Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2329428880', 'doi': 'https://doi.org/10.1136/heartjnl-2013-305297.5', 'title': '5 Catalase Inhibition Augments Reactive Oxygen Species Production in Isolated Ventricular Myocytes', 'display_name': '5 Catalase Inhibition Augments Reactive Oxygen Species Production in Isolated Ventricular Myocytes', 'publication_year': 2014, 'publication_date': '2014-01-01', 'ids': {'openalex': 'https://openalex.org/W2329428880', 'doi': 'https://doi.org/10.1136/heartjnl-2013-305297.5', 'mag': '2329428880'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1136/heartjnl-2013-305297.5', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S191565391', 'display_name': 'Heart', 'issn_l': '1355-6037', 'issn': ['1355-6037', '1468-201X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5057122935', 'display_name': 'Sophie Boles', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210132465', 'display_name': 'NIHR Bristol Cardiovascular Biomedical Research Unit', 'ror': 'https://ror.org/03gna4510', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I34931013', 'https://openalex.org/I4210132465']}, {'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'S Boles', 'raw_affiliation_strings': ['Bristol Heart Institute and School of Physiology and Pharmacology, University of Bristol, Bristol, UK'], 'affiliations': [{'raw_affiliation_string': 'Bristol Heart Institute and School of Physiology and Pharmacology, University of Bristol, Bristol, UK', 'institution_ids': ['https://openalex.org/I4210132465', 'https://openalex.org/I36234482']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003325753', 'display_name': 'Anna Polak', 'orcid': 'https://orcid.org/0000-0001-8686-3429'}, 'institutions': [{'id': 'https://openalex.org/I4210132465', 'display_name': 'NIHR Bristol Cardiovascular Biomedical Research Unit', 'ror': 'https://ror.org/03gna4510', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I34931013', 'https://openalex.org/I4210132465']}, {'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'A Polak', 'raw_affiliation_strings': ['Bristol Heart Institute and School of Physiology and Pharmacology, University of Bristol, Bristol, UK'], 'affiliations': [{'raw_affiliation_string': 'Bristol Heart Institute and School of Physiology and Pharmacology, University of Bristol, Bristol, UK', 'institution_ids': ['https://openalex.org/I4210132465', 'https://openalex.org/I36234482']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019200149', 'display_name': 'Ben Littlejohns', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210132465', 'display_name': 'NIHR Bristol Cardiovascular Biomedical Research Unit', 'ror': 'https://ror.org/03gna4510', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I34931013', 'https://openalex.org/I4210132465']}, {'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'B Littlejohns', 'raw_affiliation_strings': ['Bristol Heart Institute and School of Physiology and Pharmacology, University of Bristol, Bristol, UK'], 'affiliations': [{'raw_affiliation_string': 'Bristol Heart Institute and School of Physiology and Pharmacology, University of Bristol, Bristol, UK', 'institution_ids': ['https://openalex.org/I4210132465', 'https://openalex.org/I36234482']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021007344', 'display_name': 'Hua Lin', 'orcid': 'https://orcid.org/0000-0002-8795-1997'}, 'institutions': [{'id': 'https://openalex.org/I4210132465', 'display_name': 'NIHR Bristol Cardiovascular Biomedical Research Unit', 'ror': 'https://ror.org/03gna4510', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I34931013', 'https://openalex.org/I4210132465']}, {'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'H Lin', 'raw_affiliation_strings': ['Bristol Heart Institute and School of Physiology and Pharmacology, University of Bristol, Bristol, UK'], 