Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2332439340', 'doi': 'https://doi.org/10.1021/jm500941m', 'title': 'Natural Products in Medicine: Transformational Outcome of Synthetic Chemistry', 'display_name': 'Natural Products in Medicine: Transformational Outcome of Synthetic Chemistry', 'publication_year': 2014, 'publication_date': '2014-09-10', 'ids': {'openalex': 'https://openalex.org/W2332439340', 'doi': 'https://doi.org/10.1021/jm500941m', 'mag': '2332439340', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25144261'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm500941m', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061801707', 'display_name': 'Janek Szychowski', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210156899', 'display_name': 'Vertex Pharmaceuticals (Canada)', 'ror': 'https://ror.org/05a8pa318', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210156899', 'https://openalex.org/I61970326']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Janek Szychowski', 'raw_affiliation_strings': ['Vertex Pharmaceuticals (Canada), Inc., 275 Armand-Frappier, Laval, Québec H7V 4A7, Canada'], 'affiliations': [{'raw_affiliation_string': 'Vertex Pharmaceuticals (Canada), Inc., 275 Armand-Frappier, Laval, Québec H7V 4A7, Canada', 'institution_ids': ['https://openalex.org/I4210156899']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012570845', 'display_name': 'Jean‐François Truchon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210156899', 'display_name': 'Vertex Pharmaceuticals (Canada)', 'ror': 'https://ror.org/05a8pa318', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210156899', 'https://openalex.org/I61970326']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Jean-François Truchon', 'raw_affiliation_strings': ['Vertex Pharmaceuticals (Canada), Inc., 275 Armand-Frappier, Laval, Québec H7V 4A7, Canada'], 'affiliations': [{'raw_affiliation_string': 'Vertex Pharmaceuticals (Canada), Inc., 275 Armand-Frappier, Laval, Québec H7V 4A7, Canada', 'institution_ids': ['https://openalex.org/I4210156899']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062267873', 'display_name': 'Youssef L. Bennani', 'orcid': 'https://orcid.org/0000-0003-4748-3268'}, 'institutions': [{'id': 'https://openalex.org/I4210156899', 'display_name': 'Vertex Pharmaceuticals (Canada)', 'ror': 'https://ror.org/05a8pa318', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210156899', 'https://openalex.org/I61970326']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Youssef L. Bennani', 'raw_affiliation_strings': ['Vertex Pharmaceuticals (Canada), Inc., 275 Armand-Frappier, Laval, Québec H7V 4A7, Canada'], 'affiliations': [{'raw_affiliation_string': 'Vertex Pharmaceuticals (Canada), Inc., 275 Armand-Frappier, Laval, Québec H7V 4A7, Canada', 'institution_ids': ['https://openalex.org/I4210156899']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.322, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 83, 'citation_normalized_percentile': {'value': 0.666983, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '57', 'issue': '22', 'first_page': '9292', 'last_page': '9308'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10252', 'display_name': 'Natural Products as Sources of New Drugs', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10252', 'display_name': 'Natural Products as Sources of New Drugs', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11752', 'display_name': 'Chemotherapy-Induced Peripheral Neuropathy in Cancer Treatment', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11340', 'display_name': 'Sponge-Associated Microorganisms and Biotechnological Potential', 'score': 0.9934, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/natural-products', 'display_name': 'Natural Products', 'score': 0.530005}, {'id': 'https://openalex.org/keywords/metabolic-stability', 'display_name': 'Metabolic stability', 'score': 0.47784588}, {'id': 'https://openalex.org/keywords/natural-product', 'display_name': 'Natural product', 'score': 0.43264338}], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.79651046}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.5040916}, {'id': 'https://openalex.org/C183696295', 'wikidata': 'https://www.wikidata.org/wiki/Q2487696', 'display_name': 'Biochemical engineering', 'level': 1, 'score': 0.4858515}, {'id': 'https://openalex.org/C2991874392', 'wikidata': 'https://www.wikidata.org/wiki/Q1124842', 'display_name': 'Metabolic stability', 'level': 3, 'score': 0.47784588}, {'id': 'https://openalex.org/C74187038', 'wikidata': 'https://www.wikidata.org/wiki/Q1418791', 'display_name': 'Drug discovery', 'level': 2, 'score': 0.45992526}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.4334643}, {'id': 'https://openalex.org/C2779396153', 'wikidata': 'https://www.wikidata.org/wiki/Q901227', 'display_name': 'Natural product', 'level': 2, 'score': 0.43264338}, {'id': 'https://openalex.org/C171250308', 