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{'GC/MSによるヒト血しょう中のアンフェナクナトリウム(AMF)及び代謝物(S1,S2,S3)の測定法を開発した.アルカリ条件下でS1を溶媒抽出により分離し,その後酸処理によりAMFをS1に変換しS2,': [0], 'S3と共に溶媒抽出した.S1及びS1に変換されたAMFはそのまま,S2,S3はメチルエステル誘導体に導きGC/MSで定量した.この測定法の開発によりAMF,S1に併せ,': [1], 'S2,': [2], 'S3の同時定量が可能となった.ヒトにAMF製剤を投与し,その血しょう中濃度を測定したところ,AMFとその代謝物の血しょう中濃度はそれぞれ異なる推移を示した.': [3]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2327448060', 'counts_by_year': [], 'updated_date': '2024-09-18T21:07:46.548238', 'created_date': '2016-06-24'}