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312], 'or': [17, 27, 49, 135, 205, 282, 293, 313], 'greater': [18, 314], 'among': [19], 'emergency': [20], 'department': [21], '(ED)': [22], 'patients': [23, 45, 185], 'with': [24, 31, 46, 53, 88, 193, 240, 289], 'severe': [25, 47], 'sepsis': [26, 48], 'septic': [28, 50], 'shock': [29, 51, 132], 'treated': [30, 52], 'early': [32], 'goal-directed': [33], 'therapy': [34], '(EGDT).': [35], 'Methods:': [36], 'Retrospective': [37], 'analysis': [38, 233], 'prospective': [41], 'database': [42], '2894': [44], 'EGDT': [54, 113], 'in': [55, 323, 340], '21': [56], 'EDs': [57], 'between': [58], 'March': [59], '2010': [60], 'and': [61, 97, 152, 217, 222, 265, 301], 'September': [62], '2012.': [63], 'Patients': [64, 192], 'were': [65, 186, 196, 243, 285, 304], 'included': [66, 114], 'if': [67], 'they': [68], 'qualified': [69], 'for': [70, 296], 'ScvO2-guided': [71], 'therapies': [72], 'as': [73], 'defined': [74], 'by': [75], 'two': [76], 'consecutive': [77], 'ScvO2': [78, 281, 284, 310], 'measurements': [79], 'less': [80, 268], 'than': [81, 269], 'at': [83, 93, 101], 'least': [84, 94, 102], '15': [85], 'minutes': [86], 'apart': [87], 'concomitant': [90], 'CVP': [91, 300], '8': [95], 'mmHg': [96], 'MAP': [99, 302], '65': [103], 'mmHg.': [104], 'Variables': [105], 'abstracted': [106], 'during': [107], 'first': [109], 'six': [110], 'hours': [111], 'age,': [115], 'gender,': [116], 'initial': [117, 123, 210, 258, 280], 'ScvO2,': [118, 120], 'final': [119, 283], 'highest': [121], 'CVP,': [122], 'serum': [124, 127, 211, 226], 'lactate,': [125], 'percent': [126], 'lactate': [128, 227, 259, 266, 332], 'clearance,': [129], 'mechanical': [130, 202], 'ventilation,': [131], 'index,': [133], 'vasopressor': [134], 'dobutamine': [136], 'administration,': [137, 277], 'red': [138], 'blood': [139], 'cell': [140], '(RBC)': [141], 'transfusion,': [142, 279], 'lowest': [143], 'hemoglobin,': [144], '6-hour': [145, 214, 244], 'Sequential': [146], 'Organ': [147], 'Failure': [148], 'Assessment': [149], '(SOFA)': [150], 'score': [151], 'modified': [154], 'electronic': [155], 'Simplified': [156], 'Acute': [157], 'Physiology': [158], 'Score': [159], 'III': [160], '(eSAPS': [161], '3).': [162], 'Multivariable': [163], 'logistic': [164, 231], 'regression': [165, 232], 'was': [166, 190, 315], 'used': [167], 'to': [168, 200, 308], 'assess': [169], 'each': [174], 'variable': [175], 'on': [176], 'outcome': [178, 242, 291], 'in-hospital': [180, 194, 321], 'mortality.': [181], 'Results:': [182], '580': [183], '(20%)': [184], 'included.': [187], 'In-hospital': [188], 'mortality': [189, 195, 322], '21%.': [191], 'older(p-0.001),': [197], 'more': [198], 'likely': [199], 'require': [201], 'ventilation': [203], '(p<0.001)': [204], 'vasopressors': [206], '(p=0.02),': [207], 'had': [208, 223], 'higher': [209], 'lactates': [212], '(p<0.001),': [213, 221], 'SOFA': [215, 245], '(P<0.001)': [216], 'eSAPS': [218, 251], '3': [219, 252], 'scores': [220], 'lower': [224], 'percentage': 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