USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15

Name: Work Video:
Duration: 3 min 30 s
Nidhi Sharma; Qianzheng Zhu; Gulzar Wani; Jingshan He; Qi-En Wang; Altaf A. Wani
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[15], 'genomic': [16], 'integrity': [17], 'eukaryotic': [19], 'cells.': [20], 'In': [21, 135], 'DDR,': [22], 'of': [24, 33, 43, 59, 83, 103, 109, 142, 173, 184, 202], 'histone': [25], 'H2A': [26, 86, 111, 174], 'and': [27, 38, 85, 112, 147, 158, 171, 175, 182, 207], 'γH2AX': [28, 84, 113, 133], 'by': [29, 95], 'the': [30, 57, 77, 91, 107, 140, 150, 164, 193], 'concerted': [31], 'action': [32], 'ubiquitin': [34], '(Ub)': [35], 'ligases,': [36], 'RNF168': [37], 'RNF8,': [39], 'generates': [40], 'cascade': [42], 'signaling.': [45], 'However,': [46], 'little': [47], 'known': [49], 'about': [50], 'deubiquitinating': [51, 80], 'enzymes': [52], '(DUBs)': [53], 'that': [54, 67, 100, 163, 196], 'may': [55], 'catalyze': [56], 'removal': [58], 'Ub': [60, 81, 167], 'from': [61, 87], 'these': [62], 'histones.': [63], 'This': [64], 'study': [65], 'demonstrated': [66], 'USP3,': [68], 'an': [69], 'apparent': [70], 'DUB': [71], 'mono-ubiquitinated': [73], 'H2A,': [74], 'indeed': [76], 'enzyme': [78], 'conjugates': [82], 'lysine': [88, 169, 180], 'sites,': [89], 'where': [90], 'initiated': [94], 'RNF168.': [96], 'Here,': [97], 'we': [98], 'showed': [99], 'ectopic': [101, 121], 'expression': [102, 123], 'USP3': [104, 122, 137, 165, 197], 'led': [105], 'to': [106, 116, 155, 188], 'deubiquitination': [108], 'both': [110, 156], 'UV-induced': [117], 'damage.': [119, 190], 'Moreover,': [120], 'abrogated': [124], 'FK2': [125], 'antibody-reactive': [126], 'Ub-conjugate': [127], 'foci,': [128], 'co-localize': [130], 'with': [131], 'damage-induced': [132], 'foci.': [134], 'addition,': [136], 'overexpression': [138], 'impaired': [139], 'accumulation': [141], 'downstream': [143], 'repair': [144], 'factors': [145], 'BRCA1': [146], '53BP1': [148], 'at': [149, 168], 'sites': [152], 'UV': [157], 'γ-irradiation.': [159], 'We': [160], 'further': [161], 'identified': [162], 'removes': [166], '13': [170], '15': [172], 'γH2AX,': [176], 'as': [177, 179], 'well': [178], '118': [181], '119': [183], 'H2AX': [185], 'Taken': [191], 'together,': [192], 'results': [194], 'suggested': [195], 'negative': [200], 'regulator': [201], 'signaling,': [204], 'counteracting': [205], 'RNF168-': [206], 'RNF8-mediated': [208], 'ubiquitination.': [209]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2325525628', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-08T17:46:58.242853', 'created_date': '2016-06-24'}
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