Abstract: Objectives : To study the nature and outcome of pregnancy in Obstetric Cholestasis. Methods : This study included 892 women admitted during the period April 2003-March 2005. Eighty three women were diagnosed as having obstetric cholestasis. The protocol for antenatal checkup and induction of labor was as per obstetric indications. All the patients were given ursodeoxycholic acid. Results: Incidence was 9.3% (83/892). Symptoms appeared after 30 weeks in 85% (71/83). Multipara were 16% (13/83) and primipara were 84% (70/83). Cesarean section rate was 66% (55/83). Intrapartum abnormal cardiotocography was noted in 7.2% (6/83) and thick meconium was in 9.6% (8/83). Women delivering after 38 weeks had a higher incidence of thick meconium, 12.9% (8/62) and abnormal CTG was 9.6% (6/62). There was no patient with meconium and abnormal CTG before 38 weeks. There was no neonatal nursery admission and no perinatal mortality. The difference regarding thick meconium was statistically not significant by Fisher’s exact test (P=0.19) although the number of cases with meconium after 38 weeks were more. Conclusions : Obstetric cholestasis is associated with increased perinatal mortality and morbidity if delivered after 38 weeks. An attempt to deliver prior to 38 weeks may improve the perinatal outcome.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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