Publication Information

{'id': 'https://openalex.org/W2327960937', 'doi': 'https://doi.org/10.3389/conf.neuro.03.2009.17.043', 'title': 'Mitochondrial sirtuin sirt3: a novel cytoprotective factor?', 'display_name': 'Mitochondrial sirtuin sirt3: a novel cytoprotective factor?', 'publication_year': 2009, 'publication_date': '2009-01-01', 'ids': {'openalex': 'https://openalex.org/W2327960937', 'doi': 'https://doi.org/10.3389/conf.neuro.03.2009.17.043', 'mag': '2327960937'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/conf.neuro.03.2009.17.043', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S115201632', 'display_name': 'Frontiers in Neuroscience', 'issn_l': '1662-453X', 'issn': ['1662-453X', '1662-4548'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.3389/conf.neuro.03.2009.17.043', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5088839047', 'display_name': 'James H. Eubanks', 'orcid': 'https://orcid.org/0000-0001-8595-2024'}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Eubanks James', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5088839047'], 'corresponding_institution_ids': [], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 64}, 'biblio': {'volume': '3', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11051', 'display_name': 'Sirtuins and Resveratrol in Medicine', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11051', 'display_name': 'Sirtuins and Resveratrol in Medicine', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11411', 'display_name': 'Tea Polyphenols and Effects', 'score': 0.9799, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9568, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sirt3', 'display_name': 'SIRT3', 'score': 0.9892709}, {'id': 'https://openalex.org/keywords/mitochondrial-ros', 'display_name': 'Mitochondrial ROS', 'score': 0.4189706}], 'concepts': [{'id': 'https://openalex.org/C138488276', 'wikidata': 'https://www.wikidata.org/wiki/Q18037158', 'display_name': 'SIRT3', 'level': 5, 'score': 0.9892709}, {'id': 'https://openalex.org/C2780561631', 'wikidata': 'https://www.wikidata.org/wiki/Q421331', 'display_name': 'Sirtuin', 'level': 4, 'score': 0.9546267}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.62000483}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6081069}, {'id': 'https://openalex.org/C2776759703', 'wikidata': 'https://www.wikidata.org/wiki/Q1066907', 'display_name': 'Longevity', 'level': 2, 'score': 0.57821095}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5097789}, {'id': 'https://openalex.org/C2778175917', 'wikidata': 'https://www.wikidata.org/wiki/Q17125553', 'display_name': 'Mitochondrial ROS', 'level': 3, 'score': 0.4189706}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.34127715}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.29859823}, {'id': 'https://openalex.org/C119157956', 'wikidata': 'https://www.wikidata.org/wiki/Q796604', 'display_name': 'Acetylation', 'level': 3, 'score': 0.07659605}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/conf.neuro.03.2009.17.043', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S115201632', 'display_name': 'Frontiers in Neuroscience', 'issn_l': '1662-453X', 'issn': ['1662-453X', '1662-4548'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/conf.neuro.03.2009.17.043', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S115201632', 'display_name': 'Frontiers in Neuroscience', 'issn_l': '1662-453X', 'issn': ['1662-453X', '1662-4548'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/12', 'display_name': 'Responsible consumption and production', 'score': 0.43}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4306154087', 'https://openalex.org/W3176207652', 'https://openalex.org/W3030507612', 'https://openalex.org/W2750260074', 'https://openalex.org/W2544727711', 'https://openalex.org/W2416620290', 'https://openalex.org/W2385595320', 'https://openalex.org/W2384152305', 'https://openalex.org/W2327960937', 'https://openalex.org/W1980114602'], 'abstract_inverted_index': {'Event': [0, 4], 'Abstract': [1, 