Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2337207909', 'doi': 'https://doi.org/10.1371/journal.pone.0153853', 'title': 'Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis', 'display_name': 'Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis', 'publication_year': 2016, 'publication_date': '2016-04-15', 'ids': {'openalex': 'https://openalex.org/W2337207909', 'doi': 'https://doi.org/10.1371/journal.pone.0153853', 'mag': '2337207909', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27082428', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4833283'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0153853', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0153853&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0153853&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056394263', 'display_name': 'Visesato Mor', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I59553526', 'display_name': 'Stony Brook University', 'ror': 'https://ror.org/05qghxh33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I59553526']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Visesato Mor', 'raw_affiliation_strings': ['Department of Molecular Genetics and Microbiology, Stony Brook University, 145 Life Sciences Building, Stony Brook, NY, 11794, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics and Microbiology, Stony Brook University, 145 Life Sciences Building, Stony Brook, NY, 11794, United States of America', 'institution_ids': ['https://openalex.org/I59553526']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072309089', 'display_name': 'Amir M. Farnoud', 'orcid': 'https://orcid.org/0000-0001-8572-6588'}, 'institutions': [{'id': 'https://openalex.org/I59553526', 'display_name': 'Stony Brook University', 'ror': 'https://ror.org/05qghxh33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I59553526']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Amir M. Farnoud', 'raw_affiliation_strings': ['Department of Molecular Genetics and Microbiology, Stony Brook University, 145 Life Sciences Building, Stony Brook, NY, 11794, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics and Microbiology, Stony Brook University, 145 Life Sciences Building, Stony Brook, NY, 11794, United States of America', 'institution_ids': ['https://openalex.org/I59553526']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055278867', 'display_name': 'Ashutosh Singh', 'orcid': 'https://orcid.org/0000-0002-0995-6696'}, 'institutions': [{'id': 'https://openalex.org/I59553526', 'display_name': 'Stony Brook University', 'ror': 'https://ror.org/05qghxh33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I59553526']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Ashutosh Singh', 'raw_affiliation_strings': ['Department of Molecular Genetics and Microbiology, Stony Brook University, 145 Life Sciences Building, Stony Brook, NY, 11794, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics and Microbiology, Stony Brook University, 145 Life Sciences Building, Stony Brook, NY, 11794, United States of America', 'institution_ids': ['https://openalex.org/I59553526']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046968677', 'display_name': 'Antonella Rella', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I59553526', 'display_name': 'Stony Brook University', 'ror': 'https://ror.org/05qghxh33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I59553526']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Antonella Rella', 'raw_affiliation_strings': ['Department of Molecular Genetics and Microbiology, Stony Brook University, 145 Life Sciences Building, Stony Brook, NY, 11794, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics and Microbiology, Stony Brook University, 145 Life Sciences Building, Stony Brook, NY, 11794, United States of America', 'institution_ids': ['https://openalex.org/I59553526']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030324982', 'display_name': 'Hiromasa Tanno', 'orcid': 'https://orcid.org/0000-0002-6031-6432'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Hiromasa Tanno', 'raw_affiliation_strings': ['Department of Science of Nursing Practice, Tohoku University Graduate School of Medicine, 2–1 Seiryo-cho, Aoba-ku, Sendai, Miyagi, 980–8575, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Science of Nursing Practice, Tohoku