Publication Information

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614, 629, 1069, 1093, 1352, 1373, 1394, 1412, 1897, 1911, 1990, 2000, 2149, 2446], 'blood': [58, 106, 246, 388, 513, 544, 577, 585, 610, 702, 740, 958, 1017, 1028, 1610, 1675, 2171, 2202, 2386], 'pressure,': [59, 361, 812, 822, 1037], 'more': [61, 2170, 2420], 'tissue': [69, 112], 'oxygen': [70], 'delivery."': [71], 'This': [72, 1225, 1462, 1620, 1656, 1890, 2168, 2298, 2534], 'unfortunately': [74], 'runs': [75], 'through': [76, 1612, 1941, 2319], 'much': [77, 887, 912, 1097, 1212, 1754, 1935], 'our': [79, 2498], 'regular': [80], 'resuscitation': [81], 'practices,': [82], 'al.': [87, 174, 401, 453, 1064, 2466], 'demonstrate': [88], 'in': [89, 120, 130, 156, 239, 315, 390, 531, 617, 621, 686, 704, 724, 742, 767, 840, 860, 876, 901, 904, 920, 936, 1030, 1046, 1071, 1192, 1247, 1312, 1324, 1411, 1431, 1440, 1451, 1464, 1471, 1482, 1487, 1618, 1627, 1636, 1640, 1644, 1650, 1654, 1660, 1668, 1734, 1785, 1835, 1893, 1902, 1923, 1946, 1952, 2082, 2086, 2157, 2182, 2231, 2252, 2259, 2288, 2377, 2385, 2393, 2400, 2427, 2434, 2508], 'their': [90, 419, 2040, 2378], 'comprehensive': [91, 404], 'reviews,': [92], 'is': [95, 200, 286, 305, 325, 352, 479, 495, 535, 546, 605, 659, 728, 745, 796, 824, 839, 851, 869, 885, 990, 1008, 1043, 1095, 1137, 1159, 1204, 1239, 1263, 1287, 1316, 1321, 1328, 1335, 1339, 1406, 1446, 1460, 1504, 1563, 1597, 1623, 1631, 1648, 1657, 1685, 1698, 1709, 1715, 1718, 1773, 1790, 1832, 1864, 1881, 1892, 1900, 1913, 1921, 1933, 2044, 2055, 2058, 2088, 2212, 2228, 2246, 2283, 2304, 2327, 2388, 2483, 2490, 2503], 'especially': [96, 321, 1455], 'true': [97, 2475, 2485, 2492, 2505], 'for': [98, 111, 168, 196, 231, 260, 338, 443, 539, 769, 845, 950, 1570, 1638, 1652, 1677, 1884, 2084, 2223, 2486, 2493, 2506], 'phenylephrine,': [102, 2487], 'which': [103, 121, 362, 369, 557, 657, 753, 763, 795, 802, 823, 963, 2043, 2197, 2271, 2509], 'effectively': [104], 'increases': [105, 1495, 2230], 'pressure': [107, 247, 252, 255, 310, 499, 510, 545, 563, 568, 591, 600, 650, 933, 949, 978, 1148, 1173, 1278, 1330, 1353, 1374, 1418, 1470, 1514, 1543, 1562, 1679, 1821, 1852, 1862, 1912, 1977, 1991, 2278, 2387, 2447], 'does': [109, 569, 970, 1208, 1424, 1435, 1693, 1781, 1959, 1972, 2033, 2126], 'little': [110, 336, 1086, 1160], 'perfusion.': [113], 'There': [114, 224], 'are': [115, 415, 558, 587, 754, 760, 941, 1535, 2009, 2018, 2104], 'perhaps': [116], 'some': [117, 428, 1119, 2375], 'clinical': [118], 'situations': [119], 'might': [123, 226], 'be': [124, 128, 222, 228, 269, 335, 662, 1122, 1355, 1568, 1605, 1723, 1761, 1878, 2348, 2480, 2517], 'helpful.': [125], 'Phenylephrine': [126], 'lifesaving': [129], 'hypotensive': [131], 'patients': [132, 157, 176, 189, 2365], 'who': [133, 158, 1359], 'have': [134, 152, 159, 427, 1387, 2111, 2235, 2367, 2416], 'dynamic': [135], 'aortic': [136, 192], 'outflow-tract': [137], 'obstruction.': [138], 'It': [139, 2135, 2482], 'has': [140, 204, 216, 679, 848, 1078, 1226, 1360, 1370, 1807, 2136, 2336, 2398], 'been': [141, 206, 217, 1227, 2138, 2338], 'shown': [142, 218, 2139], 'increase': [144, 244, 312, 350, 439, 1168, 