Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2333689347', 'doi': 'https://doi.org/10.1016/j.juro.2016.02.2216', 'title': 'MP07-13 BASELINE SERUM DEHYDROEPIANDROSTERONE SULFATE (DHEAS) CAN PREDICT RESPONSIVENESS TO PRIMARY ANDROGEN DEPRIVATION THERAPY IN PATIENTS WITH HORMONE NAÏVE METASTATIC PROSTATE CANCER', 'display_name': 'MP07-13 BASELINE SERUM DEHYDROEPIANDROSTERONE SULFATE (DHEAS) CAN PREDICT RESPONSIVENESS TO PRIMARY ANDROGEN DEPRIVATION THERAPY IN PATIENTS WITH HORMONE NAÏVE METASTATIC PROSTATE CANCER', 'publication_year': 2016, 'publication_date': '2016-03-28', 'ids': {'openalex': 'https://openalex.org/W2333689347', 'doi': 'https://doi.org/10.1016/j.juro.2016.02.2216', 'mag': '2333689347'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.juro.2016.02.2216', 'pdf_url': 'https://www.auajournals.org/doi/pdf/10.1016/j.juro.2016.02.2216', 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.auajournals.org/doi/pdf/10.1016/j.juro.2016.02.2216', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024884433', 'display_name': 'Akihiro Yano', 'orcid': 'https://orcid.org/0000-0001-8453-2474'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akihiro Yano', 'raw_affiliation_strings': ['Kawagoe, Japan'], 'affiliations': [{'raw_affiliation_string': 'Kawagoe, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038745917', 'display_name': 'Hironori Sugiyama', 'orcid': 'https://orcid.org/0000-0002-6925-1823'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hironori Sugiyama', 'raw_affiliation_strings': ['Kawagoe, Japan'], 'affiliations': [{'raw_affiliation_string': 'Kawagoe, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045043082', 'display_name': 'Eiken Cho', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Eiken Cho', 'raw_affiliation_strings': ['Kawagoe, Japan'], 'affiliations': [{'raw_affiliation_string': 'Kawagoe, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078603406', 'display_name': 'Hideki Takeshita', 'orcid': 'https://orcid.org/0000-0002-1512-6904'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hideki Takeshita', 'raw_affiliation_strings': ['Kawagoe, Japan'], 'affiliations': [{'raw_affiliation_string': 'Kawagoe, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072492344', 'display_name': 'Yohei Okada', 'orcid': 'https://orcid.org/0000-0002-2266-476X'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yohei Okada', 'raw_affiliation_strings': ['Kawagoe, Japan'], 'affiliations': [{'raw_affiliation_string': 'Kawagoe, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025121046', 'display_name': 'Makoto Morozumi', 'orcid': 'https://orcid.org/0000-0001-9834-8774'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Makoto Morozumi', 'raw_affiliation_strings': ['Kawagoe, Japan'], 'affiliations': [{'raw_affiliation_string': 'Kawagoe, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031050928', 'display_name': 'Satoru Kawakami', 'orcid': 'https://orcid.org/0000-0001-6319-3821'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Satoru Kawakami', 'raw_affiliation_strings': ['Kawagoe, Japan'], 'affiliations': [{'raw_affiliation_string': 'Kawagoe, Japan', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100896822', 'display_name': 'Takumi Yamada', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takumi Yamada', 'raw_affiliation_strings': ['Kawagoe, Japan'], 'affiliations': [{'raw_affiliation_string': 'Kawagoe, Japan', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 67}, 'biblio': {'volume': '195', 'issue': '4S', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Advancements in Prostate Cancer Research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Advancements in Prostate Cancer Research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10124', 'display_name': 'Prostate Cancer Research and Treatment', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Long-Term Effects of Testosterone on Health', 'score': 0.9624, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hormone-therapy', 'display_name': 'Hormone Therapy', 'score': 0.508602}, {'id': 'https://openalex.org/keywords/metastatic-prostate-cancer', 'display_name': 'Metastatic Prostate Cancer', 'score': 0.502335}], 'concepts': [{'id': 