Publication Information

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'https://openalex.org/W1637842267', 'https://openalex.org/W1963788239', 'https://openalex.org/W1988311586', 'https://openalex.org/W2092706135', 'https://openalex.org/W2276857226', 'https://openalex.org/W2396658039', 'https://openalex.org/W2418774746'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3038368404', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2952799419', 'https://openalex.org/W2949225309', 'https://openalex.org/W2803559780', 'https://openalex.org/W2760404309', 'https://openalex.org/W2748952813', 'https://openalex.org/W2417584819'], 'abstract_inverted_index': {'老化とともに免疫能に異常をきたすことが知られている.': [0], 'この老年者の免疫異常におけるmonocyte': [1], 'の役割を知るために以下の検索をおこなった.Mitogen': [2], 'に対する末梢リンパ球の反応が,': [3], 'monocyte': [4, 10, 13, 23, 26, 29, 33, 38, 40, 45, 47, 52, 54, 57, 59], 'の': [5, 34, 41, 60], 'helper': [6, 35, 42, 61], '能を必要とすることを確認するために,': [7], '25～35歳の健常若年者末梢単核球より,': [8], 'リンパ球と': [9], 'を分離して,': [11], 'リンパ球+MMC処理': [12], 'の組み合わせを作成し,': [14], 'PWMおよび': [15], 'Con': [16, 31], 'A刺激下に培養した.': [17], '培養3日目に3H-TdRの取りこみを,': [18], '8日目にIgG産生量を測定して検討した.PWMおよびCon': [19], 'A刺激培養とも,': [20], 'リンパ球のみの場合は3H-TdRの取りこみは低値であり,': [21], '加える': [22], 'の数を増加するにつれて3H-TdRの取りこみは高値を示すようになった.': [24], 'またPWM刺激培養時のIgG産生もリンパ球のみの場合は極めて低値であり,': [25], '数を増加するにつれて高値を示した.': [27], 'しかし': [28], 'の数が1×105/0.2mlと過剰になると逆にIgG産生が低下する例もみられた.以上によりPWM,': [30], 'A刺激下でのリンパ球反応は': [32], '能を必要とするが,': [36], '培養中の': [37], 'が過剰になると反応が抑制される場合もあることを示している.この': [39], '能を若年者と老年者で比較検討するために,': [43], '若年者リンパ球+若年者': [44], 'または老年者': [46], 'の組み合わせを作成して,': [48], 'PWMおよびCon': [49], 'A刺激下培養をおこなった.': [50], '3日間培養とも若年者リンパ球+若年者': [51], 'の培義のほうが若年者リンパ球+老年者': [53], 'の培養に比較して高値を示した.': [55], 'また8日間培養時のIgG産生も同様の傾向にあったが,': [56], 'の数が5×104コ/0.2mlの場合両者に差を認めなかった.以上により老年者': [58], '能に一部異常があることが示唆された.': [62]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2324949846', 'counts_by_year': [], 'updated_date': '2024-12-07T23:57:59.455692', 'created_date': '2016-06-24'}