1191, 1210, 1301, 1402, 1410, 1439, 2128, 2181, 2273, 2287, 2316, 2450], 'cardiac': [145, 410, 493, 552, 761, 927, 997, 1193, 1349, 1377, 1390, 1399, 1422, 1483, 1491, 2183, 2207, 2241, 2294, 2311, 2354, 2394, 2411, 2428], 'filling': [146, 1939], 'during': [147], 'postural': [148], 'hypotension3': [149], 'could': [151], 'potential': [154, 683, 712, 955], 'an': [160, 295, 353, 455, 654, 680, 809, 1438, 2067, 2180], 'acute': [161], 'loss': [162], 'α-adrenergic': [164, 2012], 'tone.': [165], 'Other': [166], 'recipients': [167], 'cited': [170], 'include': [175, 1052], 'with': [177, 183, 190, 209, 317, 636, 695, 1202, 1382, 1895, 2011, 2106, 2249], 'decompensated': [178, 191], 'tetralogy': [179], 'Fallot,': [181], 'women': [182], 'hypotension': [184, 2147], 'undergoing': [185], 'cesarean': [186], 'delivery,': [187], 'stenosis.': [193], 'The': [194, 345, 372, 566, 738, 829, 932, 1001, 1024, 1346, 1426, 1642, 1665, 1711, 2049, 2098, 2206], 'evidence': [195], 'last': [198], 'indication': [199], 'limited,': [201], 'there': [203, 332, 414, 1158, 1286, 1405], 'not': [205, 570, 971, 1044, 1209, 1276, 1340, 1436, 1536, 1694, 1782, 1791, 1960, 1973, 2034, 2089, 2127], 'comparison': [208], 'norepinephrine;': [213], 'it': [214, 285, 375, 1315, 1327, 1772, 1867, 2057, 2502], 'even': [215, 688, 2137], 'nitroprusside': [220], 'helpful!4': [223], 'also': [225, 380, 426, 1494, 2110, 2154, 2299, 2489, 2504], 'still': [227, 298, 699, 1544], 'place': [230], 'anesthetists': [232], 'carry': [234], 'syringe': [236], 'pocket': [241], 'transiently': [243, 307], 'ensure': [249], 'coronary': [250], 'perfusion': [251], 'when': [253, 1965, 2015, 2224, 2521], 'rapidly': [256], 'decreases': [257, 1466, 2155, 2198], 'after': [258], 'induction': [259], 'intubation;': [261], 'study': [263], 'prove': [265], 'point': [267], 'would': [268, 2359], 'very': [270, 1882, 1934, 2213, 2484], 'difficult': [271], 'perform': [273], 'and,': [274, 2279], 'based': [275, 458], 'on': [276, 459, 1082, 1088, 1110, 2215, 2240, 2305, 2343, 2405], 'review': [278, 405], 'al.,': [282], 'I': [283, 422, 425, 480, 964, 2358], 'suspect': [284], 'beneficial': [288], 'than': [289, 730, 889, 1099, 2285, 2474], 'norepinephrine.5': [293], 'Finally,': [294], 'old': [296], 'likely': [299, 2347, 2421, 2449, 2491], 'valid': [300, 537], 'boluses': [304], 'raise': [308], 'vagal': [313], 'output': [314, 494, 553, 768, 928, 1350, 1391, 1400, 1423, 1492, 1929, 2208, 2295, 2318, 2355], 'someone': [316], 'supraventricular': [319], 'tachycardia,': [320], 'if': [322, 1285, 1456, 2060, 2280], 'person': [324, 2245], 'already': [326, 2337, 2366], 'hypotensive.': [327], 'Besides': [328], 'these': [329, 817, 2016, 2029], 'special': [330], 'situations,': [331], 'seems': [333, 714], 'value': [337, 1565], 'sustained': [339], 'agonists.': [344], 'failure': [346, 435], 'flow': [351, 379, 389, 440, 514, 573, 604, 611, 624, 703, 723, 741, 986, 1084, 1091, 1107, 1211, 1217, 1234, 1964, 1998], 'excellent': [354], 'example': [355], 'distinction': [358], 'between': [359], 'increasing': [360, 367, 1179, 1608], 'see,': [365], 'flow,': [368, 467, 586], 'cannot.': [371], 'reason': [373, 1712], 'why': [374, 1522, 1713], 