, 196, 215, 285, 393, 456, 538, 601, 1138, 1304, 1367, 1403, 1614, 1670, 1750, 1865, 1896, 1908, 1970, 2014, 2041, 2317, 2407, 2458, 2847, 2957, 3256, 3374, 3483], 'pathogenesis': [22, 197, 493], 'has': [26, 105, 201, 280, 497, 2860], 'been': [27, 106, 202, 281, 498, 736, 948, 1355, 2861, 3191], 'proposed': [28, 203, 499], 'to': [29, 204, 428, 500, 556, 927, 950, 1037, 1236, 1301, 1310, 1378, 1471, 1543, 1588, 1597, 1620, 1635, 1643, 1655, 1698, 1763, 1777, 1820, 1872, 1915, 1944, 2048, 2451, 2600, 2639, 2751, 2767, 2819, 2838, 2842, 2863, 2964, 3058, 3105, 3117, 3123, 3139, 3205, 3267, 3382, 3426, 3449, 3458, 3487, 3517], 'arise': [30, 205, 501], 'from': [31, 78, 206, 253, 502, 746, 1043, 1060, 1071, 1097, 1113, 1151, 1593, 1689, 1796, 1805, 1849, 1884, 1942, 1953, 2214, 2233, 2370, 2389, 2677, 2740, 2770, 2826, 2870, 2980, 2998, 3068, 3175], 'accumulation': [33, 114, 208, 289, 626, 643, 753, 892, 1891, 2085, 2260, 2279, 2341, 3359, 3379], 'cytotoxic': [36, 211, 507], 'metabolite': [37, 212, 646, 756, 2282], 'galactosylsphingosine': [38, 67, 116, 159, 213, 242, 291, 335, 509, 628, 671, 693, 742, 781, 803, 849, 864, 1042, 1268, 1396, 1492, 1527, 1544, 1575, 1619, 1630, 1719, 1739, 1755, 1774, 1827, 1847, 1893, 1912, 1977, 2060, 2067, 2087, 2104, 2123, 2152, 2195, 2262, 2303, 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547, 610, 1961, 3469], 'leukodystrophy.': [52, 227, 321, 3471], 'We': [53, 228, 2608, 2784, 3169], 'have': [54, 229, 621, 735, 913, 939, 947, 2941, 3190], 'developed': [55, 230, 3448, 3467], 'rapid,': [57, 232, 1026, 2577], 'sensitive,': [58, 233, 1027], 'and': [59, 87, 92, 122, 154, 234, 262, 267, 297, 330, 402, 408, 419, 458, 553, 563, 632, 743, 895, 921, 924, 946, 976, 999, 1028, 1039, 1054, 1079, 1172, 1180, 1260, 1321, 1416, 1448, 1459, 1493, 1496, 1547, 1559, 1579, 1611, 1625, 1678, 1693, 1785, 1810, 1828, 1925, 2053, 2094, 2218, 2237, 2253, 2335, 2373, 2392, 2421, 2447, 2467, 2580, 2587, 2619, 2635, 2689, 2697, 2735, 2814, 2816, 2959, 3013, 3129, 3132, 3202, 3225, 3249, 3363, 3495, 3500], 'specific': [60, 235, 1029], 'mass': [61, 99, 167, 236, 274, 343, 937, 974, 1010, 1034, 1428, 1442, 1470, 1897, 2032, 3402, 3510, 3516], 'spectrometric': [62, 237, 1429, 3403], 'method': [63, 132, 238, 307, 994, 1030, 1256, 2442, 2717, 2731, 3404, 3422, 3444], 'for': [64, 108, 143, 239, 283, 318, 516, 717, 738, 827, 1469, 1555, 1840, 1975, 2172, 2542, 2612, 2645, 2649, 2686, 2693, 2732, 2928, 3042, 3107, 3341, 3405, 3468, 3478, 3492, 3504], 'determining': [65, 240], 'concentration': [68, 243, 1627, 1978, 2058, 2121, 2204, 2356, 3155], 'in': [69, 81, 117, 137, 160, 244, 256, 292, 312, 336, 416, 421, 485, 580, 629, 647, 695, 757, 805, 866, 893, 904, 943, 966, 1211, 1270, 1418, 1476, 1721, 1741, 1822, 1923, 1979, 2051, 2088, 2108, 2117, 2127, 2132, 2205, 2247, 2283, 2305, 2324, 2346, 2357, 2403, 2411, 2431, 2520, 2655, 2666, 2845, 2856, 2865, 2881, 2906, 3023, 3119, 3142, 3246, 3261, 3269, 3319, 3357, 3360, 3385, 3388, 3411, 3433, 3452], 'tissues': [71, 80, 246, 255, 487, 634, 747, 1045, 1182, 1928, 2055, 2110, 2130, 2412, 2599, 2667, 2685, 2946, 2982, 3001, 3075, 3264, 3413], 'mice.': [74, 126, 249, 301, 1048, 2099, 2113, 2691, 3255, 3416], 'Galactosylsphingosine': [75, 250, 1053, 1246, 1458, 1565, 1859, 2386], 'extracted': [77, 252, 1150, 2979, 3067], 'methanol,': [82, 257, 1315], 'isolated': [83, 258, 1249, 2675], 'using': [84, 96, 164, 259, 271, 340, 1031, 1250, 1343, 1435, 1512, 1530, 2469, 2572, 2778, 2966], 'strong': [85, 260, 1084, 3520], 'cation-exchange': [86, 261, 1085, 3521], 'C18': [88, 263, 1104, 1346, 1679, 2448], 'solid-phase': [89, 264, 1087, 1105, 1281, 1347, 2625, 2789], 'extraction': [90, 265, 918, 1004, 1088, 1106, 1282, 1348, 2626, 2713, 2790, 2858, 2952, 3103, 3128], 'chromatography,': [91, 266], 'then': [93, 268, 922, 1184, 1248, 1307, 1328, 1341, 1375, 1605, 1683, 2461, 2962], 'directly': [94, 269, 1376, 1500], 'analyzed': [95, 