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'高度の嘔気': [14], '(grade3)': [15, 22], 'を訴えたために6日間で内服中止としたが,': [16], '重篤な白血球減少': [17], '(grade4),': [18], '血小板減少': [19], '(grade3),': [20], '粘膜障害': [21], 'が出現し,': [23], '内服開始日から28日後に多臓器不全で死亡した.': [24], '尿中Uracil': [25], '593.0μmol/g・cre': [26], 'に対してdihydrouracil': [27], 'は2.1μmol/g・creであり,': [28], 'dihy-drouracil/uracil比0.004': [29], '(基準値:': [30], '0.23~0.67)': [31], 'と著しく低値であること,': [32], '末梢血単核球dihydro-pyrimidine': [33], 'dehydrogenase': [34], '(以下,': [35], 'DPD)': [36], '活性値が感度以下であったことからDPD欠損症と診断した.': [37], '本邦においてDPD欠損症はわずか6例の報告があるのみで非常にまれである.': [38], 'しかし,': [39], '重篤な有害事象を招く恐れがあるため,': [40], 'DPD活性低下が疑われた場合はただちに投薬を中止し,': [41], '速やかに支持療法を開始する必要がある.': [42]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2331160204', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-09-15T07:59:33.724961', 'created_date': '2016-06-24'}