'fails': [376], 'improve': [378], 'provides': [381, 441], 'insights': [383], 'into': [384, 1019, 1725, 1763, 2519], 'regulation': [386, 408, 465, 925], 'circulation.': [392, 541, 1746], 'To': [393], 'help': [394], 'interpret': [395], 'empiric': [397], 'data,': [398], 'present': [402, 1045], 'output,1': [411], 'although': [413, 1049], 'many': [416, 2494], 'parts': [417, 2511], 'discussion': [420], 'agree': [423], 'with,': [424], 'fundamental': [429], 'disagreements,': [430], 'will': [432, 1877, 2272, 2296, 2346, 2356, 2415, 2422, 2448], 'support': [442], 'my': [444, 532], 'view': [445], 'how': [447], 'circulation': [449, 678, 952, 989, 1344], 'works.': [450, 1345], 'electrical': [456, 640, 644, 675, 1047, 1325, 1595, 1628, 1786, 1925], 'analogy': [457], "Ohm's": [460, 477], 'law': [461, 478, 525], 'explain': [463], 'start': [469], 'arguing': [471], 'proper': [474], 'formulation': [475], '(current)': [481], 'equals': [482], 'V': [483, 527], '(voltage)': [484], 'divided': [485, 500, 592], 'R': [487], '(resistance).': [488], 'Accordingly,': [489], 'they': [490, 505, 1050], 'determined': [496, 547, 588, 606, 746, 992, 1218, 1240], 'vascular': [502, 555, 1143, 1663, 1669, 2020], 'resistance,': [503, 556, 596, 1898, 2290], 'because': [504, 1012, 1092, 1133, 1510, 1525, 1626, 1771, 1788, 1866, 1993], 'believe': [506], 'determines': [511, 518], 'total': [512, 572, 609, 613, 864, 1090, 1609, 1674, 1678, 1896], 'just': [515], 'voltage': [517], 'current.': [520], 'Ohm': [521], 'actually': [522], 'wrote': [523, 2536], 'his': [524], '=': [528], 'IR,': [529], 'view,': [533], 'form': [538], 'That': [542], 'is,': [543], 'product': [550], 'regulated': [559], 'keep': [561, 1200], 'relatively': [564, 1155, 1915, 1987], 'constant.6,7': [565], 'determine': [571], '(cardiac': [574], 'output).': [575], 'Regional': [576], 'flows,': [578], 'coronary,': [581], 'cerebral,': [582], 'or': [583, 1575, 1615, 1978, 2419], 'renal': [584], 'regional': [595, 603, 618], 'driving': [601, 957], 'resistance.': [615, 2001], 'Even': [616], 'circulations,': [619], 'changes': [620, 1617, 1945, 1967], 'resistance': [622, 1815, 1891, 2130, 2156, 2195, 2345], 'regulate': [623], 'range': [627, 1837], 'pressures.': [630], 'Part': [631], 'problem': [634], 'arises': [635], 'analogy.': [641], 'approach,': [645, 1509], 'voltage—the': [646], 'equivalent': [647, 664, 1054], 'difference—is': [651], 'fixed': [652], 'external': [655], 'source,': [656], 'then': [658, 2071, 2340], 'taken': [660, 1058, 2518], 'energy': [667, 684, 713, 956, 1979], 'provided': [668], 'heart.': [671, 2205], 'However,': [672, 1521, 1539, 2031, 2185, 2444], 'unlike': [673], 'analogy,': [676], 'resting': [682, 1748], 'stored': [685], 'vessels,': [687, 818, 2196], 'without': [689], 'contracting': [691], 'heart;': [692], 'puncturing': [693], 'vessels': [694, 859, 1739, 2120, 2150, 2159], 'heart': [697, 718, 777, 975, 1007, 1014, 1164, 1197, 1458, 1550, 1579, 1587, 1831, 1932, 1947, 1958, 2303, 2403], 'stopped': [698], 'leads': [700, 2178], 'system,': [706], 'albeit': [707], 'only': [708, 916, 1077, 1185, 1264, 1407, 1581, 1834, 1845, 2236], 'temporarily.': [709], 'Although': [710, 1819, 1910], 'low,': [715], 