270, 2213, 2232, 2369, 2388, 3134], 'electrospray': [97, 165, 272, 341, 1032, 1504, 3508], 'ionization-tandem': [98, 166, 273, 342, 1033, 3509], 'spectrometry.': [100, 168, 275, 344], 'A': [101, 276, 730, 1119, 1191, 1279, 2100, 2729, 3354], 'lactosylsphingosine': [102, 277, 1055, 1233, 1461, 1549, 1585, 1665, 1874, 3094, 3167], 'internal': [103, 278, 1243, 3512], 'standard': [104, 279, 1244, 1576, 3513], 'employed': [107, 282, 737, 3425], 'quantification.': [109, 284], 'assay': [111, 286, 1941, 1990], 'demonstrated': [112, 287, 623, 2068, 2987, 3238], 'significant': [113, 288, 2084, 2850], 'brain,': [119, 294, 1167, 2093], 'spinal': [120, 295, 1168, 2095, 2254, 2326, 2698, 3250, 3364, 3389], 'cord,': [121, 296, 1169, 2699], 'kidney': [123, 298, 1173, 2190], 'It': [127, 302, 3417], 'anticipated': [129, 304, 3419], 'that': [130, 305, 425, 550, 1353, 1652, 2664, 2975, 2988, 3032, 3149, 3164, 3171, 3239, 3420], 'this': [131, 306, 1018, 2562, 2971, 3172, 3197, 3421, 3443], 'may': [133, 308], 'be': [134, 309, 1699, 1916, 2046, 2049, 2601, 2706, 3268, 3383, 3424, 3446], 'use': [136, 311, 2444, 2621, 3089], 'monitoring': [139, 314, 1533, 3515], 'experimental': [141, 316], 'therapies': [142, 317, 3464], 'leukodystrophy.—Whitfield,': [146], 'P.': [147, 149, 155, 323, 325, 331], 'D.,': [148, 324], 'C.': [150, 326], 'Sharp,': [151, 327], 'R.': [152, 328, 884], 'Taylor,': [153, 329], 'Meikle.': [156, 332], 'Quantification': [157, 333, 1525, 3081], 'J.': [169, 345, 2723], 'Lipid': [170, 346, 852, 869, 1273, 1744, 2434, 2884, 3026], 'Res.': [171, 347, 615, 853, 870, 906, 1274, 1745, 2435, 2885, 3027], '2001.': [172, 348], '42:': [173, 349], '2092–2095.': [174, 350], '—Whitfield,': [322], 'β-galactosylceramidase': [369], '(EC': [370], '3.2.1.46)': [371], '(1Suzuki': [372], 'K.': [373, 436, 440, 523, 600, 641, 751, 861, 990, 1265, 1736, 2277, 2426, 2876, 3018], 'Suzuki': [374, 437, 439, 522, 599, 640, 663, 750, 773, 860, 1261, 1264, 1735, 2144, 2276, 2422, 2425, 2488, 2875, 3014, 3017, 3287], 'Y.': [375, 438, 664, 714, 774, 824, 2145, 2169, 2489, 2539, 2925, 3288, 3338], 'leucodystrophy': [378, 579], "(Krabbe's": [379], 'disease):': [380], 'galactocerebroside': [383], 'β-galactosidase.Proc.': [384], 'Natl.': [385], 'Acad.': [386], 'Sci.': [387], 'USA.': [388], '1970;': [389], '66:': [390], '302-309Google': [391], 'Scholar).': [392, 468, 537, 619, 729, 910, 1016, 1278, 1749, 2184, 2316, 2439, 2554, 2889, 3235, 3353], 'disease': [394, 414, 496, 562, 901, 2657], 'characterized': [396, 1832], 'degeneration': [399], 'oligodendroglia': [401], 'progressive': [403], 'demyelination': [404], 'central': [407, 2359], 'peripheral': [409], 'nervous': [410, 2129, 2360], 'system.': [411], 'Clinically,': [412], 'manifests': [415], 'early': [417, 903], 'infancy': [418], 'results': [420], 'complete': [422, 1940], 'neurological': [423], 'dysfunction': [424], 'often': [426], 'leads': [427], 'death': [429], '2': [431, 899], 'years': [432], 'age': [434, 2265, 3370], '(2Suzuki': [435], 'Galactosylceramide': [441], 'lipidosis:': [442], 'disease).in:': [447], 'Scriver': [448], 'C.R.': [449], 'Beaudet': [450], 'A.L.': [451], 'Sly': [452], 'W.S.': [453], 'Valle': [454], 'D.': [455, 886], 'Metabolic': [457], 'Molecular': [459], 'Basis': [460], 'Inherited': [462], 'Disease.': [463], 'McGraw-Hill,': [464], 'New': [465], 'York1995:': [466], '2671-2692Google': [467], 'In': [469, 934, 1017, 1767, 1876, 1984, 2251, 2582, 2970, 3004, 3396, 3441], 'galactosylceramide,': [473], 'primary': [475], 'natural': [476], 'substrate': [477, 515], 'deficient': [480], 'does': [482], 'not': [483, 2993, 3079, 3199], 'accumulate': [484], 'affected': [489], 'individuals.': [490], 'Rather,': [491], 'storage': [504, 673, 783, 2154, 2498, 3297], 'metabolite,': [508], '(psychosine),': [510], 'which': [511, 1294, 1382, 1603, 3098], 'also': [513, 622, 1668, 1995, 2020, 2106, 3372, 3485], 'missing': [518], '(3Miyatake': [520], 