Publication Information

{'id': 'https://openalex.org/W2323195313', 'doi': 'https://doi.org/10.1080/14728222.2016.1177023', 'title': 'Polydatin ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3 activation-mediated mitochondrial protection', 'display_name': 'Polydatin ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3 activation-mediated mitochondrial protection', 'publication_year': 2016, 'publication_date': '2016-04-12', 'ids': {'openalex': 'https://openalex.org/W2323195313', 'doi': 'https://doi.org/10.1080/14728222.2016.1177023', 'mag': '2323195313', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27067422'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/14728222.2016.1177023', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S149756942', 'display_name': 'Expert Opinion on Therapeutic Targets', 'issn_l': '1472-8222', 'issn': ['1472-8222', '1744-7631'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012742428', 'display_name': 'Zhenhua Zeng', 'orcid': 'https://orcid.org/0000-0002-9509-1536'}, 'institutions': [{'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}, {'id': 'https://openalex.org/I4210103346', 'display_name': 'Nanfang Hospital', 'ror': 'https://ror.org/01eq10738', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103346']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhenhua Zeng', 'raw_affiliation_strings': ['Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, P. 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'https://openalex.org/W3004977503', 'https://openalex.org/W2871319946', 'https://openalex.org/W2732745478', 'https://openalex.org/W2519035758', 'https://openalex.org/W2027896438', 'https://openalex.org/W1579826661'], 'abstract_inverted_index': {'Background:': [0], 'Previously,': [1], 'we': [2], 'demonstrated': [3], 'that': [4, 22], 'sirtuin': [5], '(SIRT)1': [6], 'plays': [7], 'vital': [8], 'roles': [9], 'in': [10, 40, 54, 68, 97, 170], 'the': [11, 34, 152, 183], 'small': [12], 'intestine': [13], '(SI),': [14], 'protecting': [15], 'against': [16], 'severe': [17], 'hemorrhagic': [18], 'shock': [19], '(HS),': [20], 'and': [21, 38, 45, 62, 71, 77, 81, 85, 91, 100, 114, 130, 140, 186], 'polydatin': [23], '(PD)': [24], 'can': [25], 'attenuate': [26], 'SI': [27, 41, 98], 'injury': [28, 42], 'via': [29, 180], 'SIRT1': [30, 162], 'activation.Objective:': [31], 'To': [32], 'explore': [33, 46], 'role': [35], 'of': [36, 52, 59, 79, 93, 146, 155, 182], 'SIRT3': [37, 47], 'mitochondria': [39], 'after': [43, 103], 'HS,': [44], 'as': [48], 'a': [49, 189], 'therapeutic': [50], 'target': [51], 'PD': [53, 119, 176], 'HS.Methods:': [55], 'An': [56], 'H2O2-induced': [57], 'model': [58, 65], 'oxidative': [60, 106], 'stress': [61], 'an': [63, 110], 'HS': [64, 104, 193], 'were': [66, 88, 95], 'created': [67], 'IEC-6': [69, 101], 'cells': [70, 102], 'Sprague–Dawley': [72], 'rats,': [73], 'respectively.': [74], 'Protein': [75], 'content': [76], 'activity': [78, 92, 124, 139], 'SIRT1/3': [80, 94, 123, 127], 'SOD2,': [82], 'acetylated-SOD2': [83, 112, 132], 'level,': [84], 'mitochondrial': [86, 142, 171, 178], 'morphology/function': [87], 'determined.Results:': [89], 'Expression': [90], 'reduced': [96, 131], 'tissue': [99], 'or': [105, 120], 'stress,': [107], 'accompanied': [108], 'by': [109, 174], 'increased': [111, 161], 'level': [113], 'damaged': [115], 'mitochondria.': [116], 'Treatment': [117], 'with': [118], 'resveratrol': [121], 'restored': [122, 126], 'considerably,': [125], 'expression': [128], 'slightly,': [129], 'levels,': [133], 'which': [134], 'lead': [135], 'to': [136], 'elevated': [137], 'SOD2': [138], 'ameliorated': [141], 'function.': [143], 'The': [144, 164], 'addition': [145], '3-TYP': [147], '(SIRT3': [148], 'inhibitor)': [149], 'partially': [150], 'blocked': [151], 'mitochondrial-protective': [153], 'effects': [154], 'PD,': [156], 'but': [157], 'did': [158], 'not': [159], 'affect': [160], 'activity.Conclusions:': [163], 'SIRT3–SOD2': [165, 184], 'signaling': [166], 'pathway': [167], 'is': [168], 'involved': [169], 'dysfunction': [172, 179], 'induced': [173], 'HS.': [175], 'attenuates': [177], 'activation': [181], 'pathway,': [185], 'may': [187], 'be': [188], 'new': [190], 'approach': [191], 'for': [192], 'treatment.': [194]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2323195313', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2025-01-07T18:05:41.095010', 'created_date': '2016-06-24'}