574, 576, 616], 'Back': [2, 618], 'to': [3, 73, 76, 120, 139, 156, 224, 292, 433, 458, 560, 619, 633], 'Mitochondrial': [5, 403], 'sirtuin': [6, 404], 'sirt3:': [7, 405], 'a': [8, 42, 93, 106, 131, 134, 149, 180, 279, 293, 362, 406, 456, 495], 'novel': [9, 407], 'cytoprotective': [10, 192, 202, 348, 408], 'factor?': [11], 'Elena': [12, 543, 581, 588, 596, 603], 'Sidorova1,': [13], '2*,': [14], 'D.': [15, 583, 590, 598, 605], 'Mutabdzic2': [16], 'and': [17, 37, 58, 99, 143, 169, 193, 238, 268, 307, 322, 350, 399, 440, 461, 503, 510, 520, 527, 565], 'James': [18, 585, 592, 600, 607], 'Eubanks1,': [19], '2': [20, 29], '1': [21], 'University': [22, 545], 'of': [23, 26, 35, 45, 55, 62, 108, 126, 133, 151, 186, 474, 490, 514, 546, 549], 'Toronto,': [24, 378, 547, 551], 'Department': [25, 548], 'Physiology,': [27, 550], 'Canada': [28, 39], 'Toronto': [30], 'Western': [31], 'Research': [32], 'Institute,': [33], 'Division': [34], 'Genetics': [36], 'Development,': [38], 'Ageing': [40], 'brings': [41], 'greater': [43], 'risk': [44], 'debilitating': [46], 'conditions,': [47], 'which': [48, 82, 220], 'often': [49], 'arise': [50], 'from': [51, 265], 'an': [52], 'overall': [53], 'reduction': [54], 'metabolic': [56], 'efficiency': [57], 'the': [59, 109, 114, 144, 152, 165, 240, 299, 355, 451, 466, 472, 488, 512, 518, 636], 'increased': [60], 'genesis': [61], 'reactive': [63], 'oxygen': [64], 'species': [65], '(ROS).': [66], 'Impaired': [67], 'mitochondrial': [68, 83, 217, 226], 'function': [69], 'has': [70, 221], 'been': [71, 222, 431], 'hypothesized': [72], 'contribute': [74], 'significantly': [75, 331], 'age-related': [77, 98], 'decline.': [78], 'Identifying': [79], 'means': [80], 'by': [81, 164, 174, 246, 444, 471], 'activity': [84, 161], 'can': [85], 'be': [86, 118, 361, 506, 511, 561], 'strengthened,': [87], 'and/or': [88], 'less': [89], 'ROS': [90, 236, 243], 'generated,': [91], 'is': [92, 130, 162, 172, 351, 469, 622], 'common': [94], 'theme': [95], 'in': [96, 148, 210, 242, 250, 281, 298, 314, 334, 354, 366, 373, 416, 426, 465, 579, 611, 627, 631], 'many': [97], 'research': [100], 'programs.': [101], 'Recent': [102], 'work': [103], 'suggests': [104], 'that': [105, 206, 232, 259, 305, 340, 344, 358], 'member': [107], 'Sirtuin': [110], 'protein': [111], 'family,': [112], 'namely': [113], 'Sirtuin,': [115], 'SIRT3,': [116], 'may': [117, 277, 360, 504], 'able': [119], 'directly': [121], 'or': [122, 438, 477, 570], 'indirectly': [123], 'influence': [124], 'both': [125, 266], 'these': [127], 'processes.': [128], 'SIRT3': [129, 145, 160, 188, 200, 208, 233, 262, 276, 306, 327, 345], 'descended': [132], 'yeast': [135], 'ancestral': [136], 'gene': [137, 146], 'known': [138, 155, 294], 'possess': [140, 191], 'longevity-enhancing': [141, 158, 175, 194], 'activity,': [142], 'resides': [147], 'region': [150], 'human': [153], 'genome': [154], 'contain': [157], 'genes.': [159], 'activated': [163], 'red': [166], 'wine': [167], 'resveratrol,': [168], 'its': [170, 290], 'expression': [171, 209, 291], 'induced': [173], 'diets.': [176], 'These': [177], 'observations': [178], 'provide': [179], 'strong': [181], 'rationale': [182], 'for': [183], 'further': [184], 'investigation': [185], 'whether': [187, 199, 275], 'does,': [189], 'indeed,': [190], 'potential.': [195], 'To': [196, 273, 568], 'begin': [197], 'addressing': [198], 'possesses': [201, 346], 'factors': [203], 'I': [204, 229, 255, 288], 'demonstrated': [205, 223], 'elevating': [207], 'cultured': [211, 251], 'cells': [212, 260], 'partially': [213], 'decreases': [214, 234], 'their': [215], 'resting': [216], 'membrane': [218], 'potential-': [219], 'improve': [225], 'efficiency.': [227], 'Additionally': [228], 'have': [230, 257, 429], 'shown': [231], 'basal': [235], 'levels,': [237], 'attenuates': [239], 'increase': [241], 'levels': [244, 310, 333], 'caused': [245], 'Glucose': [247], 'Deprivation': [248], '(GD)': [249], 'cell': [252], 'lines.': [253], 'Importantly,': [254], 'also': [256], 'found': [258], 'over-expressing': [261], 'are': [263, 311, 441, 447, 