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'https://openalex.org/W1894641937', 'https://openalex.org/W1982002509', 'https://openalex.org/W1989849817', 'https://openalex.org/W1994341785', 'https://openalex.org/W2008357215', 'https://openalex.org/W2026578950', 'https://openalex.org/W2029047604', 'https://openalex.org/W2034185792', 'https://openalex.org/W2049583947', 'https://openalex.org/W2057857734', 'https://openalex.org/W2099182146', 'https://openalex.org/W2171246715', 'https://openalex.org/W2414406028', 'https://openalex.org/W637937615'], 'related_works': ['https://openalex.org/W269202733', 'https://openalex.org/W2166259620', 'https://openalex.org/W2144899041', 'https://openalex.org/W2101846726', 'https://openalex.org/W2073189641', 'https://openalex.org/W2021791231', 'https://openalex.org/W2020521634', 'https://openalex.org/W1993223505', 'https://openalex.org/W1963544682', 'https://openalex.org/W196351422'], 'abstract_inverted_index': {'大腸癌症例82例(Dukes': [0], 'A:23例,': [1], 'Dukes': [2, 4, 6], 'B:19例,': [3], 'C:33例,': [5], 'D:7例)を対象に,EGF血清学的測定と組織EGF染色を行い,大腸癌のautocrine': [7], 'mechanismによる自律性増殖の可能性を探り,血清EGF値が大腸癌進展度の予測因子となり得るか,その臨床的意義を検討した.大腸癌術前血清EGF値は,対照群と比べ有意に高値であり,癌の進行とともに高値を示した.また免疫組織染色においてもEGF発現は癌の進行とともに高発現となり,陽性症例は進展度が強い傾向を認めた.さらにEGF血清学的測定と組織EGF染色の検討より,大腸癌により発現したEGFは血中に移行すると考えられ,免疫染色にてEGF陽性大腸癌は,血清値300pg/ml以上で多い傾向にあった.予後は,血清EGF値300pg/ml以上の症例は300pg/ml未満の症例よりも,免疫染色陽性症例は陰性症例よりも有意に予後が悪かった.このことから血清EGF値が300pg/ml以上の症例は進展度が強く,術前血清EGF値を測定することは,術前からの進展度評価につながると思われた.': [8]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2333507068', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-19T14:04:14.130654', 'created_date': '2016-06-24'}