Publication Information

{'id': 'https://openalex.org/W2327903814', 'doi': 'https://doi.org/10.2307/3279470', 'title': 'Effect of Pyrimethamine and Sulfadiazine on the Fine Structure and Multiplication of Toxoplasma gondii in Cell Cultures', 'display_name': 'Effect of Pyrimethamine and Sulfadiazine on the Fine Structure and Multiplication of Toxoplasma gondii in Cell Cultures', 'publication_year': 1975, 'publication_date': '1975-08-01', 'ids': {'openalex': 'https://openalex.org/W2327903814', 'doi': 'https://doi.org/10.2307/3279470', 'mag': '2327903814', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1165554'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2307/3279470', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S31573680', 'display_name': 'Journal of Parasitology', 'issn_l': '0022-3395', 'issn': ['0022-3395', '1937-2345'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316431', 'host_organization_name': 'American Society of Parasitologists', 'host_organization_lineage': ['https://openalex.org/P4310316431'], 'host_organization_lineage_names': ['American Society of Parasitologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048933422', 'display_name': 'Harley G. Sheffield', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Harley G. Sheffield', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5083348234', 'display_name': 'Marjorie L. Melton', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Marjorie L. Melton', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 42, 'citation_normalized_percentile': {'value': 0.9446, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '61', 'issue': '4', 'first_page': '704', 'last_page': '704'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11155', 'display_name': 'Toxoplasma gondii Research Studies', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11155', 'display_name': 'Toxoplasma gondii Research Studies', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 0.9784, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13639', 'display_name': 'Paraquat toxicity studies and treatments', 'score': 0.9688, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/toxoplasmosis', 'display_name': 'Toxoplasmosis', 'score': 0.75837445}, {'id': 'https://openalex.org/keywords/hemocytometer', 'display_name': 'Hemocytometer', 'score': 0.4823122}], 'concepts': [{'id': 'https://openalex.org/C2778269047', 'wikidata': 'https://www.wikidata.org/wiki/Q2555060', 'display_name': 'Sulfadiazine', 'level': 3, 'score': 0.9782175}, {'id': 'https://openalex.org/C2777035104', 'wikidata': 'https://www.wikidata.org/wiki/Q421072', 'display_name': 'Pyrimethamine', 'level': 4, 'score': 0.9632827}, {'id': 'https://openalex.org/C2778128430', 'wikidata': 'https://www.wikidata.org/wiki/Q131003', 'display_name': 'Toxoplasma gondii', 'level': 3, 'score': 0.89643925}, {'id': 'https://openalex.org/C2778062946', 'wikidata': 'https://www.wikidata.org/wiki/Q154878', 'display_name': 'Toxoplasmosis', 'level': 2, 'score': 0.75837445}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.660084}, {'id': 'https://openalex.org/C180032290', 'wikidata': 'https://www.wikidata.org/wiki/Q1664296', 'display_name': 'Inoculation', 'level': 2, 'score': 0.55940074}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.48365104}, {'id': 'https://openalex.org/C19374876', 'wikidata': 'https://www.wikidata.org/wiki/Q247170', 'display_name': 'Hemocytometer', 'level': 2, 'score': 0.4823122}, {'id': 'https://openalex.org/C32611913', 'wikidata': 'https://www.wikidata.org/wiki/Q2166189', 'display_name': 'Titer', 'level': 3, 'score': 0.45660356}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.4510554}, {'id': 'https://openalex.org/C2778566189', 'wikidata': 'https://www.wikidata.org/wiki/Q101274', 'display_name': 'Protozoa', 'level': 2, 'score': 0.44458714}, {'id': 'https://openalex.org/C71928629', 'wikidata': 'https://www.wikidata.org/wiki/Q804206', 'display_name': 'Parasite hosting', 'level': 2, 'score': 0.44398132}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.32878405}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.23869005}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.19950321}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11924726}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.08009553}, {'id': 