Publication Information

{'id': 'https://openalex.org/W2336225226', 'doi': 'https://doi.org/10.1152/ajpcell.1993.265.4.c1030', 'title': 'Temporal patterns of alpha 1-receptor stimulation regulate amplitude and frequency of calcium transients', 'display_name': 'Temporal patterns of alpha 1-receptor stimulation regulate amplitude and frequency of calcium transients', 'publication_year': 1993, 'publication_date': '1993-10-01', 'ids': {'openalex': 'https://openalex.org/W2336225226', 'doi': 'https://doi.org/10.1152/ajpcell.1993.265.4.c1030', 'mag': '2336225226', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7901996'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpcell.1993.265.4.c1030', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62704344', 'display_name': 'AJP Cell Physiology', 'issn_l': '0363-6143', 'issn': ['0363-6143', '1522-1563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008757811', 'display_name': 'Christof Schöfl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'C. Schofl', 'raw_affiliation_strings': ['Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover,Germany.'], 'affiliations': [{'raw_affiliation_string': 'Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover,Germany.', 'institution_ids': ['https://openalex.org/I34809795']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015947439', 'display_name': 'Georg Brabant', 'orcid': 'https://orcid.org/0000-0001-8532-7632'}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'G. Brabant', 'raw_affiliation_strings': ['Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover,Germany.'], 'affiliations': [{'raw_affiliation_string': 'Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover,Germany.', 'institution_ids': ['https://openalex.org/I34809795']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069389986', 'display_name': 'R. D. Hesch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'R. D. Hesch', 'raw_affiliation_strings': ['Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover,Germany.'], 'affiliations': [{'raw_affiliation_string': 'Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover,Germany.', 'institution_ids': ['https://openalex.org/I34809795']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109289328', 'display_name': 'A. von zur Mühlen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'A. von zur Muhlen', 'raw_affiliation_strings': ['Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover,Germany.'], 'affiliations': [{'raw_affiliation_string': 'Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover,Germany.', 'institution_ids': ['https://openalex.org/I34809795']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021381146', 'display_name': 'P H Cobbold', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'P. H. Cobbold', 'raw_affiliation_strings': ['Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover,Germany.'], 'affiliations': [{'raw_affiliation_string': 'Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover,Germany.', 'institution_ids': ['https://openalex.org/I34809795']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5015556263', 'display_name': 'Kevin Cuthbertson', 'orcid': 'https://orcid.org/0000-0002-8344-287X'}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'K. S. Cuthbertson', 'raw_affiliation_strings': ['Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover,Germany.'], 'affiliations': [{'raw_affiliation_string': 'Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover,Germany.', 'institution_ids': ['https://openalex.org/I34809795']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.663, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 39, 'citation_normalized_percentile': {'value': 0.847366, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '265', 'issue': '4', 'first_page': 'C1030', 'last_page': 'C1036'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/phenylephrine', 'display_name': 'Phenylephrine', 'score': 0.92219204}, {'id': 'https://openalex.org/keywords/aequorin', 'display_name': 'Aequorin', 'score': 0.48711157}, {'id': 'https://openalex.org/keywords/alpha', 'display_name': 'Alpha (finance)', 'score': 0.42533714}], 'concepts': [{'id': 'https://openalex.org/C2777952589', 'wikidata': 'https://www.wikidata.org/wiki/Q421910', 'display_name': 'Phenylephrine', 'level': 3, 'score': 0.92219204}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.7777454}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.55221856}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5344789}, {'id': 'https://openalex.org/C80933277', 'wikidata': 'https://www.wikidata.org/wiki/Q381068', 'display_name': 'Aequorin', 'level': 3, 'score': 0.48711157}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46735978}, {'id': 'https://openalex.org/C519063684', 'wikidata': 'https://www.wikidata.org/wiki/Q706', 'display_name': 'Calcium', 'level': 2, 'score': 0.4667858}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.43663776}, {'id': 'https://openalex.org/C64943373', 'wikidata': 'https://www.wikidata.org/wiki/Q2651003', 'display_name': 'Alpha (finance)', 'level': 4, 'score': 0.42533714}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.39455765}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.23412248}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.19839233}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.18141454}, {'id': 