492, 522], 'protected': [264], 'GD': [267], 'Hydrogen': [269], 'Peroxide': [270], '(H2O2)': [271], 'challenges.': [272], 'investigate': [274], 'play': [278], 'role': [280], 'neuroprotection': [282], 'using': [283], 'quantitative': [284], 'real': [285], 'time': [286], 'PCR': [287], 'compared': [289], 'neuroprotective': [295, 364], 'sirtuin,': [296], 'SIRT1,': [297], 'murine': [300], 'brain.': [301], 'My': [302], 'results': [303, 342], 'show': [304, 343], 'SIRT1': [308], 'mRNA': [309], 'robustly': [312], 'expressed': [313, 329, 353], 'different': [315], 'brain': [316, 336, 356], 'regions': [317], 'including': [318], 'hippocampus,': [319], 'cortex,': [320], 'striatum,': [321], 'cerebellum': [323], 'throughout': [324], 'development,': [325], 'with': [326, 563], 'being': [328], 'at': [330], 'higher': [332], 'each': [335, 475], 'region.': [337], 'The': [338, 424, 463, 577], 'fact': [339], 'my': [341], 'robust': [347], 'ability,': [349], 'highly': [352], 'demonstrates': [357], 'it': [359], 'potential': [363], 'target': [365], 'age': [367], 'related': [368], 'decline': [369], 'Conference:': [370], 'B.R.A.I.N.': [371, 414], 'platform': [372, 415, 454], 'Physiology': [374, 417], 'poster': [375, 418], 'day': [376, 419], '2009,': [377], 'ON,': [379], 'Canada,': [380, 552], '16': [381, 384], 'Dec': [382, 534, 539], '-': [383], 'Dec,': [385], '2009.': [386, 420, 540], 'Presentation': [387, 390], 'Type:': [388], 'Poster': [389, 392], 'Topic:': [391], 'presentations': [393], 'Citation:': [394], 'Sidorova': [395, 582, 589, 597, 604], 'E,': [396], 'Mutabdzic': [397, 584, 591, 599, 606], 'D': [398], 'Eubanks': [400, 586, 593, 601, 608], 'J': [401], '(2009).': [402], 'factor?.': [409], 'Front.': [410], 'Neurosci.': [411], 'Conference': [412], 'Abstract:': [413], 'doi:': [421], '10.3389/conf.neuro.03.2009.17.043': [422], 'Copyright:': [423], 'abstracts': [425, 468], 'this': [427, 639], 'collection': [428, 489], 'not': [430, 442], 'subject': [432, 513], 'any': [434], 'Frontiers': [435, 452, 521, 564, 580, 612], 'peer': [436], 'review': [437], 'checks,': [439], 'endorsed': [443], 'Frontiers.': [445], 'They': [446], 'made': [448], 'available': [449], 'through': [450], 'publishing': [453], 'as': [455, 485, 487], 'service': [457], 'conference': [459], 'organizers': [460], 'presenters.': [462], 'copyright': [464], 'individual': [467], 'owned': [470], 'author': [473], 'abstract': [476], 'his/her': [478], 'employer': [479], 'unless': [480], 'otherwise': [481], 'stated.': [482], 'Each': [483], 'abstract,': [484], 'well': [486], 'abstracts,': [491], 'published': [493], 'under': [494], 'Creative': [496], 'Commons': [497], 'CC-BY': [498], '4.0': [499], '(attribution)': [500], 'licence': [501], '(https://creativecommons.org/licenses/by/4.0/)': [502], 'thus': [505], 'reproduced,': [507], 'translated,': [508], 'adapted': [509], 'derivative': [515], 'works': [516], 'provided': [517], 'authors': [519], 'attributed.': [523], 'For': [524], 'Frontiers’': [525], 'terms': [526], 'conditions': [528], 'please': [529], 'see': [530, 634], 'https://www.frontiersin.org/legal/terms-and-conditions.': [531], 'Received:': [532], '18': [533, 538], '2009;': [535], 'Published': [536], 'Online:': [537], '*': [541], 'Correspondence:': [542], 'Sidorova,': [544], '[email protected]': [553], 'Login': [554], 'Required': [555], 'This': [556], 'action': [557], 'requires': [558], 'you': [559], 'registered': [562], 'logged': [566], 'in.': [567], 'register': [569], 'login': [571], 'click': [572], 'here.': [573], 'Info': [575], 'Authors': [578], 'Google': [587, 594, 613], 'Scholar': [595, 614], 'PubMed': [602, 615], 'Related': [609], 'Article': [610], 'Close': [617], 'top': [620], 'Javascript': [621, 626], 'disabled.': [623], 'Please': [624], 'enable': [625], 'your': [628], 'browser': [629], 'settings': [630], 'order': [632], 'all': [635], 'content': [637], 'on': [638], 'page.': [640]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2327960937', 'counts_by_year': [], 'updated_date': '2024-12-12T17:59:01.399069', 'created_date': '2016-06-24'}