'wikidata': 'https://www.wikidata.org/wiki/Q11468', 'display_name': 'Nanotechnology', 'level': 1, 'score': 0.41442388}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.40262997}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.32608637}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.16535807}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12745598}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.107426554}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.07882702}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000701', 'descriptor_name': 'Analgesics, Opioid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000701', 'descriptor_name': 'Analgesics, Opioid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060326', 'descriptor_name': 'Chemistry Techniques, Synthetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055808', 'descriptor_name': 'Drug Discovery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018942', 'descriptor_name': 'Macrolides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018942', 'descriptor_name': 'Macrolides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D012995', 'descriptor_name': 'Solubility', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012997', 'descriptor_name': 'Solvents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013256', 'descriptor_name': 'Steroids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013256', 'descriptor_name': 'Steroids', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043823', 'descriptor_name': 'Taxoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043823', 'descriptor_name': 'Taxoids', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm500941m', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25144261', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.54, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 151, 'referenced_works': ['https://openalex.org/W102942568', 'https://openalex.org/W122784847', 'https://openalex.org/W132204', 'https://openalex.org/W14069750', 'https://openalex.org/W1480098000', 'https://openalex.org/W1500847299', 'https://openalex.org/W1519761207', 'https://openalex.org/W1545486630', 'https://openalex.org/W1546736698', 'https://openalex.org/W1546988495', 'https://openalex.org/W155317839', 'https://openalex.org/W1569017728', 'https://openalex.org/W1773752366', 'https://openalex.org/W1853524990', 'https://openalex.org/W1885786785', 'https://openalex.org/W1893825468', 'https://openalex.org/W190517501', 'https://openalex.org/W1907321242', 'https://openalex.org/W1939955036', 'https://openalex.org/W1966316733', 'https://openalex.org/W1967212924', 'https://openalex.org/W1972770043', 'https://openalex.org/W1976239857', 'https://openalex.org/W1977105806', 'https://openalex.org/W1978485989', 'https://openalex.org/W1978973541', 'https://openalex.org/W1983351797', 'https://openalex.org/W1986142951', 'https://openalex.org/W1988219803', 'https://openalex.org/W1992103956', 'https://openalex.org/W1992553452', 'https://openalex.org/W1992716708', 'https://openalex.org/W1993862445', 'https://openalex.org/W1995197723', 'https://openalex.org/W1996061414', 'https://openalex.org/W1997479221', 'https://openalex.org/W1997592404', 'https://openalex.org/W2006187126', 'https://openalex.org/W2010734528', 'https://openalex.org/W2011145513', 'https://openalex.org/W2012128092', 'https://openalex.org/W2013030981', 'https://openalex.org/W2017640872', 'https://openalex.org/W2022850278', 'https://openalex.org/W2024843373', 'https://openalex.org/W2024930414', 'https://openalex.org/W2025662936', 'https://openalex.org/W2027452609', 'https://openalex.org/W2027740621', 'https://openalex.org/W2027828676', 'https://openalex.org/W2031167955', 'https://openalex.org/W2033480003', 'https://openalex.org/W2034599708', 'https://openalex.org/W2034650535', 'https://openalex.org/W2037490361', 'https://openalex.org/W2042721486', 'https://openalex.org/W2047213008', 'https://openalex.org/W2049004196', 'https://openalex.org/W2052941480', 'https://openalex.org/W2053770173', 'https://openalex.org/W2054423951', 'https://openalex.org/W2055305943', 'https://openalex.org/W2056438721', 'https://openalex.org/W2057100665', 'https://openalex.org/W2060050979', 'https://openalex.org/W2062153657', 'https://openalex.org/W2063539450', 'https://openalex.org/W2066982995', 'https://openalex.org/W2070116427', 'https://openalex.org/W2071307134', 'https://openalex.org/W2071698131', 'https://openalex.org/W2073369590', 'https://openalex.org/W2073533584', 'https://openalex.org/W2073836271', 'https://openalex.org/W2075556908', 'https://openalex.org/W2077670274', 'https://openalex.org/W2078145018', 'https://openalex.org/W2080960938', 'https://openalex.org/W2082030213', 'https://openalex.org/W2082806762', 'https://openalex.org/W2083725367', 'https://openalex.org/W2086256204', 'https://openalex.org/W2087112245', 'https://openalex.org/W2087838477', 'https://openalex.org/W2089078508', 