'T.': [521, 592, 594, 656, 662, 684, 710, 712, 766, 772, 794, 820, 822, 958, 986, 1710, 2137, 2143, 2165, 2167, 2294, 2481, 2487, 2509, 2535, 2537, 2895, 2921, 2923, 3280, 3286, 3308, 3334, 3336], 'leukodystrophy:': [526], 'additional': [527], 'psychosine': [530, 719, 829, 2174, 2544, 2930, 3047, 3343], 'galactosidase.Biochim.': [531], 'Biophys.': [532, 675, 785, 2156, 2500, 3299], 'Acta.': [533, 676, 786, 2157, 2501, 3300], '1972;': [534], '48:': [535, 908], '538-543Google': [536], 'authentic': [543, 606], 'genetically': [552], 'enzymatically': [554, 605], 'equivalent': [555, 1654], 'human': [558, 609], 'form': [559, 1253], 'displays': [564], 'similar': [565, 3121], 'pathological': [566], 'features': [567], '(4Duchen': [568], 'L.W.': [569], 'Eicher': [570], 'E.M.': [571], 'Jacobs': [572, 595], 'J.M.': [573, 596, 3218], 'Scaravilli': [574], 'F.': [575, 577, 598], 'Teixira': [576], 'Hereditary': [578], 'mouse:': [582, 603, 698, 808, 1724, 2308, 2523, 2909, 3322], 'new': [584, 2249, 2405], 'mutant': [585], 'twitcher.Brain.': [586], '1980;': [587, 616, 854], '103:': [588], '695-710Google': [589], 'Scholar,': [590, 654, 680, 706, 764, 790, 816, 839, 857, 874, 984, 1732, 2161, 2290, 2505, 2531, 2917, 3304, 3330], '5Kobayashi': [591], 'Yamanaka': [593, 661, 771, 2142, 2486, 3285], 'Teixeira': [597], 'leuckodystrophy': [612], 'disease).Brain': [614], '202:': [617], '479-483Google': [618], 'Studies': [620], 'marked': [625, 1890], 'brain': [631, 1590, 1651, 1851, 1881, 1956, 1981, 2001, 2252, 2348, 2696, 3248, 3362, 3386], 'other': [633, 2775], 'mice': [637, 894, 1123, 1143, 1595, 1927, 2217, 2221, 2236, 2240, 2352, 2376, 2395, 2415, 2695, 3368, 3393, 3499], '(6Igisu': [638, 748, 2274], 'H.': [639, 658, 682, 690, 749, 768, 792, 800, 859, 1263, 1708, 1716, 1734, 2139, 2275, 2292, 2300, 2424, 2483, 2507, 2515, 2874, 2893, 2901, 3016, 3282, 3306, 3314], 'Progressive': [642, 752, 2278], 'toxic': [645, 755, 2281], 'genetic': [649, 759, 1139, 2285], 'leukodystrophy.Science.': [650, 760, 2286], '1984;': [651, 761, 871, 1275, 1746, 2287, 2436, 2886, 3028], '224:': [652, 762, 2288], '753-755Google': [653, 763, 2289], '7Kobayashi': [655, 765], 'Shinoda': [657, 767, 2138, 2482, 3281], 'Goto': [659, 687, 769, 797, 1713, 2140, 2297, 2484, 2512, 2898, 3283, 3311], 'I.': [660, 688, 770, 798, 1714, 2141, 2298, 2485, 2513, 2899, 3284, 3312], 'generalized': [670, 780, 2151, 2495, 3294], '(psychosine)': [672, 694, 782, 804, 850, 865, 1269, 1720, 1740, 2153, 2304, 2430, 2497, 2519, 2880, 2905, 3022, 3296, 3318], 'disease.Biochim.': [674, 784, 2155, 2499, 3298], '1987;': [677, 703, 787, 813, 1729, 2158, 2313, 2502, 2528, 2914, 3301, 3327], '144:': [678, 788, 2159, 2503, 3302], '41-46Google': [679, 789, 2160, 2504, 3303], '8Shinoda': [681, 791, 2291, 2506, 3305], 'Kobayashi': [683, 793, 1709, 2293, 2508, 2894, 3307], 'Katayama': [685, 795, 1711, 2295, 2510, 2896, 3309], 'M.': [686, 708, 796, 818, 1712, 2163, 2296, 2511, 2533, 2725, 2897, 2919, 3310, 3332], 'Nagara': [689, 799, 1715, 2299, 2514, 2900, 3313], 'Accumulation': [691, 801, 1717, 2301, 2516, 2902, 3315], 'determination': [699, 809, 1725, 2309, 2408, 2524, 2910, 3323], 'HPLC.J.': [701, 811, 1727, 2311, 2526, 2912, 3325], 'Neurochem.': [702, 725, 812, 835, 1728, 2180, 2312, 2527, 2550, 2913, 2936, 3326, 3349], '49:': [704, 814, 1730, 2314, 2529, 2915, 3328], '92-99Google': [705, 815, 1731, 2315, 2530, 2916, 3329], '9Nozawa': [707, 817, 2162, 2532, 2918, 3331], 'Iwamaoto': [709, 819, 2164, 2534, 2920, 3333], 'Tokoro': [711, 821, 2166, 2536, 2922, 3335], 'Eto': [713, 823, 2168, 2538, 2924, 3337], 'Novel': [715, 825, 2170, 2540, 2926, 3339], 'procedure': [716, 826, 2171, 2541, 2575, 2927, 3131, 3340], 'measuring': [718, 828, 2173, 2543, 2929, 3342], 'derivatives': [720, 830, 2175, 2545, 2931, 3344], 'HPLC': [723, 833, 2178, 2479, 2548, 2934, 3277, 3347], 'method.J.': [724, 834, 2179, 2549, 2935, 3348], '1992;': [726, 836, 2181, 2551, 2937, 