Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2337212060', 'doi': 'https://doi.org/10.1042/cs20160197', 'title': 'Blood pressure-independent renoprotection in diabetic rats treated with AT1 receptor–neprilysin inhibition compared with AT1 receptor blockade alone', 'display_name': 'Blood pressure-independent renoprotection in diabetic rats treated with AT1 receptor–neprilysin inhibition compared with AT1 receptor blockade alone', 'publication_year': 2016, 'publication_date': '2016-06-01', 'ids': {'openalex': 'https://openalex.org/W2337212060', 'doi': 'https://doi.org/10.1042/cs20160197', 'mag': '2337212060', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27129187'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/cs20160197', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S206649051', 'display_name': 'Clinical Science', 'issn_l': '0143-5221', 'issn': ['0143-5221', '1470-8736'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5088277860', 'display_name': 'Lodi C.W. Roksnoer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}, {'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Lodi\xa0C.W. Roksnoer', 'raw_affiliation_strings': ['Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2801952686', 'https://openalex.org/I913958620']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060852803', 'display_name': 'Richard van Veghel', 'orcid': 'https://orcid.org/0000-0002-2249-1002'}, 'institutions': [{'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}, {'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Richard van Veghel', 'raw_affiliation_strings': ['Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038813258', 'display_name': 'Marian C. Clahsen‐van Groningen', 'orcid': 'https://orcid.org/0000-0003-0565-9560'}, 'institutions': [{'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}, {'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Marian C.\xa0Clahsen- van Groningen', 'raw_affiliation_strings': ['Department of Pathology, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067633360', 'display_name': 'René de Vries', 'orcid': 'https://orcid.org/0000-0002-6956-5312'}, 'institutions': [{'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}, {'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'René de Vries', 'raw_affiliation_strings': ['Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059858622', 'display_name': 'Ingrid M. Garrelds', 'orcid': 'https://orcid.org/0000-0003-2061-6737'}, 'institutions': [{'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}, {'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Ingrid\xa0M. Garrelds', 'raw_affiliation_strings': ['Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015385391', 'display_name': 'Usha M. Bhaggoe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}, {'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Usha\xa0M. Bhaggoe', 'raw_affiliation_strings': ['Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071914727', 'display_name': 'Jeanette M.G. van Gool', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}, {'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jeanette\xa0M.G. van Gool', 'raw_affiliation_strings': ['Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010664668', 'display_name': 'Edith C. H. Friesema', 'orcid': 'https://orcid.org/0000-0001-7743-1907'}, 'institutions': [{'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}, {'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Edith\xa0C.H. Friesema', 'raw_affiliation_strings': ['Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050153201', 'display_name': 'Frank Leijten', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}, {'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Frank\xa0P.J. Leijten', 'raw_affiliation_strings': ['Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027968873', 'display_name': 'Ewout J. Hoorn', 'orcid': 'https://orcid.org/0000-0002-8738-3571'}, 'institutions': [{'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}, {'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Ewout\xa0J. Hoorn', 'raw_affiliation_strings': ['Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046295598', 'display_name': 'A.H. Jan Danser', 'orcid': 'https://orcid.org/0000-0002-5052-3585'}, 'institutions': [{'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}, {'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'A.H.