Title: Duloxetine in the Treatment of Stress Urinary Incontinence
Abstract: Objective: To review the available literature regarding the use of duloxetine in the treatment of stress urinary incontinence. Data Sources: Clinical trials were obtained through a PubMed search (1966–December 2004) with the key words duloxetine, urinary incontinence, and stress. Data Synthesis: This article analyzes 5 clinical studies comparing duloxetine with placebo. The randomized, double-blind, multicenter trials were performed in the US and throughout the world and had strict inclusion criteria to enroll only patients with confirmed stess urinary incontinence. All trials showed a statistically significant decrease in incontinence episode frequency of 50–60% for duloxetine compared with a placebo response of 27–40%. Conclusions: Duloxetine appears to be an effective treatment for stress urinary incontinence. Additional trials comparing duloxetine with pelvic floor muscle training would better define duloxetine's place in therapy.
Publication Year: 2005
Publication Date: 2005-11-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 10
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