'beating': [717], 'never': [720, 1300], 'create': [721], 'system': [726, 868, 1333, 1647, 2514], 'higher': [729], 'produced': [732], 'elastic': [735, 810, 947, 1035, 1146, 1171, 1468, 2068, 2276], 'recoil': [736, 811, 948, 1036, 1147, 1172, 1220, 1253, 1469, 2277], 'pressure.8': [737], 'actual': [739], 'body': [744, 903], 'intersection': [749, 995], '2': [751], 'functions,6,9': [752], 'both': [755], 'sensitive': [756], 'volume.': [758, 2381], 'They': [759], 'function,': [762, 794, 1011, 1557, 1954, 2222, 2395], 'gives': [764, 1588], 'change': [766, 1635, 1639, 1649, 1653, 1951, 2036, 2081, 2085], 'given': [771], 'end-diastolic': [772], 'volume': [773, 935, 1029, 1056, 1120, 1161, 1246, 1268, 1293, 1319, 1449, 1465, 1486, 1611, 1651, 1676, 1683, 1702, 1721, 1727, 1759, 1780, 1789, 1940, 2247, 2254, 2335], 'at': [774, 825, 2093, 2122], 'constant': [776, 779, 782, 1916, 1963, 1976, 1988], 'rate,': [778, 1948], 'afterload,': [780], 'contractility,': [783], 'defined': [785, 797], 'Frank': [787], 'Starling,': [789], 'second,': [791], 'return': [793, 967, 999, 1556, 2200, 2221, 2292, 2352], 'stressed': [800, 832, 1726, 1764], 'volume,': [801, 833, 1765, 2270], 'stretches': [803, 1704], 'compliant': [804, 938, 1127, 1152, 1742, 1826, 2102, 2133, 2162, 2264], 'vessel': [805, 1690, 1706], 'walls': [806, 1691, 1707, 1736], 'produces': [808, 1186], 'drainage': [814, 1257, 1870], 'characteristics': [815, 1258], 'downstream': [821, 979], 'right': [827, 1115, 1457, 1512, 1533, 1541, 1560, 1586, 1830, 2402], 'atrium.': [828], 'bulk': [830], 'almost': [834, 1769], '70%': [835], 'total,': [838], 'small': [841, 918, 1190, 1848, 2005, 2238], 'venules': [842, 882, 1021, 1476, 2008], 'veins,': [844], 'region': [847, 907, 939, 1128, 1827, 2103, 2163, 2176], 'compliance': [849, 865, 880, 900, 1070, 1094, 1136, 1528, 1659], '30': [852], '40': [854], 'times': [855], 'other': [858, 1130, 1142, 2495], 'body.': [862], 'Because': [863], 'sum': [871], 'individual': [874], 'compliances': [875], 'series,': [877], 'veins': [884, 982, 1103, 1222, 1474, 2006, 2099, 2261], 'so': [886, 1096, 1138, 1716, 1955, 2078], 'larger': [888], 'remainder': [893], 'body,': [896], 'lumping': [897], 'all': [898, 2510], 'one': [906, 1792, 2061], 'makes': [908], 'overall': [910, 2096], 'analysis': [911], 'simpler': [913], 'adds': [915], 'error': [919], 'assessment': [922], 'under': [929, 1774, 1917], 'most': [930, 2362, 2435], 'conditions.': [931], 'thus': [940, 991, 1175, 1559, 1681, 1969, 2374], 'primary': [943], 'determinants': [944], 'back': [959, 1018, 1857, 2076], 'heart,': [962, 1860], 'call': [965], 'function.': [968], 'Flow': [969], 'occur': [972], 'unless': [973], 'lowers': [976], 'from': [980, 1124, 1351, 1593, 1823, 1854, 2174], 'venules.': [984, 1105, 1224], 'Actual': [985], 'around': [987], 'functions.': [1000], 'second': [1002], 'role': [1004, 1026, 1067], 'restorative': [1010], 'puts': [1015], 'veins.': [1023], 'key': [1025], 'determination': [1032], 'major': [1039, 1383], 'determinant': [1040], 'flow,10': [1042], 'models,': [1048, 1314, 1787], 'do': [1051], 'being': [1057, 2468], 'up': [1059, 1201, 1784], 'capacitors.': [1061], 'emphasize': [1065], 'Windkessel': [1073], 