CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer

Name: Work Video:
Duration: 3 min 30 s
Christine Woischke; Cristina Blaj; Eva Marina Schmidt; Sebastian Lamprecht; Jutta Engel; Heiko Hermeking; Thomas Kirchner; David Horst
{'id': 'https://openalex.org/W2339383329', 'doi': 'https://doi.org/10.18632/oncotarget.8912', 'title': 'CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer', 'display_name': 'CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer', 'publication_year': 2016, 'publication_date': '2016-04-22', 'ids': {'openalex': 'https://openalex.org/W2339383329', 'doi': 'https://doi.org/10.18632/oncotarget.8912', 'mag': '2339383329', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27120783', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5058761'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.8912', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=8912&path%5B%5D=26934', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=8912&path%5B%5D=26934', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5038873253', 'display_name': 'Christine Woischke', 'orcid': 'https://orcid.org/0000-0003-1804-5904'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Christine Woischke', 'raw_affiliation_strings': ['Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany'], 'affiliations': [{'raw_affiliation_string': 'Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078182587', 'display_name': 'Cristina Blaj', 'orcid': 'https://orcid.org/0000-0003-0449-2690'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Cristina Blaj', 'raw_affiliation_strings': ['Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany'], 'affiliations': [{'raw_affiliation_string': 'Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084469679', 'display_name': 'Eva Marina Schmidt', 'orcid': 'https://orcid.org/0000-0001-6577-7513'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Eva Marina Schmidt', 'raw_affiliation_strings': ['Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany'], 'affiliations': [{'raw_affiliation_string': 'Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024584094', 'display_name': 'Sebastian Lamprecht', 'orcid': 'https://orcid.org/0000-0001-8601-7476'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Sebastian Lamprecht', 'raw_affiliation_strings': ['Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany'], 'affiliations': [{'raw_affiliation_string': 'Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111969769', 'display_name': 'Jutta Engel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jutta Engel', 'raw_affiliation_strings': ['Tumorregister München, Institut für medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität München, München, Germany'], 'affiliations': [{'raw_affiliation_string': 'Tumorregister München, Institut für medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität München, München, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018105714', 'display_name': 'Heiko Hermeking', 'orcid': 'https://orcid.org/0000-0001-6586-4406'}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}, {'id': 'https://openalex.org/I4391767962', 'display_name': 'Deutschen Konsortium für Translationale Krebsforschung', 'ror': 'https://ror.org/02pqn3g31', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I4391767962']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Heiko Hermeking', 'raw_affiliation_strings': ['German Cancer Consortium (DKTK), Heidelberg, Germany', 'German Cancer Research Center (DKFZ), Heidelberg, Germany', 'Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany'], 'affiliations': [{'raw_affiliation_string': 'German Cancer Research Center (DKFZ), Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}, {'raw_affiliation_string': 'Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany', 'institution_ids': ['https://openalex.org/I8204097']}, {'raw_affiliation_string': 'German Cancer Consortium (DKTK), Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I4391767962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011137037', 'display_name': 'Thomas Kirchner', 'orcid': 'https://orcid.org/0000-0001-5226-6407'}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}, {'id': 'https://openalex.org/I4391767962', 'display_name': 'Deutschen Konsortium für Translationale Krebsforschung', 'ror': 'https://ror.org/02pqn3g31', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I4391767962']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Thomas Kirchner', 'raw_affiliation_strings': ['German Cancer Consortium (DKTK), Heidelberg, Germany', 'German Cancer Research Center (DKFZ), Heidelberg, Germany', 'Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany'], 'affiliations': [{'raw_affiliation_string': 'German Cancer Research Center (DKFZ), Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}, {'raw_affiliation_string': 'Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany', 'institution_ids': ['https://openalex.org/I8204097']}, {'raw_affiliation_string': 'German Cancer Consortium (DKTK), Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I4391767962']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070494503', 'display_name': 'David Horst', 'orcid': 'https://orcid.org/0000-0003-4755-5743'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}, {'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I4391767962', 'display_name': 'Deutschen Konsortium für Translationale Krebsforschung', 'ror': 'https://ror.org/02pqn3g31', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I4391767962']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'David Horst', 'raw_affiliation_strings': ['German Cancer Consortium (DKTK), Heidelberg, Germany', 'German Cancer Research Center (DKFZ), Heidelberg, Germany', 'Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany'], 'affiliations': [{'raw_affiliation_string': 'Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany', 'institution_ids': ['https://openalex.org/I8204097']}, {'raw_affiliation_string': 'German Cancer Research Center (DKFZ), Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}, {'raw_affiliation_string': 'German Cancer Consortium (DKTK), Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I4391767962']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5070494503'], 'corresponding_institution_ids': ['https://openalex.org/I8204097', 'https://openalex.org/I17937529', 'https://openalex.org/I223822909', 'https://openalex.org/I4391767962'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.177, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.999955, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '7', 'issue': '21', 'first_page': '31350', 'last_page': '31360'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.81572425}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.58705723}, {'id': 'https://openalex.org/C76419328', 'wikidata': 'https://www.wikidata.org/wiki/Q74419', 'display_name': 'Epithelial–mesenchymal transition', 'level': 4, 'score': 0.5126309}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.50569725}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4620167}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.43760052}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.35953477}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3303879}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.26122308}], 'mesh': [{'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D042966', 'descriptor_name': 'Cytochrome-B(5) Reductase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000601', 'qualifier_name': 'surgery', 'is_major_topic': False}, {'descriptor_ui': 'D042966', 'descriptor_name': 'Cytochrome-B(5) Reductase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D042966', 'descriptor_name': 'Cytochrome-B(5) Reductase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053208', 'descriptor_name': 'Kaplan-Meier Estimate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015999', 'descriptor_name': 'Multivariate Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.8912', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=8912&path%5B%5D=26934', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5058761', 'pdf_url': 'https://europepmc.org/articles/pmc5058761?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058761', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27120783', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.8912', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=8912&path%5B%5D=26934', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/1', 'display_name': 'No poverty', 'score': 0.63}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1444168786', 'https://openalex.org/W1480706413', 'https://openalex.org/W1500959740', 'https://openalex.org/W1809013339', 'https://openalex.org/W1906566368', 'https://openalex.org/W1966298854', 'https://openalex.org/W1989562366', 'https://openalex.org/W1990989609', 'https://openalex.org/W1992682395', 'https://openalex.org/W2007115760', 'https://openalex.org/W2012117840', 'https://openalex.org/W2015062551', 'https://openalex.org/W2015617213', 