'https://openalex.org/C2777899217', 'wikidata': 'https://www.wikidata.org/wiki/Q4759439', 'display_name': 'Androgen deprivation therapy', 'level': 4, 'score': 0.87755644}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8613053}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8573688}, {'id': 'https://openalex.org/C2780657110', 'wikidata': 'https://www.wikidata.org/wiki/Q2505402', 'display_name': 'Dehydroepiandrosterone sulfate', 'level': 4, 'score': 0.64021593}, {'id': 'https://openalex.org/C2779279991', 'wikidata': 'https://www.wikidata.org/wiki/Q6058681', 'display_name': 'Testosterone (patch)', 'level': 2, 'score': 0.58567405}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.57656175}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5584333}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.5069804}, {'id': 'https://openalex.org/C2776992908', 'wikidata': 'https://www.wikidata.org/wiki/Q408376', 'display_name': 'Dehydroepiandrosterone', 'level': 4, 'score': 0.47697482}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4063859}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.3987187}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.38580757}, {'id': 'https://openalex.org/C29456083', 'wikidata': 'https://www.wikidata.org/wiki/Q1221899', 'display_name': 'Gynecology', 'level': 1, 'score': 0.37183762}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.juro.2016.02.2216', 'pdf_url': 'https://www.auajournals.org/doi/pdf/10.1016/j.juro.2016.02.2216', 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.juro.2016.02.2216', 'pdf_url': 'https://www.auajournals.org/doi/pdf/10.1016/j.juro.2016.02.2216', 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W384183208', 'https://openalex.org/W2419379761', 'https://openalex.org/W2415632568', 'https://openalex.org/W2415262826', 'https://openalex.org/W2150421446', 'https://openalex.org/W2117196859', 'https://openalex.org/W2083344966', 'https://openalex.org/W2077442251', 'https://openalex.org/W2023189202', 'https://openalex.org/W2002917234'], 'abstract_inverted_index': {'You': [0], 'have': [1], 'accessJournal': [2], 'of': [3, 135, 160, 185, 193, 230, 255, 279, 327, 369, 412, 426], 'UrologyProstate': [4], 'Cancer:': [5], 'Markers': [6], 'II1': [7], 'Apr': [8], '2016MP07-13': [9], 'BASELINE': [10], 'SERUM': [11], 'DEHYDROEPIANDROSTERONE': [12], 'SULFATE': [13], '(DHEAS)': [14], 'CAN': [15], 'PREDICT': [16], 'RESPONSIVENESS': [17], 'TO': [18], 'PRIMARY': [19], 'ANDROGEN': [20], 'DEPRIVATION': [21], 'THERAPY': [22], 'IN': [23], 'PATIENTS': [24], 'WITH': [25], 'HORMONE': [26], 'NAÏVE': [27], 'METASTATIC': [28], 'PROSTATE': [29], 'CANCER': [30], 'Akihiro': [31, 48, 448], 'Yano,': [32], 'Hironori': [33, 57, 455], 'Sugiyama,': [34], 'Eiken': [35, 66, 462], 'Cho,': [36], 'Hideki': [37, 75, 469], 'Takeshita,': [38], 'Yohei': [39, 84, 476], 'Okada,': [40], 'Makoto': [41, 93, 483], 'Morozumi,': [42], 'Satoru': [43, 102, 490], 'Kawakami,': [44], 'and': [45, 111, 197, 224, 251, 310, 355, 362], 'Takumi': [46, 112, 497], 'Yamada': [47, 114, 498], 'YanoAkihiro': [49], 'Yano': [50, 449], 'More': [51, 60, 69, 78, 87, 96, 105, 115, 450, 457, 464, 471, 478, 485, 492, 499], 'articles': [52, 61, 70, 79, 88, 97, 106, 116, 451, 458, 465, 472, 479, 486, 493, 500], 'by': [53, 62, 71, 80, 89, 98, 107, 117, 452, 459, 466, 473, 480, 487, 494, 501], 'this': [54, 63, 72, 81, 90, 99, 108, 118, 186, 453, 460, 467, 474, 481, 488, 495, 502], 'author': [55, 64, 73, 82, 91, 100, 109, 119, 454, 461, 468, 475, 482, 489, 496, 503], ',': [56, 65, 74, 83, 92, 101, 110], 'SugiyamaHironori': [58], 'Sugiyama': [59, 456], 'ChoEiken': [67], 'Cho': [68, 463], 'TakeshitaHideki': [76], 'Takeshita': [77, 470], 'OkadaYohei': [85], 'Okada': [86, 477], 'MorozumiMakoto': [94], 'Morozumi': [95, 484], 'KawakamiSatoru': [103], 'Kawakami': [104, 491], 'YamadaTakumi': [113], 'View': [120], 'All': [121, 505], 'Author': [122], 'Informationhttps://doi.org/10.1016/j.juro.2016.02.2216AboutPDF': [123], 'ToolsAdd': [124], 'to': [125, 137, 145, 165, 189, 200, 228, 237, 242, 245, 253, 297, 367, 431], 'favoritesDownload': [126], 'CitationsTrack': [127], 'CitationsPermissionsReprints': [128], 'ShareFacebookTwitterLinked': [129], 'InEmail': [130], 