Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2333536181', 'doi': 'https://doi.org/10.1038/sj.onc.1203056', 'title': 'Mitochondrial DNA determines the cellular response to cancer therapeutic agents', 'display_name': 'Mitochondrial DNA determines the cellular response to cancer therapeutic agents', 'publication_year': 1999, 'publication_date': '1999-11-18', 'ids': {'openalex': 'https://openalex.org/W2333536181', 'doi': 'https://doi.org/10.1038/sj.onc.1203056', 'mag': '2333536181', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10597269'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/sj.onc.1203056', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024832022', 'display_name': 'Keshav K. Singh', 'orcid': 'https://orcid.org/0000-0002-0047-8616'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Keshav K Singh', 'raw_affiliation_strings': ['Johns Hopkins Oncology Center, 600 North Wolfe Street, Room 2-121, Baltimore, 21287, Maryland, MD, USA'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins Oncology Center, 600 North Wolfe Street, Room 2-121, Baltimore, 21287, Maryland, MD, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048986880', 'display_name': 'James Russell', 'orcid': 'https://orcid.org/0000-0003-0827-1801'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James Russell', 'raw_affiliation_strings': ['Johns Hopkins Oncology Center, 600 North Wolfe Street, Room 2-121, Baltimore, 21287, Maryland, MD, USA'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins Oncology Center, 600 North Wolfe Street, Room 2-121, Baltimore, 21287, Maryland, MD, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050265525', 'display_name': 'Barbara Sigala', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Barbara Sigala', 'raw_affiliation_strings': ['Johns Hopkins Oncology Center, 600 North Wolfe Street, Room 2-121, Baltimore, 21287, Maryland, MD, USA'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins Oncology Center, 600 North Wolfe Street, Room 2-121, Baltimore, 21287, Maryland, MD, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000926784', 'display_name': 'Yonggong Zhang', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yonggong Zhang', 'raw_affiliation_strings': ['Johns Hopkins Oncology Center, 600 North Wolfe Street, Room 2-121, Baltimore, 21287, Maryland, MD, USA'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins Oncology Center, 600 North Wolfe Street, Room 2-121, Baltimore, 21287, Maryland, MD, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044695553', 'display_name': 'Jerry R. Williams', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jerry Williams', 'raw_affiliation_strings': ['Johns Hopkins Oncology Center, 600 North Wolfe Street, Room 2-121, Baltimore, 21287, Maryland, MD, USA'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins Oncology Center, 600 North Wolfe Street, Room 2-121, Baltimore, 21287, Maryland, MD, USA', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040895153', 'display_name': 'K F Keshav', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I72816309', 'display_name': 'Drexel University', 'ror': 'https://ror.org/04bdffz58', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I72816309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kylie F Keshav', 'raw_affiliation_strings': ['Department of Bioscience and Biotechnology, Drexel University, 32nd and Chestnut Streets, Philadelphia, 19104, Pennsylvania, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Bioscience and Biotechnology, Drexel University, 32nd and Chestnut Streets, Philadelphia, 19104, Pennsylvania, PA, USA', 'institution_ids': ['https://openalex.org/I72816309']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4390, 'currency': 'EUR', 'value_usd': 5490, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.84, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 180, 'citation_normalized_percentile': {'value': 0.95681, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '18', 'issue': '48', 'first_page': '6641', 'last_page': '6646'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Dynamics and Reactive Oxygen Species Regulation', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Dynamics and Reactive Oxygen Species Regulation', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'DNA Topoisomerases: Structure, Function, and Inhibition', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Metabolic Reprogramming in Cancer Biology', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hela', 'display_name': 'HeLa', 'score': 0.6291925}, {'id': 'https://openalex.org/keywords/clonogenic-assay', 'display_name': 'Clonogenic assay', 'score': 0.6258671}, {'id': 'https://openalex.org/keywords/mitochondrial-metabolism', 'display_name': 'Mitochondrial Metabolism', 'score': 0.512604}, {'id': 'https://openalex.org/keywords/cancer-cell-metabolism', 'display_name': 'Cancer Cell Metabolism', 'score': 0.512538}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8616918}, {'id': 'https://openalex.org/C2777366897', 'wikidata': 'https://www.wikidata.org/wiki/Q847482', 'display_name': 'HeLa', 'level': 3, 'score': 0.6291925}, {'id': 'https://openalex.org/C117262875', 'wikidata': 'https://www.wikidata.org/wiki/Q5135057', 'display_name': 'Clonogenic assay', 'level': 3, 'score': 0.6258671}, {'id': 'https://openalex.org/C24586158', 'wikidata': 'https://www.wikidata.org/wiki/Q27075', 'display_name': 'Mitochondrial DNA', 'level': 3, 'score': 0.6080628}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6016045}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.5865682}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.5546603}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.55135906}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.5374736}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.5362002}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.5017762}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4673757}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.45771283}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.26883888}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.24285948}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.2359682}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.10921055}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/sj.onc.1203056', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10597269', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.83}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1512984914', 'https://openalex.org/W1515699320', 'https://openalex.org/W1568086081', 'https://openalex.org/W1597306414', 'https://openalex.org/W163292076', 'https://openalex.org/W1657827244', 'https://openalex.org/W1802480460', 'https://openalex.org/W1828224642', 'https://openalex.org/W1950485111', 'https://openalex.org/W1967405734', 'https://openalex.org/W1976347407', 'https://openalex.org/W1978115920', 'https://openalex.org/W2004120067', 'https://openalex.org/W2016743086', 'https://openalex.org/W2019889997', 'https://openalex.org/W2022731838', 'https://openalex.org/W2028081562', 'https://openalex.org/W2029516193', 'https://openalex.org/W2029750351', 'https://openalex.org/W2030378746', 'https://openalex.org/W2033222884', 'https://openalex.org/W2036536995', 'https://openalex.org/W2041625089', 'https://openalex.org/W2051695140', 'https://openalex.org/W2056264634', 'https://openalex.org/W2062646486', 'https://openalex.org/W2064502414', 'https://openalex.org/W2072614621', 'https://openalex.org/W2076503522', 'https://openalex.org/W2079641121', 'https://openalex.org/W2099572184', 'https://openalex.org/W2106163599', 'https://openalex.org/W2117267802', 'https://openalex.org/W2151531122', 'https://openalex.org/W2169907463', 'https://openalex.org/W2278971704', 'https://openalex.org/W2333164646', 'https://openalex.org/W2500572885', 'https://openalex.org/W4231938391', 'https://openalex.org/W4236182608', 'https://openalex.org/W76561018', 'https://openalex.org/W97035578'], 'related_works': ['https://openalex.org/W2537749074', 'https://openalex.org/W2473729498', 'https://openalex.org/W2368940306', 'https://openalex.org/W2366206075', 'https://openalex.org/W2352055696', 'https://openalex.org/W2186559937', 'https://openalex.org/W2061946546', 'https://openalex.org/W2060602897', 'https://openalex.org/W2013018052', 'https://openalex.org/W1988043557'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2333536181', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-13T12:15:34.224909', 'created_date': '2016-06-24'}