'https://openalex.org/W2093190222', 'https://openalex.org/W2093649670', 'https://openalex.org/W2094768455', 'https://openalex.org/W2096095251', 'https://openalex.org/W2098184601', 'https://openalex.org/W2100458911', 'https://openalex.org/W2102739518', 'https://openalex.org/W2107841008', 'https://openalex.org/W2109918049', 'https://openalex.org/W2111115182', 'https://openalex.org/W2112637801', 'https://openalex.org/W2114731556', 'https://openalex.org/W2119666961', 'https://openalex.org/W2119966574', 'https://openalex.org/W2124038924', 'https://openalex.org/W2124304530', 'https://openalex.org/W2125149319', 'https://openalex.org/W2126662293', 'https://openalex.org/W2129585918', 'https://openalex.org/W2131290017', 'https://openalex.org/W2133142423', 'https://openalex.org/W2135957877', 'https://openalex.org/W2142376954', 'https://openalex.org/W2147177606', 'https://openalex.org/W2150691073', 'https://openalex.org/W2154094988', 'https://openalex.org/W2158749015', 'https://openalex.org/W2159348270', 'https://openalex.org/W2163279482', 'https://openalex.org/W2167141095', 'https://openalex.org/W2167223040', 'https://openalex.org/W2170243611', 'https://openalex.org/W2171498933', 'https://openalex.org/W2172095238', 'https://openalex.org/W2188872902', 'https://openalex.org/W2241911645', 'https://openalex.org/W2286346607', 'https://openalex.org/W2317591885', 'https://openalex.org/W2317596416', 'https://openalex.org/W2318434110', 'https://openalex.org/W2321544728', 'https://openalex.org/W2323469046', 'https://openalex.org/W2330208171', 'https://openalex.org/W2331212599', 'https://openalex.org/W2410728832', 'https://openalex.org/W2510236000', 'https://openalex.org/W2514404994', 'https://openalex.org/W2517054293', 'https://openalex.org/W2620176919', 'https://openalex.org/W269196495', 'https://openalex.org/W2864975895', 'https://openalex.org/W2917702355', 'https://openalex.org/W2952850141', 'https://openalex.org/W2993308727', 'https://openalex.org/W3146908657', 'https://openalex.org/W4233628679', 'https://openalex.org/W4240354991', 'https://openalex.org/W424467158', 'https://openalex.org/W4246680660', 'https://openalex.org/W4248107770', 'https://openalex.org/W4285719527', 'https://openalex.org/W66836368', 'https://openalex.org/W67879530', 'https://openalex.org/W79955725', 'https://openalex.org/W80197466', 'https://openalex.org/W98654885'], 'related_works': ['https://openalex.org/W4388019188', 'https://openalex.org/W4367601179', 'https://openalex.org/W4327862425', 'https://openalex.org/W3201311513', 'https://openalex.org/W2904244272', 'https://openalex.org/W2807319911', 'https://openalex.org/W2765570325', 'https://openalex.org/W2584285938', 'https://openalex.org/W2325550854', 'https://openalex.org/W2127597456'], 'abstract_inverted_index': {'This': [0], 'review': [1], 'brings': [2], 'to': [3, 56, 114], 'the': [4, 23, 31, 78, 85, 101, 123], 'forefront': [5], 'key': [6], 'synthetic': [7, 94, 126], 'modifications': [8, 127], 'on': [9, 22], 'natural': [10], 'products': [11], '(NPs)': [12], 'that': [13, 122], 'have': [14], 'yielded': [15], 'successful': [16], 'drugs.': [17], 'The': [18], 'emphasis': [19], 'is': [20], 'placed': [21], 'power': [24], 'of': [25, 34, 38, 46, 60, 74, 84, 103], 'targeted': [26], 'chemical': [27], 'transformations': [28], 'in': [29, 81, 93, 96, 100, 135], 'enhancing': [30], 'therapeutic': [32, 82], 'value': [33, 83], 'NPs': [35, 47, 87, 116, 125, 136], 'through': [36], 'optimization': [37], 'pharmacokinetics,': [39], 'stability,': [40], 'potency,': [41], 'and/or': [42], 'selectivity.': [43], 'Multiple': [44], 'classes': [45], 'such': [48, 62], 'as': [49, 63, 117], 'macrolides,': [50], 'opioids,': [51], 'steroids,': [52], 'and': [53, 99, 137], 'β-lactams': [54], 'used': [55], 'treat': [57], 'a': [58], 'variety': [59], 'conditions': [61], 'cancers,': [64], 'infections,': [65], 'inflammation': [66], 'are': [67, 88], 'exemplified.': [68], 'Molecular': [69], 'modeling': [70], 'or': [71], 'X-ray': [72], 'structures': [73], 'NP/protein': [75], 'complexes': [76], 'supporting': [77], 'observed': [79], 'boost': [80], 'modified': [86], 'also': [89], 'discussed.': [90], 'Significant': [91], 'advancement': [92], 'chemistry,': [95], 'structure': [97], 'determination,': [98], 'understanding': [102], 'factors': [104], 'controlling': [105], 'pharmacokinetics': [106], 'can': [107], 'now': [108], 'better': [109], 'position': [110], 'drug': [111], 'discovery': [112], 'teams': [113], 'undertake': [115], 'valuable': [118], 'leads.': [119], 'We': [120], 'hope': [121], 'beneficial': [124], 'outlined': [128], 'here': [129], 'will': [130], 'reignite': [131], 'medicinal': [132], "chemists'": [133], 'interest': [134], 'their': [138], 'derivatives.': [139]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2332439340', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 19}, {'year': 2015, 'cited_by_count': 16}], 'updated_date': '2024-09-15T19:53:36.759348', 'created_date': '2016-06-24'}