University Graduate School of Medicine, 2–1 Seiryo-cho, Aoba-ku, Sendai, Miyagi, 980–8575, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083323267', 'display_name': 'Keiko Ishii', 'orcid': 'https://orcid.org/0000-0003-0794-746X'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Keiko Ishii', 'raw_affiliation_strings': ['Department of Medical Microbiology, Mycology and Immunology, Tohoku University Graduate School of Medicine, 2–1 Seiryo-cho, Aoba-ku, Sendai, Miyagi, 980–8575, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, Mycology and Immunology, Tohoku University Graduate School of Medicine, 2–1 Seiryo-cho, Aoba-ku, Sendai, Miyagi, 980–8575, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102863645', 'display_name': 'Kazuyoshi Kawakami', 'orcid': 'https://orcid.org/0000-0001-6599-1915'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Kazuyoshi Kawakami', 'raw_affiliation_strings': ['Department of Medical Microbiology, Mycology and Immunology, Tohoku University Graduate School of Medicine, 2–1 Seiryo-cho, Aoba-ku, Sendai, Miyagi, 980–8575, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, Mycology and Immunology, Tohoku University Graduate School of Medicine, 2–1 Seiryo-cho, Aoba-ku, Sendai, Miyagi, 980–8575, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075514615', 'display_name': 'Toshiya Sato', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Toshiya Sato', 'raw_affiliation_strings': ['Kohjin Life Sciences Co., Ltd. 1–3 Yurakucho 1-Chome.Chiyoda-KU, Tokyo, 100–0006, Japan'], 'affiliations': [{'raw_affiliation_string': 'Kohjin Life Sciences Co., Ltd. 1–3 Yurakucho 1-Chome.Chiyoda-KU, Tokyo, 100–0006, Japan', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064137145', 'display_name': 'Maurizio Del Poeta', 'orcid': 'https://orcid.org/0000-0001-8418-3120'}, 'institutions': [{'id': 'https://openalex.org/I4210109353', 'display_name': 'Northport VA Medical Center', 'ror': 'https://ror.org/01xtpc441', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210094901', 'https://openalex.org/I4210109353']}, {'id': 'https://openalex.org/I59553526', 'display_name': 'Stony Brook University', 'ror': 'https://ror.org/05qghxh33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I59553526']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Maurizio Del Poeta', 'raw_affiliation_strings': ['Department of Molecular Genetics and Microbiology, Stony Brook University, 145 Life Sciences Building, Stony Brook, NY, 11794, United States of America', 'Veterans Administration Medical Center, Northport, NY, 11768, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Veterans Administration Medical Center, Northport, NY, 11768, United States of America', 'institution_ids': ['https://openalex.org/I4210109353']}, {'raw_affiliation_string': 'Department of Molecular Genetics and Microbiology, Stony Brook University, 145 Life Sciences Building, Stony Brook, NY, 11794, United States of America', 'institution_ids': ['https://openalex.org/I59553526']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5056394263', 'https://openalex.org/A5072309089', 'https://openalex.org/A5055278867', 'https://openalex.org/A5046968677', 'https://openalex.org/A5030324982', 'https://openalex.org/A5083323267', 'https://openalex.org/A5102863645', 'https://openalex.org/A5075514615', 'https://openalex.org/A5064137145'], 'corresponding_institution_ids': ['https://openalex.org/I59553526', 'https://openalex.org/I59553526', 'https://openalex.org/I59553526', 'https://openalex.org/I59553526', 'https://openalex.org/I201537933', 'https://openalex.org/I201537933', 'https://openalex.org/I201537933', 'https://openalex.org/I4210109353', 'https://openalex.org/I59553526'], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 2.73, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 25, 'citation_normalized_percentile': {'value': 0.904359, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '11', 'issue': '4', 'first_page': 'e0153853', 'last_page': 'e0153853'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11037', 'display_name': 'Epidemiology and Management of Fungal Infections', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11037', 'display_name': 'Epidemiology and Management of Fungal Infections', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10150', 'display_name': 'Diagnosis and Management