\xa0Jan Danser', 'raw_affiliation_strings': ['Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5075999664', 'display_name': 'Wendy W. Batenburg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}, {'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Wendy\xa0W. Batenburg', 'raw_affiliation_strings': ['Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.892, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 40, 'citation_normalized_percentile': {'value': 0.999958, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '130', 'issue': '14', 'first_page': '1209', 'last_page': '1220'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10198', 'display_name': 'Diagnosis and Treatment of Heart Failure', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10198', 'display_name': 'Diagnosis and Treatment of Heart Failure', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System in Cardiovascular Physiology and Pathology', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11839', 'display_name': 'Management of Primary Aldosteronism', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/irbesartan', 'display_name': 'Irbesartan', 'score': 0.66271055}, {'id': 'https://openalex.org/keywords/albuminuria', 'display_name': 'Albuminuria', 'score': 0.6320486}, {'id': 'https://openalex.org/keywords/adrenal-vein-sampling', 'display_name': 'Adrenal Vein Sampling', 'score': 0.514588}], 'concepts': [{'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.78049266}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.77942234}, {'id': 'https://openalex.org/C2780259554', 'wikidata': 'https://www.wikidata.org/wiki/Q947266', 'display_name': 'Irbesartan', 'level': 3, 'score': 0.66271055}, {'id': 'https://openalex.org/C2776174234', 'wikidata': 'https://www.wikidata.org/wiki/Q974792', 'display_name': 'Albuminuria', 'level': 3, 'score': 0.6320486}, {'id': 'https://openalex.org/C123915805', 'wikidata': 'https://www.wikidata.org/wiki/Q15332826', 'display_name': 'Angiotensin II receptor type 1', 'level': 4, 'score': 0.60265046}, {'id': 'https://openalex.org/C2780288358', 'wikidata': 'https://www.wikidata.org/wiki/Q410074', 'display_name': 'Losartan', 'level': 4, 'score': 0.46564186}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.46373287}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.45513096}, {'id': 'https://openalex.org/C174459258', 'wikidata': 'https://www.wikidata.org/wiki/Q6980232', 'display_name': 'Natriuresis', 'level': 3, 'score': 0.44074076}, {'id': 'https://openalex.org/C2908929049', 'wikidata': 'https://www.wikidata.org/wiki/Q65963433', 'display_name': 'Angiotensin II', 'level': 3, 'score': 0.43778244}, {'id': 'https://openalex.org/C2777387769', 'wikidata': 'https://www.wikidata.org/wiki/Q155472', 'display_name': 'Valsartan', 'level': 3, 'score': 0.41744217}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32170573}], 'mesh': [{'descriptor_ui': 'D047228', 'descriptor_name': 'Angiotensin II Type 1 Receptor Blockers', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D015260', 'descriptor_name': 'Neprilysin', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000613', 'descriptor_name': 'Aminobutyrates', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000613', 'descriptor_name': 'Aminobutyrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047228', 'descriptor_name': 'Angiotensin II Type 1 Receptor Blockers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009320', 'descriptor_name': 'Atrial Natriuretic Factor', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D009320', 'descriptor_name': 'Atrial Natriuretic Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004338', 'descriptor_name': 'Drug Combinations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015260', 'descriptor_name': 'Neprilysin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013311', 'descriptor_name': 'Streptozocin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013777', 'descriptor_name': 'Tetrazoles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D013777', 'descriptor_name': 'Tetrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/cs20160197', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S206649051', 'display_name': 'Clinical Science', 'issn_l': '0143-5221', 'issn': ['0143-5221', '1470-8736'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27129187', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.84, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1964952529', 'https://openalex.org/W1970445852', 'https://openalex.org/W1973762119', 'https://openalex.org/W1977675408', 'https://openalex.org/W1995791071', 'https://openalex.org/W2000525463', 'https://openalex.org/W2001489721', 'https://openalex.org/W2007576218', 