'affiliations': [{'raw_affiliation_string': 'Bristol Heart Institute and School of Physiology and Pharmacology, University of Bristol, Bristol, UK', 'institution_ids': ['https://openalex.org/I4210132465', 'https://openalex.org/I36234482']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062819756', 'display_name': 'M.Saadeh Suleiman', 'orcid': 'https://orcid.org/0000-0001-6080-480X'}, 'institutions': [{'id': 'https://openalex.org/I4210132465', 'display_name': 'NIHR Bristol Cardiovascular Biomedical Research Unit', 'ror': 'https://ror.org/03gna4510', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I34931013', 'https://openalex.org/I4210132465']}, {'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'M S Suleiman', 'raw_affiliation_strings': ['Bristol Heart Institute and School of Physiology and Pharmacology, University of Bristol, Bristol, UK'], 'affiliations': [{'raw_affiliation_string': 'Bristol Heart Institute and School of Physiology and Pharmacology, University of Bristol, Bristol, UK', 'institution_ids': ['https://openalex.org/I4210132465', 'https://openalex.org/I36234482']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.163, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.343594, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 66, 'max': 73}, 'biblio': {'volume': '100', 'issue': 'Suppl 1', 'first_page': 'A3.1', 'last_page': 'A3'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11434', 'display_name': 'Electrochemical Analysis and Applications', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1603', 'display_name': 'Electrochemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11434', 'display_name': 'Electrochemical Analysis and Applications', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1603', 'display_name': 'Electrochemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12381', 'display_name': 'Electron Spin Resonance Studies', 'score': 0.9732, 'subfield': {'id': 'https://openalex.org/subfields/1304', 'display_name': 'Biophysics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dichlorofluorescein', 'display_name': 'Dichlorofluorescein', 'score': 0.7436286}], 'concepts': [{'id': 'https://openalex.org/C2778979269', 'wikidata': 'https://www.wikidata.org/wiki/Q106951292', 'display_name': 'Catalase', 'level': 3, 'score': 0.95671463}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.8842092}, {'id': 'https://openalex.org/C2779964046', 'wikidata': 'https://www.wikidata.org/wiki/Q209286', 'display_name': 'Dichlorofluorescein', 'level': 3, 'score': 0.7436286}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.6988267}, {'id': 'https://openalex.org/C207200792', 'wikidata': 'https://www.wikidata.org/wiki/Q428914', 'display_name': 'Myocyte', 'level': 2, 'score': 0.60774684}, {'id': 'https://openalex.org/C16613235', 'wikidata': 'https://www.wikidata.org/wiki/Q285982', 'display_name': 'Endogeny', 'level': 2, 'score': 0.5999787}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.46733248}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.39033103}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3528348}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.34902054}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.33540314}, {'id': 'https://openalex.org/C16685009', 'wikidata': 'https://www.wikidata.org/wiki/Q335057', 'display_name': 'Andrology', 'level': 1, 'score': 0.32610774}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.2744059}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1136/heartjnl-2013-305297.5', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S191565391', 'display_name': 'Heart', 'issn_l': '1355-6037', 'issn': ['1355-6037', '1468-201X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15', 'score': 0.4}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W76704356', 'https://openalex.org/W3185005104', 'https://openalex.org/W2471941216', 