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'(以下PC)': [2], '系及びセファロスポリン': [3], '(以下CEP)': [4], '系の抗生剤は,': [5], 'それぞれ中心骨格にβ-lactam環を有することから,': [6], 'β-lactam系抗生剤と総称されてきた.': [7], 'β-lactam剤は不活化酵素β-lactamase': [8], '(Penicillinase,': [9], 'Cephalosporinase)': [10], 'によって分解され,': [11], '抗菌活性を失う.β-lactamase産生菌による感染症の増加に伴い,': [12], 'その対策が検討されてきたが,': [13], 'CEP系薬剤のβ-lactam環の7α位にmethoxy基': [14], '(-OCH3)': [15], 'を導入したものがβ-lactamaseに対して安定であり,': [16], 'この構造を基本骨格とする薬剤をcephamycim系と呼ぶことになった.': [17], '今日では一般のCEP剤とcephamycin剤とをあわせてcephem系抗生剤と呼び,': [18], 'PC剤と区別している.': [19], 'PC系では構造上β-lactamaseに対して安定なものはまだつくられていない.過去10年ほどの間に抗菌剤はPC系,': [20], 'cephem系,': [21], 'それにアミノグルコシド': [22], '(以下AG)': [23], '系を中心としてめざましい進歩をとげてきた.': [24], '新しい薬剤開発の主眼点は抗菌スペクトルの拡大と抗菌力の強化,': [25], '高い血中濃度の持続,': [26], 'cephem系の場合のβ-lactamaseへの安定性,': [27], 'そして副作用の軽減にある.': [28], 'これら新しい薬剤のいくつかはすでに実地医家の使用し得るところとなっているが,': [29], 'それぞれの特徴を生かした適正な使用が望まれる.透析患者の場合,': [30], '感染症の合併はいわゆるcompromised': [31], 'hostへのそれに該当し,': [32], '特異な病態を呈するとともに,': [33], '抗菌剤の使用に際しては多くの薬剤の主要排泄経路である腎の機能廃絶による体内動態の特殊性に対する慎重な配慮が必要となる.': [34]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2327607621', 'counts_by_year': [], 'updated_date': '2024-09-19T19:04:36.647730', 'created_date': '2016-06-24'}