'https://openalex.org/W2007850369', 'https://openalex.org/W2010512879', 'https://openalex.org/W2018903719', 'https://openalex.org/W2024197237', 'https://openalex.org/W2024849017', 'https://openalex.org/W2027314542', 'https://openalex.org/W2048665589', 'https://openalex.org/W2049111510', 'https://openalex.org/W2050537336', 'https://openalex.org/W2057501387', 'https://openalex.org/W2058413869', 'https://openalex.org/W2061624989', 'https://openalex.org/W2073915925', 'https://openalex.org/W2074289890', 'https://openalex.org/W2109328478', 'https://openalex.org/W2112275531', 'https://openalex.org/W2113698123', 'https://openalex.org/W2115624311', 'https://openalex.org/W2125399797', 'https://openalex.org/W2133954273', 'https://openalex.org/W2135074047', 'https://openalex.org/W2135521686', 'https://openalex.org/W2136092602', 'https://openalex.org/W2138282359', 'https://openalex.org/W2142197398', 'https://openalex.org/W2143094666', 'https://openalex.org/W2146615272', 'https://openalex.org/W2161255076', 'https://openalex.org/W2163957982', 'https://openalex.org/W2281691222', 'https://openalex.org/W2283724467', 'https://openalex.org/W2419104702'], 'related_works': ['https://openalex.org/W2417150366', 'https://openalex.org/W2389642767', 'https://openalex.org/W2375916719', 'https://openalex.org/W2351251703', 'https://openalex.org/W2185055791', 'https://openalex.org/W2118700340', 'https://openalex.org/W2022729051', 'https://openalex.org/W2010062988', 'https://openalex.org/W1966165595', 'https://openalex.org/W1630275671'], 'abstract_inverted_index': {'ARNI': [0, 31, 100, 116, 181], '[dual': [1], 'AT1': [2], '(angiotensin': [3], 'II': [4], 'type': [5, 175], '1)': [6], 'receptor–neprilysin': [7], 'inhibition]': [8], 'exerts': [9], 'beneficial': [10], 'effects': [11], 'on': [12], 'blood': [13, 202], 'pressure': [14], 'and': [15, 34, 86, 106, 123, 152, 185, 197], 'kidney': [16, 35, 167], 'function': [17], 'in': [18, 37, 77, 93, 188], 'heart': [19, 89, 186], 'failure,': [20], 'compared': [21, 101], 'with': [22, 50, 65, 102], 'ARB': [23, 85], '(AT1': [24], 'receptor': [25], 'blockade)': [26], 'alone.': [27], 'We': [28], 'hypothesized': [29], 'that': [30], 'improves': [32], 'cardiac': [33], 'parameters': [36], 'diabetic': [38, 49, 95, 189], 'TGR(mREN2)27': [39, 190], 'rats,': [40], 'an': [41], 'angiotensin': [42], 'II-dependent': [43], 'hypertension': [44], 'model.': [45], 'Rats': [46], 'were': [47, 63, 108, 155], 'made': [48], 'streptozotocin': [51], 'for': [52, 129], '5': [53], 'or': [54, 69, 166], '12': [55, 146], 'weeks.': [56], 'In': [57, 179], 'the': [58, 78], 'final': [59], '3': [60], 'weeks,': [61, 147], 'rats': [62, 172, 191], 'treated': [64], 'vehicle,': [66], 'irbesartan': [67], '(ARB)': [68], 'irbesartan+thiorphan': [70], '(ARNI).': [71], 'Blood': [72], 'pressure,': [73], 'measured': [74], 'by': [75, 84], 'telemetry': [76], '5-week': [79], 'group,': [80], 'was': [81, 97, 127], 'lowered': [82], 'identically': [83], 'ARNI.': [87], 'The': [88], 'weight/tibia': [90], 'length': [91], 'ratio': [92], '12-week': [94], 'animals': [96, 134, 154], 'lower': [98], 'after': [99, 103], 'ARB.': [104], 'Proteinuria': [105], 'albuminuria': [107], 'observed': [109], 'from': [110], '8': [111], 'weeks': [112], 'of': [113, 132, 142, 201], 'diabetes': [114], 'onwards.': [115], 'reduced': [117], 'proteinuria': [118], 'more': [119, 192], 'strongly': [120, 193], 'than': [121, 140, 194], 'ARB,': [122, 196], 'a': [124], 'similar': [125], 'trend': [126], 'seen': [128], 'albuminuria.': [130], 'Kidneys': [131], 'ARNI-treated': [133, 171], 'showed': [135], 'less': [136], 'severe': [137], 'segmental': [138], 'glomerulosclerosis': [139, 184], 'those': [141], 'ARB-treated': [143, 153], 'animals.': [144], 'After': [145], 'no': [148], 'differences': [149], 'between': [150], 'ARNI-': [151], 'found': [156], 'regarding': [157], 'diuresis,': [158], 'natriuresis,': [159], 'plasma': [160], 'endothelin-1,': [161], 'vascular': [162], 'reactivity': [163], '(acetylcholine': [164], 'response)': [165], 'sodium': [168], 'transporters.': [169], 'Only': [170], 'displayed': [173], 'endothelin': [174], 'B': [176], 'receptor-mediated': [177], 'vasodilation.': [178], 'conclusion,': [180], 'reduces': [182], 'proteinuria,': [183], 'weight': [187], 'does': [195], 'this': [198], 'occurs': [199], 'independently': [200], 'pressure.': [203]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2337212060', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}], 'updated_date': '2024-09-01T05:47:33.611284', 'created_date': '2016-06-24'}