3350], '59:': [727, 837, 2182, 2552, 2938, 3351], '607-609Google': [728, 838, 2183, 2553, 2939, 3352], 'number': [731], 'methods': [733, 912, 2710, 3278], 'previously': [734, 2115], 'analysis': [740, 1764, 1947, 1998, 2065], 'related': [744], 'compounds': [745], '10Svennerholm': [840], 'L.': [841], 'Vanier': [842], 'M-T.': [843], 'Mansson': [844], 'J-E.': [845], 'Krabbe': [846], 'disease:': [847], 'lipidosis.J.': [851], '21:': [855], '53-64Google': [856], '11Igisu': [858, 1733], 'Analysis': [862, 1266, 1737, 2427, 2877, 3019], 'brain.J.': [868, 1272, 1743, 2433, 2883, 3025], '25:': [872, 1276, 1747, 2437, 2887, 3029], '1000-1006Google': [873, 1277, 1748, 2438, 2888, 3030], '12Orvisky': [875], 'E.': [876, 878, 992], 'Sidransky': [877], 'McKinney': [879], 'C.E.': [880], 'LaMarca': [881], 'M.E.': [882], 'Samimi': [883], 'Krasnewich': [885], 'Martin': [887], 'B.M.': [888], 'Ginns': [889], 'E.I.': [890], 'Glucosylsphingosine': [891], 'patients': [896], 'with': [897, 1202, 1289, 1312, 1330, 1357, 1387, 1397, 1413, 1444, 1487, 1704, 1960, 2264, 2271, 2801, 2947, 2953, 3272, 3369], 'type': [898], 'gaucher': [900], 'begins': [902], 'gestation.Pediatr.': [905], '2000;': [907, 3232], '233-237Google': [909], 'These': [911, 1793, 2593, 2794], 'typically': [914, 1921, 2799, 2942, 3159], 'involved': [915, 2943], 'solvent': [917, 2951], 'galactosylsphingosine,': [920, 2641, 2834], 'isolation': [923, 1610, 1680, 2591, 2734, 2832], 'derivatization': [925], 'prior': [926], 'detection': [928, 2073], 'either': [930, 2755], 'TLC': [931], 'or': [932, 1155, 1801, 2199, 2683, 2758, 3455], 'HPLC.': [933], 'recent': [935], 'years,': [936], 'spectrometers': [938], 'become': [940], 'more': [941, 2603, 2996, 3069], 'common': [942], 'metabolic': [944], 'laboratories': [945, 3210], 'applied': [949, 1300, 1377, 3077], 'study': [952], 'lysoglycosphingolipids': [954, 998, 3432], '(13Hara': [955], 'A.': [956, 988], 'Taketomi': [957], 'Chemical': [959], 'properties': [960], 'heterogenous': [962], 'long': [963], 'chain': [964], 'bases': [965], 'lysosphingolipids': [967], 'positive': [969, 1478, 1768], 'ion': [970, 1467, 1479, 1769, 1781, 1789, 1838, 1867, 1905, 2805], 'fast': [971], 'atom': [972], 'bombardment': [973], 'spectrometry': [975, 1035, 2033, 3511], 'carbon-13': [977], 'NMR': [978], 'spectroscopy.J.': [979], 'Biochem.': [980, 1012], '1986;': [981], '100:': [982], '415-423Google': [983], '14Taketomi': [985], 'Hara': [987], 'Uemura': [989], 'Sugiyama': [991], 'Rapid': [993], 'preparation': [996, 2803], 'their': [1000], 'confirmation': [1001], 'delayed': [1003], 'matrix-assisted': [1005], 'laser': [1006], 'desorption': [1007], 'ionization': [1008, 3144], 'time-of-flight': [1009], 'spectrometry.J.': [1011], '1996;': [1013], '120:': [1014], '573-579Google': [1015], 'study,': [1019, 2972], 'we': [1020, 2585, 2629, 2673, 2973, 3398], 'describe': [1021], 'development': [1023], '(ESI-MS/MS)': [1036], 'characterize': [1038], 'quantify': [1040], 'underivatized': [1041], 'Solvents': [1049], 'were': [1050, 1058, 1095, 1111, 1164, 1174, 1178, 1183, 1226, 1327, 1431, 1463, 1499, 1553, 1563, 1568, 1604, 1687, 1831, 2212, 2231, 2322, 2817, 3056, 3076, 3245, 3265], 'analytical': [1051], 'grade.': [1052], '(lyso-lactosyl': [1056], 'ceramide)': [1057], 'purchased': [1059, 1096, 1112], 'Matreya': [1061], 'Inc.': [1062, 1075, 1115], '(Pleasant': [1063], 'Gap,': [1064], 'PA).': [1065, 1100], '[6-3H]galactosylsphingosine': [1066, 1640, 1674], '(psychosine,': [1067], '[galactose-6-3H])': [1068], 'was': [1069, 1124, 1144, 1200, 1234, 1247, 1287, 1299, 1306, 1340, 1374, 1385, 1408, 1485, 1528, 1623, 1631, 1641, 1653, 1667, 1682, 1696, 1818, 1862, 1899, 1913, 1964, 1982, 1994, 2019, 2082, 2105, 2124, 2344, 2368, 2387, 2416, 2460, 2476, 2977, 3040, 3085, 3099, 3115, 3147, 3158, 3371, 3380], 'obtained': [1070, 1688, 1856], 'American': [1072], 'Radiolabeled': [1073], 'Chemicals,': [1074], '(St.': [1076], 'Louis,': [1077], 