of Fungal Infections', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11253', 'display_name': 'Epidemiology and Management of Fungal Skin Infections', 'score': 0.9635, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cryptococcal-disease', 'display_name': 'Cryptococcal Disease', 'score': 0.544515}, {'id': 'https://openalex.org/keywords/naegleria-fowleri', 'display_name': 'Naegleria fowleri', 'score': 0.43709457}], 'concepts': [{'id': 'https://openalex.org/C2777893358', 'wikidata': 'https://www.wikidata.org/wiki/Q131924', 'display_name': 'Cryptococcus neoformans', 'level': 2, 'score': 0.98804224}, {'id': 'https://openalex.org/C2779413141', 'wikidata': 'https://www.wikidata.org/wiki/Q1470140', 'display_name': 'Cryptococcosis', 'level': 2, 'score': 0.9481318}, {'id': 'https://openalex.org/C2778952914', 'wikidata': 'https://www.wikidata.org/wiki/Q309498', 'display_name': 'Cryptococcus', 'level': 2, 'score': 0.6404022}, {'id': 'https://openalex.org/C2778621254', 'wikidata': 'https://www.wikidata.org/wiki/Q2346415', 'display_name': 'Meningoencephalitis', 'level': 2, 'score': 0.6157758}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6012372}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.58842105}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.56201285}, {'id': 'https://openalex.org/C22070199', 'wikidata': 'https://www.wikidata.org/wiki/Q192995', 'display_name': 'Vaccination', 'level': 2, 'score': 0.53104264}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.44886976}, {'id': 'https://openalex.org/C2781155112', 'wikidata': 'https://www.wikidata.org/wiki/Q131273', 'display_name': 'Naegleria fowleri', 'level': 3, 'score': 0.43709457}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.41933167}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.3819879}], 'mesh': [{'descriptor_ui': 'D003453', 'descriptor_name': 'Cryptococcosis', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D005657', 'descriptor_name': 'Fungal Vaccines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D005963', 'descriptor_name': 'Glucosylceramides', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003453', 'descriptor_name': 'Cryptococcosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003455', 'descriptor_name': 'Cryptococcus neoformans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004797', 'descriptor_name': 'Enzyme-Linked Immunosorbent Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005657', 'descriptor_name': 'Fungal Vaccines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005963', 'descriptor_name': 'Glucosylceramides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007958', 'descriptor_name': 'Leukocyte Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D008111', 'descriptor_name': 'Liver Function Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008808', 'descriptor_name': 'Mice, Inbred CBA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014611', 'descriptor_name': 'Vaccination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037521', 'descriptor_name': 'Virulence Factors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D037521', 'descriptor_name': 'Virulence Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0153853', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0153853&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/adcfa3f9872d46388f4d3a4c51a0b7f7', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4833283', 'pdf_url': 'https://europepmc.org/articles/pmc4833283?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833283', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27082428', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0153853', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0153853&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.78, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320306127', 'funder_display_name': 'U.S. Department of Veterans Affairs', 'award_id': 'Merit Review grant I01BX002624'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'AI56168, AI100631, AI116420'}], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1557480900', 'https://openalex.org/W1579650598', 'https://openalex.org/W1653749361', 'https://openalex.org/W1923209545', 'https://openalex.org/W1940362182', 'https://openalex.org/W1964576347', 'https://openalex.org/W1966404042', 'https://openalex.org/W1969430561', 