'INTRODUCTION': [131], 'AND': [132], 'OBJECTIVES': [133], 'Prediction': [134], 'responsiveness': [136, 179, 203, 244, 411], 'primary': [138], 'androgen': [139, 174], 'deprivation': [140], 'therapy': [141], '(pADT)': [142], 'is': [143, 188], 'pivotal': [144], 'individualize': [146], 'the': [147, 191, 298, 307, 314, 328], 'multimodal': [148], 'treatment': [149], 'strategy': [150], 'for': [151, 365, 374, 386], 'patients': [152, 209, 330, 375, 413], 'with': [153, 210, 219, 262, 376, 388, 404, 414, 423], 'advanced': [154], 'prostate': [155, 215, 232, 418], 'cancer.': [156, 419], 'Although': [157], 'a': [158, 263, 319], 'panel': [159], 'prognosticator': [161], 'has': [162, 168], 'been': [163, 169], 'revealed': [164, 335], 'date,': [166], 'little': [167], 'known': [170], 'about': [171], 'whether': [172], 'baseline': [173, 194, 249, 341, 378, 390, 399], 'status': [175], 'can': [176, 408], 'predict': [177, 201, 409], 'pADT': [178, 202, 220, 410], 'in': [180, 204], 'these': [181, 205], 'patients.': [182, 206], 'The': [183, 394], 'aim': [184], 'study': [187], 'clarify': [190], 'ability': [192], 'serum': [195, 400], 'DHEAS': [196, 311, 356, 379, 391, 401], 'testosterone': [198], '(T)': [199], 'METHODS': [207], 'Twenty-six': [208], 'hormone': [211, 415], 'naive': [212, 416], 'bone': [213], 'metastatic': [214, 417], 'cancer': [216, 233], 'were': [217, 257], 'treated': [218], 'between': [221, 248], 'May': [222], '2013': [223], 'Sep': [225], '2015.': [226], 'Time': [227], 'development': [229, 254, 368], 'castration-resistant': [231], '(CRPC),': [234], 'defined': [235], 'according': [236, 296], 'PCWG2': [238], 'criteria,': [239], 'was': [240, 381], 'used': [241], 'evaluate': [243], 'pADT.': [246], 'Relationships': [247], 'parameters': [250], 'time': [252, 366], 'CRPC': [256], 'evaluated': [258], 'using': [259], 'multivariate': [260], 'analysis': [261, 334], 'Cox': [264], 'proportional': [265], 'hazards': [266], 'model.': [267], 'Parameters': [268], '(and': [269], 'its': [270], 'cut-off': [271], 'value)': [272], 'analyzed': [273], 'were,': [274], 'age': [275, 337], '(70': [276], 'years),': [277], 'presence': [278], 'visceral': [280], 'metastasis,': [281], 'alkaline': [282, 346], 'phosphatase': [283, 347], '(340': [284], 'U/L),': [285, 289], 'lactate': [286], 'dehydrogenase': [287], '(290': [288], 'hemoglobin': [290, 351], '(13.2': [291], 'g/dL),': [292], 'PSA': [293, 342], '(65': [294], 'ng/mL': [295], 'Glass': [299], 'model),': [300], 'Gleason': [301], 'score': [302], '(7),': [303], 'T': [304], '(359': [305], 'ng/dL;': [306], 'fourth': [308], 'decile),': [309], '(23.8': [312], 'µg/dL;': [313], 'first': [315], 'decile).': [316], 'RESULTS': [317], 'During': [318], 'median': [320], '17': [321], 'months': [322], 'follow-up': [323], 'period,': [324], '13': [325], 'out': [326], '26': [329], 'developed': [331], 'CRPC.': [332, 370], 'Multivariate': [333], 'that': [336, 385, 398], '(p': [338, 343, 348, 352, 357], '=': [339, 349], '0.03),': [340], '<': [344, 353, 358], '0.001),': [345, 354], '0.01),': [350], '0.001)': [359], 'are': [360], 'significant': [361], 'independent': [363], 'predictors': [364], 'CRPC-free': [371], 'survival': [372], 'rate': [373], 'higher': [377], 'level': [380], 'significantly': [382], 'better': [383], 'than': [384], 'those': [387], 'lower': [389], '(Fig).': [392], 'CONCLUSIONS': [393], 'current': [395], 'results': [396], 'indicate': [397], 'level,': [402], 'along': [403], 'previously': [405], 'established': [406], 'prognosticators,': [407], 'Further': [420], 'prospective': [421], 'analyses': [422], 'large': [424], 'number': [425], 'cohorts': [427], 'will': [428], 'be': [429], 'needed': [430], 'confirm': [432], 'our': [433], 'results.': [434], '©': [435], '2016FiguresReferencesRelatedDetails': [436], 'Volume': [437], '195Issue': [438], '4SApril': [439], '2016Page:': [440], 'e81-e82': [441], 'Advertisement': [442, 506, 507], 'Copyright': [443], '&': [444], 'Permissions©': [445], '2016MetricsAuthor': [446], 'Information': [447], 'Expand': [504], 'PDF': [508], 'downloadLoading': [509], '...': [510]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2333689347', 'counts_by_year': [], 'updated_date': '2024-09-19T05:46:20.006667', 'created_date': '2016-06-24'}