'MO)': [1078], 'used': [1080, 2785, 3192], 'after': [1081, 1293, 1381, 2454], 'purification.': [1082], 'Supelclean™': [1083], '(SCX)': [1086], 'cartridges': [1089, 1107, 2795], '(sodium': [1090, 2792], 'form,': [1091], '500': [1092], 'mg/3': [1093, 1285], 'ml)': [1094, 1110, 1286, 1352], 'Supelco': [1098], '(Bellefonte,': [1099], 'Bond': [1101], 'Elut®': [1102], 'endcapped': [1103, 1345], '(500': [1108, 1284, 1350], 'mg/6': [1109, 1351], 'Varian,': [1114], '(Harbor': [1116], 'City,': [1117], 'CA).': [1118], 'colony': [1120], 'maintained': [1125], 'under': [1126, 1410], 'Animal': [1127], 'Ethics': [1128], 'Committee': [1129], 'approval': [1130], 'at': [1131, 1157, 1186, 1221, 1518, 1782, 1790, 1868, 2222, 2241, 3101], 'University': [1133], 'Sydney': [1135], 'Veterinary': [1136], 'School.': [1137], 'status': [1140], 'individual': [1142], 'determined': [1145, 1632, 3274], 'PCR': [1147], 'on': [1148, 1966, 2464, 3048], 'DNA': [1149], 'clipped': [1153], 'toe': [1154], 'tail': [1156], 'postnatal': [1158, 2223, 2242], 'day': [1159, 2224, 2243], '5.': [1160], 'After': [1161, 1215, 2365], 'animals': [1163], 'decapitated,': [1165], 'whole': [1166], 'liver,': [1170, 2090], 'spleen,': [1171, 2092], 'dissected.': [1175], 'Wet': [1176], 'weights': [1177], 'measured': [1179], 'stored': [1185], '−70': [1187], '°C': [1188], 'until': [1189], 'use.': [1190], 'maximum': [1192], '100': [1194, 1556, 1560, 1598, 1656, 2678, 3071], 'mg': [1195, 1599, 1657, 2077, 2226, 2381, 2679, 3072], 'wet': [1197, 1600, 1658, 2078, 2227, 2382, 2680, 3073], 'weight': [1198, 1601, 1659, 2079, 2228, 2383, 2681, 3074], 'tissue': [1199, 1297, 2455, 2704, 2772], 'homogenized': [1201], 'Ultra': [1204], 'Turrax': [1205], '(IKA)': [1206], 'T25': [1207], 'Basic': [1208], 'mechanical': [1209], 'homogenizer': [1210], '3': [1212, 1290], 'ml': [1213, 1291, 1314, 1317, 1323, 1332, 1359, 1364, 1389, 1399], 'methanol.': [1214, 1324, 2846, 2984, 3003], 'minimum': [1217], '1': [1219, 1488], 'h': [1220], 'room': [1222], 'temperature,': [1223], 'denatured': [1224], 'solids': [1225], 'pelleted': [1227], 'centrifugation.': [1229], 'Five': [1230, 1661, 2022], 'nanomoles': [1231, 1662], 'added': [1235, 1642, 3100], 'methanol': [1238, 1292, 1296, 1360, 1421], 'extract': [1239, 1298, 1646, 1883, 1952, 2002, 2994], 'supernatant': [1240], 'as': [1241, 2715, 2809, 3095, 3193], '(ISTD).': [1245], 'modified': [1252], 'described': [1257, 2418, 3399], 'Igisu': [1259, 2420, 3012], '(11Igisu': [1262, 2423, 2873, 3015], 'SCX': [1280, 1677, 2446, 2782, 2788, 2843, 2871, 3050, 3062], 'cartridge': [1283, 1349], 'washed': [1288, 1309, 1386], 'column.': [1303], 'column': [1305, 1380, 1384, 3063], 'successively': [1308], 'waste': [1311], '5': [1313, 1316, 1322, 1331, 1358, 1363, 1423], 'chloroform–methanol': [1318, 1400, 1404, 2954, 2989], '2:1': [1319, 2955, 2990], '(v/v),': [1320], 'Cationic': [1325], 'lipids': [1326, 2739, 3066], 'eluted': [1329], 'methanol–0.4': [1333, 1368], 'M': [1334, 1369], 'CaCl2': [1335, 1370], '3:1': [1336, 1371], '(v/v).': [1337, 1402, 2956], 'This': [1338, 2574, 2647, 3113], 'eluate': [1339], 'desalted': [1342], 'had': [1354], 'primed': [1356], 'followed': [1361, 2949], 'distilled': [1365, 1390], 'water.': [1366], '(v/v)': [1372, 1406, 2991], 'fraction': [1373, 1407], '15': [1388, 1967], 'water': [1391, 1803, 2855, 2948, 2958], 'before': [1392], 'elution': [1393], '7.5': [1398], '1:2': [1401, 1405], 'dried': [1409], 'nitrogen': [1411], 'gas': [1412], 'gentle': [1414], 'heat': [1415], 'reconstituted': [1417], '100–200': [1419], 'μl': [1420], 'containing': [1422], 'mM': [1424], 'ammonium': [1425], 'formate.': [1426], 'All': [1427], 'analyses': [1430], 'performed': [1432, 1529, 1965], 'ESI-MS/MS': [1434, 1483, 2018, 2064, 2638], 'Perkin-Elmer': [1437], 'Sciex': [1438], 'API': [1439], '365': [1440], 'triple-quadrupole': [1441], 'spectrometer': [1443], 'Ionspray': [1446], 'source': [1447, 1505], 'LC': [1449], 