'https://openalex.org/W2024919757', 'https://openalex.org/W2025647419', 'https://openalex.org/W2050089891', 'https://openalex.org/W2056822151', 'https://openalex.org/W2066808368', 'https://openalex.org/W2084863590', 'https://openalex.org/W2095165967', 'https://openalex.org/W2104268053', 'https://openalex.org/W2113787968', 'https://openalex.org/W2117692326', 'https://openalex.org/W2120981549', 'https://openalex.org/W2124381835', 'https://openalex.org/W2153284298', 'https://openalex.org/W2154589460', 'https://openalex.org/W2154896712', 'https://openalex.org/W2262414037', 'https://openalex.org/W2917837889', 'https://openalex.org/W4254732828'], 'related_works': ['https://openalex.org/W4386462333', 'https://openalex.org/W4377092742', 'https://openalex.org/W4362606997', 'https://openalex.org/W4361825250', 'https://openalex.org/W4229447658', 'https://openalex.org/W2375232943', 'https://openalex.org/W2374019147', 'https://openalex.org/W2370262613', 'https://openalex.org/W2172237894', 'https://openalex.org/W2015369371'], 'abstract_inverted_index': {'//': [0], 'Christine': [1], 'Woischke': [2], '1,': [3, 8, 14, 27, 33, 39], '*': [4, 9, 15, 78], ',': [5, 10, 16, 20, 24, 30, 36], 'Cristina': [6], 'Blaj': [7], 'Eva': [11], 'Marina': [12], 'Schmidt': [13], 'Sebastian': [17], 'Lamprecht': [18], '1': [19, 42], 'Jutta': [21], 'Engel': [22], '2': [23, 49], 'Heiko': [25], 'Hermeking': [26], '3,': [28, 34, 40], '4': [29, 35, 41, 70], 'Thomas': [31], 'Kirchner': [32], 'David': [37, 89], 'Horst': [38], 'Pathologisches': [43], 'Institut,': [44], 'Ludwig-Maximilians-Universität': [45, 59], 'München,': [46, 47, 51, 60, 61], 'Germany': [48, 62, 69, 77], 'Tumorregister': [50], 'Institut': [52], 'für': [53], 'medizinische': [54], 'Informationsverarbeitung,': [55], 'Biometrie': [56], 'und': [57], 'Epidemiologie,': [58], '3': [63], 'German': [64, 71], 'Cancer': [65, 72, 208], 'Consortium': [66], '(DKTK),': [67], 'Heidelberg,': [68, 76], 'Research': [73], 'Center': [74], '(DKFZ),': [75], 'These': [79], 'authors': [80], 'have': [81, 236], 'contributed': [82], 'equally': [83], 'to': [84], 'this': [85, 136], 'work': [86], 'Correspondence': [87], 'to:': [88], 'Horst,': [90], 'email:': [91], '[email protected]': [92], 'Keywords:': [93], 'CYB5R1,': [94, 147], 'colorectal': [95, 141, 172, 232], 'cancer,': [96], 'EMT,': [97], 'survival,': [98], 'drug': [99, 156], 'metabolism': [100], 'Received:': [101], 'October': [102], '13,': [103], '2015': [104], 'Accepted:': [105], 'April': [106, 110], '10,': [107], '2016': [108, 112], 'Published:': [109], '22,': [111], 'ABSTRACT': [113], 'Colorectal': [114], 'cancers': [115], 'show': [116], 'significant': [117], 'tumor': [118, 180, 222], 'cell': [119, 223], 'heterogeneity': [120, 137], 'within': [121], 'the': [122, 178], 'same': [123], 'core': [124, 193], 'genetic': [125], 'background.': [126], 'Epithelial-mesenchymal': [127], 'transition': [128], '(EMT)': [129], 'is': [130, 217], 'an': [131, 148, 159, 184, 220], 'important': [132, 237], 'functional': [133], 'aspect': [134], 'of': [135, 140, 161, 188], 'and': [138, 155, 182, 225, 245, 251], 'hallmark': [139], 'cancer': [142, 173, 203, 241], 'progression.': [143], 'Here,': [144], 'we': [145, 213], 'identify': [146], 'enzyme': [149], 'involved': [150], 'in': [151, 163, 171, 198, 231], 'oxidative': [152], 'stress': [153], 'protection': [154], 'metabolism,': [157], 'as': [158], 'indicator': [160], 'EMT': [162, 176, 194, 244], 'colon': [164, 202, 240], 'cancer.': [165, 233], 'We': [166], 'demonstrate': [167, 214], 'high': [168], 'CYB5R1': [169, 189, 216], 'expression': [170, 190, 196], 'cells': [174, 242], 'undergoing': [175, 243], 'at': [177], 'infiltrative': [179, 221], 'edge': [181], 'reveal': [183], 'extraordinarily': [185], 'strong': [186], 'association': [187], 'with': [191, 228], 'two': [192], 'gene': [195], 'signatures': [197], 'a': [199], 'large': [200], 'independent': [201], 'data': [204], 'set': [205], 'from': [206], 'The': [207], 'Genome': [209], 'Atlas': [210], '(TCGA).': [211], 'Furthermore,': [212], 'that': [215], 'required': [218], 'for': [219, 239, 249], 'phenotype,': [224], 'robustly': [226], 'linked': [227], 'poor': [229], 'prognosis': [230], 'Our': [234], 'findings': [235], 'implications': [238], 'may': [246], 'be': [247], 'exploited': [248], 'diagnostic': [250], 'therapeutic': [252], 'purposes.': [253]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2339383329', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-15T01:51:24.031033', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
