Title: Kinetics of Inhibition by Acetazolamide and Sulfanilamide of Bicarbonate Dehydration Catalyzed by Bovine Carbonic Anhydrase.
Abstract:The kinetics of inhibition by acetazolamide and sulfanilamide of the formation of carbon dioxide from bicarbonate, catalyzed by partially purified carbonic an-hydrase preparations from bovine erythroc...The kinetics of inhibition by acetazolamide and sulfanilamide of the formation of carbon dioxide from bicarbonate, catalyzed by partially purified carbonic an-hydrase preparations from bovine erythrocytes, were those of competitive inhibition. This is contrasted with the non-competitive kinetics of sulfonamide inhibition of a number of carbonic anhydrase-mediated hydration reactions. K1 for acetazolamide was 8.6 × 10-8 M while that for sulfanilamide was 1.8 × 10-5 M; these values are similar to those reported for inhibition of CO2 hydration in the presence of bovine erythrocyte enzyme.Read More
Publication Year: 1967
Publication Date: 1967-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 8
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