'Tune/Multiview': [1450], 'data': [1451, 1686], 'system': [1452, 2361], '(PE': [1453], 'Sciex,': [1454], 'Concord,': [1455], 'Ontario,': [1456], 'Canada).': [1457], 'ISTD': [1462, 1550, 1622, 1666, 1830], 'identified': [1464], 'precursor': [1466, 1837], 'scanning': [1468], 'charge': [1472, 3518], 'ratio': [1473, 1616, 3519], '(m/z)': [1474], '282': [1475, 1784], 'mode.': [1480, 1535], 'Optimization': [1481], 'parameters': [1484], 'achieved': [1486, 3086], 'μM': [1489], 'solutions': [1490], 'lactosylsphingosine.': [1494, 3182], 'Tissues': [1495], 'calibration': [1497, 1566, 1637, 1909], 'samples': [1498], 'infused': [1501], 'into': [1502, 2029, 2754, 2983], 'via': [1506], 'fused': [1508], 'silica': [1509], 'transfer': [1510], 'line': [1511], 'Harvard': [1514], 'Apparatus': [1515], 'syringe': [1516], 'pump': [1517], 'flow': [1520], 'rate': [1521, 2339], '10': [1523], 'μl/min.': [1524], 'multiple-reaction': [1532, 3514], '(MRM)': [1534], 'For': [1536, 2671, 2830], 'each': [1537], 'quantitative': [1538], 'measurement,': [1539], 'ions': [1541, 1794], 'relating': [1542], '(m/z': [1545, 1551, 1860], '462)': [1546, 1861], '624)': [1552], 'monitored': [1554], 'ms': [1557], 'each,': [1558], 'consecutive': [1561], 'scans': [1562], 'averaged.': [1564], 'curves': [1567], 'constructed': [1569], 'adding': [1571], 'varying': [1572], 'amounts': [1573, 2193, 3053], '(0–8': [1577, 1929], 'nmol)': [1578, 1587], 'constant': [1581], 'amount': [1582, 2661], '(5': [1586], 'lipid': [1591, 1645, 1882, 1951, 2456, 2712, 2840, 3038], 'extracts': [1592, 2841], 'normal': [1594], '(equivalent': [1596], 'tissue),': [1602], 'carried': [1606], 'through': [1607, 1675, 3060], 'entire': [1609], 'purification': [1612, 2736, 3130], 'procedure.': [1613], 'response': [1615], 'calculated,': [1624], 'comparison': [1634], 'curve.': [1638], 'Purified': [1639], 'tissue.': [1660, 2080], 'added.': [1669], 'recovery': [1671, 1695], 'steps': [1681], 'calculated.': [1684], 'Recovery': [1685], 'three': [1690], 'repeat': [1691], 'experiments,': [1692], 'estimated': [1697], '45–60%,': [1700], 'finding': [1702, 2269, 3010], 'consistent': [1703, 2270], 'previous': [1705, 2272], 'reports': [1706], '(8Shinoda': [1707, 2892], 'free': [1751], 'amino': [1752], 'group': [1753], 'ionizes': [1756], 'very': [1757, 2669], 'efficiently,': [1758], 'making': [1759], 'it': [1760, 2764, 2835, 3146], 'highly': [1761, 2821], 'amenable': [1762], 'ESI-MS/MS.': [1766, 1858, 2573, 3136], 'mode,': [1770], 'collision-induced': [1771], 'dissociation': [1772], 'gave': [1775], 'rise': [1776], 'major': [1779], 'product': [1780, 1788], 'm/z': [1783, 1791, 1841, 1869], 'minor': [1787], '264.': [1792], 'result': [1795, 2864], 'loss': [1798], 'one': [1800], 'two': [1802, 2215, 2219, 2234, 2238, 2371, 2374, 2390, 2393], 'molecules': [1804], 'sphingosine': [1807], 'backbone,': [1808], 'respectively,': [1809], 'elimination': [1812], 'galactose': [1815], 'moiety.': [1816], 'Lactosylsphingosine': [1817], 'found': [1819, 1914, 2818, 2974, 3057, 3116, 3148, 3266, 3381], 'fragment': [1821], 'identical': [1824], 'manner.': [1825], 'Therefore,': [1826], 'means': [1834], 'scan': [1839], '282.': [1842], 'Figure': [1843], '1A': [1844], 'shows': [1845], 'profile': [1848], 'control': [1854, 1924, 2052, 2112, 2220, 2239, 2375, 2394, 2688], 'barely': [1863], 'detectable.': [1864], 'intense': [1866], '624': [1870], 'corresponds': [1871], 'ISTD.': [1875, 3168], 'contrast,': [1877], 'examination': [1878], 'showed': [1888], '(Fig.': [1894], '1B).': [1895], 'spectrum': [1898], 'dominated': [1900], '[M': [1903], '+H]+': [1904], 'galactosylsphingosine.': [1907], 'curve': [1910], 'linear': [1917], 'over': [1918], 'range': [1920, 3430], 'encountered': [1922], 'nmol,': [1930], 'regression': [1931], 'coefficient': [1932, 1972, 2009, 2036], '=': [1933, 2004], '0.986).': [1934], 'To': [1935, 2555], 'access': [1936], 'reproducibility': [1937, 1987, 2015], 'batch': [1943, 1993], 