'https://openalex.org/W2329428880', 'https://openalex.org/W2086275695', 'https://openalex.org/W2021835840', 'https://openalex.org/W1973240521', 'https://openalex.org/W1967629452', 'https://openalex.org/W1857445414', 'https://openalex.org/W1533341901'], 'abstract_inverted_index': {'<h3></h3>': [0], 'Myocardial': [1], 'damage': [2], 'during': [3, 72, 252], 'ischaemia-reperfusion': [4, 41], 'is': [5, 249], 'partly': [6], 'mediated': [7], 'by': [8, 75, 119, 125], 'the': [9, 61, 77, 99, 121, 139, 161, 181, 205, 221, 235], 'accelerated': [10], 'production': [11, 112], 'of': [12, 63, 103, 106, 149, 180, 207, 238, 246, 254], 'reactive': [13], 'oxygen': [14], 'species': [15], '(ROS).': [16], 'Under': [17], 'physiological': [18], 'conditions,': [19], 'antioxidants,': [20], 'such': [21], 'as': [22], 'catalase,': [23], 'regulate': [24], 'ROS': [25, 68, 111, 140, 162, 183, 208, 222, 247], 'levels.': [26], 'The': [27, 110], 'capacity': [28], 'for': [29], 'elevated': [30], 'catalase': [31, 54, 65, 78, 199, 240], 'levels': [32, 209, 228, 237], 'to': [33, 37, 40, 187, 204], 'offer': [34], 'cardio-protective': [35], 'benefits': [36], 'hearts': [38], 'exposed': [39], 'has': [42, 200], 'been': [43], 'demonstrated': [44], 'previously.': [45], 'However,': [46, 146, 214], 'no': [47], 'studies': [48], 'thus': [49], 'far': [50], 'have': [51], 'selectively': [52], 'inhibited': [53], 'in': [55, 66, 98, 114, 156, 160, 177, 210, 219, 242], 'isolated': [56, 84], 'cardiomyocytes,': [57, 243], 'This': [58, 168, 194], 'study': [59, 195], 'investigated': [60], 'importance': [62], 'endogenous': [64, 198, 239], 'regulating': [67], 'generation': [69, 141, 163, 184, 223, 248], 'basally': [70], 'and': [71], 'oxidative': [73, 256], 'stress': [74], 'using': [76, 128], 'inhibitor,': [79], '3-amino-1,2,4-triazole': [80], '(3-AT).': [81], 'Cardiomyocytes': [82], 'were': [83, 90], 'from': [85], 'adult': [86], 'rat': [87], 'hearts.': [88], 'Cells': [89], 'loaded': [91], 'with': [92, 134, 171], '5-(and-6)-chloromethyl-2’,7’-dichlorodihydrofluorescein': [93], 'diacetate': [94], 'acetyl': [95], 'ester': [96], '(CM-H2DCFDA)': [97], 'presence': [100], 'or': [101], 'absence': [102], 'different': [104], 'concentrations': [105], '3-AT': [107, 135, 153, 190], '(0–40': [108], 'mM).': [109], 'rate': [113, 142, 164, 185, 224], 'quiescent': [115], 'cardiomyocytes': [116], 'was': [117], 'estimated': [118], 'measuring': [120], 'fluorescence': [122, 130], 'signal': [123], 'emitted': [124], '5-(and': [126], '6)-chloromethyl-2′,7′-dichlorofluorescein,': [127], 'a': [129, 157, 178, 201], 'plate': [131], 'reader.': [132], 'Incubation': [133], 'did': [136], 'not': [137], 'affect': [138], 'under': [143], 'basal': [144], 'conditions.': [145], 'upon': [147], 'addition': [148], '10': [150], 'mM': [151, 173, 189], 'H<sub>2</sub>O<sub>2</sub>,': [152], 'administration': [154], 'resulted': [155, 176], 'dose-dependent': [158], 'increase': [159, 169], '(P': [165, 191], '<': [166, 192], '0.0001).': [167], 'plateaued': [170], '20': [172], '3-AT,': [174], 'which': [175], 'near-tripling': [179], 'mean': [182], 'compared': [186], '0': [188], '0.01).': [193], 'demonstrates': [196], 'that': [197], 'limited': [202], 'contribution': [203], 'regulation': [206, 245], 'resting,': [211], 'unstressed': [212], 'cardiomyocytes.': [213], 'its': [215, 244], 'activity': [216], 'appears': [217], 'important': [218, 251], 'reducing': [220], 'when': [225], 'intracellular': [226], 'H<sub>2</sub>O<sub>2</sub>': [227], 'are': [229], 'elevated.': [230], 'We': [231], 'conclude': [232], 'that,': [233], 'despite': [234], 'low': [236], 'present': [241], 'very': [250], 'conditions': [253], 'significant': [255], 'stress.': [257]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2329428880', 'counts_by_year': [{'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-15T02:23:06.196557', 'created_date': '2016-06-24'}