'https://openalex.org/C49453240', 'wikidata': 'https://www.wikidata.org/wiki/Q1592163', 'display_name': 'Construct validity', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C159110408', 'wikidata': 'https://www.wikidata.org/wiki/Q121176', 'display_name': 'Nursing', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2775944032', 'wikidata': 'https://www.wikidata.org/wiki/Q22907659', 'display_name': 'Patient satisfaction', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000316', 'descriptor_name': 'Adrenergic alpha-Agonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000316', 'descriptor_name': 'Adrenergic alpha-Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000331', 'descriptor_name': 'Aequorin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004594', 'descriptor_name': 'Electrophysiology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010656', 'descriptor_name': 'Phenylephrine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010656', 'descriptor_name': 'Phenylephrine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011673', 'descriptor_name': 'Pulsatile Flow', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpcell.1993.265.4.c1030', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62704344', 'display_name': 'AJP Cell Physiology', 'issn_l': '0363-6143', 'issn': ['0363-6143', '1522-1563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7901996', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 15, 'referenced_works': ['https://openalex.org/W1492343139', 'https://openalex.org/W1563645938', 'https://openalex.org/W1932786359', 'https://openalex.org/W1963846154', 'https://openalex.org/W1967343333', 'https://openalex.org/W1985233226', 'https://openalex.org/W1986765506', 'https://openalex.org/W1998984757', 'https://openalex.org/W2003445644', 'https://openalex.org/W2010070719', 'https://openalex.org/W2028469352', 'https://openalex.org/W2053107240', 'https://openalex.org/W2054027081', 'https://openalex.org/W2061521415', 'https://openalex.org/W2094058963'], 'related_works': ['https://openalex.org/W2412730724', 'https://openalex.org/W2404725696', 'https://openalex.org/W2343514960', 'https://openalex.org/W2138975710', 'https://openalex.org/W2111523408', 'https://openalex.org/W2076129711', 'https://openalex.org/W2060907832', 'https://openalex.org/W2027314634', 'https://openalex.org/W2025508492', 'https://openalex.org/W1977420815'], 'abstract_inverted_index': {'The': [0, 31, 68, 146, 162], 'pulsatile': [1], 'release': [2], 'of': [3, 33, 84, 93, 102, 173, 184, 192], 'neurotransmitters': [4], 'and': [5, 45, 140, 151, 164, 176], 'many': [6], 'hormones': [7], 'might': [8], 'encode': [9], 'specific': [10], 'biological': [11], 'information': [12], 'according': [13], 'to': [14, 27, 55, 65, 118, 190], 'temporal': [15], 'pattern.': [16], 'We': [17], 'tested': [18], 'this': [19], 'hypothesis': [20], 'by': [21, 38, 196], 'applying': [22], 'pulsed': [23, 85, 94, 132], 'alpha': [24, 193], '1-adrenoceptor': [25], 'stimulation': [26, 47, 87, 96, 112], 'single': [28], 'aequorin-injected': [29], 'hepatocytes.': [30], 'amplitude': [32, 163], 'free': [34, 103, 121, 152, 202], 'Ca2+': [35, 122, 153, 203], 'transients': [36, 154], 'induced': [37], 'rapid': [39, 111], 'phenylephrine': [40, 80, 86, 95, 128, 149], 'pulses': [41, 116, 150, 160], '(20-s': [42], 'interpulse': [43, 61], 'interval)': [44], 'continuous': [46, 107], 'was': [48, 63, 72], 'similar': [49], '(approximately': [50], '640': [51], 'nM)': [52], 'but': [53], 'increased': [54, 64], 'approximately': [56, 185], '1,000': [57], 'nM': [58], 'as': [59, 156], 'the': [60, 125, 157], 'interval': [62], '120': [66], 's.': [67], 'same': [69, 126], 'overall': [70], 'response': [71], 'maintained': [73], 'despite': [74], 'a': [75, 90, 99, 120, 170, 177, 181], '13-fold': [76], 'reduction': [77], 'in': [78, 136], 'average': [79, 127], 'concentration.': [81], 'Some': [82], 'regimes': [83, 133], 'could': [88, 97, 134], 'give': [89, 98], 'higher': [91, 100, 138], 'frequency': [92, 101], 'calcium': [104], 'oscillations': [105], 'than': [106, 143], 'stimulation,': [108], 'or': [109], 'more': [110], 'when': [113], 'some': [114], 'agonist': [115], 'failed': [117], 'elicit': [119], 'transient.': [123, 204], 'For': [124], 'concentration': [129], '(0.3-0.6': [130], 'microM),': [131], 'result': [135], 'significantly': [137], 'frequencies': [139], 'integrated': [141], 'responses': [142], 'constant': [144, 183], 'application.': [145], 'lags': [147], 'between': [148, 159], 'reduced': [155], 'period': [158, 172], 'increased.': [161], 'lag': [165], 'data': [166], 'are': [167], 'consistent': [168], 'with': [169, 180], 'refractory': [171], '18': [174], 's': [175], 'recovery': [178], 'phase': [179], 'time': [182], '100': [186], 's,': [187], 'perhaps': [188], 'corresponding': [189], 'dephosphorylation': [191], '1-adrenoceptors': [194], 'phosphorylated': [195], 'protein': [197], 'kinase': [198], 'C': [199], 'during': [200], 'each': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2336225226', 'counts_by_year': [{'year': 2021, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-12-08T19:04:06.514016', 'created_date': '2016-06-24'}