'batch,': [1945], 'replicate': [1946], 'single': [1950], 'postmortum': [1955], 'patient': [1959], 'separate': [1968, 2023], 'occasions.': [1969], 'interbatch': [1971], 'variation': [1974, 2011, 2038], '12.1%.': [1983], 'addition,': [1985, 3005, 3442], 'within': [1991], 'assessed.': [1996], 'Simultaneous': [1997], '(n': [2003], '5)': [2005], 'produced': [2006, 2034], 'intrabatch': [2008], '4.1%.': [2013], 'examined.': [2021], 'infusions': [2024], 'same': [2027], 'sample': [2028, 3039], 'tandem': [2031, 3401], '1.2%.': [2040], 'margin': [2042], 'error': [2044], 'would': [2045, 3189], 'expected': [2047], 'greater': [2050, 2126, 3162, 3384], 'somatic': [2054, 2134, 2187, 2206, 2684], 'where': [2056], 'extremely': [2062], 'low.': [2063], 'lower': [2070], 'limit': [2071], '1–5': [2075], 'ng/100': [2076], 'There': [2081], 'kidney,': [2091], 'cord': [2096, 2255, 3251, 3365, 3390], 'small': [2101], 'quantity': [2102], 'detected': [2107, 2468, 2477], 'As': [2114, 2761], 'reported': [2116, 2862], 'mice,': [2119, 2258], 'much': [2125], 'than': [2131, 2196, 2605, 3002, 3070, 3163, 3387], 'organs': [2135, 2207], '(7Kobayashi': [2136, 2480, 3279], 'Among': [2185], 'organs,': [2188], 'accumulated': [2191], 'larger': [2192, 2596], 'liver': [2198], 'spleen': [2200], '(Table': [2201, 2266, 2353, 3394], '1).TABLE': [2202], '1.Galactosylsphingosine': [2203], 'miceTissueGalactosylsphingosine': [2210], 'ConcentrationaSamples': [2211], '40.ControlTwitcherng/100': [2225], 'tissueLiver665558Kidney759491Spleen10106047a': [2229], 'Samples': [2230], '40.': [2244], 'Open': [2245, 2401], 'table': [2246, 2402], 'tab': [2250, 2406], 'increased': [2263], '2),': [2267], 'studies': [2273, 2891], 'absolute': [2318, 2660, 3257], 'concentrations': [2319, 3242, 3258], 'greatest': [2323], 'cord;': [2327], 'however,': [2328], 'interestingly,': [2329], 'between': [2330], 'ages': [2332], '25': [2334], '40': [2336], 'days,': [2337], 'highest': [2345, 3241], '2).TABLE': [2354], '2.Galactosylsphingosine': [2355], 'miceDays': [2364], 'BirthGalactosylsphingosine': [2366], 'ConcentrationaGalactosylsphingosine': [2367], 'various': [2378, 2397, 3434], 'ages.BrainSpinal': [2379], 'CordControlTwitcherControlTwitcherng/100': [2380], 'tissue257674995484679848415430—bNot': [2384], 'determined.1313—5800—1030—609335—1489—7092—1201—48374015124312255421115471087739a': [2385], 'ages.b': [2398], 'Not': [2399], 'determined.': [2400], 'originally': [2417], 'Their': [2440], 'elegant': [2441], 'made': [2443, 2620], 'reverse-phase': [2449], 'chromatography': [2450], 'isolate': [2452, 2768], 'extraction.': [2457], 'derivatized,': [2462], 'chromatographed': [2463], 'thin-layer': [2465], 'plates,': [2466], 'fluorescence': [2470], 'densitometry.In': [2471], 'later': [2472], 'studies,': [2473], 'derivatized': [2474], 'best': [2557], "authors'": [2560], 'knowledge,': [2561], 'first': [2565], 'report': [2566], 'quantification': [2569, 3408], 'selective,': [2578], 'reproducible,': [2579], 'sensitive.': [2581], 'our': [2583, 3006], 'method,': [2584], 'adapted': [2586], 'simplified': [2588], 'original': [2590], 'procedures.': [2592, 2607], 'improvements': [2594], 'enable': [2595], 'numbers': [2597], 'prepared': [2602], 'rapidly': [2604], 'conventional': [2606, 3276], 'removed': [2609], 'need': [2611, 2644, 2648], 'time-consuming': [2614], 'postextraction': [2615], 'rotary': [2616, 2968], 'evaporation': [2617], 'step,': [2618], 'commercially': [2623, 2786, 3092, 3200], 'available': [2624, 2787, 3093, 3201], 'cartridges.': [2627], 'Furthermore,': [2628], 'took': [2630], 'advantage': [2631], 'selectivity': [2634], 'sensitivity': [2636, 2650], 'detect': [2640], 'eliminating': [2642], 'derivatization.': [2646], 'vital': [2652], 'because': [2653], 'even': [2654], 'state,': [2658], 'accumulates': [2665], 'small.': [2670], 'analysis,': [2672], 'routinely': [2674], 'neural': [2682, 3263], 'both': [2687, 3125], 'However,': [2692, 3137], 