'model,1': [1074], 'smoothing': [1080], 'effect': [1081, 1087, 1600, 2239, 2282, 2342], 'lower': [1098], 'Under': [1106, 1747], 'conditions,': [1108, 1750, 1919], 'depending': [1109], 'functions': [1112, 1198], 'left': [1117, 1432, 1443, 1518, 1531, 1578, 2225, 2232], 'ventricles,': [1118], 'redistributed': [1123], 'venous': [1126, 1151, 1170, 1176, 1805, 1825, 1874, 2194, 2275, 2289, 2291, 2344, 2351], 'regions,': [1131, 1144], 'its': [1134, 1938, 2317], 'large': [1135, 1139, 1804, 1873, 2331], 'relative': [1140], 'regions': [1153], 'remains': [1154], 'constant.': [1156], 'Furthermore,': [1157, 1284], 'recruit': [1166, 2268], 'return.': [1177], 'Consequently,': [1178], 'pump': [1180, 1289, 1298, 1553, 1582], 'function': [1181, 1434, 1459, 2227, 2312, 2412], 'above': [1182, 1213, 1307], 'normal': [1183, 1918, 1989], 'levels': [1184], 'itself': [1188, 1971], 'output.': [1194, 1484, 2184], 'Thus,': [1195, 1311, 2114], 'coming': [1205, 1269, 1279], 'back,': [1206], 'level': [1215], 'referred': [1228], '"bathtub"': [1232], 'analogy11;': [1233], 'out': [1235, 1270, 1280, 1583, 1689, 2063], 'bathtub': [1238, 1306], 'height': [1243, 1303], 'tub': [1249], '(equivalent': [1250], 'pressure)': [1254], 'tub,': [1261], 'affected': [1265, 1936], 'inflow': [1273, 1966], 'tap': [1274], 'tap.': [1283], 'returning': [1290], 'draining': [1292, 1816, 2100, 2131, 2160, 2262], 'bathtub,': [1296], 'starting': [1309, 2217], 'condition.': [1310], 'hydraulic': [1313, 1646], 'initial': [1318, 2257], 'fixed,10': [1322], 'whereas': [1323, 1379], 'models': [1326, 1629], 'across': [1331], 'fixed,': [1336], 'way': [1342, 2050], 'independence': [1347], 'should': [1354, 1523, 1567], 'evident': [1356], 'anyone': [1358], 'managed': [1361], 'critically': [1362, 2363], 'ill': [1363, 2364], 'patients.': [1364], 'For': [1365], 'example,': [1366], 'septic': [1368], 'patient': [1369, 1381], 'low': [1372, 1389], 'high': [1376], 'output,': [1378, 2429], 'ventricular': [1384, 1433, 1444, 1519, 2226, 2233], 'dysfunction': [1385, 1445], 'increased': [1393, 2328], 'pressure.': [1395, 1413, 1655], 'During': [1396], 'aerobic': [1397], 'exercise,': [1398, 1416], '5-fold,': [1403], 'modest': [1409], 'isometric': [1415], 'increases,': [1419], 'not.': [1425], 'consequence': [1427], 'decrease': [1430, 1481, 1822, 1853, 1863, 2025, 2384, 2392, 2426], 'mirror': [1437], 'function.10': [1441], 'If': [1442, 2243, 2382], 'severe': [1447], 'enough,': [1448], 'accumulates': [1450], 'pulmonary': [1453, 1496, 1661], 'compartment,': [1454], 'preserved.': [1461], 'shift': [1463], 'systemic': [1473], 'contributes': [1478], 'Adding': [1485], 'situation': [1489], 'restores': [1490], 'edema!': [1497], 'al.1': [1500, 1909], 'limitation': [1506], "Guyton's": [1508], 'atrial': [1513, 1542, 1561], 'no': [1515, 2417], 'longer': [1516], 'predicts': [1517], 'filling.': [1520], 'it,': [1524], 'diastolic': [1527], 'ventricles': [1534], 'same.': [1538], 'describes': [1545], 'interaction': [1547], 'used': [1569, 1632, 1905], 'assessing': [1571, 2522], 'responses': [1572], 'fluids': [1574], 'inotropes12;': [1576], 'it.': [1589], 'An': [1590], 'difference': [1592], 'model': [1596], 'circuit': [1603], 