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[2], 'are': [3, 23], 'the': [4, 18, 36, 44, 112, 135, 149, 173, 182, 189], 'most': [5], 'common': [6], 'benign': [7], 'tumours': [8], 'in': [9, 52, 109, 117, 148, 188], 'women,': [10], 'which': [11], 'arise': [12], 'from': [13], 'smooth': [14], 'muscle': [15], 'cells': [16, 187], 'of': [17, 26, 38, 47, 62, 114, 121, 137, 160, 175, 184, 191], 'uterine': [19, 161], 'myometrium': [20], 'and': [21, 55, 68, 85, 88, 139, 177, 181], 'usually': [22], 'multicentric.In': [24], 'spite': [25], 'their': [27], 'frequency': [28], 'pathogenesis': [29], 'is': [30], 'widely': [31], 'unknown,': [32], 'mainly': [33], 'due': [34], 'to': [35, 125, 144, 194], 'absence': [37], 'a': [39, 118], 'suitable': [40], 'model': [41, 170], 'system.We': [42], 'describe': [43], 'systematic': [45], 'optimization': [46], 'culturing': [48, 96, 157], 'leiomyoma': [49, 162], 'tissue': [50, 98, 130, 158, 168], 'explants': [51, 99, 159], 'an': [53, 104], 'economical': [54], 'effective': [56], 'ex': [57], 'vivo': [58], 'system.Methods:': [59], 'Different': [60], 'concentrations': [61], 'oxygen,': [63], 'different': [64], 'media,': [65], 'sera,': [66], 'hormones,': [67], 'growth': [69, 141], 'factor': [70, 142], 'supplements': [71], 'were': [72, 91, 100, 165], 'tested.Immunohistochemical': [73], 'stainings': [74], 'with': [75, 111], 'antibodies': [76], 'against': [77], 'hormone': [78], 'receptors': [79], 'as': [80, 82, 132, 134], 'well': [81, 133], 'specifying': [83], 'proliferation': [84], 'apoptotic': [86], 'indices': [87], 'real-time': [89], 'PCR': [90], 'performed.Results:': [92], 'Main': [93], 'parameters': [94], 'for': [95, 102, 128, 198], 'myoma': [97], 'tested': [101], 'finding': [103], 'optimal': [105, 127], 'protocol.Standard': [106], 'medium': [107], 'D-MEM-F12': [108], 'combination': [110], 'use': [113], 'horse': [115], 'serum': [116], 'reduced': [119], 'concentration': [120], '1%': [122], 'turned': [123], 'out': [124], 'be': [126], 'these': [129], 'cultures': [131], 'addition': [136], 'estradiol': [138], 'epidermal': [140], 'EGF': [143], 'media.Reduced': [145], 'oxygen': [146], 'content': [147], 'incubator': [150], 'air': [151], 'showed': [152], 'no': [153], 'positive': [154], 'effect.Conclusions:': [155], 'For': [156], 'several': [163], 'conditions': [164], 'optimized.The': [166], 'established': [167], 'culture': [169], 'allows': [171], 'examining': [172], 'effects': [174], 'known': [176], 'potential': [178], 'therapeutic': [179], 'substances': [180], 'influence': [183], 'immune': [185], 'competent': [186], 'process': [190], 'tumour': [192], 'formation': [193], 'find': [195], 'new': [196], 'targets': [197], 'medical': [199], 'treatment.': [200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2328895733', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-08-26T17:07:49.057507', 'created_date': '2016-06-24'}