'considerably': [2700], 'smaller': [2701], 'quantities': [2702, 2851], 'could': [2705, 3423, 3445], 'reliably': [2707], 'used.': [2708], 'Classical': [2709], 'such': [2714, 2808], 'Folch': [2719], 'et': [2720], 'al.': [2721], '(15Folch': [2722], 'Lees': [2724], 'Sloane': [2726], 'Stanley': [2727], 'G.H.': [2728], 'simple': [2730], 'total': [2738, 3037], 'animal': [2741], 'tissues.J.': [2742], 'Biol.': [2743], 'Chem.': [2744, 3228], '1957;': [2745], '226:': [2746], '497-509Google': [2747], 'Scholar)': [2748, 2940, 3031], 'are': [2749, 2961], 'unable': [2750], 'partition': [2752], 'chloroform': [2757, 2853], 'methanol/water': [2759], 'phase.': [2760], 'result,': [2763], 'necessary': [2766], 'all': [2771], 'components': [2773], 'including': [2774, 3437], 'bulk': [2776], 'lipids,': [2777], 'specificity': [2780], 'chromatography.': [2783], 'columns': [2791, 2844, 2872], 'form).': [2793], 'avoided': [2796], 'problems': [2798], 'associated': [2800], 'exchange': [2806], 'resins,': [2807], 'variable': [2810], 'packing': [2811], 'density,': [2812], 'pH,': [2813], 'stability,': [2815], 'give': [2820], 'reproducible': [2822], 'recoveries': [2823], 'tissues.': [2829], 'important': [2837, 3041], 'apply': [2839], 'presence': [2848], 'and/or': [2854], 'solvents': [2859, 2960], 'considerable': [2866], 'losses': [2867], 'Previous': [2890], 'homogenizing': [2944], 'evaporated': [2963], 'dryness': [2965], 'evaporator.': [2969], 'satisfactorily': [2978], 'Our': [2985, 3236], 'experiments': [2986, 3007], 'did': [2992], 'significantly': [2995], 'confirmed': [3008], 'size': [3034], 'efficient': [3044], 'retention': [3045], 'cartridge.': [3051], 'Varying': [3052], 'pass': [3059], 'when': [3064, 3133], '(data': [3078], 'shown).': [3080], 'pure': [3091], 'ISTD,': [3097, 3195], 'stage': [3104], 'account': [3106], 'any': [3108], 'loses': [3109], 'throughout': [3110, 3126], 'preparation.': [3112], 'analog': [3114], 'behave': [3118], 'manner': [3122], 'due': [3138], 'differences': [3141], 'efficiencies,': [3145], 'signal': [3151], 'intensity': [3152], 'equimolar': [3154], '1.5': [3160], 'times': [3161], 'believe': [3170], 'difference': [3173], 'arises': [3174], 'longer': [3177], 'carbohydrate': [3178], 'moiety': [3179], 'Ideally,': [3183], 'stable': [3185], 'isotope': [3186], 'but': [3196], 'difficult': [3204], 'produce': [3206], 'outside': [3207], 'specialist': [3209], '(16Duffin': [3211], 'G.R.': [3212], 'Ellamas': [3213], 'G.J.': [3214], 'Hartmann': [3215], 'S.': [3216], 'Herbert': [3217], 'Smith': [3219], 'D.I.': [3220], 'Practical': [3221], 'synthesis': [3222], '[13C]-': [3224], '[14C]-labelled': [3226], 'glycosphingolipids.J.': [3227], 'Soc.': [3229], 'Perkin': [3230], 'Trans.': [3231], '1:': [3233], '2237-2242Google': [3234], 'findings': [3237], 'close': [3270], 'agreement': [3271], 'those': [3273], 'clear': [3355], 'increase': [3356, 3376], 'observed.': [3373], 'percentage': [3375], '2).': [3395], 'conclusion,': [3397], 'accurate': [3407], 'analyze': [3427, 3450], 'wide': [3429], 'biological': [3435], 'matrices,': [3436], 'cultured': [3438], 'neuronal': [3439], 'cells.': [3440], 'further': [3447], 'plasma,': [3453], 'urine,': [3454], 'cerebrospinal': [3456], 'fluid': [3457], 'monitor': [3459], 'efficacy': [3461], 'potential': [3463], 'currently': [3465], 'being': [3466], 'PDW': [3472], 'gratefully': [3473], 'acknowledges': [3474], "Hunter's": [3475], 'Hope': [3476], 'Foundation': [3477], 'Postdoctoral': [3480], 'Research': [3481], 'Fellowship.': [3482], 'authors': [3484], 'wish': [3486], 'thank': [3488], 'Ms.': [3489], 'Kerrie': [3490], 'Murdoch': [3491], 'care': [3494], 'management': [3496], 'Professor': [3501], 'John': [3502], 'Hopwood': [3503], 'his': [3505], 'helpful': [3506], 'comments.': [3507]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2339603802', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 8}], 'updated_date': '2024-12-12T12:51:58.938792', 'created_date': '2016-06-24'}