'https://openalex.org/W1988464052', 'https://openalex.org/W1991297834', 'https://openalex.org/W1997047110', 'https://openalex.org/W1997345052', 'https://openalex.org/W2005309617', 'https://openalex.org/W2016548343', 'https://openalex.org/W2021311755', 'https://openalex.org/W2033143827', 'https://openalex.org/W2043577263', 'https://openalex.org/W2076677132', 'https://openalex.org/W2079513681', 'https://openalex.org/W2082328477', 'https://openalex.org/W2083450799', 'https://openalex.org/W2087404142', 'https://openalex.org/W2099723019', 'https://openalex.org/W2103699386', 'https://openalex.org/W2105512727', 'https://openalex.org/W2111828785', 'https://openalex.org/W2131063054', 'https://openalex.org/W2134106722', 'https://openalex.org/W2155607658', 'https://openalex.org/W2157745908', 'https://openalex.org/W2160310527', 'https://openalex.org/W2166259331', 'https://openalex.org/W2171953577'], 'related_works': ['https://openalex.org/W965312423', 'https://openalex.org/W4365398204', 'https://openalex.org/W4242299022', 'https://openalex.org/W4225146044', 'https://openalex.org/W3121448498', 'https://openalex.org/W2147846847', 'https://openalex.org/W2134164254', 'https://openalex.org/W1998885405', 'https://openalex.org/W1773156315', 'https://openalex.org/W1497995855'], 'abstract_inverted_index': {'Cryptococcus': [0, 61, 73], 'neoformans': [1, 92, 122, 158, 214], 'is': [2, 16, 68, 86], 'an': [3, 180], 'opportunistic': [4], 'fungal': [5, 99, 204], 'pathogen': [6], 'and': [7, 22, 33, 93, 101, 165, 178, 193, 216], 'the': [8, 12, 30, 48, 60, 75, 82, 105, 111, 154, 160, 163, 189, 194], 'causative': [9], 'agent': [10, 119], 'of': [11, 25, 43, 50, 59, 113, 127, 148, 156, 188, 191, 196, 212], 'disease': [13], 'cryptococcosis.': [14, 128], 'Cryptococcosis': [15], 'initiated': [17], 'as': [18, 64, 116], 'a': [19, 51, 87, 117, 132, 145, 219], 'pulmonary': [20], 'infection': [21, 215], 'in': [23, 38, 74, 90, 124], 'conditions': [24], 'immune': [26], 'deficiency': [27], 'disseminates': [28], 'to': [29, 141, 162, 167], 'blood': [31], 'stream': [32], 'central': [34], 'nervous': [35], 'system,': [36], 'resulting': [37], 'life-threatening': [39], 'meningoencephalitis.': [40], 'A': [41], 'number': [42], 'studies': [44, 78], 'have': [45, 79, 109], 'focused': [46], 'on': [47], 'development': [49], 'vaccine': [52, 71], 'against': [53, 72, 95, 120, 209, 223], 'Cryptococcus,': [54], 'primarily': [55], 'utilizing': [56], 'protein-conjugated': [57], 'components': [58], 'polysaccharide': [62], 'capsule': [63], 'antigen.': [65], 'However,': [66], 'there': [67], 'currently': [69], 'no': [70], 'clinic.': [76], 'Previous': [77], 'shown': [80], 'that': [81, 203], 'glycosphingolipid,': [83], 'glucosylceramide': [84], '(GlcCer),': [85], 'virulence': [88], 'factor': [89], 'C.': [91, 121, 149, 157, 213], 'antibodies': [94], 'this': [96], 'lipid': [97], 'inhibit': [98], 'growth': [100], 'cell': [102], 'division.': [103], 'In': [104], 'present': [106], 'study,': [107], 'we': [108], 'investigated': [110], 'possibility': [112], 'using': [114], 'GlcCer': [115, 129, 151, 171, 205], 'therapeutic': [118], 'infections': [123], 'mouse': [125, 169], 'models': [126], 'purified': [130], 'from': [131, 159], 'non-pathogenic': [133], 'fungus,': [134], 'Candida': [135], 'utilis,': [136], 'was': [137, 185], 'administered': [138], 'intraperitoneally,': [139], 'prior': [140], 'infecting': [142], 'mice': [143, 208], 'with': [144], 'lethal': [146, 210], 'dose': [147], 'neoformans.': [150], 'administration': [152, 172, 192], 'prevented': [153], 'dissemination': [155], 'lungs': [161], 'brain': [164], 'led': [166], '60%': [168], 'survival.': [170], 'did': [173], 'not': [174], 'cause': [175], 'hepatic': [176], 'injury': [177], 'elicited': [179], 'anti-GlcCer': [181], 'antibody': [182], 'response,': [183], 'which': [184], 'observed': [186], 'independent': [187], 'route': [190], 'strains': [195], 'mouse.': [197], 'Taken': [198], 'together,': [199], 'our': [200], 'results': [201], 'suggest': [202], 'can': [206, 217], 'protect': [207], 'doses': [211], 'provide': [218], 'viable': [220], 'vaccination': [221], 'strategy': [222], 'Cryptococcus.': [224]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2337207909', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}], 'updated_date': '2024-09-01T05:47:33.331528', 'created_date': '2016-06-24'}