'https://openalex.org/C2777425658', 'wikidata': 'https://www.wikidata.org/wiki/Q422438', 'display_name': 'Chloroquine', 'level': 3, 'score': 0.07657704}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.07535192}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.06991139}, {'id': 'https://openalex.org/C136764020', 'wikidata': 'https://www.wikidata.org/wiki/Q466', 'display_name': 'World Wide Web', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D011739', 'descriptor_name': 'Pyrimethamine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D013411', 'descriptor_name': 'Sulfadiazine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D014122', 'descriptor_name': 'Toxoplasma', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011739', 'descriptor_name': 'Pyrimethamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013411', 'descriptor_name': 'Sulfadiazine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014122', 'descriptor_name': 'Toxoplasma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014122', 'descriptor_name': 'Toxoplasma', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2307/3279470', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S31573680', 'display_name': 'Journal of Parasitology', 'issn_l': '0022-3395', 'issn': ['0022-3395', '1937-2345'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316431', 'host_organization_name': 'American Society of Parasitologists', 'host_organization_lineage': ['https://openalex.org/P4310316431'], 'host_organization_lineage_names': ['American Society of Parasitologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1165554', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4230614452', 'https://openalex.org/W2461196744', 'https://openalex.org/W2405062015', 'https://openalex.org/W2338582275', 'https://openalex.org/W2328289254', 'https://openalex.org/W2327903814', 'https://openalex.org/W2087668195', 'https://openalex.org/W2066355362', 'https://openalex.org/W1949182617', 'https://openalex.org/W1480418187'], 'abstract_inverted_index': {'Rhesus': [0], 'monkey': [1], 'kidney': [2], 'cell': [3], 'cultures': [4, 34], 'were': [5, 25, 50, 71, 104], 'inoculated': [6], 'with': [7, 18], 'Toxoplasma': [8], 'gondii': [9], 'organisms': [10], 'obtained': [11], 'from': [12], 'peritoneal': [13], 'fluid': [14], 'of': [15, 44, 62, 108, 111, 129, 135], 'mice': [16], 'infected': [17], 'the': [19, 33, 42, 45, 48, 63, 136], 'RH': [20], 'strain.': [21], 'Pyrimethamine': [22, 57], 'and': [23, 54, 65, 73, 115], 'sulfadiazine': [24, 116], 'added': [26], 'either': [27], 'singly': [28], 'or': [29], 'in': [30, 95], 'combination': [31, 107], 'to': [32, 101, 122], '4': [35], 'hr': [36], 'after': [37], 'inoculation.': [38], 'Twenty-four': [39], 'hours': [40], 'later': [41], 'effect': [43, 92], 'drugs': [46], 'on': [47], 'parasites': [49, 64, 97], 'studied': [51], 'by': [52, 84], 'light': [53], 'electron': [55], 'microscopy.': [56], '(1.0': [58], 'mug/ml)': [59, 114, 118], 'inhibited': [60, 81], 'multiplication': [61], 'caused': [66], 'striking': [67], 'morphological': [68], 'changes.': [69], 'Organisms': [70], 'rounded': [72], 'often': [74], 'had': [75], 'a': [76, 126, 132], 'fragmented': [77], 'nucleus.': [78], 'Division': [79], 'was': [80, 93], 'as': [82], 'indicated': [83], 'abnormal': [85], 'daughter': [86], 'membrane': [87], 'formation': [88], 'during': [89], 'endodyogeny.': [90], 'No': [91], 'evident': [94], 'sulfadiazine-treated': [96], 'when': [98], 'concentrations': [99], 'up': [100], '50': [102], 'mug/ml': [103], 'used.': [105], 'However,': [106], 'ineffective': [109], 'levels': [110], 'pyrimethamine': [112, 130], '(0.1': [113], '(0.5': [117], 'produced': [119], 'effects': [120], 'similar': [121], 'those': [123], 'seen': [124], 'at': [125], 'higher': [127], 'concentration': [128], 'indicating': [131], 'synergistic': [133], 'action': [134], '2': [137], 'drugs.': [138]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2327903814', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-13T13:29:08.217149', 'created_date': '2016-06-24'}