'changed': [1606, 2090], 'fluid': [1613], 'retention': [1614], 'capacitance.': [1619], 'latter': [1621], 'term': [1622, 1666], 'often': [1624], 'confused,': [1625], 'capacitance': [1630, 1667, 2027, 2119], 'charge': [1637], 'voltage.': [1641], 'equivalence': [1643], 'called': [1658], 'physiology.': [1664], 'physiology': [1670], 'refers': [1671], 'includes': [1682], 'necessary': [1686], 'round': [1688], 'stretch': [1695], 'them': [1696], '"unstressed,"': [1699], '"stressed."13': [1710], 'unstressed': [1720, 1758, 1779, 2253, 2269, 2334, 2380], 'converted': [1724], 'contractions': [1729], 'smooth': [1732, 2021], 'muscles': [1733, 2003, 2022], 'part': [1743, 2308, 2408], 'volume-replete': [1749], '10': [1751], '18': [1756], 'mL/kg': [1757], 'recruited': [1762], 'occurs': [1768, 1992, 2092], 'instantaneously': [1770], 'neural': [1775], 'control.14': [1776], 'Recruitment': [1777], 'show': [1783], 'set': [1795], 'variables.': [1796], 'Failure': [1797], 'consider': [1799], 'importance': [1801, 1813], 'reservoir': [1806], 'led': [1808], 'underappreciation': [1810], 'region.10': [1818], 'normally': [1833], '4': [1839], '8': [1841], 'mm': [1842], 'Hg,': [1843], 'represents': [1846], 'proportion': [1849], 'aorta': [1856], 'critical': [1865], 'controls': [1868], 'reservoir.': [1875], 'As': [1876], 'seen,': [1879], 'understanding': [1885], 'response': [1887, 2209], 'phenylephrine.': [1889], 'series': [1894], 'missing': [1901], 'equations': [1904], 'maintained': [1914], 'implied': [1922], 'model,': [1926], 'stroke': [1928], "Starling's": [1942], 'law,': [1943], 'contractile': [1953], 'provide': [1961, 1974, 2452], 'source': [1980], 'system.': [1983], 'Maintenance': [1984], 'integration': [1995], 'Smooth': [2002], 'innervated': [2010, 2105], 'receptors,': [2013, 2108], 'receptors': [2017], 'activated,': [2019], 'shorten': [2023], 'vessels.': [2030], 'usually': [2035], 'slope': [2038], 'pressure-volume': [2041], 'relationship,': [2042], 'inverse': [2046], 'compliance.': [2048], 'think': [2052], 'cut': [2062], 'piece': [2065], 'band': [2069, 2075], 'put': [2072], 'remaining': [2074], 'together,': [2077], 'tension': [2083], 'length': [2087], 'shorter': [2095], 'length.': [2097], 'β': [2112], 'receptors.': [2113], 'norepinephrine': [2115], 'constrict': [2117], 'same': [2124], 'time': [2125], 'region.15': [2134], 'activation': [2141, 2372], 'baroreceptor': [2144], 'reflex': [2145], 'constricts': [2148, 2193], 'expected': [2152], 'splanchnic': [2166], 'bed.14': [2167], 'allows': [2169], 'drain': [2173], 'agonist': [2189], 'dependent': [2214], 'conditions': [2218], 'normal,': [2229], 'afterload': [2234], 'output.10': [2242], 'replete,': [2248], 'good': [2250], 'reserves': [2251], 'minimal': [2256], 'tone': [2258, 2326], 'region,': [2265], 'greater': [2284], 'increase.': [2297], 'assumes': [2300], 'ascending': [2307], 'curve': [2313], 'Starling': [2321], 'mechanism.': [2322], 'If,': [2323], 'however,': [2324], 'sympathetic': [2325, 2371], 'portion': [2332], 'recruited,': [2339], 'dominant': [2349], 'decrease.': [2357], 'predict': [2360], 'degree': [2369], 'reduction': [2376], 'recruitable': 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