Title: Drug-induced alterations in the metabolome of primary hepatocytes
Abstract: Background: Xenobiotics can induce rapid changes in the metabolome of cells even at non-toxic doses. This might result in the disturbance of metabolite and cell membrane compositions. The latter affects cellular signaling and transport processes. The effect of low, non-toxic doses of acetaminophen on the cell membrane composition was studied in primary hepatocytes, using ToF-SIMS.
Publication Year: 2013
Publication Date: 2013-01-11
Language: en
Type: article
Indexed In: ['crossref']
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